Clinical trials: Nerve Condition
Neuroinflammatory Response, Nerve Injury
Assessment of Nerve Damage Biomarkers in Acute and Chronic Organophosphate Toxicity
The aim of this observational study is to answer the following questions in individuals with acute and chronic exposure to organophosphates. The main questions to be addressed are 1.
- Conditions
- Neuroinflammatory Response, Nerve Injury, Nerve Damage, Neurotoxicity
- Trial name
- NCT06021262
- Testing
- exposure to organophosphates
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Epilepsy
Assessment of Effect of Vagal Nerve Stimulator (VNS) on Electrocorticograms Recorded by Responsive Neurostimulator (RNS) in Patients With Drug Resistant Epilepsy
This study will investigate whether a Vagal Nerve Stimulator (VNS) causes measurable desynchronization and reduces epileptiform activity, such as spikes and seizures, in electrocorticograms (ECOGs) recorded by a Responsive…
- Trial name
- NCT03595072
- Testing
- observation of VNS stimulation effects
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Amblyopia, Strabismus
Amblyopia and Strabismus Detection Using Retinal Birefringence Imaging
The purpose of this project is to compare the accuracy of two products at detecting amblyopia and strabismus in children. The devices will be Rebiscan's "blinq" (Pediatric Vision Scanner; PVS) and Rebiscan's RBI (Retinal…
- Trial name
- RBI (NCT03919708)
- Testing
- Retinal Birefringence Imager
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rebiscan, Inc.
Spinal Cord Injuries, Bladder, Neurogenic
Functional Changes in the Brain After Tibial Nerve Stimulation: a Pilot Study
The lower urinary tract is innervated by the autonomous (sympathetic, parasympathetic) and the somatic nervous system. Afferent information from the lower urinary tract (LUT) (e.g.
- Trial name
- NCT03908047
- Testing
- magnetic resonance imaging
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Neuropathy, Diabetic, Neuropathy, Painful
Methods of Early Detection and Grading Of Diabetic Peripheral Neuropathy (MEDON)
MEDON aims to examine new methods for early detection and grading of diabetic peripheral neuropathy focusing on both small- and large nerve fibers.
- Trial name
- MEDON (NCT04078516)
- Testing
- Perception Threshold Tracking (PTT), Axon-flair mediated respons, Heart rate variability
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Carpal Tunnel Syndrome (CTS), Biomarkers / Blood
Hematological and Metabolic Markers in Carpal Tunnel Syndrome
Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy, but the severity of symptoms experienced by patients does not always correspond to abnormalities detected by nerve conduction studies.
- Trial name
- NCT06952647
- Where
- Turkey (Türkiye)
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Ankara Training and Research Hospital
Multiple Sclerosis
Measuring Blood Vessel Density in the Optic Nerve of Multiple Sclerosis Patients With OCTA
The goal of this observational study is to learn about the effect of multiple sclerosis on the blood flow of the optic nerve of affected patients compared to normal subjects by OCTA. The main question it aims to answer is: 1.
- Trial name
- NCT07629804
- Testing
- Optical Coherence Tomography Angiography
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Pelvic Organ Prolapse
Preoperative Analgesia by Infiltration of the Pudendal Nerve Prior to Sacrospinous Ligament Suspension
Pelvic organ prolapse is a common problem. It affects about half of women and causes uncomfortable bulge sensations (similar to sitting on a ball), urine and stool problems, difficulty with sexual activity and embarrassment.
- Trial name
- PAINS (NCT04733560)
- Testing
- Pudendal nerve block, Bupivacaine Injectable Product
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fraser Health
Bell's Palsy
Kabat Rehabilitation Technique Versus Conventional Physical Therapy in Treatment of Bell's Palsy
To evaluate the comparative effectiveness of the Kabat rehabilitation technique with conventional physical therapy along with electrical stimulation in both, for reducing facial disability in patients with Bell's palsy.
- Trial name
- NCT06083389
- Testing
- kabat technique for rehabilitation of facial palsy, electrotherapy
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Minia University
vHIT- and VOG-model for Bilateral Vestibular Neuronitis
Ethanol-induced Vestibular Dysfunction as a Model for Bilateral Vestibular Syndrome.
