Clinical trials: Neuroimaging
Brain Injuries
MRI Markers of Outcome After Severe Pediatric TBI
Traumatic brain injury (TBI) is the leading cause of death or disability in children. Each year in the United States, pediatric TBI results in an estimated 630,000 emergency room visits, 58,900 hospitalizations, and 7000 deaths.
- Trial name
- NCT02688660
- Testing
- MRI Scans
- Where
- 21 sites in United States, Australia and 1 more
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Healthy, Gait Disorders, Neurologic
Exoskeleton and Brain Activity With fNIRS
Background. Force control is one of the major parameter of motor activity. There is few study concerning the cortical activity imply for different levels of force during gait. Objective.
- Trial name
- ExoNIRS (NCT05298943)
- Testing
- walking in 4 situations
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
Psychotic Disorders, Cannabis Use Disorder
Investigating the Neural Correlates of Cognitive Function in Psychosis Patients and Non-Psychiatric Controls With Cannabis Use
Cognitive impairment is well established in people with psychosis and is associated with cannabis use. The current study will investigate the neurobiological basis of cognitive change associated with 28-days of cannabis…
- Conditions
- Psychotic Disorders, Cannabis Use Disorder, Cannabis Dependence, Cannabis Use
- Trial name
- NCT05445180
- Testing
- Contingency management
- Where
- Canada
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Musculoskeletal Pain, Pain, Chronic
NEPAL (Neuromodulatory Examination of Pain and Mobility Across the Lifespan)
Musculoskeletal pain represents the leading cause of disability worldwide. It has been traditionally attributed to peripheral mechanisms, but peripheral damage, inflammation, and psychological factors have failed to significantly…
- Trial name
- NEPAL (NCT02488863)
- Testing
- MRI Neuroimaging, Quantitative Sensory Testing, Questionnaires
- Where
- 4 sites in United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Florida
Alzheimer Disease, Amyloid Beta-Peptides
Risk Evaluation and Education for Alzheimer's Disease - the Study of Communicating Amyloid Neuroimaging (REVEAL-SCAN)
This study is intended to examine the impact of learning amyloid brain imaging results among asymptomatic older adults, and how to safely communicate these results and educate on the risk of developing Alzheimer's disease.
- Conditions
- Alzheimer Disease, Amyloid Beta-Peptides, Risk Assessment, Education
- Trial name
- REVEAL-SCAN (NCT02959489)
- Testing
- Alzheimer's Disease Risk Disclosure, Amyloid Brain Imaging and Alzheimer's Disease Risk Disclosure
- Where
- 4 sites in United States
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Neuropathic Pain
Brain Activation During Thermal Stimulation in Neuropathic Pain
Patients with peripheral neuropathy frequently exhibit treatment-refractory neuropathic pain. Although both peripheral and central determinants are recognized for the pathophysiological basis of neuropathic pain following…
- Trial name
- NCT00525018
- Testing
- contact heat evoked potential stimulator
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Anesthesia, Pain
Remimazolam NeuroImaging
This is a single-arm functional MRI study that will determine the effects of remimazolam on cognition and brain activity and connectivity at rest, during noxious stimulation, and during a memory encoding task
- Conditions
- Anesthesia, Pain, Remimazolam
- Trial name
- REMAZ (NCT07290205)
- Testing
- Remimazolam, Peripheral Nerve Stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Keith M Vogt
Alzheimer's Disease
Multi-modal Neuroimaging in Alzheimer's Disease IMAP+
Alzheimer's disease (AD) is a major public health problem due to its socio-economic weight. An early diagnosis of AD is urgently needed as it would constitute a determinant breakthrough from a social, financial and research…
- Trial name
- IMAP+ (NCT01638949)
- Testing
- Memory assessment, Circulating biomarkers measure, ApoE4
- Where
- 7 sites in France
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Overweight and Obesity
Neuronal and Behavioral Effects of an Implicit Priming Approach to Improve Eating Behaviors in Obesity
The purpose of this study is to determine how different behavioral interventions designed to alter food perceptions and behaviors affect brain responses to food, eating behaviors, and body weight.
