Clinical trials: Nerve Condition
Melanoma (Skin Cancer), Health Volunteers
Study of Melanoma-Resistant PET Monitoring Based on Key Rate-limiting Enzymes for Fatty Acid Metabolism in Healthy Volunteers
This is a small-sample safety study involving 15 healthy volunteers who were divided into groups and underwent 68Ga-ACC-DE, 68Ga-FASN-DE, and 68Ga-ACLY-DE PET/CT imaging for safety, biodistribution, and radiation dosimetry…
- Conditions
- Melanoma (Skin Cancer), Health Volunteers, PET / CT
- Trial name
- NCT07114172
- Testing
- 68Ga-ACC-DE/68Ga-FASN-DE/68Ga-ACLY-DE PET/CT
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Laparoscopic Cholecystectomy, Peripheral Nerve Block
Effectiveness Of Modified-Thoracoabdominal Nerve Block Perichondrial Approach (M-TAPA) In Laparoscopic Cholecystectomy
The Goal of this clinical trial is to determine the advantages of using Peripheral Nerve Block by injecting drugs under the skin on both sides of the abdomen in the upper abdominal area in patients undergoing laparoscopic…
- Trial name
- NCT06652581
- Testing
- Modified Thorachoabdominal Nerve Block Perichondrial Approach(M-TAPA, Opioid Intravena
- Where
- Indonesia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Udayana University
Malignant Melanoma, Pigmented Nevi
Early Diagnosis of Malignant Transformation of Pigmentary Skin Lesions
Malignant Melanoma is a deadly skin cancer that can be cured if diagnosed early. To date atypical pigmented skin lesions are diagnosed by appearance alone and many moles and lesions are excised unnecessarily and on the other hand…
- Conditions
- Malignant Melanoma, Pigmented Nevi, Skin Neoplasm
- Trial name
- NCT01167998
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Epilepsy (Treatment Refractory), Epilepsy
Retinal OCT Changes and Biomarkers in Drug-Resistant Epilepsy
This prospective, longitudinal observational study investigates whether epilepsy involves a progressive neurodegenerative process.
- Trial name
- NCT07716930
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Kemal Tutkavul
Neurofibromatosis
Relationship Between Psychosocial Factors, Health Literacy, Quality of Life and Satisfaction With Medical Visits in Adults With NF
This is a prospective study through the NF clinic at Massachusetts General Hospital that will examine the relationship between psychosocial factors, health literacy, and satisfaction with the medical visit in adults with NF1…
- Trial name
- NCT02435628
- Testing
- Questionnaires
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Acute Stress Reaction, Cognitive Performance
Effect of Transcutaneous Auricular Neurostimulation on Cognitive Performance in a Laboratory Model of Acute Stress Reaction
The objective of this study is to test the effects of transcutaneous auricular neurostimulation (tAN) in treating or preventing performance degradation after an acute stressor.
- Trial name
- ASR (NCT06390267)
- Testing
- Sparrow Hawk (Active)
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Spark Biomedical, Inc.
Inguinal Hernias
Local Anaesthetic Following Hernia Repair
Inguinal hernia repair is a common surgical procedure. The major current debates revolve around laparoscopic hernia repair. The most recent Cochrane review concluded that laparoscopic inguinal hernia repair was associated with…
- Trial name
- NCT00471692
- Testing
- Ropivicaine
- Where
- Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Royal Hobart Hospital
Local Anesthesia
Effectiveness of Sodium Bicarbonate Buffered Anaesthetic Solution on Pain During Injection
This study will test the effectiveness of addition of Sodium Bicarbonate as a buffering agent to the anaesthetic solution on minimizing the pain of injection and increasing the onset time and potency of the anaesthetic solution…
- Trial name
- NCT05473819
- Testing
- Buffered Local Anesthesia, Conventional Unbuffered Local Anesthesia
- Where
- Egypt
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Metastatic Olfactory Neuroblastoma, Recurrent Olfactory Neuroblastoma
A Phase II Study of Rivoceranib for Patients With Recurrent or Metastatic Olfactory Neuroblastoma
To learn if rivoceranib can help to control olfactory neuroblastoma. The safety of this drug in participants with olfactory neuroblastoma will also be studied.
- Trial name
- NCT06308575
- Testing
- Rivoceranib
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Pain, Postoperative
Ultrasound Guided Pectoral Nerve I and II Blocks in Multimodal Analgesia for Breast Surgery
The primary objective of this study is to access the effect of Pectoral nerve I and II blocks in breast surgery as measured by consumption of postoperative morphine or its equivalent.
- Trial name
- NCT02672813
- Testing
- Pectoral nerve I and II block
- Where
- Nepal
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Knee Injuries
Femoral/Sciatic Block for Knee Surgery
Knee arthroplasty has a high potential for postoperative pain. This study compares analgesia and postoperative bleeding from intrathecal morphine with the continuous femoral and a single-shot sciatic nerve blockades.
- Trial name
- NCT02882152
- Testing
- femoral nerve blockade, morphine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Thoracic Outlet Syndrome
Dysfunctional Breathing in Individuals With Thoracic Outlet Syndrome
The aim of this observational study was to learn about the characteristics of dysfunctional breathing in individuals with thoracic outlet syndrome.
- Trial name
- NCT06992752
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Benign Prostatic Hypertrophy With Outflow Obstruction, Overactive Detrusor
Prognostic Value of the Urinary Nerve Growth Factor in the Patients With Benign Prostatic Hyperplasia
Persistent detrusor overactivity (DO) after transurethral prostatectomy results in symptomatic failure in more than one third of the patients.
- Trial name
- NCT01781117
- Testing
- Holmium Laser Enucleation of the Prostate (HoLEP), Holmium laser enucleation system and morcellator
- Where
- South Korea
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- KYU-SUNG LEE
Breast Cancer, Colon Cancer
Genomic Structural Variation in Cancer Susceptibility
This study will look for new types of gene changes that may be related to cancer in some patients. Some gene changes (mutations) are passed on from parents to offspring (child).
- Conditions
- Breast Cancer, Colon Cancer, Germ Cell Cancer, Neuroblastoma
- Trial name
- NCT00996710
- Where
- United States
- Volunteers
- 1,275 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Open-angle Glaucoma, Low Tension Glaucoma
Waveform Analysis of the Doppler Curve of Ophthalmic Arteries in Glaucoma Patients
Color Doppler Imaging (CDI) has been providing information about ocular blood flow over the past decades. This non-invasive procedure based on ultrasound technique has identified increased resistance and decreased systolic blood…
- Trial name
- NCT01487655
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Glioblastoma, Glioblastoma Multiforme
Surgical Tissue Flap to Bypass the Blood Brain Barrier in GBM
This study assesses the safety of using tissue autograft of a pedicled temporoparietal fascial (TPF) or pericranial flap into the resection cavity of newly diagnosed glioblastoma multiforme (GBM) patients.
- Conditions
- Glioblastoma, Glioblastoma Multiforme, GBM, Brain Cancer
- Trial name
- NCT03630289
- Testing
- Tissue autograft of pedicled temporoparietal fascial (TPF) or pericranial flap to bypass the blood brain barrier (BBB)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Dermatologic Conditions, Healthy Volunteers
Studies of Dermatologic Diseases Biospecimen Acquisition Protocol
Background: Skin disease can have many causes. It can have widespread consequences, and in rare cases can lead to death. Researchers want to determine the causes of various types of skin diseases and find a way to treat them.
- Conditions
- Dermatologic Conditions, Healthy Volunteers, Normal Volunteers, Carcinoma, Merkel Cell
- Trial name
- NCT02471352
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Esophageal Diseases
The Effect of Transcutaneous Vagal Nerve Stimulation on Reducing Oesophageal Pain Hypersensitivity
We are evaluating the role of transcutaneous electrical vagal nerve stimulation in the prevention of oesophageal pain hypersensitivity using a validated human model in healthy volunteers.
- Trial name
- NCT02620176
- Testing
- Transcutaneous vagal nerve stimulation
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Wingate Institute of Neurogastroenterology
Sensory Nerve Conduction, Oxyneurogram Index
Effect of Tourniquet on Sensory Nerve Conduction Threshold (sNCT) and OxyNeuroGram (ONG) Index- A Volunteer Study
There are a number of risk factors for development of chronic pain that have been evaluated including age, gender, type and duration of surgery, duration of pain prior to surgery and tourniquet application.
- Trial name
- NCT01970839
- Testing
- tourniquet, sensory nerve conduction abnormality
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Duke University
Overactive Bladder
Association Between Metabolic Syndrome and Serum Nerve Growth Factor Levels in Women With Overactive Bladder
Nerve growth factor (NGF-R) receptors are between the detrusor muscle fibers and can cause afferent signals. Metabolic syndrome and obesity have been advocated to be risk factors for the development of overactive bladder.
- Trial name
- NGF (NCT02335853)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
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