Clinical trials: Nerve Condition
NMO Spectrum Disorder
Efficacy and Safety of Belimumab in Neuromyelitis Optica Spectrum Disorders
Neuromyelitis Optica Spectrum Disorders (NMOSD) is associated with a pathological humoral immune response against the aquaporin-4(AQP-4) water channel.
- Trial name
- NCT05154734
- Testing
- Belimumab
- Where
- China
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Cognitive Decline
Preventing Cognitive Decline with Metformin
A randomised control study of metformin in people with mild cognitive impairment and without diabetes mellitus to determine effects on cognitive decline and neuroimaging over 3 years.
- Trial name
- MetMemory (NCT04511416)
- Testing
- Metformin XR, 500-2000mg nocte
- Where
- Australia
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Garvan Institute of Medical Research
Transcutaneous Electric Nerve Stimulation, Analgesia
Transcutaneous Electrical Nerve Stimulation for Post-Cesarean Pain Control
Purpose of study is to evaluate the efficacy of transcutaneous electrical nerve stimulation (TENS) for post-operative pain control after a cesarean delivery compared to placebo and no TENS.
- Conditions
- Transcutaneous Electric Nerve Stimulation, Analgesia, Cesarean Section
- Trial name
- NCT04399707
- Testing
- Transcutaneous electrical nerve stimulation (TENS) unit
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Hawaii Pacific Health
Parkinson's Disease, Progressive Supranuclear Palsy(PSP)
Study on Artificial Intelligence-Based Facial and Speech-Related Patterns in Parkinson's Disease and Their Digital Biomarkers
This research employs AI to analyze facial expressions and speech patterns, aiming to develop new digital tools for diagnosing and differentiating Parkinson's disease and similar disorders.
- Conditions
- Parkinson's Disease, Progressive Supranuclear Palsy(PSP), Multiple System Atrophy, Healthy Control
- Trial name
- NCT07392411
- Testing
- video recording
- Where
- China
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Intracranial Pressure Increase, Abdominal Pain
Different Intraperitoneal Pressures on Optic Nerve Sheath Diameter in Laparoscopic Surgeries
The aim of this study is to investigate the effects of low and normal intraperitoneal pressures on intraoperative optic nerve sheath diameter in laparoscopic gyneco-oncologic surgeries.
- Conditions
- Intracranial Pressure Increase, Abdominal Pain, Head Pain
- Trial name
- NCT07155109
- Testing
- Low pressure group, Normal pressure group
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Cubital Tunnel Syndrome
Comparison of Effect of Anterior Subcutaneous and Submuscular Transposition on Cubital Tunnel Syndrome
The purpose of this study is to determine which surgical method is better for cubital tunnel syndrome in outcomes.
- Trial name
- NCT01109901
- Testing
- anterior subcutaneous transposition, Anterior submuscular transposition
- Where
- Iran
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Obstructive Sleep Apnea, Sleep-Disordered Breathing
Tongue Morphology and Posterior Airway Space as Predictors of Response in Patientswith Hypoglossal Nerve Stimulation Therapy
Hypoglossal nerve stimulation (HNS) plays an increasingly important role in managing patients with obstructive sleep apnea (OSA) who do not tolerate CPAP therapy and are not eligible for other alternative treatment options, such…
- Trial name
- NCT06154577
- Testing
- Ultrasonography
- Where
- 2 sites in Switzerland
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Cantonal Hospital, Baselland
Obesity, Craving
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Food Craving in Obese Individuals.
Background: Obesity is one of the most important diseases around the globe; with a continuous increase and public health concern. Current treatments present some limitations.
- Trial name
- taVNS (NCT03217929)
- Testing
- Active-taVNS
- Where
- Brazil
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Malignant Melanoma
A Phase II Trial OF Carboplatin, ABI-007 (Abraxane) And Sorafenib (BAY 43-9006) in Metastatic Melanoma
The purpose of this study is to compare the effects, good and/or bad, of Carboplatin and ABI-007 (Abraxane) in combination with Sorafenib (BAY 43-9006) on Melanoma.
- Trial name
- NCT00483301
- Testing
- Sorafenib (BAY 43-9006), ABI-007(Abraxane)
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Mt. Sinai Medical Center, Miami
GBM, DIPG Brain Tumor
Clinical Study of Allogeneic Vγ9Vδ2 T Cells in the Treatment of Brain Malignant Glioma
Primary brain malignant tumor has become the first lethal tumor in children and young adults, and the treatment is limited, and the prognosis of patients is poor.
