Clinical trials: Nerve Condition
Malignant Meningioma
γδ T-PD-1 Ab Cells in the Treatment of Malignant Meningioma
This study intends to combine the advantages of γδ T cells and PD-1 monoclonal antibody to conduct an exploratory clinical study on the safety and efficacy of PD-1 antibody armored γδ T cells (γδ T-PD-1 Ab cells) in the treatment…
- Trial name
- NCT07172178
- Testing
- γδ T-PD-1 Ab cells
- Volunteers
- 12 people
- Sponsor
- Nanjing Medical University
Brain Meningioma
Sphenoorbital Meningioma Management.
Investigators will discuss the different surgical techniques for removal of spheno_orbital meningiomas with proptosis.investigators also will follow up the patient to know the outcome of removal of these tumours.
- Trial name
- NCT04710485
- Volunteers
- 24 people
- Sponsor
- Assiut University
Asthma
Relief of Acute Bronchoconstriction/Asthma Using the Non-Invasive AlphaCore Device
The purpose of this pilot study is to collect preliminary clinical data related to the safety and preliminary clinical benefits of non-invasive vagal nerve stimulation with the AlphaCore™ device for the relief of acute…
- Trial name
- NCT01532817
- Testing
- AlphaCore
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- ElectroCore INC
Diffuse Intrinsic Pontine Glioma (DIPG)
Molecular Profiling for Individualized Treatment Plan for DIPG
This is a single arm multi-center pilot trial within the Pacific Pediatric Neuro-Oncology Consortium (PNOC). The current study will use a new treatment approach based on each patient's tumor genomic profiling consisting of whole…
- Trial name
- NCT02274987
- Testing
- Specialized tumor board recommendation, Standard radiation therapy
- Where
- 5 sites in United States
- Volunteers
- 38 people
- Sponsor
- University of California, San Francisco
Bone Resorption, Nerve
Innervation of Vascularized Iliac Transplant Avoids Resorption in Jaw Bone Reconstruction
The purpose of this study is to determine the efficacy of simultaneous innervation to prevent graft bone resorption in maxillofacial reconstruction.
- Trial name
- INVITATION (NCT03889587)
- Testing
- Innervation, Non-innervation
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Melanoma, Neoplasm Metastasis
Study to Compare the Efficacy and Safety of CC-5013 vs. Placebo in Subjects With Metastatic Malignant Melanoma.
Subjects are randomized to one of two treatment arms. All subjects are screened for eligibility within 28 days prior to randomization. The study consists of a treatment phase and a follow-up phase.
- Trial name
- NCT00057616
- Testing
- CC-5013
- Where
- 49 sites in Australia, Estonia and 7 more
- Volunteers
- 274 people
- Sponsor
- Celgene
Pain, Chronic
Intradural Percutaneous Stimulation
The purpose of the study is to test the effects of intradural, spinal cord stimulation using a device placed in the same manner as a lumbar drain performed during a standard epidural spinal cord stimulation (SCS) trial routinely…
- Trial name
- NCT03380104
- Testing
- Intradural Spinal Cord Stimulation, Administration of Questionnaires
- Where
- United States
- Sponsor
- Matthew Howard
Pain Management
TENS for Testicular Pain (ICO): A Randomized Controlled Trial
Idiopathic Chronic Orchialgia (i.e., testicular pain) is a challenging condition to treat, with unresolved testicular pain leading to distress, diminished activities of daily living and decreased quality of life.
- Trial name
- NCT04866784
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Jennifer E. Lee
Cancer
Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer
RATIONALE: Cyproheptadine hydrochloride may prevent weight loss caused by cancer or cancer treatment. It is not yet known whether cyproheptadine is more effective than a placebo in preventing weight loss in young patients…
- Trial name
- NCT01132547
- Testing
- cyproheptadine hydrochloride
- Where
- 14 sites in United States
- Volunteers
- 22 people
- Sponsor
- University of South Florida
Sciatica Acute, Sciatica Pain
Ultrasound-guided Transgluteal Sciatic Nerve Hydrodissection for the Treatment of Sciatica in the Emergency Department
The goal of this observational study is to see whether it would be feasible to treat patients who come to the emergency department with pain related to sciatica using an ultrasound guided injection of dextrose in water solution…
- Trial name
- NCT07588126
- Testing
- Ultrasound guided transgluteal sciatic nerve hydrodissection
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Kaiser Permanente
Glioblastoma, Gliosarcoma
Ph II Erlotinib + Sirolimus for Pts w Recurrent Malignant Glioma Multiforme
Primary objective: To determine the 6-month progression free survival of patients with recurrent glioblastoma multiforme (GBM) treated with Erlotinib plus Sirolimus.
