Clinical trials: Nervous System Cancer
Neurofibromatosis Type 1
A Randomized Placebo-Controlled Study of Lovastatin in Children With Neurofibromatosis Type 1
The specific aim of this study is to determine whether Lovastatin ™ significantly improves visual spatial learning and/or sustained attention in children with NF1.
- Trial name
- STARS (NCT00853580)
- Testing
- Lovastatin ™
- Where
- 12 sites in United States, Australia
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pediatric Cancer
Efficacy of Cognitive and Physical Trainings in Pediatric Cancer Survivors
Cancer survival comes at a price: pediatric cancer survivors have a high risk for a wide range of cognitive difficulties, particularly survivors of cancer involving the central nervous system (CNS, e.g., brain tumors [BT]) are…
- Trial name
- NCT02749877
- Testing
- Working Memory Training, Physical Training
- Where
- Switzerland
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Androgen Deprivation Therapy, Prostate Cancer
Autonomic and Renal Contributions to Hypertension With ADT
This study plans to learn more about contributors to high blood pressure in men who undergo androgen deprivation therapy (ADT) to treat prostate cancer.
- Conditions
- Androgen Deprivation Therapy, Prostate Cancer, Hypertension, Autonomic Dysfunction
- Trial name
- ARCH (NCT07848828)
- Testing
- Gonadotropin Releasing Hormone Agonists (GNRH), Androgen receptor (AR) inhibitor
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Periodontal Disease, Gingivitis and Periodontal Diseases
Hippo Signaling Pathway Proteins in Gingival Crevicular Fluid of Individuals With Periodontal Disease
Periodontal disease is a chronic inflammatory condition of the tooth-supporting tissues in which the host inflammatory response drives the destruction of alveolar bone and periodontal attachment.
- Conditions
- Periodontal Disease, Gingivitis and Periodontal Diseases, Biomarker Discovery and Validation, Pathways
- Trial name
- BYHN-GCF-HIPPO (NCT07759466)
- Testing
- ELISA Biomarker Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Inonu University
Neuroendocrine Neoplasm, Neuroendocrine Neoplasm of Gastrointestinal Tract
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients
Neuroendocrine neoplasms (NENs) are a heterogeneous group of lesions derived from cells with the ability to produce hormones that may arise from multiple different organs.
- Conditions
- Neuroendocrine Neoplasm, Neuroendocrine Neoplasm of Gastrointestinal Tract, Neuroendocrine Neoplasm of Lung, Thymic Neuroendocrine Neoplasm
- Trial name
- NCT06523582
- Where
- 3 sites in Mexico
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Mexico
Intervention, Control
A Sleep Intervention for Cancer Patients and Their Caregivers
The purpose of the study is to design and test a dyadic sleep intervention for patients diagnosed with cancer and their intimate partner.
- Trial name
- NCT04969146
- Testing
- Dyadic Intervention, Patient Only Intervention
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Multiple Sclerosis, Clinically Isolated Syndrome
Pregnancy Registry, Infants, Serum/Milk Analysis (PRISMA)
PRISMA, is a pregnancy registry study, focused on comprehensively collecting information about pregnancy in women with chronic neurological conditions from across the United States and internationally.
- Conditions
- Multiple Sclerosis, Clinically Isolated Syndrome, NMOSD, Myasthenia Gravis
- Trial name
- NCT06940323
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Dengue, Chikungunya
Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
RACSMEI addresses the high burden of infectious diseases in low- and middle-income countries, including Cambodia, where limited surveillance and laboratory capacity often obscure etiologies and transmission dynamics.
- Conditions
- Dengue, Chikungunya, Zika Virus Infection, Japanese Encephalitis
- Trial name
- RACSMEI (NCT07358910)
- Where
- Cambodia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Alzheimer Disease
A Study to Investigate the Regional Brain Kinetics of Brain Drug Transporters Using P-glycoprotein and Breast Cancer Resistance Protein Substrates and by Using the Positron Emission Tomography Ligand 11C-JNJ-63779586 in the Human Brain
The purpose of this study is to investigate the total body biodistribution and radiation dosimetry of 11C-JNJ-63779586 by Positron Emission Tomography (PET) in healthy young adult males (Part A); to estimate and compare the…
- Trial name
- NCT03089918
- Testing
- 11C-JNJ-63779586
- Where
- 2 sites in Belgium
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Breast Cancer Female, Pain, Postoperative
Pectoral Nerve Block During Mastectomy
Impact of pectoral nerve block on postoperative pain and quality of recovery in patients undergoing breast cancer surgery: A prospective study
- Trial name
- PNB (NCT05699902)
- Testing
- PECs block during mastectomy
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Glioma
Magnetic Resonance Elastography in Glioma: Exploring Tumor Stiffness and Adhesion
this study will investigate the relationship between tumor stiffness and adhesion in gliomas using MRE. By utilizing preoperative MRE and Intraoperative neuronavigation, followed by comprehensive molecular pathology analysis, we…
- Trial name
- NCT05990244
- Testing
- Magnetic Resonance Elastography, Assessment and Recording
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Fatigue, Pain
Molecular Determinants of Persistent Cancer Related Fatigue
The purpose of this study is to determine if inflammatory markers in blood as well as brain neurotransmitters (markers of in-brain activity and metabolism) are related to long-term or chronic fatigue.