- Conditions
- GBM, DIPG Brain Tumor, Medulloblastoma
- Trial name
- CSAγδTBMG (NCT06396481)
- Testing
- Vγ9Vδ2 T cell
- Where
- China
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Pain
Femoral Nerve Block Versus Adductor Canal Nerve Block for Peri-Operative Analgesia Following Anterior Cruciate Ligament (ACL) Reconstruction: Evaluation of Post-operative Pain and Strength
All patients over the age of 16 undergoing primary or revision anterior cruciate ligament reconstruction with the use of bone-patellar-bone autograft are eligible for the study.
- Trial name
- NCT03033589
- Testing
- Marcaine 0.25 % Injectable Solution
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Pain, Postoperative, Appendicitis
Choose the Best Concentration of Ropivacaine on TAP Block for Open Appendectomy in Children
Blockage of the transverse abdomen (TAP) promotes excellent analgesia of the abdominal wall and the parietal peritoneum. The TAP block could advange the postoperative pain of Appendectomy in children.
- Trial name
- NCT03005808
- Testing
- Ropivacaine
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital Infantil Albert Sabin
A Study of Clinical and Genetic Mutations in a Family of Neuromyotonia, so Called Isaac's Syndrome
Inherited Myokymia: A Clinical and Genetic Study of a Family
Neuromyotonia (NMT), so called Isaac's syndrome, is a rare disorder in which hyperexcitability of peripheral motor nerves leads to intermittent muscle contractions.
- Trial name
- NCT01250704
- Where
- 3 sites in Taiwan
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
HIV, Brain Tumors
Analysis of Data Collected From Individuals Administered Neurobehavioral Assessments
Background: People with chronic illness often are at risk for developing neurobehavioral problems due to effects of the disease or associated treatments.
- Conditions
- HIV, Brain Tumors, Neurofibromatosis Type 1
- Trial name
- NCT01445314
- Where
- United States
- Volunteers
- 598 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Esophageal Cancer, Bile Duct Neoplasms
Collection of Tissue & Blood From Patients w/ Benign & Malignant Tumors of the Soft Tissue & Gastrointestinal Tract
Doctors at Memorial Sloan Kettering Cancer Center and at other institutions study normal and cancer cells. To study these cells we need to have human tissue, body fluids, and blood.
- Conditions
- Esophageal Cancer, Bile Duct Neoplasms, Gastric Cancer, Liver Cancer
- Trial name
- NCT00582647
- Where
- United States
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Opioid-use Disorder, Opioid Withdrawal
Novel Earpiece for Transcutaneous Auricular Neurostimulation (tAN) for Symptoms of Opioid Withdrawal
The objective of this study is to evaluate whether tAN via the tragus (vagal) and auriculotemporal (trigeminal) nerve pathways results in a clinically meaningful reduction in opioid withdrawal symptoms.
- Trial name
- NCT04731935
- Testing
- Sparrow Therapy System
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Spark Biomedical, Inc.
Pelvic Organ Prolapse
Use of Pre-Emptive Pudendal Nerve Block for Pelvic Reconstructive Surgery
The purpose of this study is to determine the effectiveness of perineal pain control via injection of a local anesthetic to numb the pudendal nerve. The medication which is commonly used for this block is called marcaine.
- Trial name
- NCT02409498
- Testing
- pudendal block, no pudendal block
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Fibromyalgia
Evaluation of the Sural Nerve With Ultrasonography and Electromyography in Patients With Fibromyalgia
By evaluating the ultrasonographic and electromyographic measurements of the sural nerve in patients with and without a diagnosis of fibromyalgia; to determine the relationship of these measures to each other and to the FIQ…
- Trial name
- NCT04985149
- Testing
- Electromyographic measurement:, Ultrasonographic measurement:
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Piriformis Syndrome
Muscle Energy Technique and Stretching Exercise in Working Pregnant Women With Piriformis Syndrome
Piriformis syndrome is a neuro muscular disorder which occur due to the compression and irritation of the sciatic nerve by the piriformis muscle causing pain, tingling, and numbness in the buttocks and along the sciatic nerve.
- Trial name
- NCT05915858
- Testing
- muscle energy technique, stretching exercise
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Pain Management
Acute Effects of Transcutaneous Electrical Nerve Stimulation at Acupoints on Nociceptive Transmission
The goal of this clinical trial is to learn if transcutaneous electrical nerve stimulation (TENS) applied to acupoints can modulate pain transmission and cortical processing in healthy adult volunteers.
- Trial name
- NCT07267052
- Testing
- transcutaneous electrical nerve stimulation (TENS), EEG machine
- Where
- Taiwan
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
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