Clinical trials: Nerve Condition
Pancreatic Cancer
Resection of the Nerve Plexus on the Right Half of Celiac and SMA Associated With Extended Pancreatoduodenectomy in the Surgical Treatment for Adenocarcinoma of the Head of Pancreas
This study is performed to confirm whether resection of the nerve plexus on the right half of celiac and SMA associated with extended pancreatoduodenectomy could improve survival and relieve pain of pancreatic cancer patients.
- Trial name
- NCT02514928
- Testing
- resection of the nerve plexus on the right half of celiac and SMA associated with extended pancreatoduodenectomy, standard pancreatoduodenectomy
- Where
- China
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Fudan University
Urinary Retention
Treatment for Acute Postoperative Voiding Dysfunction
If patients are unable to have their foley catheter removed because their bladder is not emptying well, they may be eligible for study participation.
- Trial name
- PTNS (NCT01189136)
- Testing
- PTNS Active Treatment
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Colon Cancer, Nerve Preserve
The Role of Total Abdominal Autonomic Nerve Preservation During the Resection of Right/Left Colon Cancer: Prospective Clinical Trial
Preservation of pelvic autonomic nerves to retain genitourinary function without compromise of oncologic clearance of tumor has been extensively studied in rectal cancer surgery.
- Trial name
- NCT07825766
- Testing
- Abdominal autonomic nerve preserverd in the TNP arm
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University
V Pattern Esotropia, Monocular Exotropia With V Pattern
Correction of V-pattern Strabismus by Graded Recession of Inferior Oblique Muscle .
V pattern strabismus is the commonest of alphabet pattern. Its identification is essential to plan a proper surgical management. Graded recession is a very logical approach to treat inferior oblique overaction (IOOA).
- Trial name
- Pattern (NCT05786053)
- Testing
- graded recession of inferior oblique muscle
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Carpal Tunnel Syndrome
Post-Operative Splinting After Short-Incision Carpal Tunnel Release: a Prospective Study
This research study is for patients who are schedule to have carpal tunnel release surgery. The investigators have developed this study in order to determine if post-operative splinting is effective in improvement of patient…
- Trial name
- NCT01897272
- Testing
- Splinting
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Christine M. Kleinert Institute for Hand and Microsurgery
Concussion, Convergence Insufficiency
Interventions for Convergence Insufficiency in Concussed Children
The ICONICC Study is a randomized controlled clinical trial designed to compare the proportion of successful treatment outcomes between children assigned to standard concussion care only, standard concussion care plus simple…
- Trial name
- ICONICC (NCT03908112)
- Testing
- Standard Community Concussion Care (SC), SC plus Simple Convergence Exercises (SC+), SC plus Office-based Vergence/Accommodative Therapy (SC+OBVAT)
- Where
- 8 sites in United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Mitchell Scheiman
Malignant Glioma, Glioma
A Study of Aminolevulinic Acid Used to Enhance Visualization and Surgical Removal of Brain Tumors
In this study subjects will be administered a single oral dose of Aminolevulinic Acid (ALA) prior to surgical resection of their brain tumor.
- Conditions
- Malignant Glioma, Glioma, Glioblastoma, Glioblastoma Multiforme
- Trial name
- NCT01351519
- Testing
- Aminolevulinic Acid
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- MultiCare Health System Research Institute
Intracranial Hypertension
Optic Nerve Sheath Diameter in Low-flow and Normal-flow Rate Anesthesia
Laparoscopic cholecystectomy is one of the regularly performed laparoscopic surgical procedures. It resulted in shorter hospital stays, improved cosmetic outcomes, and reduced bleeding and pain.
- Trial name
- NCT05946200
- Testing
- Low flow technique in general anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Konya City Hospital
Post Operative Pain
Comparison of M-TAPA and TAP Blocks on Postoperative Analgesia in Laparoscopic Inguinal Hernia Surgeries
The goal of this study is to compare the analgesic efficacy of M-TAPA block and TAP block in patients undergoing laparoscopic inguinal hernia surgeries.
- Trial name
- NCT06483607
- Testing
- M-TAPA block with bupivacaine 25%, TAP block with bupivacaine 25%
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Cumhuriyet University
Multiple Sclerosis, Neurodegeneration
Central and Peripheral Nervous System Changes as Markers of Disease Progression in Multiple Sclerosis
OBJECTIVE To investigate neurodegeneration and demyelination in the central and peripheral nervous system in multiple sclerosis linked to disease progression and mechanisms that can explain different responses to Fampridine…
- Conditions
- Multiple Sclerosis, Neurodegeneration, Central Nervous System Lesion, Peripheral Nervous System Problem
- Trial name
- NCT03401307
- Where
- Denmark
- Volunteers
- 49 people
- Sponsor
- University of Southern Denmark
Metastatic Melanoma
Generation of an Artificial Intelligence Algorithm Based on the Analysis of Melanoma Peri-scar Dermatoheliosis, as a Predictive Factor of Response to Anti-PD-1
In the last decade, the advent of immunotherapies with inhibitors of immune checkpoints, such as anti-PD-1 and anti-CTLA-4, has revolutionized the treatment of advanced or metastatic melanoma.
