Clinical trials: Neuroinflammatory Disorders
Inflammation, Brain
Control of Leukocyte Function
The protocol is to draw peripheral blood from healthy volunteers for in vitro studies. The aims of these in vitro studies are to determine the cellular and intracellular mechanisms by which hypertonic saline and ATP release…
- Trial name
- NCT03027232
- Testing
- No intervention (drugs) will be given. Purpose: collecting blood for in vitro studies
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Meningitis, Meningococcal
A Phase III Clinical Trial of the Group A Meningococcal Polysaccharide Vaccine
This study is a randomized, double-blinded, and controlled phase III clinical trial of the Group A meningococcal polysaccharide vaccine to evaluate the safety and immunogenicity of the vaccine in healthy infants aged 6-15 months.
- Trial name
- NCT04689165
- Testing
- Experimental Group A meningococcal polysaccharide vaccine, Control Group A meningococcal polysaccharide vaccine
- Where
- China
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- Wei Cun
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
A Trial of Solriamfetol in the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
This study is an 8-week single center, randomized, double-blind, placebo-controlled, flexible titration trial evaluating the efficacy of solriamfetol in the treatment of fatigue symptoms in adult patients with chronic fatigue…
- Trial name
- NCT04622293
- Testing
- Solriamfetol Oral Tablet [Sunosi]
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Rochester Center for Behavioral Medicine
Diphtheria, Tetanus
Antibody Persistence to REVAXIS or DT Polio and Immune Response to TETRAVAC-ACELLULAIRE
PRIMARY OBJECTIVES To describe in 11 to 13-year-old children previously vaccinated with either REVAXIS or DT Polio at 6 years of age the antibody persistence against diphtheria, tetanus, and poliovirus types 1, 2 and 3 To…
- Conditions
- Diphtheria, Tetanus, Poliomyelitis
- Trial name
- NCT01546909
- Testing
- Diphtheria, tetanus, polio and pertussis vaccination
- Where
- 45 sites in France
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Encephalitis, Japanese B
Determining Long-Term Safety and Efficacy of Japanese Encephalitis Vaccine When Given With Measles Vaccine
The previously conducted JEV01 study looked at the immunogenicity and safety of the concurrent administration of Japanese Live Attenuated SA 14-14-2 and measles vaccines at the one month post vaccination time point.
- Trial name
- NCT00412516
- Testing
- Live attenuated SA 14-14-2 vaccine
- Where
- Philippines
- Volunteers
- 519 people, healthy volunteers welcome
- Sponsor
- PATH
Migraine Disorders, Headache, Migraine
The Impact of Triptan and Doxycycline on Neuroinflammatory Biomarkers in Acute Migraine
The purpose of this study is to determine the effects of triptans and doxycycline on neuroinflammatory markers in acute migraine.
- Conditions
- Migraine Disorders, Headache, Migraine, Migraine, Migraine Headache
- Trial name
- NCT01653522
- Testing
- Triptan, Doxycycline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Healthy, Neuromuscular Disease
Electromyography to Diagnose Neuromuscular Disorders
This study will investigate problems with muscle weakness and control using electromyography-a test of nerve-muscle cell communication.
- Conditions
- Healthy, Neuromuscular Disease, Postpoliomyelitis Syndrome
- Trial name
- NCT00004553
- Testing
- Electromyography
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Polio, Hepatitis A
Phase IV Study of Concomitant Administration of the sIPV and HepA
This study is a randomized, open-labeled phase IV clinical trial to evaluate the immunogenicity and safety of concomitant administration of sIPV and HepA-L or HepA-I in children aged 18 months.
- Trial name
- NCT06460545
- Testing
- sIPV (booster dose at 18 months of age), HepA-L, HepA-I
- Where
- 3 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Institute of Medical Biology, Chinese Academy of Medical Sciences
Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
Longitudinal Profiling of Plasma-Derived Glial Extracellular Vesicles in Alzheimer's Disease
This project aims to longitudinally profile plasma-derived GDEVs and plasma biomarkers of neuroinflammation across three stages of the AD continuum (Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's…
- Conditions
- Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, Alzheimer's Disease Dementia, Alzheimer's Disease (AD)
- Trial name
- GLEVAD (NCT07803055)
- Testing
- blood sampling
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Diphtheria, Tetanus
Evaluating a Caregiver SMS Reminder Intervention to Reduce Immunization Drop-out in Arua, Uganda
Faced with high rates of immunization drop-out, Uganda's immunization program requires innovative approaches to address this weakness.
- Conditions
- Diphtheria, Tetanus, Pertussis, Polio
- Trial name
- NCT04177485
- Testing
- SMS text reminders
- Volunteers
- 1,962 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Meningococcal Meningitis, Tetanus
Study of Menactra® in Children Aged 4 to 6 Years When Administered Concomitantly With a Fifth Dose of DAPTACEL®
The purpose of this study is to evaluate the immunogenicity and safety of the concomitant administration of Menactra® vaccine and DAPTACEL® vaccine.
- Conditions
- Meningococcal Meningitis, Tetanus, Diphtheria, Pertussis
- Trial name
- NCT00355121
- Testing
- Polysaccharide Diphtheria Toxoid Conjugate Vaccine
- Where
- 26 sites in United States
- Volunteers
- 882 people, healthy volunteers welcome
- Sponsor
- Sanofi
Meningitis, Meningococcal Meningitis
Persistence of Bactericidal Antibodies in Adults Who Received a Booster Dose of Menactra® Approximately 4 Years Earlier
The aim of this study is to provide information on the persistence of bactericidal antibodies following Menactra booster vaccination in study MTA77 ( NCT01442675).
- Conditions
- Meningitis, Meningococcal Meningitis, Meningococcal Infections
- Trial name
- NCT02633787
- Testing
- Meningococcal (Groups A, C, Y, and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine
- Where
- 4 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Poliomyelitis
Effect of Lactoferrin on Polio Seroconversion
A massive decline in cases of poliomyelitis was observed worldwide since 1988; however its transmission continues in Pakistan and Afghanistan.
- Trial name
- NCT04432935
- Testing
- Bovine Lactoferrin
- Where
- Pakistan
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Venezuelan Equine Encephalitis, Venezuelan Equine Encephalitis Virus Infection
A Phase 1 Study Evaluating the Safety, Tolerability, and Immunogenicity of V4020 Vaccine in Healthy Volunteers
The purpose of the study is to evaluate the safety and immunogenicity of a novel Venezuelan Equine Encephalitis virus (VEEV) vaccine (V4020) for the first time in humans compared to placebo when administered by subcutaneous or…
- Trial name
- VEEV (NCT07088822)
- Testing
- V4020
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Medigen, Inc.
Anhedonia in Healthy Volunteers, Older Adults (50-90 Years)
A Study of Psychedelics in Healthy Older Adults With Low Well-being
This study is being conducted to understand changes in brain activity following administration of two different drugs (Psilocybin and Dextromethorphan) in older adults with low well-being.
- Trial name
- OAD1 (NCT07386730)
- Testing
- Psilocybin (drug), Dextromethorphan (DXM)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jennifer Mitchell
Chronic Fatigue Syndrome
Acupuncture for the Sleep Disorder of Chronic Fatigue Syndrome
The investigators will conduct acupuncture for participants with chronic fatigue syndrome(CFS). Firstly the investigators aim to figure out the characteristic of sleep structure of CFS and the changes caused by acupuncture.
- Trial name
- NCT01534130
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Meningitis, Bacterial
A Controlled Study to Assess Safety, Colonisation and Immunogenicity of Reconstituted Lyophilised Neisseria Lactamica
This study is part of a series of projects to develop and test new vaccines for meningitis. Previously researchers have given nose drops containing N.
- Trial name
- Lac5-Nasal (NCT04135053)
- Testing
- Lyophilised Neisseria lactamica
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Equine Encephalitis
Vaccination Trial of a Recombinant MVA-BN-WEV Vaccine in Healthy Adult Subjects
To assess safety and tolerability as well as immune responses to the MVA-BN-WEV vaccine in the 3 treatment groups receiving different doses.
- Trial name
- NCT04131595
- Testing
- MVA-BN-WEV Dose 1, MVA-BN-WEV Dose 2, MVA-BN-WEV Dose 3
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Bavarian Nordic
Bacterial Infections, Virus Diseases
Safety, Tolerability, and Immunogenicity of V419 Given Concomitantly With Prevnar 13™ and RotaTeq™ (V419-005)
This is a study to assess the safety, tolerability, and immunogenicity of V419 (PR5I) when administered as an infant series at 2, 4, and 6 months of age followed by a toddler dose of DAPTACEL™, Prevnar 13™ and PedvaxHIB™ at 15…
- Trial name
- NCT01337167
- Testing
- V419, DAPTACEL™, PedvaxHIB™
- Volunteers
- 1,473 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC