Clinical trials: Neurocognitive Disorders
Mild Cognitive Impairment, Cognitive Impairment
SNIFF Multi-Device Study 2
The SNIFF Device study will involve using one of three devices to administer insulin through each participant's nose or intra-nasally, accompanied by a lumbar puncture.
- Trial name
- NCT04199767
- Testing
- 20 IU Humulin® R U-100 (NDC: 0002-8215, Eli Lilly & Company), 40 IU Humulin® R U-100 (NDC: 0002-8215, Eli Lilly & Company)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Alzheimer's Disease
Cerebral and Peripheral Perfusion Pilot Study
The purpose of this study is to evaluate the hypothesis that in middle-aged, asymptomatic, adult children of persons with Alzheimer's disease (AD), atorvastatin therapy will beneficially affect mechanisms thought to contribute to…
- Trial name
- CAPP (NCT00751907)
- Testing
- atorvastatin
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Mild Cognitive Impairment
Effects of an Empowerment-based Psycho-behavioral Program on Persons With Mild Cognitive Impairment
This study aims to evaluate the effects of a 13-week empowerment-based psycho-behavioral program to improve neuropsychiatric symptoms, cognitive functions, and health-related quality of life among persons with mild cognitive…
- Trial name
- NCT04723667
- Testing
- 13-week multimodal intervention, 5-week health education programme
- Where
- 2 sites in Hong Kong
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Heart Arrest, Cardiac Arrest
Resuscitation Outcomes in the Netherlands
The Resuscitation Outcomes in the Netherlands - study assesses one-year survival and quality of life after In-Hospital Cardiac Arrest(IHCA).
- Conditions
- Heart Arrest, Cardiac Arrest, Cardiac Arrest as A Complication of Care, Outcome, Fatal
- Trial name
- ROUTiNE (NCT03120507)
- Where
- 12 sites in Netherlands
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Alzheimer Disease
ADDIA Chronobiological Study
The present single center clinical chronobiological study on 24 subjects (12 patients with mild to moderate form of Alzheimer's disease and 12 Healthy subjects) aims at characterizing the ADDIA biomarkers: a) blood cell-based…
- Trial name
- NCT02973971
- Testing
- volumeric MRI
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Amoneta Diagnostics SAS
Postoperative Delirium, Strabismus
Does Preoperative Sleep Quality Affect the Postoperative Emergence Delirium in Children Undergoing Strabismus Surgery
Sleep is important in maintaining the physiological function of the human body. Recently several studies have reported that preoperative sleep quality is associated with postoperative emergence delirium (ED) The ED is a common in…
- Conditions
- Postoperative Delirium, Strabismus, Sleep Disorder
- Trial name
- NCT03332407
- Where
- South Korea
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Age-related Cognitive Decline, Computers, Handheld
Interest of Two Digital Devices for the Diagnosis of Neurocognitive Disorders in Elderly People With Cognitive Symptoms.
The goal of this clinical trial is to compare conventional clinical data collected as part of usual practice with data collected by the two digital tools to help diagnose major and minor neurocognitive disorders in elderly people…
- Conditions
- Age-related Cognitive Decline, Computers, Handheld, Neurocognitive Disorders
- Trial name
- NCT06032611
- Testing
- COGNUM_ALZVR
- Where
- 2 sites in France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- RIVAGES
Mild Cognitive Impairment, Age-associated Memory Impairment
Effectiveness of an Intervention Using Observation/Action Therapy Among Patients With Mild Cognitive Impairment
Mild cognitive impairment (MCI) is a transitional state between normal aging and early dementia, characterized by memory deficits without functional impairment.
- Trial name
- NCT05934344
- Testing
- Action observation training
- Where
- Spain
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Alzheimer Disease, Dementia
Cognitive Impairment Cohort Study of the Elderly Population in SheMountain
This study is a prospective observational study, which involves a cohort of 2000 all-sex and all-ethnic people aged 60 years and above with permanent residence in Tianma area, SheMountain Town, Songjiang District (suburban area)…
- Conditions
- Alzheimer Disease, Dementia, Neurodegenerative Diseases, Cognitive Impairment
- Trial name
- SheMountain (NCT05667935)
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Mild Cognitive Impairment, Mild Cognitive Impairment (MCI)
Community-based Multi-domain Intervention to Detect and Delay Cognitive Decline in Community-dwelling Older Adults: A Pilot Study
The incidence of cognitive impairment and its burden are increasing with a rapidly ageing population. In Singapore, the prevalence of dementia among older adults aged 60 and above is approximately 10%, which will translate to…
- Trial name
- NCT07099040
- Testing
- Social support, Health coaching, Physical Activity
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Alzheimer Disease
A Preliminary Study of 18F-AV-45 in Alzheimer's Disease and Healthy Elderly Volunteers
A preliminary study to test how florbetapir F 18 (18F-AV-45) acts in the brains and bodies of healthy elderly people and patients with Alzheimer's Disease (AD) by using a positron emission tomography (PET) scanner.
