Clinical trials: Neurocognitive Disorders, Mild
Alzheimer Disease 1
Progress of Mild Alzheimer's Disease in Participants on Acupuncture Versus Sham Acupuncture
To determine if adjunctive acupuncture acts as an AD treatment rather than a placebo.
- Trial name
- NCT05078944
- Testing
- Active acupuncture, Donepezil Hydrochloride
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Dementia With Lewy Bodies
Study to Evaluate the Safety, Tolerability and Efficacy of CT1812 in Subjects With Mild to Moderate Dementia With Lewy Bodies
Multi-center, randomized, double-blind, placebo-controlled, 6- month study in subjects with mild to moderate Dementia with Lewy Bodies.
- Trial name
- COG1201 (NCT05225415)
- Testing
- CT1812
- Where
- 34 sites in United States
- Volunteers
- 130 people
- Sponsor
- Cognition Therapeutics
Alzheimer's Disease, Sleep Disorder
Efficacy of Circadin® 2 mg in Patients With Mild to Moderate Alzheimer Disease Treated With AChE Inhibitor
The aim of this exploratory randomized, placebo controlled study is to evaluate the efficacy of Circadin® 2mg in patients with mild to moderate Alzheimer Disease (AD) treated with the acetylcholinesterase (AChE) inhibitor.
- Trial name
- NCT00940589
- Testing
- Circadin
- Where
- 6 sites in United States, Israel and 1 more
- Volunteers
- 73 people
- Sponsor
- Neurim Pharmaceuticals Ltd.
Mild Cognitive Impairment
Pioglitazone Or Exercise to Treat Mild Cognitive Impairment (MCI)
The purpose of this study is to investigate novel treatments to delay progression to dementia in patients with mild cognitive impairment (MCI) and metabolic syndrome (MS).
- Trial name
- POEM (NCT00736996)
- Testing
- Pioglitazone, Endurance Exercise Training
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cognition Disorders in Old Age, Mild Cognitive Impairment
Crossover Trial for Nicotinamide Riboside in Subjective Cognitive Decline and Mild Cognitive Impairment
In this research study we want to learn more about whether taking Niagen, a daily supplement containing a form of Vitamin B3, will improve cognitive function, mood, and daily activity in people with Subjective Cognitive Decline…
- Conditions
- Cognition Disorders in Old Age, Mild Cognitive Impairment, Cognitive Decline
- Trial name
- NCT04078178
- Testing
- Niagen
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Steven E Arnold, MD
Alzheimer's Disease
[18F]MK-3328 as a Possible Novel Positron Emission Tomography (PET) Tracer for the Detection of Brain Amyloid Plaques (MK-3328-002)
The purpose of this study is to evaluate radiolabeled [18F]MK-3328 as a PET tracer for estimating the regional distribution and extent of amyloid plaques in participants suffering from amnestic mild cognitive impairment (aMCI)…
- Trial name
- NCT01385033
- Testing
- [18F]MK-3328
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Hypertension, Mild Cognitive Impairment
CAndesartan vs LIsinopril Effects on the BRain
The aim of this study is to conduct a 1-year double blind randomized control trial comparing candesartan to lisinopril in 140 individuals with hypertension and executive mild cognitive impairment in their effects on executive…
- Trial name
- CALIBREX (NCT01984164)
- Testing
- Candesartan, Lisinopril
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Emory University
Alzheimer's Disease
A Study of Gantenerumab in Participants With Mild Alzheimer Disease
Part 1 is a multicenter, randomized, double-blind, placebo-controlled, parallel-group study will evaluate the efficacy and safety of gantenerumab in participants with mild Alzheimer disease.
- Trial name
- NCT02051608
- Testing
- Gantenerumab
- Where
- 131 sites in United States, Argentina and 20 more
- Volunteers
- 389 people
- Sponsor
- Hoffmann-La Roche
Mild Cognitive Impairment
Mnemonic Strategy Versus Spaced Retrieval Training in Those With Mild Cognitive Impairment
This study compared two active cognitive interventions to evaluate whether one improved memory more than the other in patients with mild cognitive impairment.
- Trial name
- MST training (NCT04533204)
- Testing
- mnemonic strategy training, spaced retrieval training
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- VA Office of Research and Development
Mild Cognitive Impairment, Herpes Simplex 1
Valacyclovir for Mild Cognitive Impairment
Anti-viral treatment in Mild Cognitive Impairment (MCI) is a Phase II, placebo-controlled, 52-week trial using oral valacyclovir 4 g/day in 50 HSV seropositive, AD biomarker-positive, amnestic mild cognitive impairment (MCI)…
- Conditions
- Mild Cognitive Impairment, Herpes Simplex 1, Herpes Simplex 2
- Trial name
- VALMCI (NCT04710030)
- Testing
- Valacyclovir hydrochloride 500mg caplet
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- New York State Psychiatric Institute
Alzheimer's Disease
Study Evaluating TheSafety And Efficacy Of PF-05212377 Or Placebo In Subjects With Alzheimer's Disease With Existing Neuropsychiatric Symptoms On Donepezil
This study will evaluate safety and efficacy of PF-05212377 in subjects with mild-to-moderate Alzheimer's Disease with existing neuropsychiatric symptoms on a stable dose of Donepezil.