- Trial name
- HELIOPREDICT (NCT05856565)
- Testing
- Photo
- Where
- 20 sites in France
- Volunteers
- 700 people
- Sponsor
- Nantes University Hospital
Lymphoma, Non-Hodgkin, Lymphoma, Follicular
A Study Of PF-05082566 As A Single Agent And In Combination With Rituximab
A study of PF-05082566, a 4-1BB agonist monoclonal antibody (mAb), in patients with solid tumors or b-cell lymphomas, and in combination with rituximab in patients with CD20 positive Non-Hodgkin's Lymphoma (NHL).
- Conditions
- Lymphoma, Non-Hodgkin, Lymphoma, Follicular, Lymphoma, Large B-Cell, Diffuse, Carcinoma, Non-Small-Cell Lung
- Trial name
- NCT01307267
- Testing
- PF-05082566, rituximab
- Where
- 42 sites in United States, Australia and 3 more
- Volunteers
- 190 people
- Sponsor
- Pfizer
Melanoma
Efficacy and Safety of TQB2618 Injection Combined With Toripalimab Injection in Patients With Advanced Melanoma
This study is an open, single-center, multi-cohort phase Ib exploratory study, and 50 subjects are planned to be enrolled to observe the objective response rate of each subject.
- Trial name
- NCT05451407
- Testing
- TQB2618 injection, Toripalimab injection
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Neoplastic Disease, Glioblastoma
131I-TLX-101 for Treatment of Newly Diagnosed Glioblastoma (IPAX-2)
This is an open label, single arm, parallel-group, multicentre, and dose finding study to evaluate the safety of ascending radioactive dose levels of 131I-TLX101 administered intravenously in combination with best standard of…
- Conditions
- Neoplastic Disease, Glioblastoma, Glioblastoma Multiforme
- Trial name
- IPAX-2 (NCT05450744)
- Testing
- 131I-IPA
- Where
- 5 sites in Australia, Austria and 1 more
- Volunteers
- 12 people
- Sponsor
- Telix Pharmaceuticals (Innovations) Pty Limited
Melanoma
Using High Resolution Function Imaging To Detect Melanoma and Dysplastic Nevi
A novel infrared imaging tool to aid in the clinical detection of atypical pigmented lesions and melanoma is developed. Goals include evaluation of the utility of high-resolution infrared scanning of cutaneous lesions in the…
- Trial name
- NCT01118832
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Skin Cancer, Melanoma of Skin
How Consistent is the Output of DERM, When Used to Assess Images of Potentially Cancerous Skin Lesions.
DERM is a Medical Device that uses artificial intelligence to help doctors check if a skin lesion might be cancerous. It works by analysing close-up pictures of skin lesions taken with a smartphone.
- Conditions
- Skin Cancer, Melanoma of Skin, Squamous Cell Cancer, Basal Cell Cancer
- Trial name
- NCT06654999
- Testing
- Deep Ensemble for the Recognition of Malignancy (DERM)
- Where
- 3 sites in United Kingdom
- Volunteers
- 115 people
- Sponsor
- Skin Analytics Limited
Epilepsy
Transcutaneous Non-invasive Stimulation of the Vagus Nerve for the Treatment of Difficult-to-treat Epilepsy
The aim of the study is to prove the feasibility and safety of transcutaneous, electrical stimulation of the vagus nerve in patients with difficult-to-treat forms of epilepsy.
- Trial name
- NCT01178437
- Testing
- T-VNS® Stimulator cM02 (Transcutaneous Stimulation of the Vagus Nerve)
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- cerbomed GmbH
Carpal Tunnel Syndrome
Exparel and Education to Avoid Opioids After Carpal Tunnel Release
This trial seeks to use the long acting local anesthetic Exparel, in conjunction with opioid education, to attempt to avoid any post-operative opioid use following carpal tunnel surgery.
- Trial name
- NCT03867539
- Testing
- Differing pain management strategy
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- Kettering Health Network
Tumor Infiltrating Lymphocytes, Safety
A Study of GC101 TIL in Advanced Melanoma (BZ)
20 participants are expected to be enrolled for the Phase Ib clinical trial，this trail is expected to be finished in 20 months.
- Conditions
- Tumor Infiltrating Lymphocytes, Safety, Melanoma, Efficacy
- Trial name
- MIZAR-002 (NCT06120712)
- Testing
- GC101 TIL
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai Juncell Therapeutics
Brain and Central Nervous System Tumors, Hereditary Wilms Tumor
Gene Mutation in Samples From Young Patients With Pleuropulmonary Blastoma Syndrome at Risk for Developing Cancer
RATIONALE: The identification of gene mutations in young patients with pleuropulmonary blastoma syndrome may allow doctors to better understand the genetic processes involved in the development of some types of cancer, and may…
- Conditions
- Brain and Central Nervous System Tumors, Hereditary Wilms Tumor, Kidney Cancer, Liver Cancer
- Trial name
- NCT01353300
- Testing
- DNA analysis, cytogenetic analysis, gene expression analysis
- Volunteers
- 31 people
- Sponsor
- Children's Oncology Group
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