Clinical trials: Neurologic Complications
Pain, Postoperative
Transversus Abdominis Plane(TAP) Block Versus Local Anesthetic Infiltration
There have been some studies to compared trans abdominis plane(TAP) block with wound infiltration of local anesthetics in multiport laparoscopic surgery, but there have been no studies in single incision laparoscopic gastrectomy.
- Trial name
- NCT03805269
- Testing
- TAP block, wound infiltration
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Seoul National University Bundang Hospital
Surgery, Laparoscopic
Low Versus Standard Pressure Pneumoperitoneum on Shoulder Tip Pain
This proposed study is a single-center, double blind, parallel group RCT comparing the use of low (10 mm Hg) versus standard pressure (15 mm Hg) pneumoperitoneum at the time of benign gynecologic laparoscopic surgery.
- Conditions
- Surgery, Laparoscopic, Laparoscopy, Penumoperitoneum
- Trial name
- NCT06504277
- Testing
- Low Pressure Penumoperitoneum, Standard Pressure Group (No intervention- active comparator)
- Where
- Canada
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Endometriosis, Pain
Endocare® (Single Care) in Pain-related Endometriosis
Endocare® treatment is a stand-alone software medical device, which is composed of a mobile application and an accessory VR headset, intended to mitigate the pain for patients prone to endometriosis.
- Trial name
- NCT04650516
- Testing
- Virtual reality, Digital control
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Lucine
Diabetic Neuropathy
An Evaluation of the Efficacy and Safety of E2007 in Patients With Painful Diabetic Neuropathy
The purpose of this study is to determine the efficacy and safety of Perampanel in patients with painful diabetic neuropathy.
- Trial name
- NCT00505284
- Testing
- E2007 (2 mg), E2007 (4 mg), E2007 (6 mg)
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- Eisai Inc.
Cerebrovascular Accident, Chronic Obstructive Pulmonary Disease
Tocilizumab for the Treatment of Cytokine Release Syndrome in Patients With COVID-19 (SARS-CoV-2 Infection)
This phase III trial compares the effect of adding tocilizumab to standard of care versus standard of care alone in treating cytokine release syndrome (CRS) in patients with SARS-CoV-2 infection.
- Conditions
- Cerebrovascular Accident, Chronic Obstructive Pulmonary Disease, Chronic Renal Failure, Coronary Artery Disease
- Trial name
- NCT04361552
- Testing
- Best Practice, Tocilizumab
- Where
- United States
- Sponsor
- Emory University
Parkinson Disease
Study to Evaluate the Efficacy, Safety, and Tolerability of PXT002331 (Foliglurax) in Reducing Levodopa-Induced Dyskinesia and Wearing OFF in Subjects With Parkinson's Disease Experiencing Motor Complications of Levodopa Therapy (ATTUNED)
This is a Multi-center, Double-blind, Randomized, Placebo-controlled, Parallel-arm Phase IIa proof of concept in subjects with PD treated with a stable dose of levodopa who are experiencing Motor Complications of Levodopa Therapy
- Trial name
- ATTUNED (NCT03331848)
- Testing
- PXT002331 - 20mg
- Sponsor
- Prexton Therapeutics
Postoperative Pain
Maxigesic® IV Phase 3 Exposure Study
The study aims to determine the tolerability of repeated doses of Maxigesic® IV over an extended period of exposure.
- Trial name
- NCT04005755
- Testing
- Maxigesic® IV
- Where
- 4 sites in United States, New Zealand
- Volunteers
- 232 people
- Sponsor
- AFT Pharmaceuticals, Ltd.
Diabetic Retinopathy, Diabetes Mellitus, Type 2
Confronting Unequal Eye Care in Pennsylvania
Pt. 1 Diabetic retinopathy is a common eye condition among diabetic adults and can lead to severe vision impairment and even blindness.
- Conditions
- Diabetic Retinopathy, Diabetes Mellitus, Type 2, Glaucoma
- Trial name
- NCT01179555
- Testing
- Behavioral Activation, Supportive Therapy
- Where
- 3 sites in United States
- Volunteers
- 206 people
- Sponsor
- Wills Eye
Kidney Transplantation, Delirium - Postoperative
A Predictive Model for Postoperative Delirium in Kidney Transplant Patients
This study aims to develop and prospectively validate a machine learning-based prediction model for postoperative delirium in kidney transplant recipients, using perioperative clinical data.
- Conditions
- Kidney Transplantation, Delirium - Postoperative, Cognitive
- Trial name
- NCT07078578
- Volunteers
- 4,800 people
- Sponsor
- Hua Zheng
Cerebral Stroke
Stroke: Reduction of Physical Performance Post Stroke. Inactivity or Secondary Complications?
The purpose of this project is to follow first-ever- acute stroke patients from onset, one, two and four years post stroke and study the effect of two different approaches of exercises implemented the first year post-stroke.
- Trial name
- NCT00311025
- Testing
- intensive endurance, strength and balance exercises
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Oslo University College
Postoperative Pain
Ultrasound Guided Penile Block vs Pudendal Block for Hypospadias
Pain after hypospadias surgery is a challenging issue to solve for anesthesists. Many different analgesia techniques were defined in literature for this purpose.
- Trial name
- NCT03496740
- Testing
- Penile Block, Pudendal Block, Bupivacaine (Block Drug)
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Kocaeli University
Pregnancy, Breech Presentation
Effects of Relaxing Hydrotherapy in Third Trimester of Pregnancy
This study will be the first scientific approach to investigate physical and psychological effects of the passive hydrotherapy-method WATSU (WaterShiatsu) on women and their unborn children at the third trimester of pregnancy.
- Conditions
- Pregnancy, Breech Presentation, Low Back Pain, Stress, Psychological
- Trial name
- NCT01708018
- Testing
- WATSU
- Where
- Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Postoperative Cognitive Dysfunction, Postoperative Delirium
Study of Prevention of Postoperative Delirum to Reduce Incidence of Postoperative Cognitive Dysfunction
Postoperative cognitive dysfunction describes a condition where cognitive functions such as attention, perception, concentration, learning, abstract thinking and problem solving are impaired postoperatively.
- Trial name
- DelPOCD (NCT03060174)
- Testing
- monitoring and non-medical prophylaxis of delirium
- Where
- Germany
- Volunteers
- 638 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Neurologic Manifestations, Premature Birth
The Neu-Prem Trial: Neuromonitoring of Preterm Newborn Brain During Birth Resuscitation
The purpose of this study is to characterize the normal brain function of premature infants (23 to 31+6 weeks GA) during birth transition and through the first 72 hours of life.
- Conditions
- Neurologic Manifestations, Premature Birth, Hypoxia-Ischemia, Brain
- Trial name
- Neu-Prem (NCT02605733)
- Testing
- EEG, NIRS
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Sharp HealthCare
Surgical Injury, Stress, Physiological
Effect of a Bundle of Non-pharmacological Interventions on the Stress Response to Surgery
Rationale: Surgical trauma and post-surgical pain induce a physiological stress response that can be detrimental to the patient.
- Conditions
- Surgical Injury, Stress, Physiological, Stress, Psychological, Pain, Postoperative
- Trial name
- SPACU-lab (NCT05638152)
- Testing
- implementation of a bundle of non-pharmacological interventions aimed at stress reduction
- Volunteers
- 90 people
- Sponsor
- The Netherlands Cancer Institute
Gynecological Disease
The Effectiveness of a Virtual Reality-based Multisensory Intervention
This study explores the effectiveness of a virtual reality-based multisensory intervention for postoperative recovery in patients receiving gynecological surgery.
- Trial name
- NCT06922838
- Testing
- Virtual Reality intervention, Aromatherapy
- Volunteers
- 100 people
- Sponsor
- Weifang Medical University
Parkinson's Disease
A US Study That Observes How Parkinson's Disease Changes Over Time in Patients Who Still Have Movement Symptoms Despite Taking Parkinson's Medications
This is an observational study in which data are collected and studied from Parkinson's disease patients who have movement symptoms despite taking standard Parkinson's medications.
- Trial name
- NCT07330258
- Testing
- Standard of Care
- Where
- 27 sites in United States
- Volunteers
- 300 people
- Sponsor
- Bayer
Posterior Fossa Hemorrhage, Lung Cancer
Pilot Study of Model Based Iterative Reconstruction Using 64-Slice
This study is being performed to confirm that the new technique, Model-Based Iterative Reconstruction (MBIR) with reduced radiation dose can deliver equivalent image quality for CT scans compared to current techniques (Filtered…
- Conditions
- Posterior Fossa Hemorrhage, Lung Cancer, Flank Pain, Urolithiasis
- Trial name
- MBIR (NCT01431378)
- Where
- 3 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Carotid Stenosis, Ischemia Reperfusion Injury
Perioperative Time Course of MMP-9 and Its Inhibitor During Carotid Artery Stenting and Carotid Endarterectomy
The aim was the comparison of the perioperative time courses of matrix metalloproteinase-9 (MMP-9) and its inhibitor (TIMP-1) during elective carotid artery stenting (CAS).
- Trial name
- NCT03410576
- Testing
- Carotid artery stenting, Carotid endarterectomy
- Where
- Hungary
- Volunteers
- 25 people
- Sponsor
- University of Pecs
Fabry Disease
Study of the Safety and Efficacy of PRX-102 Compared to Agalsidase Beta on Renal Function
This was a randomized, double-blind, active control study of the enzyme replacement therapy (ERT) drug PRX-102 (pegunigalsidase alfa) in Fabry disease patients with impaired renal function.
- Trial name
- BALANCE (NCT02795676)
- Testing
- PRX-102 (pegunigalsidase alfa), agalsidase beta
- Where
- 29 sites in United States, Czechia and 10 more
- Volunteers
- 78 people
- Sponsor
- Protalix
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