Clinical trials: Nervous System Disorder
Ocular Injury
Study of Retinal Vascular Changes After Ocular Blunt Trauma
This study evaluates the retinal vascular features using optical coherence tomography angiography in patients that received ocular blunt trauma.
- Trial name
- NCT04546997
- Testing
- Optical Coherence Tomography Angiography
- Where
- Italy
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Federico II University
Healthy, Stroke
Influence of Brain Oscillation-Dependent TMS on Motor Function
Background: When people have a stroke, they often have difficulty moving their arms and hands. Transcranial magnetic stimulation (TMS) can improve how well people with and without stroke can move their arms and hands.
- Conditions
- Healthy, Stroke, Normal Physiology, Aging
- Trial name
- NCT03288220
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Restless Legs Syndrome (RLS)
Study on the Mechanism of Gut Microbiota Mediating Restless Legs Syndrome Through Iron Metabolism
The goal of this observational study is to collect fecal and serum samples from patients with restless legs syndrome (RLS) and healthy controls for differential microbiota analysis to identify key bacterial species involved in…
- Trial name
- NCT07307482
- Testing
- Not applicable- observational study
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wenxia Jiang
Strabismus
Mobile Medical Application for Cost-effective Strabismus Screening
Develop and evaluate a new smartphone based app to screen for and measure eye misalignment (strabismus). The investigators will validate the app against simulated strabismus of known magnitude and common clinical tests.
- Trial name
- NCT03450980
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Stress, Psychological, Physiological
Effects of Yoga on Objective and Self-reported Health Indicators Among Female and Male Individuals
The purpose of this study is to determine whether inversions (specific yoga postures in which the heart is higher than the head) and other dynamic and static yoga postures affect heart rate variability, oxygen uptake, blood…
- Trial name
- NCT01305096
- Testing
- Yoga intervention
- Where
- Sweden
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Postoperative Delirium, Postoperative Cognitive Dysfunction
Greek Validation of ACE III Test in Perioperative Patients
Postoperative neurocognitive disorders, including postoperative delirium (POD) and postoperaive cognitive dysfunction (POCD), are common complications of perioperative neurocognition in elderly patients undergoing surgery.
- Trial name
- NCT04312516
- Where
- Greece
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Spinal Cord Compression
White Matter Fiber Tracking and Assessment of White Matter Integrity in the Cervical Spinal Cord
White matter fiber tracking may provide a novel tool to assess the integrity of injured motor tracts in the cervical spine. It provides information about fiber directions which is not given by conventional MRI.
- Trial name
- NCT00280306
- Testing
- No interventions
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Hepatitis C, Chronic, Cognition Disorders
Study of Cerebral Function in Patients With Chronic Hepatitis C Infection (HCV/CNS)
Patients with HCV infection often suffer from chronic fatigue, depression and reduced cognition, even before evolving severe liver fibrosis, liver cirrhosis and hepatic encephalopathy.
- Conditions
- Hepatitis C, Chronic, Cognition Disorders, Fatigue Syndrome, Chronic, Major Depressive Disorder
- Trial name
- NCT00788918
- Testing
- Interferon and ribavirin
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Chronic Metabolic Disorder, Lipid Metabolism Disorders
Randomized Clinical Trial of HMR(Home Meal Replacement)-Type Omega-3-balanced-diet
Investigate whether HMR(Home meal replacement)-type omega-3-balanced-diet can improve clinical laboratory values related to chronic metabolic diseases through reducing lipids and chronic inflammation, and can prevent muscle loss.
- Conditions
- Chronic Metabolic Disorder, Lipid Metabolism Disorders, Sarcopenia
- Trial name
- NCT04552574
- Testing
- HMR(Home meal replacement)-type omega-3-balanced diet
- Where
- South Korea
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Chungbuk National University Hospital
Meningitis, Meningococcal Meningitis
Safety of a Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine in Healthy Subjects in Vietnam
The aim of the study is to assess the safety of Menactra vaccine in infants, toddlers, children, adolescents, and adults Objective: To describe the safety profile after each and any dose (when applicable) of Menactra vaccine in…
- Conditions
- Meningitis, Meningococcal Meningitis, Meningococcal Infections
- Trial name
- NCT02640404
- Testing
- Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine
- Where
- Vietnam
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Alzheimer's Disease
The Locus Coeruleus and Memory
The cause of Alzheimer's disease, the most common form of dementia, remains unknown. Neuropathological studies suggest that a small area in the brainstem, the locus coeruleus, might be the site of the onset of the disease.
