Clinical trials: Neurologic Complications
Total Knee Arthroplasty, Total Knee Arthroplasty Recovery
Femoral Triangle Block vs Adductor Canal Block on Early Quadriceps Function After Total Knee Arthroplasty
The goal of this clinical trial is to compare the effects of femoral triangle block (FTB) and adductor canal block (ACB) on early quadriceps function after total knee arthroplasty (TKA).
- Conditions
- Total Knee Arthroplasty, Total Knee Arthroplasty Recovery, Total Knee Arthroplasty Postoperative Pain
- Trial name
- NCT07524387
- Testing
- Femoral Triangle Block (FTB) Group, Adductor Canal Block (ACB) Group
- Where
- Japan
- Volunteers
- 136 people
- Sponsor
- Social Medical Corporation Daiyukai
Obesity
Erector Spina Plane Block in Laparoscopic Sleeve Gastrectomy Surgery
The aim of the study is to evaluate the effect of erector spina plane (ESP) block on pulmonary functions and postoperative analgesic consumption in patients undergoing bariatric surgery.
- Trial name
- NCT04039321
- Testing
- ESPB group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Antalya Training and Research Hospital
Mammary Cancer, Serratus Anterior Plane Block
Serratus Anterior Plane Block for Modified Radical Mastectomy: Double-point VS Single-point
Nowadays, the incidence of breast cancer is the first number of malignant tumors, and the primary treatment method is surgery. As is known to all, less postoperative complications and enhanced recovery are closely related to…
- Conditions
- Mammary Cancer, Serratus Anterior Plane Block, Postoperative Pain
- Trial name
- NCT05299021
- Testing
- Double-point SAPB, Single-point SAPB
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Fudan University
Preterm Neonate Analgesia
Melatonin As an Analgesic in Preterm Neonate
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone secreted by the pineal gland with several important functions, including regulation of the circadian rhythms, antioxidant and anti-inflammatory effects, accumulating…
- Trial name
- NCT05971485
- Testing
- Melatonin 10 mg
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Consciousness, Level Depressed, Intraoperative Awareness
Awareness During Blended Anaesthesia
the aim of this study was to estimate the relations between Bispectral Index values and explicit or implicit memory or dreams during two different minimal alveolar concentration (MAC) of sevoflurane in patients undergoing blended…
- Trial name
- NCT01800578
- Testing
- monitor for depth of hypnosis
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Germano De Cosmo
Multiple Sclerosis
Efficacy of L-carnitine Versus Placebo in the Treatment of Fatigue in Multiple Sclerosis
The objective of this study is to evaluate the efficacy of L-carnitine versus placebo in the treatment of fatigue in multiple sclerosis patients. This study will randomize 60 patients in a cross-over design.
- Trial name
- FACTSEP (NCT01149525)
- Testing
- L-Carnitine
- Where
- 6 sites in France
- Volunteers
- 59 people
- Sponsor
- University Hospital, Bordeaux
Parkinson's Disease, Falls
Falls and Balance of Patients With Parkinson's Disease With Urinary Disturbance
The aim of this study is to determine the fall and balance conditions of Parkinson's patients according to their urinary complaints.
- Conditions
- Parkinson's Disease, Falls, Balance, Urinary Bladder Diseases
- Trial name
- NCT03845725
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Ordu University
Music Therapy, General Anesthesia
Intraoperative Music Therapy in Gynecological Oncology
Background Perioperative anxiety and postoperative pain can impact surgical morbidity. We aimed to evaluate the effect of intraoperative music therapy in the reduction of immediate postoperative pain in patients undergoing…
- Conditions
- Music Therapy, General Anesthesia, Surgery, Pain
- Trial name
- NCT04694508
- Testing
- Headphones (Disok, Alicante, España)
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Analgesia, Pain, Postoperative
Comparison Between Perineural and Systemic Effect of Dexamethasone as an Adjuvant for Prolongation of Four Nerve Blocks With Bupivacaine in Total Knee Arthroplasty
The addition of dexamethasone (DxaM) to local anesthetic may significantly prolong the duration of a block in total knee arthroplasty. The aim of this study is to determine whether this is a systemic or local effect.
- Trial name
- NCT02253784
- Testing
- Dexamethasone, Bupivacaine
- Where
- Israel
- Volunteers
- 90 people
- Sponsor
- Hillel Yaffe Medical Center
Apical Periodontitis, Postoperative Pain After Endodontic Treatment
Effect of Different Apical Motion Algorithms on Postoperative Pain After Root Canal Treatment
Brief Summary This prospective, randomized clinical trial aims to evaluate the effect of different endodontic motor settings used during root canal treatment on postoperative pain.
- Trial name
- NCT07714733
- Testing
- Root Canal Treatment, Rotary Instrumentation, Reciprocating Instrumentation
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Alanya Alaaddin Keykubat University
Solid Tumors
Dose Escalation of RMC-5552 Monotherapy in Relapsed/Refractory Solid Tumors
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of escalating doses of RMC-5552 monotherapy in adult participants with relapsed/refractory solid tumors…
- Trial name
- NCT04774952
- Testing
- RMC-5552
- Where
- 8 sites in United States
- Volunteers
- 58 people
- Sponsor
- Revolution Medicines, Inc.
Diabetic Neuropathies
Role of Carnosine in Combination With Vitamin B Complex in Preventing the Progression of Diabetic Neuropathy in Type 2 Diabetes Patients
Evaluation of the influence of oral administration of carnosine in combination with vitamin B Complex in preventing the progression of diabetic neuropathy in type 2 diabetes patients.
- Trial name
- NCT05422352
- Testing
- Carnosine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Pain, Postoperative, Pain
FOREVR Peds VR Pilot
To determine the feasibility and acceptability of using immersive virtual reality technologies to impact clinical outcomes (e.g., pain and anxiety) and medication utilization (e.g., narcotics) in pediatric patients with acute and…
- Conditions
- Pain, Postoperative, Pain, Anxiety
- Trial name
- NCT04556747
- Testing
- VR - Distraction, VR - Biofeedback
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Diabetic Polyneuropathy
Safety and Efficacy of MCC-257 in the Treatment of Diabetic Polyneuropathy
The primary objectives of the study are to evaluate the efficacy and safety of three doses of MCC-257 in patients with mild to moderate diabetic polyneuropathy
- Trial name
- NCT00307749
- Testing
- MCC-257
- Volunteers
- 420 people
- Sponsor
- Tanabe Pharma Corporation
Pediatric Patients, Orthopedic Surgery
Nociception Level Index as a Verbal Tool of Pain in Children
60 children under 6 years old, scheduled for orthopedic surgery for limb fracture or neuromuscular and bone deformities will be randomized by closed envelope method into two groups (n=30) either receiving standard pain management…
- Conditions
- Pediatric Patients, Orthopedic Surgery, Extremity Fractures Lower, Extremity Fractures Upper
- Trial name
- NCT05716243
- Testing
- The nociception level index monitorization, The nociception level index measurement;postoperative
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Haseki Training and Research Hospital
Ear Throat Nose Surgery, Delirium - Postoperative
The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
Delirium is a postoperative complication that hinders a child's recovery and presents challenges in assessment and management. Ear nose throat (ENT) procedures have been suggested as a risk factor for delirium[1].
- Conditions
- Ear Throat Nose Surgery, Delirium - Postoperative, Pain Postoperative
- Trial name
- NCT07191652
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Istanbul University - Cerrahpasa
Emergence Agitation
Preemptive Intravenous Micro-dose Dexmedetomidine to Prevent Emergence Agitation in Adult Patients Undergoing Septoplasty Surgeries
This prospective randomized controlled study will be conducted to evaluate the effect of preoperative single, micro-dose of dexmedetomidine (0.3μg/kg) on the incidence and severity of EA in adults undergoing Septoplasty surgeries
- Trial name
- NCT07302815
- Testing
- Dexmedetomidine, Saline
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Tanta University
Postoperative Shoulder Pain After Gynecologic Laparoscopy
Intraperitoneal Gas Drainage to Reduce Postoperative Shoulder Pain After Gynecologic Laparoscopy .
This randomized controlled trial aims to evaluate whether the use of an intraperitoneal gas drain at the end of gynecologic laparoscopic surgery can reduce postoperative shoulder pain.
- Trial name
- NCT07262749
- Testing
- Intraperitoneal Gas Drain
- Volunteers
- 124 people
- Sponsor
- Assiut University
Postoperative Delirium
Efficacy of Erector Spinae Plane Block on Postoperative Delirium in Patients Undergoing Lumbar Spine Surgery
Lumbar vertebra surgery is one of the most common surgical procedures.Delirium is common in geriatric patients after lumbar spinae surgery.postoperative delirium usually occurs in the early postoperative period and delays patient…
- Trial name
- NCT05276648
- Testing
- CAM ICU test, MOCA test, brief pain test
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Aydin Adnan Menderes University
Emergence Agitation, General Anesthesia
Low-dose Versus Standard-dose Remimazolam for Prevention of Emergence Agitation After Nasal Surgery
Emergence agitation (EA) is a common complication during recovery from sevoflurane anesthesia, particularly after nasal surgery.
- Conditions
- Emergence Agitation, General Anesthesia, Nasal Surgical Procedures
- Trial name
- NCT07740655
- Testing
- Remimazolam
- Where
- South Korea
- Volunteers
- 138 people
- Sponsor
- Jeju National University School of Medicine
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