- Trial name
- NCT00672243
- Testing
- Erlotinib + sirolimus
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Duke University
Pediatric Medulloblastoma
Metabolomic Analysis of Body Fluid of Medulloblastoma in Children
Based on a new mass spectrometry system, body fluid samples were analyzed to verify the role of metabolite analysis in the diagnosis of pediatric medulloblastoma.
- Trial name
- NCT04065204
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Alzheimer Disease
Phase 2 Estimation Study of Fixed Dose Drugs Combination Type of Polypill
This is an estimation-focused Phase 2 study designed to explore and quantify treatment-related changes across multiple clinical outcomes in patients with Alzheimer's disease over a 210-day period.
- Trial name
- NCT06597058
- Testing
- MAR
- Where
- 16 sites in United States
- Volunteers
- 121 people
- Sponsor
- Noah Pharmaceuticals, Inc.
Medulloblastoma, Pineoblastoma
Vorinostat Combined With Isotretinoin and Chemotherapy in Treating Younger Patients With Embryonal Tumors of the Central Nervous System
This pilot clinical trial studies the side effects and the best way to give vorinostat with isotretinoin and combination chemotherapy and to see how well they work in treating younger patients with embryonal tumors of the central…
- Conditions
- Medulloblastoma, Pineoblastoma, Supratentorial Embryonal Tumor, Not Otherwise Specified
- Trial name
- NCT00867178
- Testing
- 3-Dimensional Conformal Radiation Therapy, Carboplatin, Cisplatin
- Where
- 15 sites in United States
- Volunteers
- 33 people
- Sponsor
- National Cancer Institute (NCI)
Pain
Efficacy, Safety, and Pharmacokinetics of Femoral Nerve Block With EXPAREL in Total Knee Arthroplasty
This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study in 232 adult subjects undergoing primary unilateral TKA under general or spinal anesthesia.
- Trial name
- NCT02713178
- Testing
- bupivacaine liposome injectable suspension
- Where
- 17 sites in United States, Belgium and 1 more
- Volunteers
- 232 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Glioblastoma Multiforme
Chlorpromazine and Standard of Care in Glioblastoma
This is a phase 1 study investigating the re-purposing of chlorpromazine, combined with temozolomide and radiation in the treatment of newly diagnosed glioblastoma multiforme.
- Trial name
- NCT05190315
- Testing
- Chlorpromazine, Temozolomide, Radiation Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mohammed Milhem
Metastatic Melanoma
Tolerance of Targeted Therapy Used in Metastatic Melanoma in Patients Aged Over 65 and 75-year-old
Since 2013, therapeutic care of metastatic melanoma (MM) has greatly improved, especially thanks to BRAF and MEK targeted therapies.
- Trial name
- TOLBRIPA (NCT03155217)
- Where
- France
- Volunteers
- 358 people
- Sponsor
- University Hospital, Montpellier
Anesthesia, Postoperative Pain
The Effect of Ultrasound-guided Erector Spinae Block and Intraoperative Intercostal Nerve Block on Postoperative Analgesia in Thoracic Surgery
This study aims to compare the effect of ultrasound-guided erector spinae plane block and interthoracic intercostal nerve block in thoracic surgery.
- Conditions
- Anesthesia, Postoperative Pain, Ultrasound Therapy; Complications
- Trial name
- NCT04581616
- Testing
- Intrathoracic Intercostal Nerve Block, Erector Spinae Plane Block
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Carpal Tunnel Syndrome
Median Nerve Stenosis in Carpal Tunnel Syndrome
The goal of this observational study is to test the new kind of ultrasound-based measurements in patients with carpal tunnel syndrome.
- Trial name
- NCT05861349
- Testing
- Nerve conduction study, Ultrasound
- Where
- Poland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Jakub Antczak
Solid Tumor
A Study of ASP1012 in Adults With Solid Tumors
ASP1012 is a type of virus called an oncolytic virus which is used to treat some cancers. ASP1012 was changed in a laboratory to infect and kill cancer cells, leaving healthy cells alone.
- Trial name
- NCT06171178
- Testing
- ASP1012, Pembrolizumab
- Where
- 8 sites in United States
- Volunteers
- 15 people
- Sponsor
- Astellas Pharma Global Development, Inc.
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