- Trial name
- NCT01565291
- Testing
- florbetapir F 18
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Alzheimer's Disease
Effect of REST in the Alzheimer Disease Continuum
The investigators assume that REST gene polymorphism affects REST protein concentration, and REST protein concentration in peripheral blood is related to cognitive function and hippocampus.
- Trial name
- ERADC (NCT03884023)
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Dongzhimen Hospital, Beijing
Mild Cognitive Impairment (MCI), Alzheimer Disease (AD)
Remote Digital Assessments for Cognitive Disorders
Memory and thinking problems in older adults, including mild cognitive impairment (MCI) and Alzheimer's disease (AD), can be difficult to assess promptly because evaluation often depends on in-person specialist visits.
- Trial name
- MonitorCog-AI (NCT07883746)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Dementia, Abuse Client
Partnership in Safeguarding People With Dementia From Primary and Social Care Perspectives
"Adult safeguarding is everyone's responsibility". The Care Act 2014 makes safeguarding a legal duty. It provides local authorities and other agencies in England with a responsibility to protect adults with care and support needs…
- Conditions
- Dementia, Abuse Client, Neglect; Care, Malnutrition
- Trial name
- NCT05883527
- Testing
- Not applicable as not an intervention - PLwD and family/carers, Not applicable as not an intervention - HCP's
- Where
- 5 sites in United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Alzheimer Disease, Late Onset
Does BCG Vaccination Reduce Biomarkers of Alzheimer's Disease?
The goal of this clinical trial is to test whether vaccination with the BCG vaccine may improve the blood level of a biomarker of Alzheimer's disease (AD) in participants who are cognitively- and functionally- intact elderly…
- Trial name
- BCG-AD (NCT06078891)
- Testing
- BCG vaccine
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tamir Ben-Hur
Cognitively Healthy People, Alzheimer Disease
Brain Effects of Gamma Frequency Sensory Stimulation (40Hz Light, Sound and Other Devices)
Despite the huge healthcare and economic impact of AD, there is still no disease modifying therapeutics available. In fact, the available therapeutics show low efficacy at best in the treatment of cognitive impairment in…
- Trial name
- GENUS (NCT07496918)
- Testing
- GENUS, Tactile GENUS
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Massachusetts Institute of Technology
Vestibular Function Disorder, Cognitive Decline
The Effect of Computerized Vestibular Function Assessment and Training System Combined With Cognitive/Motor Dual-task
This study aims to investigate the effect of computerized vestibular function assessment and interactive training system, combined with cognitive/motor dual-task for the elderly with dizziness.
- Conditions
- Vestibular Function Disorder, Cognitive Decline, Dizziness, Vestibular Abnormality
- Trial name
- NCT05990023
- Testing
- Traditional vestibule rehabilitation training, Dual-task vestibule rehabilitation training
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Alzheimer's Disease (Incl Subtypes), Depressive Symptoms
Beyond Listening: A Music-based Intervention
Study will be conducted to determine if caregivers who use music at home will feel less burden and whether the person they are caring for will demonstrate decreased symptoms of dementia.
- Trial name
- NCT04840173
- Testing
- Music
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- MJHS Institute for Innovation in Palliative Care
Spatial Navigation
Exploring to Remediate Behavioral Disturbances of Spatial Cognition
Spatial navigation (SN) has been reported to be one of the first cognitive domains to be affected in Alzheimer's disease (AD), which occurs as a result of progressive neuropathology involving specific brain areas.
- Trial name
- BDSC-MCI (NCT05944601)
- Testing
- Virtual and computer-based cognitive remediation training
- Where
- Italy
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Huntington Disease
Impact of Apathy on Caregiving in HD. Version 1
Huntington's disease (HD) can affect motivation. People with HD may not wash often, keep their house clean and tidy, or eating healthy food.
- Trial name
- NCT05913154
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
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