Clinical trials: Nervousness
Sarcopenia
VR-based Rehabilitation in the Treatment and Prevention of Sarcopenia of Older Residents
Background: Sarcopenia is the progressive loss of skeletal muscle mass and decline of muscle function associated with aging. The prevalence of sarcopenia among people older than 65 years old in Taiwan is over 20%.
- Trial name
- NCT03809104
- Testing
- Virtual reality-based rehabilitation programs
- Where
- Taiwan
- Volunteers
- 43 people
- Sponsor
- Cishan Hospital, Ministry of Health and Welfare
Traumatic Brain Injury, Coma
The Efficacy of Familiar Voice Stimulation During Coma Recovery
The purpose of the study is to determine whether familiar vocal stimulation, provided during coma recovery, improves outcomes for persons who are unconscious after severe TBI.
- Conditions
- Traumatic Brain Injury, Coma, Vegetative State, Minimally Conscious State
- Trial name
- FAST (NCT00557076)
- Testing
- Familiar Auditory Sensory Training
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- VA Office of Research and Development
Concussion, Brain
Developing an Implementation Strategy for Post-concussion Communication With Low Health Literacy Parents in the Emergency Department
Investigators will conduct a hybrid implementation-effectiveness evaluation of an educational intervention that supports communication with families post-concussion in the emergency department.
- Trial name
- NCT04112914
- Testing
- Post-concussion education for families
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Carotid Artery Plaque
New Technologies to Determine Carotid Plaque Vulnerability in Patients With Significant Carotid Plaques
The researchers are trying to determine if the characterization of "vulnerable" carotid artery plaques can be accomplished with ultrasound-based methods that look for vessels in the plaque and measure the plaque stiffness.
- Trial name
- NCT03335033
- Testing
- Contrast-enhanced ultrasound, Shear Wave Elastography, Ultrasound Examination
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Mayo Clinic
Pain
A Study to Evaluate Efficacy and Safety of GSK3858279 in Diabetic Peripheral Neuropathic Pain
This is a multicenter randomized, double-blind, placebo-controlled phase 2 study to evaluate efficacy, safety, tolerability, pharmacokinetics, and target engagement of GSK3858279 in adult participants with chronic Diabetic…
- Trial name
- NEPTUNE-17 (NCT05838755)
- Testing
- GSK3858279
- Where
- 81 sites in United States, Canada and 9 more
- Volunteers
- 147 people
- Sponsor
- GlaxoSmithKline
Alzheimer Disease, Dementia
Enhancing Sleep Quality for Nursing Home Residents With Dementia
This was a pilot study (R61) to prepare for a full clinical trial (R33) aiming to improve clinical outcomes for an important, growing, and vulnerable population-nursing home (NH) residents with Alzheimer's disease or related…
- Conditions
- Alzheimer Disease, Dementia, Sleep Disorder, Sleep Disturbance
- Trial name
- 40Winks (NCT04533815)
- Testing
- LOCK sleep intervention
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Alabama, Tuscaloosa
Meningococcal Disease
Persistence Of Antibody Responses Among Children Who Previously Received Novartis MenACWY Conjugate Vaccine or Meningococcal C Conjugate Vaccine
The primary purpose of this study is to evaluate the persistence of bactericidal antibodies in children of approximately 22 to 45 months of age previously enrolled in the V59P22 study (NCT00667602) who received Novartis MenACWY…
- Trial name
- NCT01345721
- Testing
- MenACWY-CRM
- Where
- 11 sites in Germany
- Volunteers
- 205 people
- Sponsor
- Novartis Vaccines
Opioid Dependence, Opioid Withdrawal
Medical Management of Sleep Disturbance During Opioid Tapering
This study will evaluate whether a dual orexin-receptor antagonist approved by the FDA for sleep disturbance, suvorexant (SUVO; Belsomra), will increase total sleep time in patients with opioid use disorder (OUD) undergoing…
- Conditions
- Opioid Dependence, Opioid Withdrawal, Sleep Disturbance
- Trial name
- NCT03789214
- Testing
- Low Dose Suvorexant, High Dose Suvorexant
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Johns Hopkins University
Glioblastoma
Feasibility Study of Modified Atkins Ketogenic Diet in the Treatment of Newly Diagnosed Malignant Glioma
The purpose of this research study is to see if people can produce ketones in their blood with the modified Atkins diet. Modified Atkins diet is a diet that produces ketones in your blood by restricting carbohydrates to <20 grams…
- Trial name
- NCT03278249
- Testing
- Modified Atkins Ketogenic Diet
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Cincinnati
Epilepsy
Acute Recording of Stereotyped High-Frequency Oscillations
Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates >=1kHz and deliver…
- Trial name
- NCT05439655
- Testing
- Brain Interchange System
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Mayo Clinic
Dermatomyositis, Adult Type
Evaluating Safety & Efficacy of Apremilast in the Treatment of Cutaneous Disease in Patients With Recalcitrant Dermatomyositis
With limited treatment options available for dermatomyositis, the investigators hypothesize that apremilast, a phosphodiesterase-4 (PDE-4) inhibitor, is a safe and efficacious add-on treatment in patients with refractory…
- Trial name
- NCT03529955
- Testing
- Apremilast 30mg
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Tulane University
Painful Diabetic Neuropathy
A Trial in Painful Diabetic Peripheral Neuropathy With GRT3983Y
This trial is assessing the analgesic efficacy and safety of a new central analgesic in subjects with pain due to diabetic peripheral neuropathy (DPN).
- Trial name
- NCT01056315
- Testing
- GRT3938Y
- Where
- 61 sites in United States
- Volunteers
- 553 people
- Sponsor
- Grünenthal GmbH
Degenerative Disc Disease, Spondylolisthesis
The European Robotic Spinal Instrumentation (EUROSPIN) Study
In a multinational prospective study, preoperative, intraoperative, perioperative and follow-up data on patients receiving thoracolumbar pedicle screw placement for degenerative disease or infections or tumors will be collected.
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Spinal Stenosis, Recurrent Disc Herniation
- Trial name
- EUROSPIN (NCT03398915)
- Testing
- Transpedicular Instrumentation
- Where
- 12 sites in Austria, France and 5 more
- Volunteers
- 932 people
- Sponsor
- Marc Schröder
Hearing Loss
A Comparison of Hearing Aid Fitting Methods
This investigation will compare hearing aid fitting methods between self-fitting and clinician fitting approaches by using a standardized questionnaire to evaluate subjective hearing aid benefit.
- Trial name
- NCT05376215
- Testing
- Experimental hearing aid
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Sonova AG
Insomnia
Polysomnographic Study Comparing the Use of Dexmedetomidine and Zolpidem to Induce Natural Sleep
The purpose of this study is to determine whether dexmedetomidine can be used to induce normal physiological sleep in humans.
- Trial name
- NCT01485393
- Testing
- Dexmedetomidine, Zolpidem
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pain Management
Combined Peripheral (BreEStim) and Central Electrical Stimulation (tDCS) for Neuropathic Pain Management - Spinal Cord Injury
This study looks at the effect of combined breathing-controlled electrical stimulation (BreEStim) and transcranial direct current stimulation (tDCS) on neuropathic pain after spinal cord injury, amputation, or brain injury.
- Trial name
- NCT03302793
- Testing
- BreEStim, tDCS
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The University of Texas Health Science Center, Houston
AIDS-Related-Primary Central Nervous System Lymphoma
Chemotherapy and HAART to Treat AIDS-related Primary Brain Lymphoma
This study will investigate the use of chemotherapy plus highly active antiretroviral therapy (HAART) in patients with Acquired Immunodeficiency Syndrome (AIDS)-related primary brain lymphoma.
- Trial name
- NCT00267865
- Testing
- Methotrexate, Rituximab, Leucovorin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Refractory Epilepsy
Bioavailability, Safety and Tolerability of Diazepam Nasal Spray Versus Diazepam Rectal Gel (Diastat®)
This is a multi-center, open-label, crossover, pharmacokinetic, bio-availability study involving adolescents and adults with refractory (drug-resistant) epilepsy.
- Trial name
- NCT02474407
- Testing
- diazepam nasal spray, diazepam rectal gel
- Where
- 22 sites in United States
- Volunteers
- 78 people
- Sponsor
- Acorda Therapeutics
Arthritis, Gout
Phone-Based Based Walk With Ease Program for Adults With Arthritis
The objective of this study is to examine the short-term (6-weeks and 6 months) and long-term (1 year) effects of a phone-based version of Walk With Ease intervention.
- Conditions
- Arthritis, Gout, Fibromyalgia, Rheumatoid Arthritis
- Trial name
- NCT05289544
- Testing
- Phone-Based Walk With Ease
- Where
- United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Adult Central Nervous System Germ Cell Tumor, Adult Teratoma
Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors
This phase II trial studies how well palifosfamide works in treating patients with recurrent germ cell tumors. Drugs used in chemotherapy, such as palifosfamide, work in different ways to stop the growth of tumor cells, either by…
- Conditions
- Adult Central Nervous System Germ Cell Tumor, Adult Teratoma, Malignant Extragonadal Germ Cell Tumor, Malignant Extragonadal Non-Seminomatous Germ Cell Tumor
- Trial name
- NCT01808534
- Testing
- palifosfamide
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Indiana University
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