Clinical trials: Nervous System Disorders
Brain Disease
Clinical Translation of a Novel Brain PET Insert for Simultaneous PET/MR
The primary goal of this project is to study the feasibility of a brain-dedicated PET insert for an MR scanner for simultaneous acquisition of PET/MR images of human brains.
- Trial name
- NCT04383808
- Testing
- Injected radiotracer with PET Insert, Pre-injected group with PET insert
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cerebral Palsy
Comparing the Effectiveness of mCIMT and Bimanual Training
This study aimed to compare the effects of Modified Constraint-Induced Movement Therapy (mCIMT) and Bimanual Training (BIT) based on the International Classification of Functioning, Disability, and Health, Children \&Youth…
- Trial name
- NCT04577391
- Testing
- Modified Constraint-Induced Movement Therapy, Bimanual Training
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Muş Alparslan University
Fibromyalgia, Primary
An Eight Week, Double-Blind Efficacy Study of Armodafinil Augmentation to Alleviate Fibromyalgia Fatigue
Armodafinil (NuvigilTM) is an isomer of a drug currently approved by the FDA for the treatment of fatigue secondary to narcolepsy, sleep apnea, and shift work sleep disorder called modafinil (ProvigilTM).
- Trial name
- NCT00678691
- Testing
- armodafinil
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Sleep Deprivation, Sleep Wake Disorders
A Comparative Analysis of Stretching Exercise and Pregnancy Exercise on Sleep Quality in Pregnancy: A Quasi Experiment
The goal of this clinical trial is to learn whether pregnancy exercise or stretching exercise can improve sleep quality in third trimester pregnant women who experience sleep disturbances.
- Conditions
- Sleep Deprivation, Sleep Wake Disorders, Pregnancy, Anxiety Disorders
- Trial name
- CESP (NCT07367360)
- Testing
- Traditional Pregnancy Exercise Group, Stretching Exercise Group (Control)
- Where
- Indonesia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Health Polytechnic of Palangka Raya
Fatigue Syndrome, Chronic
The Effect of a Self-Management Program in University Students
This study will be conducted as a randomized controlled pre-post test trial designed in accordance with the CONSORT guidelines. University students with chronic fatigue will be invited to participate; eligible participants will…
- Trial name
- NCT07455123
- Testing
- Self-Management Programme for Chronic Fatigue
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Sclerosis, Multiple
Application of ihMT MRI in Multiple Sclerosis
The development of in vivo biomarkers sensitive to myelin disruption represents a major clinical need to be able to monitor the demyelination processes as well as the effect of remyelinating therapies in multiple sclerosis.
- Trial name
- ihMTMS (NCT03600779)
- Testing
- inhomogeneous Magnetisation Transfer (ihMT) sequence, inhomogeneous Magnetisation Transfer (ihMT) sequence at 3T
- Where
- France
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Oxidative Phosphorylation Deficiencies, Electron Transport Chain Disorders, Mitochondrial
The NIH MINI Study: Metabolism, Infection, and Immunity in Inborn Errors of Metabolism
The Metabolism, Infection and Immunity (MINI) Study is a longitudinal natural history study at the National Institutes of Health (NIH) that aims to define the relationship between infection, immunity and clinical decline in…
- Conditions
- Oxidative Phosphorylation Deficiencies, Electron Transport Chain Disorders, Mitochondrial, Mitochondrial Disorders, Leigh Disease
- Trial name
- NCT01780168
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Parkinson Disease
SPEECH as Biomarker for Emotion, Movement and cOgnition in Parkinson's Disease
With this study, the investigators want to investigate whether computerized speech analysis can be used to reliably and objectively detect motor, emotional, and cognitive fluctuations in Parkinson's disease patients.
- Trial name
- EMO-SPEECH-PD (NCT05765110)
- Testing
- Dopaminergic OFF drug state, DBS OFF state, Dopaminergic ON drug state
- Where
- 2 sites in Czechia, Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Schizophrenia, Psychosis
Effects of Transcranial Direct Current Stimulation (tDCS) on Motor Function in Schizophrenia Patients and Individuals at Risk for Psychotic Onset
The purposes of this research are to investigate (1) if schizophrenia patients and at-risk individuals present bradykinesia and dyskinesia and (2) if tDCS improves motor performance in schizophrenia patients and at-risk…
- Conditions
- Schizophrenia, Psychosis, Parkinsonism, Dyskinesias
- Trial name
- NCT04086160
- Testing
- Transcranial direct current stimulation device (Soterix Medical, New York, NY)
- Where
- Hong Kong
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Dr WANG Shumei
Behavior Problem, Development Delay
Norwalk Feasibility Study
The purpose of this study is two-fold: 1) to examine the feasibility of the Drop-In model of Family Nurture Intervention (FNI); and 2) to collect pilot data concerning the mother's response to the Drop-In model of FNI and short…
- Conditions
- Behavior Problem, Development Delay, Emotional Disturbances, Family Conflict
- Trial name
- NCT04048720
- Testing
- Family Nurture Intervention
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Columbia University
Postoperative Delirium, Postoperative Cognitive Dysfunction
Modulating ApoE Signalling to Reduce Brain Inflammation, deLirium and postopErative Cognitive Dysfunction
This research study will evaluate the effectiveness and estimate the feasibility of administering an investigational drug called 'CN-105' (the study drug), to prevent postoperative cognitive decline, delirium (serious confusion)…
- Trial name
- MARBLE (NCT03802396)
- Testing
- CN-105
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Miles Berger, MD PhD
Pregnancy Related
TeamBaby - Safe, Digitally Supported Communication in Obstetrics and Gynecology
The purpose of this project with obstetric healthcare workers, pregnant women and their relatives is to improve communication between all parties involved in order to increase sustainable patient safety.
