Clinical trials: Nerve Transfers
Stroke, Ischemic, Stroke Hemorrhagic
Utility of CC7 Transfer in Stroke Subtypes
The purpose of this study is to evaluate the limb functional improvement after contralateral C7 root transfer in stroke patients.
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Spastic Hemiparesis
- Trial name
- NCT06001736
- Testing
- Contralateral C7 root transfer for the treatment of spastic hemiparesis.
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Breast Cancer, Breast Reconstruction
Sensory Restoration After DIEP Flap Neurotization
Common goals of breast reconstruction include obtaining satisfactory breast symmetry, softness, and appropriate size and shape. Advances in surgical techniques have prompted a new goal: achieving breast sensation after…
- Conditions
- Breast Cancer, Breast Reconstruction, Sensory Restoration
- Trial name
- NCT04533373
- Testing
- DIEP Flap Neurotization
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Johns Hopkins University
Complex Digital Injuries
Reconstruction of a Neurocutaneous Defect of the Proximal Phalanx With a Heterodigital Arterialized Nerve Pedicle Flap
Complex digital injuries involving soft tissue loss and digital nerve defect pose challenging problems for hand surgeons. This study uses the heterodigital arterialized nerve pedicle flap including the dorsal branch of the…
- Trial name
- NCT01837407
- Testing
- Composite Flap
- Where
- China
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Tangshan
Ulnar Nerve Injury
Ulnar Nerve Neurotization After Ulnar Nerve Injury
This study will evaluate the hand intrinsic muscles functional recovery after distal neurotization of ulnar nerve
- Trial name
- NCT05283785
- Testing
- End To End or End to side sutures
- Volunteers
- 22 people
- Sponsor
- Assiut University
Injury of Mental Nerve of One Side
Evaluation Of Cross Mental Nerve Transfer In Restoration Of Chin &Lip Sensation Post Inferior Alveolar Nerve Injury
Evaluation Of Cross Mental Nerve Transfer In Restoration Of Chin \&Lip Sensation Post Inferior Alveolar Nerve Injury
- Trial name
- NCT04218474
- Testing
- Evaluation Of Cross Mental Nerve Transfer In Restoration Of Chin &Lip Sensation Post Inferior Alveolar Nerve Injury
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ahmed Mohamed Basem
Cervical Spinal Cord Injury, Spinal Cord Injuries
Restoring Hand Function Utilizing Nerve Transfers in Persons With Cervical Spinal Cord Injuries
The primary objective of this study is to evaluate the safety and efficacy of nerve transfer surgery for restoring hand function as a therapy for patients with cervical spinal cord injury.
- Conditions
- Cervical Spinal Cord Injury, Spinal Cord Injuries, Traumatic Spinal Cord Compression
- Trial name
- NCT03451474
- Testing
- Upper extremity nerve transfer surgery
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The University of Texas Health Science Center, Houston
Brachial Plexus Injury
A Multicenter External Validation of a Novel Prediction Model for Elbow Flexion Recovery After Nerve Transfer Surgery in Brachial Plexus Injuries
The goal of this observational study is to validate a risk prediction model developed for unsuccessful elbow flexion recovery after nerve transfer surgery in patients with brachial plexus injury.
- Trial name
- NCT06237270
- Testing
- Nerve transfer surgery for elbow flexion
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Siriraj Hospital
Quadriplegia, Spinal Cord Diseases
Upper Extremity Surgery in Spinal Cord Injury
The goal of the investigators work is to establish how nerve transfers can be best used to improve upper extremity function in patients with cervical level spinal cord injury (SCI).
- Conditions
- Quadriplegia, Spinal Cord Diseases, Spinal Cord Injuries
- Trial name
- NCT01899664
- Testing
- Nerve Transfer Surgery
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Washington University School of Medicine
Neurotrophic Keratitis
Miniinvasive Corneal Neurotization. A Pilot Study.
Neurotrophic keratitis (NK) is a degenerative disease of the cornea due to the impairment of the nasociliary branch of the ophthalmic nerve.
- Trial name
- MICORNE (NCT03037450)
- Testing
- Miniinvasive corneal neurotization
- Where
- France
- Volunteers
- 1 people
- Sponsor
- University Hospital, Strasbourg, France
Facial Paralysis
A Study of NTX-001 in the Treatment and Prevention of Facial Paralysis Requiring Surgical Repair.
This study involves the use of an Investigational Product called NTX-001. It is a product used in the repair of nerve injuries. It is used in the operating room.
- Trial name
- NCT05293522
- Testing
- NTX-001
- Where
- 6 sites in United States
- Volunteers
- 2 people
- Sponsor
- Neuraptive Therapeutics Inc.
