Clinical trials: Neurocognitive Function
Psychosocial Well-being, Neurocognitive Function
taVNS + CCT for Neurocognitive Rehab
The purpose of this study is to investigate whether combining transcutaneous auricular vagus nerve stimulation (taVNS) with computerized cognitive training might help improve thinking abilities and mood.
- Conditions
- Psychosocial Well-being, Neurocognitive Function, Cognitive Complaint, Cognitive Dysfunction
- Trial name
- NeuroHUB (NCT07517237)
- Testing
- taVNS, Computerized Cognitive Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Acute Stress Reaction, Acute Stress Disorder
Prevention/Reduction of ASRs and PTSD to Sustain Civilian Performance With Sublingual Cyclobenzaprine HCl (TNX-102 SL)
This study will examine the safety and efficacy of TNX-102 SL to reduce ASR symptoms and behavioral changes among patients presenting to the emergency department (ED) after motor vehicle collision (MVC).
- Conditions
- Acute Stress Reaction, Acute Stress Disorder, Neurocognitive Function, Post-traumatic Stress
- Trial name
- OASIS (NCT06636786)
- Testing
- Cyclobenzaprine HCl
- Where
- 9 sites in United States
- Volunteers
- 180 people
- Sponsor
- University of North Carolina, Chapel Hill
Neurocognitive Function
Comparison of the Effects of Ciprofol and Propofol on Cognitive Function After Painless Gastroenteroscopy
This randomized platform trial compared ciprofol and propofol for early neurocognitive recovery in adults undergoing painless gastrointestinal endoscopy.
- Trial name
- NCT07887594
- Testing
- Ciprofol
- Where
- China
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Community-dwelling Older Adults, Neurocognitive Function of Elderly Patients
Modified Otago Exercise Program on Neurocognitive Level and Balance Parameters
This study examined the effect of an eight-week modified Otago Exercise Program on neurocognitive level and balance parameters in community-dwelling older adults.
- Conditions
- Community-dwelling Older Adults, Neurocognitive Function of Elderly Patients, Functional Mobility, Fall Prevention in Healthy Aging
- Trial name
- NCT07831174
- Testing
- Otago Exercise, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people
- Sponsor
- Alanya Alaaddin Keykubat University
Brain Metastases, Adult, Neurocognitive Function
UCSD Image-Guided Cognitive-Sparing Radiosurgery for Intracranial Lesions
In this proposal, the investigators introduce advanced diffusion and volumetric imaging techniques along with innovative, automated image parcellation methods to identify critical brain regions, incorporate into cognitive-sparing…
- Conditions
- Brain Metastases, Adult, Neurocognitive Function, Cancer, Meningioma of Brain
- Trial name
- IG-SRS (NCT04343157)
- Testing
- Cognitive Sparing Brain Stereotactic Radiosurgery (SRS)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Jona Hattangadi-Gluth
Glioma (Any Grade) in the Brain, Gliomas, Malignant
Brain Connectivity Changes in Glioma Patients During Treatment
The goal of this observational study is to better understand how the brain changes during the treatment of glioma. In particular, the study looks at changes in important brain areas that are responsible for functions such as…
- Conditions
- Glioma (Any Grade) in the Brain, Gliomas, Malignant, fMRI Research, Neurocognitive Function
- Trial name
- GliRecon (NCT07612917)
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Johannes Kepler University of Linz
Cognitive Impairment, Preoperative Cognitive Impairment
Reliability In Neurocognitive Telemedicine Screening (RING)
Perioperative neurocognitive disorders are common after surgery and pre-existing cognitive impairment is an important risk factor.
- Conditions
- Cognitive Impairment, Preoperative Cognitive Impairment, Perioperative Neurocognitive Disorders, Neurocognitive Function
- Trial name
- NCT07760545
- Testing
- Modified Mini-Cog Telephone Assessment
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- University of British Columbia
POCD - Postoperative Cognitive Dysfunction, Recovery Time
The Effects of Anesthesia on Postoperative Cognitive Functions in Patients Undergoing Sleeve Gastrectomy
In this study, the investigators want to examine the effects of intravenous anesthetic drugs and gases on cognitive functions in the postoperative period in individuals who will undergo surgery for obesity.
- Conditions
- POCD - Postoperative Cognitive Dysfunction, Recovery Time, Postoperative Neurocognitive Disorder, Postoperative Delirium
- Trial name
- NCT07637357
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Sleep Apnea Syndrome, Obstructive Sleep Apnea
Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)
Obstructive sleep apnea (OSA) and Chronic Obstructive Pulmonary Disease (COPD) are highly prevalent chronic respiratory diseases in the Veteran population.