- Conditions
- Fatigue, Pain, Poor Sleep Quality
- Trial name
- MDOF (NCT01980719)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Breast Cancer, Postoperative Pain
PECS Block in Partial Mastectomy for Postoperative Pain Control
The aim of this study is to evaluate patients who are undergoing partial mastectomy or removal of breast tissue and see if a pectoralis nerve block (PECS) can provide a meaningful improvement in postoperative pain control over…
- Conditions
- Breast Cancer, Postoperative Pain, Opioid Use, Local Anesthesia
- Trial name
- PECS (NCT04086394)
- Testing
- Pectoral Nerve Block, Surgery without Nerve Block
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Main Line Health
Brain Tumor, Surgery
The Use of Navigated Transcranial Magnetic Stimulation (nTMS) in the Inhibition of Neurofunctional Regions of Interest
The purpose of this study is to investigate the efficacy of task inhibition during TMS to confirm brain region localization. This study could provide an effective pathway for neurofunctional landmark confirmation that may be…
- Trial name
- NCT04209023
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Neurological Associates of West Los Angeles
Rhinosinusitis Chronic, Sinus Cancer
TIVA vs TXA in Sinus Surgery to Evaluate Operative Blood Loss and Surgical Field Quality
The goal of this interventional study is to compare the efficacy (surgical field quality and intra-operative blood loss) or cost of TIVA alone to general inhalational anesthetics with intravenous TXA in patient participants who…
- Conditions
- Rhinosinusitis Chronic, Sinus Cancer, Sinus Polyp, Encephalocele
- Trial name
- NCT05639686
- Testing
- Tranexamic acid injection, Total Intravenous Anesthesia, Inhalational isoflurane
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Our Lady of the Lake Hospital
Neurofibromatosis Type 1, Learning Disability
Interventions for Reading Disabilities in NF1
Neurofibromatosis Type 1 (NF1) is a common genetic disorder that is associated with a four times greater risk of learning disabilities, including reading disabilities, and a deficiency of neurofibromin - a protein important in a…
- Conditions
- Neurofibromatosis Type 1, Learning Disability, Reading Disability, NF1
- Trial name
- NCT02964884
- Testing
- Lovastatin, reading tutoring intervention
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Brain Metastases, Cancer
Study of Laser Interstitial Thermal Therapy (LITT) Treatment Response Assessment With Fluciclovine PET MR
The purpose of this study is to assess the relationship between brain malignancy volume as defined by post-contrast T1 weighted and F18 Fluciclovine before and following LITT.
- Conditions
- Brain Metastases, Cancer, Gliomas, Glioblastoma
- Trial name
- NCT05054400
- Testing
- F18 Fluciclovine, Standard of Care
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
HER2-positive Breast Cancer
PIK3CA in HER2+ BC and pCR Trial
The goal of the study is to evaluate the impact of somatic PI3KCA mutations on pCR in HER2-positive early breast cancer in real life. The main question it aims to answer iS.
- Trial name
- NCT05750693
- Testing
- PIK3CA analysis
- Where
- Italy
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Children Living Beyond Cancer (i.e. Child Cancer Survivor)
Co-creation of Pain Science Education for Children Living Beyond Cancer
A pain science education (PSE) intervention for children (8-12y) living beyond cancer (CBC) will be developed through a co-creational approach with CBC, their parents and pediatric oncology clinicians.
- Trial name
- PANACEA (NCT06345391)
- Testing
- Co-creation, Concept Mapping
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Suicide, Attempted, Suicidal Ideation
Biomarkers as Predictors of Suicidal Risk in Adolescents
Suicide is one of the most devastating events in society at all levels. The primary goal of this study is to predict suicide in adolescents at risk.
- Conditions
- Suicide, Attempted, Suicidal Ideation, Suicidal Intention, Suicide
- Trial name
- NCT03014518
- Testing
- Clinical assessments and blood samples; follow-up for 12 mos, Clinical assessments and blood samples; no 12mo follow-up
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic