Clinical trials: Neurologic Complications
Pain, Postoperative, Serratus Anterior Plane Block
Comparison of Deep Serratus Anterior Plane Block and Combination of Deep and Superficial Serratus Anterior Plane Block
Video-assisted thoracic surgery (VATS) has become a common procedure in thoracic surgery. Severe postoperative pain may be encountered in patients undergoing VATS.
- Conditions
- Pain, Postoperative, Serratus Anterior Plane Block, Multimodal Analgesia, Thoracic Surgery, Video-Assisted
- Trial name
- NCT05106283
- Testing
- Deep block and Combined Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Inguinal Hernia, Abdominal Wall Muscles
Transversus Abdominis Plane Block and Inguinal Hernia Repair
This prospective, randomized, double blinded, placebo-controlled study is designed to evaluate the postoperative analgesic efficacy of the ultrasound-guided transversus abdominis plane block with ropivacaine 0,75 %, in patients…
- Conditions
- Inguinal Hernia, Abdominal Wall Muscles, Regional Anesthesia, Postoperative Pain
- Trial name
- NCT02030223
- Testing
- Transversus abdominis plane block
- Where
- Greece
- Volunteers
- 59 people
- Sponsor
- Papacharalampous Panagiota
Postoperative Pain
Loco/Regional Anaesthesia Evaluation in Laparoscopic Hernioplasty
Laparoscopic hernioplasty is associated with lesser postoperative pain and quick return to work. TAP block is the gold standard technique in this type of hernioplasty.
- Trial name
- NCT03968523
- Testing
- Novel local infiltration technique, TAP block
- Where
- Argentina
- Volunteers
- 62 people
- Sponsor
- Hospital Italiano de Buenos Aires
Pain, Postoperative
Low Dose Caudal VS Dorsal Penile Nerve Block for Postoperative Analgesia After Circumcision
in order to eliminate fear and anxiety. Regional techniques are more effective than systemic opioids, non steroidal anti-inflammatory drugs, and acetaminophen for postoperative analgesia in circumcision, The most preferred…
- Trial name
- NCT05342259
- Testing
- Caudal nerve block /neuroaxial, Dorsal penile nerve block, Combined caudal and dorsal penile nerve block
- Where
- Egypt
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Postoperative Pain, Back Pain Lower Back Chronic
Magnesium Sulfate Infusion on Postoperative Pain in Lumbar Surgery
Effective postoperative analgesia after lumbar spine surgery (e.g., laminectomy, vertebroplasty, lumbar stabilization) is associated with faster recovery and shorter hospital stay.
- Trial name
- NCT07418580
- Testing
- Magnesium sulfate, normal saline
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Breast Cancer, Mastectomy
Serratus Anterior Muscle Plane Block vsThoracic Paravertebral Block For Unilateral Mastectomies
HYPOTHESIS Serratus Anterior Muscle Plane Block (SPB) is as effective as thoracic paravertebral block (PVB) for acute pain control after unilateral mastectomies.
- Conditions
- Breast Cancer, Mastectomy, Regional Anesthesia, Post Operative Pain
- Trial name
- NCT02822196
- Testing
- Lidocaine, Bupivacaine
- Where
- United States
- Sponsor
- The University of Texas Health Science Center, Houston
Overactive Bladder (OAB), Over Active Bladder
A Prospective Evaluation of a Prescription Digital Therapeutic for Treatment of Overactive Bladder in Women: The RiSolve Trial
The RiSolve Trial is a prospective, single-arm, post-market clinical investigation designed to evaluate the effectiveness, usability, and safety of a prescription digital therapeutic (PDTx) for women suffering from overactive…
- Trial name
- NCT07206446
- Testing
- RiSolve
- Where
- Ireland
- Volunteers
- 46 people
- Sponsor
- University of Galway
Painful Diabetic Neuropathy
Efficacy and Safety of Eslicarbazepine Acetate as Therapy for Patients With Painful Diabetic Neuropathy
The primary objective of the study is to assess the efficacy of eslicarbazepine acetate (ESL) as therapy for patients with painful diabetic neuropathy.
- Trial name
- NCT00980746
- Testing
- Eslicarbazepine acetate
- Volunteers
- 557 people
- Sponsor
- Bial - Portela C S.A.
Gastrointestinal Dysfunction, Malnutrition
Postoperative GI Dysfunction and Nutrition in Malnourished Cancer Surgery Patients
This is a prospective two-center observational cohort study in adult patients undergoing major abdominal and/or pelvic oncologic surgery with pre-existing malnutrition.
- Conditions
- Gastrointestinal Dysfunction, Malnutrition, Delirium - Postoperative, Abdominal Neoplasm
- Trial name
- GIDNUT (NCT07622888)
- Testing
- Serotonin (e.g., serotonin adipinate), Standard Prokinetic Therapy (excluding serotonin)
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- Arma Ltd.
Knee Osteoarthritis, Total Knee Arthroplasty
Effect of Preoperative Cold Therapy on Early Postoperative Outcomes in Total Knee Arthroplasty
This prospective, single-center, randomized controlled trial investigates the effects of preoperative cold therapy on early postoperative outcomes in patients undergoing unilateral primary total knee arthroplasty (TKA).
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Cryotherapy, Postoperative Pain Management
- Trial name
- NCT07134283
- Testing
- Preoperative and Postoperative Cold Therapy with Gel Cold Pack, Postoperative Cold Therapy with Gel Cold Pack
- Where
- Turkey (Türkiye)
- Volunteers
- 208 people
- Sponsor
- Ankara City Hospital Bilkent
Growth Hormone Deficiency, Turner Syndrome
Evaluation of Convenience and Compliance of the Easypod™ Electronic Self-injector
This is an international, multicenter study involving children treated with Saizen®, a growth hormone, who will be trained to use easypod, a new electronic injector and will complete a questionnaire after 12 week of use.
- Conditions
- Growth Hormone Deficiency, Turner Syndrome, Chronic Renal Failure, Small for Gestational Age
- Trial name
- NCT00738205
- Volunteers
- 834 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
ESRD, Sleep Apnea
Identification of Desaturation Episodes by Means of Continuous Measurement of Oxygen Saturation During Hemodialysis
The clinical diagnosis of sleep apnea is difficult among ESRD patients since the characteristic clinical features of sleep apnea may be absent and since sleep-related symptoms, such as fatigue and sleepiness, may be attributed to…
- Conditions
- ESRD, Sleep Apnea, Oxygen Deficiency
- Trial name
- NCT02987179
- Testing
- Observational
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Renal Research Institute
Pain, Postoperative, Pain, Chronic
Naldebain for Pain Control After Bariatric Surgery
Laparoscopic gastric sleeve and bypass surgeries the most common bariatric procedures for weight loss and improved management of metabolic syndromes.
- Conditions
- Pain, Postoperative, Pain, Chronic, Bariatric Surgery, Obesity
- Trial name
- NCT04651361
- Testing
- Dinalbuphine sebacate
- Where
- 2 sites in Taiwan
- Volunteers
- 60 people
- Sponsor
- E-DA Hospital
Diabetic Polyneuropathy, Magnetic Resonance Imaging
Diffusion Tensor Imaging of Median Nerve in Diabetic Peripheral Neuropathy
This study is a diagnostic accuracy study that aims to evaluate the role of DTI in evaluation of DPN in comparison to clinical scores and nerve conduction studies (NCS).
- Trial name
- NCT03934970
- Testing
- Diffusion tensor imaging of peripheral nerves
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Post Operative Pain
Pre-incision Versus Lapaorscopic-assisted Transversus Abdominis Plane (TAP) and Rectus Sheath Block for Post-Cholecystectomy Pain
The goal of this clinical trial is to compare pre-incision vs laparoscopic assisted Transversus abdominis plane and rectus sheath block in patients undergoing laparoscopic cholecystectomy.
- Trial name
- NCT05856682
- Testing
- Laparoscopic-assisted TAP block(LATAP) and Rectus Sheath block
- Where
- Pakistan
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Patel Hospital, Pakistan
Postoperative Delirium
Modified Tian Wang Bu Xin Dan Hydrogel Patch in Preventing Postoperative Delirium in Elderly Patients
The purpose of this study is to determine whether preoperative administration of Modified Tian Wang Bu Xin Dan Hydrogel Patch prevents the incidence of postoperative delirium in elderly patients undergoing major surgery.
- Trial name
- NCT04947761
- Testing
- modified Tian Wang Bu Xin Dan hydrogel patch
- Where
- 3 sites in China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Hypoxic-Ischemic Encephalopathy, Bronchopulmonary Dysplasia
Efficacy Evaluation of UCB-MNCs in the Treatment of Refractory Neonatal Diseases
Hypoxic-ischemic encephalopathy (HIE), bronchopulmonary dysplasia (BPD), short bowel syndrome (SBS) are refractory in clinical treatment.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Bronchopulmonary Dysplasia, Short Bowel Syndrome
- Trial name
- NCT06427642
- Testing
- Mononuclear cells, Mild hypothermia therapy, Breathing support technique
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shandong Qilu Stem Cells Engineering Co., Ltd.
Urinary Bladder, Neurogenic
Ambulatory Closed-loop Stimulation for Bladder Control
Individuals with spinal cord injury (SCI) develop neurogenic detrusor overactivity (NDO), resulting in urinary incontinence, decreased bladder capacity, and reduced quality of life.
- Trial name
- NCT05740527
- Testing
- Noninvasive electrical stimulation of genital nerves
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- MetroHealth Medical Center
Postoperative Pain, Reaction; Anesthesia
Transversus Abdominis Plane Block for Pain Relieve in Children Undergoing Groin Surgery
For surgery in the region of the lower abdominal wall the administration of local anesthetic drugs in the epidural space via the caudal route is the preferentially used technique since several decades.
- Trial name
- TAP (NCT00970086)
- Testing
- Bupivacain/levobupivacaine
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- University Hospital, Basel, Switzerland
Advanced Solid Tumors, Ovarian Cancer
A Study of PHST001 in Advanced Solid Tumors
This is a multi-center, first-in-human (FIH), open-label, Phase 1a/1b dose escalation and dose expansion study to assess the safety, PK, pharmacodynamics, and antitumor activity of PHST001 monotherapy (Phase 1a) or in combination…
- Conditions
- Advanced Solid Tumors, Ovarian Cancer, Endometrial Cancer, Cholangiocarcinoma
- Trial name
- NCT06840886
- Testing
- PHST001, Paclitaxel, Topotecan
- Where
- 20 sites in United States
- Volunteers
- 426 people
- Sponsor
- Pheast Therapeutics
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