- Trial name
- LOCUS (NCT02363504)
- Testing
- 7 Tesla MRI with memory task and non-invasive neurostimulation
- Where
- Netherlands
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Hyperalgesia, Pain
Effect of High Dose Naloxone on Secondary Hyperalgesia
Recent studies have focused on the role of endogenous opioids on central sensitization. Central sensitization is known to be impaired or altered in chronic pain conditions, as fibromyalgia or chronic tension headache.
- Conditions
- Hyperalgesia, Pain, Naloxone, Opioid Antagonist
- Trial name
- NCT01935206
- Testing
- Naloxone (2 mg/kg)
- Where
- 2 sites in Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sleep Deprivation
Effect of Work Load and Sleep Deprivation on Medical Staff's Driving Skills
Long and unorthodox working hours (e.g. 24 hours or 23pm-07am shifts for doctors and nurses respectively) combined with sleep deprivation, may affect cognitive functions such as response time and concentration.
- Trial name
- NCT00849706
- Testing
- Study participants will work their regular shifts, and tested after night shifts.No shifts will be added because of the study.
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Blindness
A Study to Evaluate the BrainPort Vision Device in Individuals Blinded by Traumatic Injury
The BrainPort V200 Device is a wearable, non-surgical, prosthetic device intended for people who are profoundly blind. The BrainPort V200 translates images captured by a digital camera into electro-tactile stimulation presented…
- Trial name
- NCT02393118
- Testing
- BrainPort V200 Device
- Where
- 3 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wicab
Multiple Sclerosis
Figure of 8 Walk Test in Multiple Sclerosis
Balance disorder is common in people with MS. As the disease worsens, it is associated with impaired balance, difficulty walking, decreased mobility, and an increased risk of falling.
- Trial name
- NCT05433714
- Testing
- Assesment
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Concussion, Brain Trauma
Field Implementation of iDETECT
The purpose of this study is to assess a new screening tool for sideline evaluation of concussion injuries in athletes. iDETECT is a new technology that combines several elements of recommended concussion screening tools into a…
- Trial name
- NCT02529618
- Testing
- integrated Display Enhanced Testing for Cognitive Impairment and mild traumatic brain injury (iDETECT), Riddell High Impact Technology (HIT) System, i1 Biometrics Vector Mouth Guard
- Where
- 4 sites in United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Emory University
Non Sarcopenic Subjects, Possible Sarcopenia
Association Between Oral Hypofunction, Sarcopenia and Social Frailty in Community-dwelling Older Adults
Previous studies have provided a preliminary understanding of the likelihood of sarcopenia and the prevalence of sarcopenia in the elderly in the community.
- Conditions
- Non Sarcopenic Subjects, Possible Sarcopenia, Sarcopenia(With Low ASM by BIM)
- Trial name
- OSSF (NCT07658625)
- Testing
- Non interventional study
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chang Gung University of Science and Technology
Chronic Subdural Hematoma
Association Between Dietary Factors and Chronic Subdural Hematoma (DISH)
A prospective, multicenter, case control trial is designed to compare difference in dietary and nutritional factors in patients with and without chronic subdural hematoma.
- Trial name
- DISH (NCT05599217)
- Testing
- Dietary and nutritional questionnaire, Neurological function, cognitive function, and life quality assessment, Peripheral blood test
- Where
- 4 sites in China
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Zygoma Fracture
Outcomes of Zygomatic Fractures: Cross- Sectional Study
Rationale: Facial trauma is a significant event for patients, often resulting in physical and psychological consequences. Fractures in the zygomatic bone area are common due to its unique shape and positioning in the face…
- Trial name
- ZY-PROM (NCT06476340)
- Testing
- No intervention
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Stair Climbing, Instrumentation
Implementation and Validation of Instrumented Stair Climb Test
The aim of this study is to design an instrumented test for the evaluation of the climb of stairs. In particular, the main purpose is to characterize and compare the performance of subjects, both pediatrics and adults, with…
- Conditions
- Stair Climbing, Instrumentation, Test
- Trial name
- SCTS (NCT06999850)
- Testing
- Instrumented Stair Climb Test, Walk Test, Repaeted Instrumented Stair Climb Test
- Where
- 3 sites in Italy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
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