Clinical trials: Neurocognitive Decline
Cognitive Impairment, Voice Disorders
Correlation Between Montreal Cognitive Assessment and Voice Therapy Outcomes in the Aging Treatment- Seeking Population
This study will investigate if the performance on the Montreal Cognitive Assessment (MoCA) is associated or predictive of the outcomes in voice, swallowing or upper airway therapy in the older laryngology treatment seeking…
- Conditions
- Cognitive Impairment, Voice Disorders, Voicebox Disorders, Cognitive Decline
- Trial name
- MoCA (NCT05187910)
- Testing
- Speech Therapy, Swallowing Therapy, Upper Airway Therapy
- Where
- 4 sites in United States
- Volunteers
- 57 people
- Sponsor
- University of California, San Francisco
Cognitive Impairment
Non-Pharmacological Treatments and Cognitive Impairment (NPT-CI2019)
The prevalence of neurodegenerative diseases is expected to increase over the next years, in parallel with the aging of the world population.
- Trial name
- NPT-CI2019 (NCT04118686)
- Testing
- CoRe software training plus non-invasive brain stimulation techniques (anodical tDCS / rTMS)
- Where
- Italy
- Volunteers
- 19 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
MCI, Mild Cognitive Impairment
Telehealth-Adapted Compensatory Training and Intervention for Cognition
The goal of this clinical trial is to develop a five-week virtual cognitive training intervention for people with Mild Cognitive Impairment (MCI) based off an existing eight-week intervention.
- Conditions
- MCI, Mild Cognitive Impairment, Mild Cognitive Impairment (MCI)
- Trial name
- TACTIC (NCT07366346)
- Testing
- Motivationally Enhanced Compensatory Cognitive Training for Mild Cognitive Impairment (ME-CCT-MCI), Brief Motivationally Enhanced Compensatory Cognitive Training for Mild Cognitive Impairment (bME-CCT-MCI)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Stroke, Cognitive Decline
Efficacy and Safety of Immersive Virtual Reality for Post-stroke Cognitive Impairment
This is a single-blind randomized controlled trial to evaluate the efficacy and safety of immersive virtual reality for post-stroke cognitive impairment.
- Trial name
- EVRPSC (NCT06704360)
- Testing
- immersive VR pathfinding training, Occupational therapy
- Volunteers
- 40 people
- Sponsor
- Dingqun Bai
Alzheimer Disease, Mild Cognitive Impairment
Cognitive Screening Made Easy for PCPs
In the United States and around the world, people are living longer lives. As the population ages, so does the number of older adults who may experience declines in memory, attention, reasoning, or other thinking skills.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Cognitive Decline
- Trial name
- NCT05082883
- Testing
- Risk Assessment Cognitive Screening
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Delirium, Postoperative Cognitive Dysfunction
Prevention of Early Postoperative Decline
The purpose of this trial is to determine whether using a brain training program in the time leading up to as well as after heart surgery will reduce confusion and cognitive loss that can occur after surgery.
- Trial name
- PEaPoD (NCT02908464)
- Testing
- Lumosity
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Beth Israel Deaconess Medical Center
Functional Ability, Cognitive Decline
Caregiver Training: Evidence of Its Effectiveness for Cognitive and Functional Improvement in Older Adults
Due to demographic changes that have resulted in an aging population, the role of caregiver of an older adult has become very important in recent years.
- Conditions
- Functional Ability, Cognitive Decline, Older Adults, Healthy Aging
- Trial name
- NCT04490070
- Testing
- Cognitive Stimulation
- Where
- 10 sites in Spain
- Volunteers
- 160 people
- Sponsor
- Universidad de Granada
Myocardial Infarction, Unstable Angina
CORonary Diet Intervention With Olive Oil and Cardiovascular PREVention
The purpose of this study is to compare the effects of the consumption of two different dietary patterns (low fat versus Mediterranean Diet) on the incidence of cardiovascular events of persons with coronary disease.
- Conditions
- Myocardial Infarction, Unstable Angina, Malignancy, Cognitive Decline
- Trial name
- CORDIOPREV (NCT00924937)
- Testing
- Mediterranean Diet, Low Fat Diet
- Where
- Spain
- Volunteers
- 1,002 people
- Sponsor
- Hospital Universitario Reina Sofia de Cordoba
Neurocognitive Deficit
Validation of MoCA-B and MoCA-Blind for Screening Cognitive Decline
The objective of this observational study is to assess the efficacy of two neuropsychological tests (MoCA-B and MoCA-Blind) in detecting cognitive decline in older adults.
- Trial name
- NCT07846839
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio Grande do Norte
Dementia, Mixed, Dementia, Vascular
Statins in Reducing Events in the Elderly Mind (STAREE-Mind) Imaging Substudy
The STAREE-Mind imaging sub-study will examine the effect of statin treatment over a 4-year period, compared with placebo, on markers of brain health.