- Trial name
- TeamBaby (NCT03855735)
- Testing
- TeamBaby Online Communication Training (IG1) and TeamBaby Web-App Communication Training (IG2)
- Where
- 2 sites in Germany
- Volunteers
- 424 people, healthy volunteers welcome
- Sponsor
- Jacobs University Bremen gGmbH
Chronic Sciatica
Efficacy and Mechanism of Acupuncture for Chronic Sciatica Using fMRI
This research is planned to build a basis about the efficacy and mechanism of acupuncture on pain and emotional disorder in patients with chronic sciatica using fMRI.
- Trial name
- NCT03350789
- Testing
- Real acupuncture
- Where
- South Korea
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Kyung Hee University Hospital at Gangdong
Polyneuropathy, Charcot Marie Tooth Disease (CMT)
Effects of Resistance Exercises in Hereditary Sensory-Motor Neuropathy (Charcot-Marie-Tooth Disease)
The goal of this clinical trial is to compare the effects of an 8-week resistance exercise training program on skeletal muscle quality, functional capacity, and quality of life in young individuals aged 15 to 29 years, with and…
- Trial name
- PNP (NCT07152197)
- Testing
- Progressive Resistance Exercise Training
- Where
- 2 sites in Chile
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Universidad de La Frontera
Vestibular Hypofunction
Improving Psychological and Vestibular Health: MINDGAPS
The purpose of this study is twofold: 1) Develop norms for measures of inner ear function and psychological health, and 2) Examine the feasibility of using the MINDGAPS system (a remote monitoring system) to track progress during…
- Trial name
- MINDGAPS (NCT05986279)
- Testing
- Rehab
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Montana
Carotid Artery Stenosis, Carotid Artery Stenosis Asymptomatic
The VANGAS-Trial. The Value of Neurofilament Light Chain and Glial Fibrillary Acid Protein in the Blood of Patients With Asymptomatic Carotid Artery Stenosis
Stroke is the second leading cause of death and the third leading cause of disability worldwide. The cause is usually either a blockage or a severe narrowing of a cerebral artery.
- Conditions
- Carotid Artery Stenosis, Carotid Artery Stenosis Asymptomatic, Carotid Artery Diseases, Carotid Artery Plaque
- Trial name
- VANGAS (NCT06211725)
- Where
- 2 sites in Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Pulmonary Disease, Autonomic Dysfunction
Meditative Movement for COPD Symptoms in Non-Smoking Flight Attendants
This study will explore the a Qigong based exercise intervention, here referred to as Meditative Movement (MM), to ameliorate the symptoms associated with chronic obstructive pulmonary disease (COPD) and its co-morbidities.
- Conditions
- Pulmonary Disease, Autonomic Dysfunction, COPD
- Trial name
- MMforFA (NCT02612389)
- Testing
- Meditative Movement taught via DVD
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Narcolepsy, REM Sleep Behavior Disorder
Investigation of Clinical Feature and Brain Function in Narcoleptic Patients
This study evaluates the PSG and cerebral metabolism and functions in narcolepsy with/without RBD
- Trial name
- NCT03376568
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Traumatic Brain Injury, Intracerebral Haemorrhage
The EBC Recovery Study
The purpose of this research study to find out if clinically unconscious acute brain injury patients that show brain activation to music and language on electroencephalogram (EEG) (bedside test) have better outcomes and wake up…
- Conditions
- Traumatic Brain Injury, Intracerebral Haemorrhage, Subarachnoid Haemorrhagic Stroke
- Trial name
- NCT04712591
- Testing
- Auditory stimuli
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Miami
CNS Germinoma, CNS Tumor
Development of Asian Consortium for Data Collection and Clinical Trial of CNS Tumors
<Purpose of the Research> Primary Establishing an Asian consortium to establish a database of pediatric CNS tumors in the prospective manner The target disease of this research focuses on pediatric tumors, and initially the…
- Conditions
- CNS Germinoma, CNS Tumor, Asian Consortium
- Trial name
- NCT05982691
- Testing
- Radiation Therapy
- Where
- South Korea
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
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