The purpose of the study is to create a vHIT- and VOG-model for bilateral vestibular neuronitis, via ethanol administration in healthy human subjects.
- Trial name
- NCT04783610
- Testing
- Ethanol
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Postoperative Pain
Peripheral Nerve Blocks for Major Lower Extremity Amputations
This study will be a double-blinded randomized controlled trial analyzing all patients who will undergo major lower extremity amputations by the vascular surgery service at University of California, San Francisco (UCSF) Fresno…
- Trial name
- NCT03174782
- Testing
- Bupivacaine, Saline Solution
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Melanoma
Long Term Quality of Life in Melanoma Patients in Netherlands
Study of late physical, psychological and social effects in patients treated with ipilimumab for advanced (stage IV or unresectable stage III) melanoma.
- Trial name
- NCT03450876
- Testing
- Non-Interventional
- Where
- Netherlands
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Analgesia, Nerve Blocks
Evaluation of Adjuvant Use in Selective Trunk Block
"Evaluation of the Anesthetic and Analgesic Efficacy of Dexamethasone in Selective Trunk Blocks
- Conditions
- Analgesia, Nerve Blocks, Postoperative Pain, Acute
- Trial name
- NCT06540534
- Testing
- Dexamethasone, kontrol group
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Spinal Cord Injury
Acute Tendon and Nerve Responses to Exercise
The purpose of this study is to use ultrasound to analyze the effects of a bout of circuit training on the upper extremity of persons with spinal cord injury and able-bodied controls.
- Trial name
- NCT01197599
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Miami
Brachial Plexus Injury
Incidence of Brachial Plexus Injury After Rotator Cuff Repair With Continuous Interscalene Block
Brachial plexus injury after shoulder surgery with continuous interscalene block is 2.4% at 1 month and 0% at 6 months, but may be higher with a systematic postoperative neurological examination.
- Trial name
- NCT01334632
- Testing
- Continuous interscalene block, PCA morphine
- Where
- Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Inflammation
Anti-inflammatory Actions of Osteopathic Manipulative Treatment
This study evaluates the hypothesis that osteopathic manipulative treatment (OMT) and non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) elicit anti-inflammatory actions through activation of the…
- Trial name
- OMT_taVNS (NCT04177264)
- Testing
- Occipito-Atlantal Decompression (OA DC), Splenic Lymphatic Pump Technique (SpLPT), Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Burrell College of Health Sciences
Cancer, Breast, Cancer, Ovarian
Family History App in Personalized Medicine
A complete family history (FH) may identify persons at high risk for certain conditions. They can be offered genetic testing and life-saving screening and treatment.
- Conditions
- Cancer, Breast, Cancer, Ovarian, Cancer, Colorectal, Cancer, Prostate
- Trial name
- FHAMe (NCT04726319)
- Testing
- FHAMe Intervention
- Where
- Canada
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Mild Cognitive Impairment (MCI), Parkinsons Disease (PD)
Study to Investigate Vagus Nerve Stimulation to Augment Executive Function in Healthy and Cognitively Impaired Populations
This study plans to learn more about how stimulating the vagus nerve through gentle electrical stimulation applied to the ear can affect decision-making, problem-solving, and other thinking abilities.
- Conditions
- Mild Cognitive Impairment (MCI), Parkinsons Disease (PD), Healthy Adult
- Trial name
- NCT07424365
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pain Management, Anesthesia , Analgesia
Comparison Between External Oblique Intercostal Plane Block and Rectus Sheath Block Combined With Transversus Abdominis Plane Block
Effective perioperative pain management remains a cornerstone in enhancing recovery and improving patient outcomes in laparoscopic cholecystectomy.
- Conditions
- Pain Management, Anesthesia , Analgesia, Nerve Block
- Trial name
- NCT07384000
- Testing
- External intercostal plane puncture, control group (nalbuphine), the single-puncture technique of (rectus sheath block) combined with (Transversus abdominis plane block)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University
Melanoma, Skin Cancer
Melanoma Risk Assessment & Tailored Intervention
The investigators are conducting a study to provide evidence about the comparative effectiveness of mailed, tailored intervention materials on cancer prevention behavioral outcomes.
- Trial name
- PennSCAPE (NCT01356771)
- Testing
- Surveys & Mailed Materials
- Where
- United States
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
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