Clinical trials: Nerve Condition
Spinal Cord Injury
Vagal Nerve Stimulation to Reduce Inflammation and Hyperadrenergia
The purpose of this research device study is to learn more about the autonomic nervous system. This system uses nerves to send information from the brain to the rest of the body by electrical signaling and has two divisions, the…
- Trial name
- NCT02983266
- Testing
- InTENsity MicroCombo
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Miami
Obstructive Sleep Apnea
BilatEral Hypoglossal Nerve StimulaTion for TreatmEnt of ObstRuctive SLEEP Apnoea With and Without Complete Concentric Collapse
The objective of this study is to explore the safety and performance of the Genio™ system in adult obstructive sleep apnoea (OSA) patients with and without complete concentric collapse of the soft palate over a period of 4.5…
- Trial name
- BETTER SLEEP (NCT03763682)
- Testing
- Genio(TM) bilateral hypoglossal nerve stimulation system
- Where
- 4 sites in Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Nyxoah S.A.
Nerve Growth Factor, Exercise
Cortical Neuroplasticity by Muscle Pain of Pain-induced Plasticity
The purpose of this study is to investigate the sensory-motor cortical excitability response to delayed onset muscle soreness (DOMS) on Extensor Carpi Radialis (ECR) muscle during muscle hyperalgesia provoked by nerve growth…
- Conditions
- Nerve Growth Factor, Exercise, Motor Activity, Abnormality of SSEPs
- Trial name
- NCT03354624
- Testing
- Sterile solutions of recombinant human nerve growth factor (NGF)
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Pain, Postoperative, Nerve Block
The Comparison of the Analgesic Efficacy and Hemodynamic Effects of Paravertebral Block Compared With Paravertebral and Intercostal Nerve Block for Thoracotomy in Adults.
Thoracotomy is a surgical procedure associated with severe post operative pain during the first day of surgery and is responsible for prolonged hospital stay, patient dissatisfaction and delayed return to normal activities along…
- Conditions
- Pain, Postoperative, Nerve Block, Thoracotomy
- Trial name
- NCT04715880
- Testing
- Paravertebral block/Intercostal Block (PVB/ICB) group, Paravertebral Block (PVB) group
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Aga Khan University Hospital, Pakistan
Postoperative Pain Management, Postoperative Pain
Postoperative Analgesic Efficacy of Modified TAPA and QL Blocks in Laparoscopic Cholecystectomies
Comparison of Postoperative Analgesic Effects of M-TAPA and Anterior Quadratus Lumborum Blocks in Laparoscopic Cholecystectomies.
- Conditions
- Postoperative Pain Management, Postoperative Pain, Analgesia, Nerve Blocks
- Trial name
- NCT06540586
- Testing
- anterior Quadratus lumborum block, M-TAPA BLOCK
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Anatomic Stage IV Breast Cancer AJCC v8, Glioblastoma
Investigating the Feasibility and Acceptability of an Innovative Interdisciplinary Supportive Care Program: Couples Coping Together Against Cancer
This study evaluates how useful and acceptable the components of the "Couples Coping Together Against Cancer", referred to as "The Program", are to the participants with cancer.
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Glioblastoma, Lung Carcinoma, Malignant Solid Neoplasm
- Trial name
- NCT07664579
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Mandibular Nerve, Mandibular Nerve Blocks
Comparative Assessment of Mental/Incisive and Inferior Alveolar Nerve Block Anesthesia in Root Canal Treatment of Mandibular Premolars
The goal of this clinical trial is to systematically compare the pain scores and anesthesia efficacy of IANB and MNB in the treatment of symptomatic mandibular first and second premolars.
- Conditions
- Mandibular Nerve, Mandibular Nerve Blocks, Premolars, Mental Nerve Block
- Trial name
- NCT06679660
- Testing
- inferior alveolar nerve block with 4% articaine, Mental/Incisive Nerve Block (%4 Articaine)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Convergence Insufficiency
Natural History of MTBI-related Convergence Insufficiency & Effectiveness of Vision Therapy for MTBI-related CI
The design of this project is a pilot study, a type of feasibility study conducted in preparation for subsequent RCTs that will assess the effectiveness of office-based vergence/accommodative therapy with movement (OBVAM) for…
- Trial name
- TBEye (NCT06848673)
- Testing
- Office-Based Vergence/Accommodative Therapy with Movement (OBVAM)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Salus University
Healthy, Neuromuscular Disease
Evaluation of Neuromuscular Disease
The peripheral nervous system is the portion of the nervous system outside of the brain and spinal cord. It includes the 12 pairs of cranial nerves, 31 pairs of spinal nerves and their branches, nerves responsible for sensation…
- Conditions
- Healthy, Neuromuscular Disease, Peripheral Nervous System Disease
- Trial name
- NCT00001201
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Pain, Postoperative, Regional Anesthesia
Quadratus Lumborum vs Erector Spinae Supplementary Blocks With Lumbar Plexus Blocks for Hip PAO
This study proposes to evaluate the efficacy of single shot erector spinae block (ESB) versus single shot quadratus lumborum block (QLB) when used in conjunction with continuous lumbar plexus block (LPB) for postoperative…
- Conditions
- Pain, Postoperative, Regional Anesthesia, Hip Dysplasia
- Trial name
- NCT04481451
- Testing
- Erector spinae block with ropivacaine 0.2%, Quadratus lumborum block with ropivacaine 0.2%, Ropivacaine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Dentofacial Deformities, Regional Anesthesia Morbidity
Ultrasound-guided Bilateral Suprazygomatic Maxillary Nerve Block and Bimaxillary Osteotomy
Bimaxillary osteotomy is a surgery procedure of the orthognathic surgery field with the aim to correct dental and facial abnormalities, for both functional and aesthetic cases.
- Trial name
- NCT03913429
- Testing
- Infiltration, Maxillary nerve blockade
- Where
- Spain
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Servei Central d'Anestesiologia
TBI (Traumatic Brain Injury), Ocular Motility Disorders
Frontoparietal Priority Maps as Biomarkers for MTBI
The purpose of this study is to determine whether there is a quantitative relationship between brain processes seen by a MRI and visual deficits caused by mild to moderate traumatic brain injuries (mTBI).
- Trial name
- NCT02251002
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Alzheimer's Disease, Mild Cognitive Impairment
Retinal Imaging in Neurodegenerative Disease
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple Sclerosis
- Trial name
- NCT03233646
- Testing
- Retinal and Choroidal Imaging
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Carpal Tunnel Syndrome
Ozone Therapy in Patients With Carpal Tunnel Syndrome
ESWT (Extracorporeal Shock Wave Therapy), which has been used in the treatment of musculoskeletal diseases in recent years, has come to the agenda as a new treatment method in Carpal Tunnel Syndrome.
- Trial name
- NCT06469931
- Testing
- range of motion exercises, Extracorporeal shock wave therapy, ozone therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Firat University
Urge Incontinence, Overactive Bladder
A Study of Transcutaneous Electrical Nerve Stimulation for Overactive Bladder
The purpose of the study is to compare patient centered- outcomes between Transcutaneous Electrical Nerve Stimulation (TENS) at three locations to treat urinary urge incontinence.
- Trial name
- NCT02922842
- Testing
- Transcutaneous Electrical Nerve Stimulation
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Glioma
Identification of Genomic Changes in Families Having Multiple Members With Tumors
This study will compare genomic alterations between the parents and the patients with high-grade glioma.
- Trial name
- NCT02386241
- Testing
- saliva or blood sample collection
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Retinoblastoma Bilateral, Retinoblastoma Unilateral
Detailed Phenotypic and Genotype Study to Correlate RB1 Mutations Relating to Primary Ocular Tumors and Secondary Extra-ocular Metastasis.
The goal of this observational study is undertake a detailed phenotypic and genotypic study of patients with ocular and secondary cancers due to mutations in the RB1 gene.
- Conditions
- Retinoblastoma Bilateral, Retinoblastoma Unilateral, Retinoblastoma, Extraocular, Retinoblastoma, Recurrent
- Trial name
- NCT06725173
- Testing
- Targeted Long-read sequencing
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Washington
Respiratory Disease
Stretching of the Diaphragm and Cervical Impulse Technique and Its Possible Spirometric Changes
This study investigates the effect of two different techniques, stretching of the diaphragm and cervical level impulse technique C3-C4, in the possible spirometric changes, vital capacity (CV), maximum expiratory flow (PEF) and…
- Trial name
- NCT03732222
- Testing
- Stretching the diaphragm muscle, Impulse technique in rotation of cervical level 3 and 4, Combined technique of diaphragm muscle stretch and cervical rotation impulse technique level 3 and 4
- Where
- Spain
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University
Melanoma and Other Malignant Neoplasms of Skin
A Prospective Multicenter Sample Collection Study Using Non-invasive Methods to Investigate Mutation Burden in Non-lesional Facial Skin of Patients With a Hx of Skin Cancer
This is a prospective, multicenter, sample collection study using DermTech's non-invasive skin collection kits to evaluate the mutation burden of non-lesional facial skin from subjects with a documented history of numerous basal…
- Trial name
- NCT05602337
- Testing
- Observational Study Only
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- DermTech
Nerve Degeneration, Healthy Aging
Quantifying the Trainability of Peripheral Nerve Function in Young and Older Adults.
The purpose of this project is to identify the effects of hand grip resistance training on nerve speed of the hand muscles and to quantify whether age plays a role in those effects.
- Trial name
- NCT06614556
- Testing
- Resistance Training
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
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