Clinical trials: Nervous System
Parkinson Disease
A Study Evaluating Potential Screening Tools for Detecting Parkinson Disease
This study is designed as a prospective cohort study to test the strategy of combining two biomarkers of parkinsonism, olfaction and brain imaging with a radioactively labeled drug, [123I]β-CIT , in a population of first-degree…
- Trial name
- NCT00387075
- Testing
- [123I]β-CIT and SPECT imaging, [123I]β-CIT
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Elective Laparoscopic Cholecystectomy
The Effect of Respiratory Exercises on Abdominal Distension in Laparoscopic Cholecystectomy Patients
Laparoscopic cholecystectomy is the first-line treatment for symptomatic gallstones. Pneumoperitoneum is the process of expanding the abdominal cavity during the surgical procedure by introducing CO2 gas into the abdomen to widen…
- Trial name
- NCT06069557
- Testing
- Respiratory exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Pompe Disease
CPAP for Infantile Pompe Disease
Patients with infantile onset Pompe disease will be trained with continuous positive airway pressure to see if hypernasality can be improved.
- Trial name
- NCT02405624
- Testing
- continuous positive airway pressure
- Where
- Taiwan
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Stress, Irritable Bowel Syndrome
Evaluating and Treating Potential Research Participants With Digestive Disorders
Background: Some research studies focus on digestive disorders, such as nutritional, gastrointestinal, and liver disorders. Researchers want to examine and treat people with digestive disorders in order to learn more about these…
- Conditions
- Stress, Irritable Bowel Syndrome, Obesity, Abdominal Pain
- Trial name
- NCT01736280
- Testing
- Standard of Care
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Medication Adherence, Medication Compliance
Connected Healthcare for Individuals Living at Home With Chronic Conditions
Managing and taking medications as prescribed can be a difficult task. This is especially true for older adults living at home with chronic conditions while managing multiple prescribed medications.
- Conditions
- Medication Adherence, Medication Compliance, Medication Nonadherence, Hypertension
- Trial name
- NCT04339296
- Testing
- Spencer
- Where
- Canada
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Alberta Health Services, Calgary
Osteoarthritis, Pain
Safety of Non-delayed Weight Bearing After Total Hip Replacement With Non-Cemented Fiber Metal Taper Stem
The purpose of this study is to determine if full weight bearing following total hip replacement can speed recovery when the hip replacement in the long bone of the leg is not cemented into the bone.
- Trial name
- NCT00179088
- Testing
- Patient may be able to put weight on the operated leg
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Friedreich Ataxia
Evaluation of the Effects of Calcitriol's in the Neurological Symptoms of Friedreich's Ataxia Patients
Friedreich's Ataxia (FA) is an autosomal recessive disease the mutation of which leads to a deficiency of a protein called frataxin, which is responsible for the symptoms of the disease.
- Trial name
- CalcitriolFA (NCT04801303)
- Testing
- Calcitriol, Blood analysis for frataxin's level measurement, Blood analysis for hypercalcemia's control
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Berta Alemany
Parkinson Disease
Respiratory Functions in Parkinson's Disease
The aim is to examine respiratory functions, inspiratory muscle strength, respiratory function, physical fitness and aerobic capacity in Parkinson's disease patients.
- Trial name
- NCT07010783
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ankara University
Lumbar Spinal Stenosis, Cardiac Amyloidosis
Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis
Primary objective: To identify older adults with transthyretin cardiac amyloidosis (ATTR-CA) early in the course of the illness, at a time when disease modifying therapies are most effective.
- Conditions
- Lumbar Spinal Stenosis, Cardiac Amyloidosis, ATTR Amyloidosis Wild Type, ATTR Gene Mutation
- Trial name
- NCT06034405
- Testing
- Tc99-PYP or Tc99-HDMP Scan
- Where
- 6 sites in United States
- Volunteers
- 1,663 people, healthy volunteers welcome
- Sponsor
- Columbia University
Hearing Loss
Validating the Hum Test
The sensitivity and specificity of the Hum Test is being investigated in it's ability to detect conductive hearing loss. The hum test is simply elicited by asking the subject to hum to him or herself for a few seconds at both a…
- Trial name
- NCT02740322
- Testing
- Hum Test, Weber Test, Audiogram
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health
Abdominal Pain, Abdominal Cramps
A Study on Intestinal Gas Symptoms to Evaluate the Effects of Gas Defense in Otherwise Healthy Adult
This is a randomized, double-blind, placebo-controlled trial to determine the safety and efficacy of Digestive Advantage™ Gas Defense formula, a probiotic dietary supplement.
- Conditions
- Abdominal Pain, Abdominal Cramps, Flatulence
- Trial name
- NCT00881322
- Testing
- BC-130 (Gas Defense)
- Where
- 2 sites in United States, Dominican Republic
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Miami Research Associates
Sleep Initiation and Maintenance Disorders
15-Day Repeated-Dose Study With SB-649868 And Its Interaction With CYP3A4 Isoenzyme In Healthy Male Subjects.
Subjects will be screened within 28 days, Simvastatin dose and single SB-649868 dose 10 and 7 days prior to repeat dosing respectively, 15 days SB-649868 repeat dosing with safety and cognition function tests.
- Trial name
- NCT00495729
- Testing
- SB-649868, Simvastatin
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cerebral Palsy, Spastic
Effect of Task-Specific Training in an Augmented Reality Context on Upper Limb Function and Activities in Children With Spastic Cerebral Palsy
Children with Cerebral Palsy (CP), a condition that affects movement and coordination, face difficulties in daily activities such as dressing, reaching for objects in high places, and getting up from seats.
- Trial name
- INTERACT (NCT06571929)
- Testing
- INTERACT
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos
Burnout, Insomnia
Improving the Mental Health and Well Being of Healthcare Providers Through the Transcendental Meditation Technique
The level of stress-related disorders experienced by Healthcare Providers (HCPs) has increased due to the recent COVID-19 Pandemic, impacting patient care and provider shortages.
- Conditions
- Burnout, Insomnia, Well Being
- Trial name
- NCT05239429
- Testing
- Transcendental Meditation Technique
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- The Center for Clinical and Cosmetic Research
UPPER CROSS SYNDROME
Effects of Segmental and Pursed Lip Breathing Exercises on Upper Cross Syndrome
Upper cross syndrome is relative prevalent 67% musculoskeletal disorder among general population due to increased usage of smart gadgets and poor postural habits.
- Trial name
- NCT06303102
- Testing
- Manual PT/ Conventional PT Treatment + Segmental and Pursed Lip Breathing Exercise, Manual PT/Conventional PT Treatment
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Aging, Healthy Aging
Biological Effects in Consumers of Resveratrol-enriched Wine
The objective of this clinical trial is to compare the health conditions of the participating population before and after an intervention with Resveratrol enriched wine. The main questions it aims to answer are: 1.
- Conditions
- Aging, Healthy Aging, Sarcopenia, Obesity
- Trial name
- NCT05981053
- Testing
- Wine enriched with Resveratrol
- Where
- Argentina
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- PINER Pastor Manfredi Winery
Stroke, Urinary Incontinence
Effect of Pelvic Floor Muscle Training in Stroke
Aim: To evaluate the long term effect of pelvic floor muscle training in women with urinary incontinence after ischemic stroke measured by quality of life paramters.
- Trial name
- NCT00258037
- Testing
- Pelvic Floor Muscle training
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Safety Issues, Effect of Drugs
The Treatment of Premature Infants With Brain Injury by Autologous Umbilical Cord Blood Stem Cells
To study the safety and effect of autologous umbilical cord blood stem cells for treatment brain injury
- Trial name
- NCT03696745
- Testing
- autologous umbilical cord blood stem cells, 0.9% Sodium-chloride
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Guangdong Women and Children Hospital
Polio
Pakistan Short Interval mOPV1 Compared With Standard Interval mOPV1 and bOPV 1,3
Globally, polio cases have decreased by over 99% since 1988. However, wild poliovirus cases continue in Pakistan. Conflict and lack of access to children due to on-going insecurity in tribal areas present special challenges in…
- Trial name
- SIAD (NCT01586572)
- Testing
- mOPV1, bOPV 1,3
- Where
- 2 sites in Pakistan
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Body Mass Index Quantitative Trait Locus 5 Disorder, Tangier Disease
Effect of High Protein Diet on Adiponectin and Inflammation Among Overweight and Obese Children
The investigators aimed to determine the effects of HP diet on adiponectin and inflammatory factors among overweight and obese children.
- Trial name
- NCT01886495
- Testing
- nutrition intervention
- Where
- Iran
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
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