- Trial name
- NCT05107908
- Testing
- Active Implicit Priming, Control Implicit Priming, Food Exposure Task
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Frontotemporal Dementia
Molecular Neuroimaging of Neuroinflammation in Neurodegenerative Dementias
Neuroinflammation is increasingly implicated as a potential critical pathogenic mechanism in a variety of neurologic and psychiatric disorders.
- Trial name
- NCT02945774
- Testing
- (18F)-FEPPA
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Focal Dystonia
Brain Changes in Patients With Focal Hand Dystonia
This study will examine how chemical changes in the brain produce symptoms of hand dystonia. Patients with dystonia have muscle spasms that cause uncontrolled twisting and repetitive movement or abnormal postures.
- Trial name
- NCT00306865
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Hearing Loss, Unilateral
Functional Near Infra-Red Spectroscopic Study of Central Auditory System Cortical Functional Reorganization
This study aims to compare the auditory cortical activity in response to monaural and binaural stimuli, measured by functional Near-Infrared Spectroscopy (fNIRS) between Single-sided Deaf (SSD) Children, and Normal-Hearing (NH)…
- Trial name
- SUN (NCT04043910)
- Testing
- fNIRS, Speech intelligibility, Sound localisation
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Parkinson's Disease (PD), GBA1 Parkinson Disease
Understanding Alpha-Synuclein Spread in Parkinson's Disease Through Blood Biomarkers and Neuroimaging
The project aims to investigate how abnormal accumulation of alpha synuclein and its interaction with tau influence brain function across the Parkinson's disease (PD) spectrum, with particular focus on individuals carrying GBA1…
- Conditions
- Parkinson's Disease (PD), GBA1 Parkinson Disease, REM Sleep Behavior Disorder (iRBD)
- Trial name
- SYNchronPD (NCT07474779)
- Testing
- brain imaging, blood draw, Skin biopsy
- Where
- 2 sites in Italy
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Subarachnoid Hemorrhage, Aneurysmal
Evaluation of Neuroinflamation of SAH
The investigators are planning that can these markers be used a predictive marker at SAH and for this aim we will study both patiens' blood sample and their CT image.
- Trial name
- BAP (NCT03822260)
- Testing
- Bezmialem VAkif Unv. Ethical board
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Overweight, Obesity
Cue-Reward Learning and Weight Gain in Youth
The objective of the study is to compare children at low risk for obesity (two healthy weight parents) to children at high risk for obesity (two overweight parents) in their response rate to food taste and in their rate of…
- Trial name
- ChildLearn (NCT03254576)
- Testing
- Functional MRI
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Epilepsy, Temporal Lobe
Study of [11C]DPA-713 for Temporal Lobe Epilepsy
Background: Some people with epilepsy have an epileptic focus, a small part of the brain that is the starting point of the seizure. This focus is like an irritant or an inflammation, and helps cause the seizure.
- Trial name
- NCT01793532
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Social Cognition, Expressed Emotion
Oxytocin, Emotions and Mirror Neurons
The purpose of this project is to investigate the possible effect of intranasally administered Oxytocin (OT) on specific mirror neuron areas in human brain.
- Trial name
- NCT02228031
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Autism Spectrum Disorders
Emotional and Change-related Attention in Autism
Several studies seem to indicate that emotional attention and change-related attention are impaired in ASD. The goal of this study is to identify the relationships between those two types of automatic attention in visual and…
- Trial name
- AUTATTEN (NCT02160119)
- Testing
- MRI-based techniques, EEG
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Major Depressive Disorder
Use of Multiple Brain Imaging Modalities (PET and MRS) to Identify Metabolic Abnormalities in Major Depression
Several lines of evidence support the existence of an underlying abnormality in brain energy metabolism may play a key role in the biology of mood disorders.
- Trial name
- NCT01465165
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Paul Carlson
Motor Cortex, Primary Motor Cortex
Evaluation of Motor-Related Beta-Activity in Relation to Naturalistic Movement in Healthy Adult Subjects
The whole body's voluntary movements are controlled by the brain. One of the brain areas most involved in controlling these voluntary movements is the motor cortex and it is often viewed as the primary 'output' region of the…
- Trial name
- MOBETA (NCT04727944)
- Testing
- Reach and grasp tasks in healthy participants using MEG technique (Experiment 1), Reach and grasp tasks in healthy participants using EEG technique (Experiment 2)
- Where
- France
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon