Clinical trials: Nephrectomy, open to volunteers
Kidney Transplant, Kidney Transplant Donor
Outcomes of a Pre-operative Exercise Programme for Live Donor and Recipient Kidney Transplant Patients
The goal of this clinical trial is to learn if a pre-operative outpatient exercise programme, monitored by a smart wearable device is acceptable to live kidney donor and recipient transplant patients.
- Conditions
- Kidney Transplant, Kidney Transplant Donor, Kidney Transplant Recipient
- Trial name
- OPERATe (NCT06858098)
- Testing
- Exercise programme, Wearable smart device
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Manchester
Tumoral Kidney
Rein 3D PRINT PERSONALIZE
The goal of this clinical trial is to compare preoperative information and patient experience using a personalized versus a generic 3D printed models of patients' tumoral kidney before and after nephron-sparing surgery.
- Trial name
- R3DP-P (NCT06379698)
- Testing
- personalized 3D model pré-opérative education, generic 3D model pré-opérative education
- Where
- France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Bordeaux
Renal Neoplasms, Localized Kidney Tumors
Effect of Non-Clamping and Sutureless Technique on Postoperative Renal Function in Robot-Assisted Partial Nephrectomy
Partial nephrectomy is an operation that removes a kidney tumor while leaving the rest of the kidney in place. It is used to treat selected patients with small tumors confined to the kidney.
- Trial name
- NCT07888608
- Testing
- Off-Clamp, Sutureless Robot-Assisted Partial Nephrectomy, Conventional Robot-Assisted Partial Nephrectomy With Artery Clamping and Sutured Reconstruction
- Where
- China
- Volunteers
- 304 people
- Sponsor
- Shao Pengfei
Vorolanib, Clear Cell Renal Cell Carcinoma (ccRCC)
Pucotenlimab Combination With Vorolanib as Neoadjuvant Therapy for ccRCC
Through the neoadjuvant treatment with a combination of Pucotenlimab and Vorolanib, it enabled the successful and safe implementation of partial nephrectomy in patients with localized renal cancer, who had indications for…
- Conditions
- Vorolanib, Clear Cell Renal Cell Carcinoma (ccRCC), Neoadjuvant Therapy
- Trial name
- NCT07386158
- Testing
- Pucotenlimab combination with Vorolanib
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Sun Yat-sen University
Laparoscopic, Nephrectomy
Low-Thoracic Epidural Anesthesia For Laparoscopic Nephrectomy.
Laparoscopic nephrectomy is a surgical technique to excise a diseased kidney. It's a minimally invasive technique, so when compared to open surgery, it can mean significantly less post-operative pain, shorter hospital stay…
- Conditions
- Laparoscopic, Nephrectomy, Anesthesia, Epidural
- Trial name
- NCT04546230
- Testing
- Low-Thoracic Epidural Anesthesia, General Anesthesia
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Nazmy Edward Seif
Kidney Cancer, Renal Cell Carcinoma Metastatic
Deferred Cytoreductive Nephrectomy in Synchronous Metastatic Renal Cell Carcinoma: The NORDIC-SUN-Trial
BACKGROUND: For synchronous metastatic renal cell carcinoma (RCC), surgical resection of the primary tumor in the presence of distant metastases has been the standard of therapy for select patients followed by systemic therapy.
- Conditions
- Kidney Cancer, Renal Cell Carcinoma Metastatic, Synchronous Neoplasm
- Trial name
- NORDIC-SUN (NCT03977571)
- Testing
- Cytoreductive nephrectomy, Tissue sampling
- Where
- 11 sites in Denmark, Finland and 2 more
- Volunteers
- 400 people
- Sponsor
- Niels Fristrup
Renal Cancer
Study to Compare Two Partial Nephrectomy Techniques for Renal Tumors: Robot-assisted vs Videolaparoscopic
Randomized, open-label clinical trial to compare renal volumetry pre and post operative in patients undergoing two types of partial nephrectomy techniques for renal tumors: robot-assisted vs videolaparoscopic.
- Trial name
- VPN x RANP (NCT06441851)
- Testing
- Videolaparoscopic Partial Nephrectomy, Robot-assisted Partial Nephrectomy
- Volunteers
- 50 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Renal Cell Cancer
Using 3D Kidney Model Based on Artificial Intelligence to Assist Partial Nephrectomy: A Prospective Validation Study
The goal of this study is to develop a real-time artificial intelligence-driven 3D kidney model to assist robotic or laparoscopic partial nephrectomy: Can this AI-powered model optimize the workflow of partial nephrectomy and…
- Trial name
- NCT07020169
- Testing
- an AI-based real-time image-guided kidney model system
- Where
- 2 sites in China
- Volunteers
- 232 people
- Sponsor
- Shao Pengfei
Nephrectomy / Methods, Intraoperative Hypothermia
Effect of Preoperative Prewarming on Serum Lactate Levels in Patients Undergoing Elective Nephrectomy
The goal of this observational study is to learn whether warming patients before surgery, called "prewarming," affects blood lactate levels (a marker of how well tissues are getting oxygen) and recovery in adults having planned…
- Conditions
- Nephrectomy / Methods, Intraoperative Hypothermia, Hyperlactatemia
- Trial name
- NCT07702487
- Testing
- Preoperative active warming (prewarming)
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Beyzanur Aydoğdu
Kidney Cancer, Clear Cell Renal Cell Carcinoma Metastatic
The Role of Cytoreductive Nephrectomy in Metastatic Renal Cell Carcinoma in Immuno-oncology Era: SEVURO-CN Trial
BACKGROUND: The role of cytoreductive nephrectomy (CN) in the treatment of metastatic renal cell carcinoma (mRCC) has been questioned and remains undetermined in the immuno-oncology era.