- Conditions
- Sleep Apnea Syndrome, Obstructive Sleep Apnea, COPD, Overlap Syndrome
- Trial name
- NCT04179981
- Testing
- Positive airway pressure, Conservative care (control arm)
- Where
- United States
- Volunteers
- 668 people
- Sponsor
- VA Office of Research and Development
Neurocognitive Function of Elderly Patients
Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP).
dexmedetomidine infusion or lidocaine infusion starting before induction of intravenous general anesthesia and continue as infusion intraoperative can reduce postoperative cognitive dysfunction incidence (primary outcome)…
- Trial name
- NCT07497009
- Testing
- Dexmedetomidine, lidocaine, normal saline
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
Sensory Science, Performance Assessment
Personalized Performance Optimization Platform
Crews of future long-duration exploration missions will have to cope with a wide range of stressors that present significant challenges for maintaining optimal performance.
- Conditions
- Sensory Science, Performance Assessment, Countermeasure Evaluation, Neurocognitive Function
- Trial name
- P-POP (NCT06979570)
- Testing
- AttentivU
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Mindfulness, Sport Performance
Mindfulness-Based Peak Performance, Endurance Performance Under Pressure, Performance-relevant Mental Attributes
The primary aim of this study is to conduct a well-designed trial to investigate the effect of an MBI program entitled Mindfulness-based Peak Performance (MBPP) on endurance performance under pressure from an interdisciplinary…
- Conditions
- Mindfulness, Sport Performance, Neurocognitive Function, Stress
- Trial name
- NCT05612295
- Testing
- MBPP, Self-talk
- Where
- Taiwan
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
HSCT, Pediatric Cancer
Neurocognitive Deficit After Paediatric Transplantation: Understanding the Role of Environment and Physical Function
Hematopoietic stem cell transplantation (HSCT) is a potentially life-saving treatment for children with relapsed or resistant leukemia and other life-threatening hematological and hereditary disorders.
- Conditions
- HSCT, Pediatric Cancer, Pediatric Patients, Late Effect
- Trial name
- NATURE (NCT07408713)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Postoperative Cognitive Dysfunction (POCD), Neurocognitive Function
Target-Controlled Infusion and Postoperative Neurocognitive Outcomes in Geriatric Patients
This prospective observational study aims to evaluate the effects of target-controlled infusion (TCI) on postoperative neurocognitive function in geriatric patients undergoing major non-cardiac surgery.
- Conditions
- Postoperative Cognitive Dysfunction (POCD), Neurocognitive Function, Sedation and Analgesia, Geriatric Patients
- Trial name
- TCI-NEURO (NCT07311447)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Namigar Turgut
Anterior Cruciate Ligament Injuries, Sports Injury
Neuromusculoskeletal Alterations After ACL Injury
This study investigated how anterior cruciate ligament (ACL) injuries affect not only the knee joint but also brain activity, reaction speed, and psychological readiness to return to sports.
- Conditions
- Anterior Cruciate Ligament Injuries, Sports Injury, Neurocognitive Function
- Trial name
- NEURO-ACL (NCT07163468)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duzce University
Athletic Performance, Neurocognitive Function
Neuro-Athletic Training in Football
This randomized controlled trial evaluates the effectiveness of an 8-week neuro-athletic training (NAT) program in enhancing sport-specific skills and physical capacities in elite male football players aged 18-23 years.
- Conditions
- Athletic Performance, Neurocognitive Function, Proprioception, Soccer
- Trial name
- NCT07092735
- Testing
- Neuro-Athletic Training, Standard Training
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Body Image, Cognition
3-Dimensional Evaluation of Body Perception
The goal of this observational study is to evaluate the changing body perception of amputees aged 18-65 years using prostheses through different personal perspectives of the right-left distinction.
- Conditions
- Body Image, Cognition, Decision Making, Visuospatial/Perceptual Abilities
- Trial name
- NCT06985329
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Trakya University
Mindfulness Training, Neurocognitive Function
Mindfulness Training, Mental Fatigue, Endurance Performance and Neurocognitive Functions
Mental fatigue has been suggested that would impair neurocognitive functions and sports performance. On the other hand, mindfulness training (MT) seems to as a promising approach to attenuate mental fatigue and counteract its…
- Conditions
- Mindfulness Training, Neurocognitive Function, Sports Performance, Mental Fatigue
- Trial name
- NCT05452460
- Testing
- Mindfulness intervention
- Where
- Taiwan
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Critical Illness, Intensive Care Unit Delirium
The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units?
Here, the investigators propose to study host responses to reduced microbiome complexity driven by treatment with broad spectrum antibiotics in patients with severe infections or sepsis.
- Conditions
- Critical Illness, Intensive Care Unit Delirium, Neurocognitive Deficit, Microbiome,immune Function, Critically Ill
- Trial name
- MS-ICU (NCT06749483)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Jena University Hospital
Exercise Training, Neurocognitive Function
Exercise and Neurocognition in Adults Relative to ApoE Genotype
The current project is a single-blinded, double-arm, 6-month randomized controlled trial aiming to assess the effects of a integrated intervention program on neurocognitive function with respect to event-related potential in…
- Conditions
- Exercise Training, Neurocognitive Function, Aging
- Trial name
- NCT05101174
- Testing
- Integrated Intervention Group (IIG), Control Group
- Where
- 2 sites in Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University