Clinical trials: Neurodevelopment
Developmental Delay
Mirror Neuron Network Dysfunction as an Early Biomarker of Neurodevelopmental Disorder
Background: People show changes in brain activity when they watch other people do actions. This may be part of early social and communication skills.
- Trial name
- NCT03307317
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Metabolic Diseases, Neurological and Mental Health Conditions
Growing Up in Singapore Towards Healthy Outcomes
This study aims to examine the role of genetic and epigenetic factors, maternal nutrition, lifestyle, emotional health, and other environmental factors in pregnancy or postpartum period that can influence future maternal risk of…
- Conditions
- Metabolic Diseases, Neurological and Mental Health Conditions, Genetic Predisposition, Skin Condition
- Trial name
- GUSTO (NCT01174875)
- Where
- Singapore
- Volunteers
- 1,247 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
HIV
Enhancing Ugandan HIV-Affected Child Development With Caregiver Training
Early childhood (up to age 5 yrs) is a period of dramatic change in the cognitive, emotional, social, and behavioral domains; children continuously progress by observing and interacting with the world around them.
- Trial name
- MISC (NCT01640561)
- Testing
- MISC, UCOBAC
- Where
- Uganda
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Type 2 Diabetes, Pregnancy
Fat Metabolism in Pregnancy and Neonatal Heart Function in Diabetes
Background: The health of the next generation is likely programmed in the womb (i.e.in utero), and our understanding of how that programming happens will allow us to favorably influence the health of future generations.
- Trial name
- NCT01346527
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Neurodevelopmental Disorder, Bilateral Inguinal Hernia
Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery in Infants
This is a prospective randomized controlled trial comparing dexmedetomidine sedation with caudal anaesthesia, and general sevoflurane anaesthesia with caudal anaesthesia for inguinal herniotomies in neonates and infants below 3…
- Trial name
- DEGA (NCT02559102)
- Testing
- Dexmedetomidine sedation, General sevoflurane anaesthesia, Caudal anaesthesia
- Where
- Singapore
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Asphyxia
BRAIN - Home Intervention Trial
We plan to test a home-based parent-provided early developmental intervention (EI) both in infants with mild to moderate birth asphyxia and in infants without perinatal complications who will constitute a healthy comparison group…
- Trial name
- BRAIN-HIT (NCT00639184)
- Testing
- Early intervention counseling, Health education counseling
- Where
- 3 sites in India, Pakistan and 1 more
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Infant Sleep Problems, Circadian Rhythm
Chrononutrition in Preterm Infants: a Randomised Controlled Trial of Time-matched Breast Milk Feeding and Its Effects on Sleep and Circadian Development
This study investigates whether the timing of feeding expressed breast milk influences infant sleep and circadian (day-night) development in preterm infants.
- Conditions
- Infant Sleep Problems, Circadian Rhythm, Neurodevelopment
- Trial name
- NCT07533578
- Testing
- Chronobiologically Timed Feeding of Expressed Breast Milk, Usual Feeding Practice (Untimed Expressed Breast Milk)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Luzerner Kantonsspital
Epilepsy
Study of Antiepileptic Drug Effects on Child Development
The specific aim of this study is to determine if in utero exposure produces differential antiepileptic drug (AED) effects on subsequent cognitive abilities and behavioral abnormalities in children
- Trial name
- NCT00353886
- Testing
- TONI-3, WRAT-3, Connor's Rating Scales PRS & TRS
- Where
- 10 sites in United States, United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Augusta University
Neurodevelopmental Disorders, Lactation
Iron Supplement Effect on Child Development
Objective: To evaluate the effect of Iron supplement with two different amounts (one in the higher limit and another in the lower limit of the suggested amount) according to the presence of mutations in the HFE gene in the…
- Trial name
- NCT02690675
- Testing
- Iron fortified formula milk
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Methamphetamine Abuse, Newborn Complication | Patient | Neonatalology
Cardiovascular Effects of Prenatal Methamphetamine Exposure
Methamphetamine (MA) is one of the commonly used drugs during pregnancy. Cardiovascular effects of MA include elevated blood pressure, acute vasospasm, atherosclerotic disease, structural and electrical remodeling of cardiac…
- Trial name
- NCT04616625
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Autism, Developmental Disabilities
Childhood Autism Risks From Genetics and the Environment (The CHARGE Study)
The purpose of this study is to understand how genes, environment, and the interplay between the two, influences the development of autism and other neurodevelopmental disorders.
- Trial name
- NCT00106652
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Hereditary Transmission, Immune Development
Maternal Grandmothers in the Born in Guangzhou Cohort Study
The MGBIG is a study exploring cross-generational effects in 5000 women and their children and grandchildren located in Guangzhou, China.
- Conditions
- Hereditary Transmission, Immune Development, Childhood Obesity, Host and Microbiome
- Trial name
- MGBIG (NCT03633162)
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Neurodevelopment Outcome, Linear Growth
Micronutrient Enhancement for Development and Health in Adolescents - The MEDHA Study
MEDHA is a randomized controlled trial among 10-18 year old girls to examine the use-case of the United Nations International Multiple Micronutrient Antenatal Preparation (UNIMMAP) multiple micronutrient supplement (MMS)…
- Conditions
- Neurodevelopment Outcome, Linear Growth, Micronutrient Status, Bone Mineral Density
- Trial name
- MEDHA (NCT07695883)
- Testing
- Iron (60 mg)- folic acid (400 ug) [IFA], Multiple micronutrient supplement [MMS], Multiple micronutrient supplement Plus [MMS+]
- Where
- Bangladesh
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Infant Neurodevelopment, Nutrition
Maternal Methyl-Nutrient Status and Infant Neurodevelopment Study
This prospective cohort study examines the relationship between maternal methyl-nutrient status during pregnancy and offspring neurodevelopment.
- Conditions
- Infant Neurodevelopment, Nutrition, Methylation, Birth Outcomes
- Trial name
- NCT07568561
- Where
- 2 sites in Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Cerebral Palsy, Preterm Birth
Infant Aquatics Neurodevelopment Premature Infants
The objective of this research is to examine the effect of Infant Aquatics on the development of and neurodevelopment of preterm and near-term infants, using the GM as prognostic estimation of future development.
- Conditions
- Cerebral Palsy, Preterm Birth, Development
- Trial name
- IA-NPI (NCT01779661)
- Testing
- Infant Aquatics, Infant Massage
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Hand Foot and Mouth Disease
Neurodevelopment Outcomes Following Severe Hand Foot and Mouth Disease in Vietnam
Hand Foot and Mouth Disease (HFMD) is a common infectious disease in childhood. Several enteroviruses are associated with the disease.
- Trial name
- 08RS (NCT02066714)
- Where
- Vietnam
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Twin Diseases, Immune Development
Twins Born in Guangzhou
The 2-BIG is a twin birth cohort study located in Guangzhou, China.Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology.
- Conditions
- Twin Diseases, Immune Development, Childhood Obesity, Host and Microbiome
- Trial name
- 2-BIG (NCT03331133)
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Covid19 and Pregnancy
Stress in Pregnancy During the Covid19 Pandemic and Impact on the Newborn Neurodevelopment
The Covid19 pandemic, paradoxically, represents a valuable opportunity to carry out cohort studies that allow us to advance our knowledge about the relationship between inflammation, brain development and an increased risk of…
- Trial name
- NCT06362486
- Testing
- Severity of infection, time of infection., Mental health assessment, biological
- Where
- Spain
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Vegan Diet
Vegan Diet in Small Children
Following increased knowledge about climate change and how food production affects greenhouse gas emissions, the interest in vegetarian diets is increasing.
- Trial name
- VHS (NCT05442281)
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Umeå University
Preterm Labor
Impact of Suspected Preterm Labour on Cardiometabolic Profile and Neurodevelopment
Suspected preterm labour (SPL), define as the presence of regular and painful uterine contractions and cervical shortening, constitute a prenatal insult with potential long-term consequences.
- Trial name
- SKs (NCT05211297)
- Where
- Spain
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria Aragón