- Trial name
- NCT01712074
- Testing
- PF-05212377 (SAM-760)
- Where
- 60 sites in United States, Canada and 5 more
- Volunteers
- 186 people
- Sponsor
- Pfizer
Prostate Cancer, Mild Cognitive Impairment
PET Imaging in MCI Following ADT for PCa
Mild cognitive impairment (MCI) with ageing is thought in part to be related to reduced serum sex hormones which is well-recognized, especially in females, but poorly understood.
- Trial name
- NCT02061345
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- Imperial College London
Alzheimer's Disease
A Multiple Dose Study of PF-04360365 In Patients With Mild to Moderate Alzheimer's Disease
The purpose of this study is to determine whether multiple dose administration is safe and well tolerated in patients with mild to moderate Alzheimer's Disease.
- Trial name
- NCT00945672
- Testing
- PF-04360365 10 mg/kg, PF-04360365 7.5 mg/kg
- Where
- 4 sites in Sweden
- Volunteers
- 36 people
- Sponsor
- Pfizer
Mild Cognitive Impairment
VR-CogMoBal Training for Reducing Falls Among Older Adults With Mild Cognitive Impairment
Older adults often display gait instability, impaired balance control and cognitive decline that lead to falls and fall risks. Approximately 60% of the elderly people with cognitive deficits experience a detrimental fall each…
- Trial name
- NCT03765398
- Testing
- VR Cognitive-motor-balance training
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Illinois Chicago
Cognitive Impairment, Depression
Problem Adaptation Therapy for Mild Cognitive Impairment and Depression
The present collaborative R01 study, between Cornell and Johns Hopkins, aims to compare Problem Adaptation Therapy for Mild Cognitively Impaired Older Adults (PATH-MCI) vs.
- Trial name
- PATH-MCI (NCT03043573)
- Testing
- PATH-MCI, Supportive Therapy
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Weill Medical College of Cornell University
Cognitive Decline, Cardiovascular Diseases
Lifestyle Physical Activity and Cognitive Training Interventions
Older women with cardiovascular disease (CVD) are at greater risk for memory loss, an important public health issue due to the negative effects to quality of life and health care costs.
- Conditions
- Cognitive Decline, Cardiovascular Diseases, Cognitive Dysfunction, Cognitive Impairment
- Trial name
- MindMoves (NCT04556305)
- Testing
- Mind, Move
- Where
- United States
- Volunteers
- 253 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Alzheimer Disease, Mild Cognitive Impairment
Deprescribing in Patients Living With Dementia With Caregiver and Provider Nudges
The objectives of this study are to demonstrate the feasibility of implementing a deprescribing nudge intervention using pragmatic methods, confirm that outcomes can be feasibly measured and evaluated at scale in a subsequent…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia
- Trial name
- NCT06347172
- Testing
- Nudge Intervention
- Where
- United States
- Volunteers
- 262 people
- Sponsor
- Brigham and Women's Hospital
HIV, Mild Neurocognitive Disorder
Cognitive Training With and Without tDCS to Improve Cognition in HIV
The purpose of this study is to develop pilot data on the potential efficacy of computer-based cognitive training or the combination of computer-based cognitive training with transcranial direct current stimulation (tDCS) in…
- Trial name
- NCT02647645
- Testing
- Transcranial direct current stimulation, Cognitive training
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Nova Southeastern University
Aging, Mild Cognitive Impairment
Enhancing Quality of Life for Older Adults With and Without Mild Cognitive Impairment (MCI) Through Social Engagement Over Video Technology
The goal of this randomized controlled trial is to rigorously assess the efficacy of an 8-week social engagement OneClick intervention.
- Conditions
- Aging, Mild Cognitive Impairment, Aging Well
- Trial name
- NCT05380180
- Testing
- OneClick Social Engagement Intervention, OneClick Social Engagement Intervention Extension
- Where
- 2 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Alzheimer's Disease, Mild Cognitive Impairment
A Phase II Trial of Florbetapir (18F) Positron Emission Tomography (PET) Imaging in Japan of Healthy Volunteers, Patients With Mild Cognitive Impairment (MCI) and Patients With Alzheimer's Disease (AD)
Evaluate florbetapir (18F) positron emission tomography (PET) imaging for distinguishing Japanese healthy control subjects, from Japanese subjects with Alzheimer's disease (AD) or Mild cognitive impairment (MCI).
- Trial name
- NCT01662882
- Testing
- florbetapir (18F)
- Where
- 2 sites in Japan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals