Clinical trials: Neurodevelopmental Disorders
Autism Spectrum Disorder
Preliminary Efficacy of Occupational Therapy Integrating Horses on Self-regulation in Youth With Autism
The goal of this clinical trial is to learn about occupational therapy integrating horses for autistic youth. The main questions it aims to answer are: Does occupational therapy integrating horses improve self-regulation in…
- Trial name
- NCT05846932
- Testing
- OTEE HORS, OT Clinic
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Attention-Deficit/Hyperactivity Disorder
Safety and Tolerability Study of ABT-089 in Children With Attention-Deficit/Hyperactivity Disorder (ADHD)
The purpose of this study is to test if the investigational medication ABT-089 is a safe and effective treatment for children with Attention Deficit Hyperactivity Disorder (ADHD).
- Trial name
- NCT00640419
- Testing
- ABT-089
- Where
- 13 sites in United States
- Volunteers
- 121 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Rett Syndrome
Safety and Preliminary Efficacy of TSHA-102 Gene Therapy in Pediatric Females Aged >2 to <4 Years With Rett Syndrome
The primary objectives of this study are to evaluate the safety, tolerability and preliminary efficacy of a single intrathecal (IT) dose of TSHA-102 in pediatric females with typical Rett syndrome.
- Trial name
- ASPIRE (NCT07480564)
- Testing
- TSHA-102
- Where
- 3 sites in United States
- Volunteers
- 4 people
- Sponsor
- Taysha Gene Therapies, Inc.
ADHD
Initial Validation of the Vanderbilt ADHD Measure for Adolescent Patients in the ICISS Project
This proposal is to evaluate the reliability and validity of the Vanderbilt ADHD screening tool for use with adolescents and young adults aged 13-21 years.
- Trial name
- NCT01964209
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
ADHD
2 Neurofeedback Protocols in the Treatment of Attention Deficit Hyperactivity Disorder in Children and Adolescents
Attention Deficit Disorder with or without Hyperactivity (ADD / H) is a public health problem since it has short and long-term consequences, affects about 5% of children of school age but remains unknown and therefore under…
- Trial name
- NCT04378699
- Testing
- SMR (12-15 Hz), alpha band (8 -12Hz)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Fondation Lenval
Autism
Vitamin/Mineral Supplement for Children and Adults With Autism
The investigators hypothesis is that a new, revised formulation of a vitamin/mineral supplement will result in: 1. improvement of nutritional status in some children/adults with autism, and 2.
- Trial name
- NCT01225198
- Testing
- Multi-Vitamin/Mineral Supplement
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Neurodevelopmental Disorders, Emotional Disorder
Strengthening Social, Emotional and Behavioral Resilience
Behavioral and emotional disorders adversely affect overall health and well-being. Prevalence rates among children and adolescents classified with behavioral and emotional disorders or neurodevelopmental disorders (NDD), as…
- Conditions
- Neurodevelopmental Disorders, Emotional Disorder, Behavior Disorders
- Trial name
- NCT04935593
- Testing
- The RENEW Intervention
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Heart Defects, Congenital
Neuroprotective Effects of Remote Ischemic Preconditioning (RIPC) During Infant Cardiac Surgery
The purpose of this study is to look at whether the use of a simple technique before surgery, which involves inflating a blood pressure cuff on the infant's leg, can improve development of language, motor and thinking skills at…
- Trial name
- NCT01835392
- Testing
- Remote Ischemic Preconditioning, Control
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Nemours Children's Clinic
Attention Deficit Hyperactivity Disorder
Dextromethorphan Added on for the Patients With ADHD
Dextromethorphan added on methylphenidate for the patients with attention deficit hyperactivity disorder
- Trial name
- DAOFTPWA (NCT01787136)
- Testing
- Dextromethorphan
- Sponsor
- Tri-Service General Hospital (TSGH)
Autistic Disorder, Autism
A Study of the Effectiveness and Safety of Two Doses of Risperidone in the Treatment of Children and Adolescents With Autistic Disorder
The purpose of this study is to evaluate the effectiveness (change in level of irritability and related behaviors) and safety and tolerability of the administration of 2 different fixed dose levels of risperidone (an atypical…
- Trial name
- NCT00576732
- Testing
- Risperidone high dose, Risperidone low dose
- Where
- 20 sites in United States
- Volunteers
- 96 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Autism Spectrum Disorder, Mental Health Disorder
Adaptation and Implementation of an ASD Executive Functioning Intervention in Children's Mental Health Services
The purpose of this project is to conduct a feasibility test of an ASD executive functioning intervention adapted for mental health settings, including examining the effectiveness and process of implementing this adapted…
- Conditions
- Autism Spectrum Disorder, Mental Health Disorder, Executive Dysfunction
- Trial name
- NCT04295512
- Testing
- Unstuck and on Target
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- San Diego State University
Autism Spectrum Disorder
Oxytocin and Social Cognitive Skills Groups
The purpose of this study is to evaluate the feasibility, safety, and preliminary efficacy of integrating targeted dosing of intranasal oxytocin with a social cognitive skills group therapy for school-aged children with autism…
- Trial name
- ION-ASD (NCT02918864)
- Testing
- Oxytocin, Social Cognitive Skills Training, Facilitated Play Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rush University Medical Center
Attention-Deficit/Hyperactivity Disorder (ADHD)
Treatment of College Students With Attention-Deficit/Hyperactivity Disorder (ADHD) Using OROS Methylphenidate
The purpose of the proposed study is to determine the effectiveness of methylphenidate HCl (Concerta) in college students with ADHD.
- Trial name
- NCT00931398
- Testing
- methylphenidate HCl (Concerta)
- Where
- United States
- Sponsor
- University of Pittsburgh
ADHD
EndeavorRx® Prospective Product Registry ("Expedition EndeavorRx")
The EndeavorRx Prospective Product Registry aims to collect real world data from participants receiving the digital therapeutic, EndeavorRx, under conditions of routine clinical practice.
- Trial name
- NCT05991167
- Testing
- EndeavorRx
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Akili Interactive Labs, Inc.
Oppositional Defiant Disorder, Conduct Disorder
Integrated Smart Speaker Promoting Positive Parenting Among Caregivers of Youth With Challenging Behaviors
This project will develop and evaluate the feasibility of an integrated smart speaker and mobile/web-based application, "FamilyNet" (FN) to assist parents in implementing empirically supported behavioral parenting strategies to…
- Trial name
- FamilyNet (NCT05535387)
- Testing
- FamilyNet smart speaker/mobile application
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
All-cause Mortality, Quality of Life
PRophylaxis Against Early VENTilator-associated Infections in Acute Brain Injury
This research is about whether treatment with a commonly used antibiotic can prevent infections in airway and lungs and improves the chance of surviving, if it is given soon after patients commence mechanical ventilation when…
- Conditions
- All-cause Mortality, Quality of Life, Disability, Intellectual, Neurological Disorder
- Trial name
- PREVENT-NEURO (NCT06819592)
- Testing
- Ceftriaxone 2g diluted in >200ml 0.9%sodium chloride
- Where
- 29 sites in Australia, Canada and 1 more
- Volunteers
- 3,300 people
- Sponsor
- The George Institute
ADHD
Neurofeedback Study ADHD
Neurofeedback has proved to be effective in treating Attention deficit hyperactivity disorder (ADHD) in experimental settings. This study investigates whether neurofeedback can be used as a therapeutic intervention in regular…
- Trial name
- NCT01879644
- Testing
- NF, SM, PE
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Philipps University Marburg
Behavior, Child, Disruptive Behavior
Randomized Controlled Trial of a Behavioral Training App
The investigators propose addressing and evaluating the efficacy of a behavioral, contingency management app by conducting a randomized controlled trial (RCT) that will evaluate the app compared to a placebo app control group.
- Conditions
- Behavior, Child, Disruptive Behavior, Executive Dysfunction, Attention-deficit
- Trial name
- NCT06447909
- Testing
- Treatment App
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- New York University
Attention Deficit Disorder With Hyperactivity
Treatment of Attention Deficit Hyperactivity Disorder in Preschool-Age Children (PATS)
This research focuses on the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in very young children. The medication being used is methylphenidate (Ritalin); it is being studied to determine its safety and how well it…
- Trial name
- NCT00018863
- Testing
- Methylphenidate
- Where
- 6 sites in United States
- Volunteers
- 165 people
- Sponsor
- New York State Psychiatric Institute
Genetic Syndrome, Language Development
Study of an Early Parenting Intervention for Children With Genetic Abnormalities and Mental Health Problems
The GAP study is a randomized controlled trial that aims to determine the feasibility and efficacy of the "Incredible Years Autism Spectrum and Language Delays" (IY-ASLD®) intervention for families of children with developmental…
- Conditions
- Genetic Syndrome, Language Development, Autism or Autistic Traits, Parenting
- Trial name
- The GAP (NCT06125093)
- Testing
- Incredible Years Autism Spectrum and Language Delays Parent Program (IY-ASLD®)
- Where
- 3 sites in Spain
- Volunteers
- 53 people
- Sponsor
- Fundació Sant Joan de Déu