- Conditions
- Dementia, Mixed, Dementia, Vascular, Dementia of Alzheimer Type, Cognitive Decline
- Trial name
- STAREE-Mind (NCT05586750)
- Testing
- Atorvastatin 40 Mg Oral Tablet
- Where
- 2 sites in Australia
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- Monash University
Aging, Aging Problems
Brain Health Virtual Reality Study
The Interventions for Brain Health Virtual Reality Study is a NIH-funded clinical research trial at the University of California San Diego (UCSD) Health under the supervision of the study principal investigator Dr. Judy Pa.
- Conditions
- Aging, Aging Problems, Memory Loss, Memory Impairment
- Trial name
- NCT06124339
- Testing
- Physical Activity, Cognitive Activity (VR), Physical and Cognitive Activity
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Alzheimer Disease, Mild Cognitive Impairment
Blood Tests for Alzheimer's Disease: Can Plasma Biomarkers Diagnose and Predict Disease Progression
BLAD is a prospective, monocentric, observational epidemiological study with an additional procedure (annual blood draw) evaluating the diagnostic and prognostic performance of plasma biomarkers for Alzheimer's disease (AD) in a…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Subjective Cognitive Decline, Dementia
- Trial name
- BLAD (NCT07717567)
- Testing
- Annual blood draw for plasma biomarker measurement
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- IRCCS San Raffaele
Cognitive Decline, Dementia Risk Factors
GOIZ ZAINDU Feasibility Multi Domain Trial to Prevent Dementia.
GOIZ ZAINDU ("caring early" in Basque) is a pilot study to adapt the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) methodology to the Basque population and evaluate feasibility and…
- Conditions
- Cognitive Decline, Dementia Risk Factors, Prevention, Multidomain Intervention
- Trial name
- GOIZ_ZAINDU (NCT06163716)
- Testing
- Multidomain intervention (MD-Int) group
- Where
- Spain
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Fundacion CITA-alzheimer
AIDS, Dementia
Predictors of Neuro-cognitive Decline and Survival in HIV-infected Subjects
Patients will be followed every 6 months for a total of 5 visits (Month 0, 6, 12, 18 and 24). The first visit is the screening and entry visit which can occur at any time after the subject finishes SEARCH 001 study but preferably…
- Trial name
- NCT00864292
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- SEARCH Research Foundation
Dementia, Cognitive Impairment
Primary Care Detection of Cognitive Impairment Leveraging Health & Consumer Technologies in Underserved Communities: The MyCog Trial
Our study intends to offer 'real world' evidence of a viable, sustainable means to mobilize primary care via a comprehensive strategy for detecting cognitive impairment and dementias, advancing next steps for referral, and…
- Conditions
- Dementia, Cognitive Impairment, Cognitive Decline, Alzheimer Disease
- Trial name
- NCT05607732
- Testing
- MyCog
- Where
- United States
- Volunteers
- 57,589 people
- Sponsor
- Northwestern University
Cognitive Decline, Physical Activity
Virtual Reality-based Mindful Movement Therapy for Seniors
The current proposal aims to 1) develop a technical platform and implementation plan for the delivery of a virtual reality-based mindful movement therapy (VR-MMT) protocol for older adults; and 2) conduct a clinical trial to…
- Conditions
- Cognitive Decline, Physical Activity, Psychological Wellbeing
- Trial name
- NCT06334328
- Testing
- Virtual reality based mindful movement therapy
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Drexel University
Aging, Aging Well
100-Year Human Aging Study
The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed clinical sites, mobile clinical sites, and an online participation pathway (current and future) to undergo…
- Conditions
- Aging, Aging Well, All-Cause Mortality, Mortality
- Trial name
- NCT07563777
- Testing
- Comprehensive Multi-System Clinical Screening
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Age-related Cognitive Decline, Alzheimer's Disease and Related Dementias
Preventing Alzheimer's With Cognitive Training
Dementia is the most expensive medical condition in the US and increases in prevalence with age. More than 5 million Americans have Alzheimer's disease, the most common form of dementia.
- Trial name
- PACT (NCT03848312)
- Testing
- Cognitive Training, Computerized Cognitive Stimulation
- Where
- 7 sites in United States
- Volunteers
- 7,600 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Cognitive and Behavioral Impairment
Incidence of Postoperative Cognitive Decline in Patients With Preexisting Cognitive Impairment
This study aims to find out how often memory and thinking problems happen after surgery in people who already have memory issues before their operation. These memory problems are called postoperative cognitive decline (POCD).
- Trial name
- NCT07135336
- Testing
- surgery, norma
- Where
- China
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Peking University Shenzhen Hospital
Gait Apraxia, Mild Cognitive Impairment
Gait as Predictor of Dementia and Falls. The Gait and Brain Cohort Study
Motor slowing and cognitive slowing are more prevalent as we age. Importantly, the presence of both in an older person increases their risk of having dementia by ten times.
- Conditions
- Gait Apraxia, Mild Cognitive Impairment, Subjective Cognitive Impairment, Cerebral Atrophy
- Trial name
- NCT03020381
- Where
- Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Manuel Montero Odasso