Nerve Injury, Surgery
AIN Transfer for Cubital Tunnel Syndrome
Ulnar nerve compressive injury due to cubital tunnel syndrome is very common. Because of the long distance to the target muscles in the hand, functional outcome in severe cases even with decompression surgery is often poor.
- Trial name
- NCT05242302
- Testing
- nerve transfer
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- University of Alberta
Severe Compressive Ulnar Nerve Neuropathy (McGowan Grade III)
Prospective Evaluation of Reverse End to Side Anterior Interosseous Nerve to Ulnar Nerve Transfer for Severe Compressive Ulnar Neuropathy at the Elbow
Ulnar nerve compression at the elbow is a common problem and can significantly affect hand function in severe cases. The current, standard treatment is Ulnar nerve decompression with or without transposition (moving the ulnar…
- Trial name
- NCT02281656
- Testing
- Surgery:ulnar nerve transposition with AIN to ulnar nerve transfer, Surgery:ulnar nerve subcutaneous transposition without AIN to ulnar nerve transfer.
- Volunteers
- 40 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Nerve Transfer
Nerve Transfers for Restoration of Hand Function in Cervical Spinal Cord Injury: Effects and Influencing Factors
The goal of this observational study is to learn about influencing factors on the clinical outcomes of nerve transfers used to restore hand function in patients with cervical spinal cord injury (CSCI).
- Trial name
- NCT06596629
- Where
- Netherlands
- Volunteers
- 19 people
- Sponsor
- Roessingh Research and Development
Breast Reconstruction, Neurotization
Effect of Neurotization on QoL and Sensory Restoration
This is a single-site, randomized, double-blinded trial to assess whether neurotization following autologous breast reconstruction in patients with breast cancer increases quality of life and sensation in the breast compared to…
- Trial name
- NCT05206565
- Testing
- Neurotization - Autologous Reconstruction with DIEP/TRAM
- Sponsor
- University of Wisconsin, Madison
Tetraplegia, Spinal Cord Injuries
Nerve Transfer After Spinal Cord Injury- Multi-center
Current treatment strategies of acute cervical spinal cord injuries remain limited. Treatment options that provide meaningful improvements in patient quality of like and long-term functional independence will provide a…
- Conditions
- Tetraplegia, Spinal Cord Injuries, Quadriplegia Flaccid
- Trial name
- NCT04023591
- Testing
- Surgery/Occupational Therapy
- Where
- 9 sites in United States, Canada
- Volunteers
- 70 people
- Sponsor
- Washington University School of Medicine
Neurotrophic Keratitis
Corneal Neurotization vs. Cenergermin for Neurotrophic Keratitis: A Pilot Study
This pilot study evaluates the feasibility and outcomes of two treatment approaches for corneal sensory dysfunction due to neurotrophic keratitis (NK): corneal neurotization surgery and topical Cenergermin (Oxervate).
- Trial name
- NCT07073729
- Testing
- Corneal Neurotization, Cenergermin
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Sensitisation
DIEP (Deep Inferior Epigastric Artery Perforator) Flap Sensory Recovery Following Neurotization
The purpose of this study is to compare the sensory return of DIEP flaps with nerve connection to DIEP flaps with no nerve connection to see which is better.
- Trial name
- NCT04818190
- Testing
- Sensory neurotization
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Breast Implant; Complications
Split Chest Breast Neurotization
Several members of the scientific community have suggested that breast neurotization can help return nipple sensation to patients undergoing implant-based breast reconstruction.
- Trial name
- NCT05757778
- Testing
- Sensory Nerve Coaptation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- NYU Langone Health
Nerve Transfer
Reanimation of Shoulder External Rotation Via Neurotization
Measurement of clinical outcome after nerve transfer in deficiency of shoulder external rotation in children with OBPP.
- Trial name
- NCT06787391
- Testing
- Neurotization of Spinal Accessory Nerve To Supra-Scapular in children with OBPP with deficiency of Shoulder External Rotation, Neurotization of Spinal Accessory Nerve To Supra-Scapular Nerve
- Volunteers
- 25 people
- Sponsor
- Assiut University
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8
Neurotization of the Nipple Areolar Complex to Restore Sensation for Patients With Breast Cancer Undergoing Nipple Sparing Mastectomy and Reconstruction
This phase II trial tests the willingness of patients undergoing nipple sparing mastectomy (NSM) to enroll in a randomized study of NSM with or without neurotization of the nipple areolar complex (NAC).
- Conditions
- Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8
- Trial name
- NCT06153836
- Testing
- Neurotization Procedure, Questionnaire Administration, Subcutaneous Mastectomy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Mayo Clinic