- Conditions
- Kidney Cancer, Clear Cell Renal Cell Carcinoma Metastatic, Synchronous Neoplasm
- Trial name
- SEVURO-CN (NCT05753839)
- Testing
- Cytoreductive nephrectomy±metastasectomy, Human-derived materials sampling
- Where
- 3 sites in South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Prostatectomy, Cystectomy
Hugo™ RAS Urology Post-Market Clinical Study
The purpose of this study is to collect evidence on the safety and performance of the Medtronic Hugo™ RAS System when used for urologic RAS procedures.
- Conditions
- Prostatectomy, Cystectomy, Nephrectomy, Urologic Cancer
- Trial name
- NCT07901049
- Testing
- Robotic Assisted Urologic Surgery
- Volunteers
- 110 people
- Sponsor
- Medtronic - MITG
Renal Cell Carcinoma
A Study of Cemiplimab and Fianlimab in People With Clear Cell Renal Cell Carcinoma
The researchers are doing this study to find out whether it is practical (feasible) to give cemiplimab and fianlimab before a nephrectomy and whether it causes any delays with surgery in people with kidney cancer.
- Trial name
- NCT06699602
- Testing
- Cemiplimab, Fianlimab
- Where
- 7 sites in United States
- Volunteers
- 10 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Postoperative Pain, Acute
Effect of Sufentanil on the Postoperative Pain
This study is a randomized, controlled trial. A total of 48 patients will be randomized to receive sufentanil or remifentanil during robot-assisted nephrectomy surgery.
- Trial name
- NCT06260046
- Testing
- Sufentanil, Remifentanil
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Seoul National University Hospital
Rhomboid Intercostal Sub-serratus Plane Block, External Oblique Intercostal Block
Rhomboid Intercostal Sub-serratus Plane Block Versus External Oblique Intercostal Block in Open Nephrectomy
This study aims to compare time of first request of analgesia among patients undergoing rhomboid intercostal sub-serratus plane block versus external oblique intercostal block for perioperative pain management in open nephrectomy.
- Conditions
- Rhomboid Intercostal Sub-serratus Plane Block, External Oblique Intercostal Block, Open Nephrectomy
- Trial name
- NCT07642193
- Testing
- Rhomboid intercostal subserratus plane block, External oblique intercostal block, Intravenous morphine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Localized Clear Cell Renal Cell Carcinoma
Pucotenlimab, Lenvatinib, and SBRT Before Surgery for Localized Clear Cell Renal Cell Carcinoma
This single-arm Phase II study will evaluate the efficacy and safety of neoadjuvant pucotenlimab, lenvatinib, and stereotactic body radiotherapy (SBRT) in adults with localized clear cell renal cell carcinoma who are candidates…
- Trial name
- PLS-NEO-RCC (NCT07922915)
- Testing
- Pucotenlimab, Lenvatinib, Stereotactic Body Radiotherapy
- Volunteers
- 24 people
- Sponsor
- Sun Yat-sen University
Metastatic Clear Cell Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma
Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial
This phase III trial compares the effect of adding surgery to a standard of care immunotherapy-based drug combination versus a standard of care immunotherapy-based drug combination alone in treating patients with kidney cancer…
- Conditions
- Metastatic Clear Cell Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma, Stage IV Renal Cell Cancer AJCC v8
- Trial name
- PROBE (NCT04510597)
- Testing
- Cytoreductive Nephrectomy, Active Comparator
- Where
- 387 sites in United States
- Volunteers
- 364 people
- Sponsor
- SWOG Cancer Research Network
Kidney Neoplasms
Cryaoablation Assisted Partial Nephrectomy a Non Ischemic Approach
Patients with renal masses eligible to partial nephrectomy often require arterial ischemia to control or prevent blood loss during this surgical procedure.
- Trial name
- RCAPN (NCT05218811)
- Testing
- Cryoablation Assisted Partial Nephrectomy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Urological Research Network, LLC
Renal Cancer
Kidney Cancer Observational Protocol
The aim of this observational study is to gather pre and post surgery clinical data belonging to patients who underwent radical or partial nephrectomy and to evaluate the impact of the surgery on the quality of life of the…
- Trial name
- NCT06147349
- Testing
- Radical or partial nephrectomy
- Where
- Italy
- Volunteers
- 2,500 people
- Sponsor
- IRCCS San Raffaele
Renal Tumor, Renal Cancer
A CCafU-UroCCR Randomized Trial: 3D Image-Guided Robot-AssisTEd Partial Nephrectomy for Renal Complex Tumor (UroCCR N°99)
The goal of this clinical trial is to evaluate peri and post-operative outcomes as well as long-term survival of 3D IGRAPN compared to conventional Robot-Assisted Partial Nephrectomy (RAPN) for moderate and highly complex renal…
- Trial name
- ACCURATE (NCT05572216)
- Testing
- Robot assisted partial nephrectomy with 3D image guidance
- Where
- 2 sites in France
- Volunteers
- 694 people
- Sponsor
- University Hospital, Grenoble
Metastatic Clear Cell Renal Cell Carcinoma, Advanced Clear Cell Renal Cell Carcinoma
TACTIC-RCC: Toripalimab Plus Axitinib Induction With Selective Deferred Cytoreductive Nephrectomy in TLS-Positive Advanced Clear Cell Renal Cell Carcinoma
This prospective, open-label, single-arm Phase 2 study is evaluating toripalimab plus axitinib as induction therapy for adults with newly diagnosed metastatic clear cell renal cell carcinoma whose primary kidney tumor remains in…
- Trial name
- TACTIC-RCC (NCT07776717)
- Testing
- Toripalimab, Axitinib, Deferred Cytoreductive Nephrectomy
- Volunteers
- 30 people
- Sponsor
- Fudan University