Clinical trials: Neurologic Deficits, open to volunteers
Epilepsy
Evaluation of the Risk of Cognitive Deficit After Surgery of Epilepsy by Dynamic Spectral Imaging (ISD) of the Cognitive Functions in Patients Explored in StereoElectroEncephaloGraphy (SEEG)
Epilepsy affects between 0.5 and 0.7% of the European population. Despite the availability of numerous drug treatments, one third of patients still have seizures, which are associated with significant cognitive and social…
- Trial name
- ISD SEEG (NCT03094312)
- Testing
- Dynamic Spectral Imaging (ISD)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Parkinson's Disease (PD)
Immediate Effects of External Trigeminal Nerve Stimulation on Motor Dysfunction in Parkinson's Disease
Parkinson's disease (PD), the most common movement disorder, is characterized by motor symptoms including tremor, rigidity, bradykinesia, and postural instability.
- Trial name
- NCT07656129
- Testing
- external Trigeminal Nerve Stimulation, eTNS
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhengli Di
Attention-deficit Hyperactivity, Attention Deficit Hyperactivity Disorder
Weighted Blankets for Sleep Disturbance Among Children With ADHD
Many children with ADHD suffer from sleep disorders and dysfunction, which may affect development and well-being. According to the clinicians, some children find relief from restlessness and difficulty sleeping by using weighted…
- Conditions
- Attention-deficit Hyperactivity, Attention Deficit Hyperactivity Disorder, Neurodevelopmental Disorders, Sleep Disturbance
- Trial name
- NCT06194162
- Testing
- Weighted blanket, Non-weighted blanket
- Where
- Denmark
- Volunteers
- 340 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Optical Phenomena
Attention Modulation of Local and Global Inhibition Mechanisms
Human behavior is both flexible and adapted to the environmental context through inhibition capabilities; the investigator control the subject's behavior by repressing inappropriate responses and selecting, among several…
- Trial name
- MILGattention (NCT04279158)
- Testing
- experience 1 "The negative priming task", experience 2 "Stop signal task", experience 3 "Anti-saccades"
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Parkinson Disease
High Frequency Light, Sound, and Tactile Stimulation to Improve Motor and Cognitive Deficits in Parkinson's Disease
Parkinson's disease (PD) impacts different types of neural oscillations in the brain, including beta (13-30Hz) and gamma oscillations (30-80Hz), which contributes to PD's cardinal symptoms of resting tremor, rigidity…
- Trial name
- NCT05268887
- Testing
- GENUS device (Active Settings)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts Institute of Technology
Attention Deficit Hyperactivity Disorder, Behavior Hyperactive
Attention Deficit Hyperactivity Disorder
The ADA cohort aims for the systematic and standardized collection of sociodemographic, clinical and neuropsychological data, during 2 visits (inclusion and 12 months), from patients suffering from the co-occurrence of ADHD…
- Conditions
- Attention Deficit Hyperactivity Disorder, Behavior Hyperactive, Behavior Disorders
- Trial name
- ADA (NCT06232226)
- Testing
- Patients suffering from the co-occurrence of ADHD and addiction(s)
- Where
- 3 sites in France
- Volunteers
- 80 people
- Sponsor
- Nantes University Hospital
T1DM, Sleep Disorders, Circadian Rhythm
Influence of Circadian Clock on Hormonal, Metabolic, Neurocognitive Markers in Adolescents With and Without Diabetes
Type 1 diabetes mellitus (T1DM), makes its appearance during childhood and youth, but management implications last till late adulthood.
- Conditions
- T1DM, Sleep Disorders, Circadian Rhythm, ADHD, Memory Impairment
- Trial name
- NCT04054934
- Testing
- Reversed Circadian Rhythm, Normal Circadian Rhythm
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
FOXP1, Mental Retardation With Language Impairment and With or Without Autistic Features
FOXP1 Syndrome: The Seaver Autism Center for Research and Treatment is Characterizing FOXP1-related Neurodevelopmental Disorders Using Genetic, Medical, and Neuropsychological Measures.
FOXP1, also known as Forkhead-box Protein P1, is a transcription factor protein belonging to the FOX gene family. Disruptions in the FOXP1 gene cause a phenotype characterized by global developmental delay, speech deficits, mild…
- Conditions
- FOXP1, Mental Retardation With Language Impairment and With or Without Autistic Features, Autism Spectrum Disorder
- Trial name
- NCT03718923
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Aphasia
Criterion-learning Naming Treatment For Addressing Comprehension Deficits in Aphasia
Aphasia is a disorder of spoken and written language, most commonly following a stroke. It is estimated that between 2.5 and 4 million Americans are living with aphasia today.
- Trial name
- NCT07179458
- Testing
- Criterion-learning practice
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Albert Einstein Healthcare Network
Chronic Stroke
Spinal Cord Stimulation Combined With Motor Imagery Brain-Computer Interface for Chronic Post-Stroke Upper Limb Motor Dysfunction
This clinical study aims to evaluate the efficacy and safety of spinal cord stimulation combined with non-invasive motor imagery brain-computer interface rehabilitation training in patients with upper limb motor dysfunction after…
- Trial name
- NCT07686822
- Testing
- Spinal Cord Stimulation, Motor Imagery Brain-Computer Interface Rehabilitation Training
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Zhejiang Provincial People's Hospital
Posttraumatic Stress Disorder (PTSD)
Methylphenidate for the Treatment of PTSD With Associated Neurocognitive Complaints
Posttraumatic stress disorder (PTSD) is frequently accompanied by difficulty concentrating, poor memory, and inability to keep up with tasks, which negatively impacts a person's ability to function at work and in relationships.
- Trial name
- IMPACT (NCT05776056)
- Testing
- Methylphenidate
- Where
- 3 sites in United States
- Volunteers
- 70 people
- Sponsor
- VA Office of Research and Development
Parkinson Disease
Study on Preliminary Safety and Efficacy of Adaptive DBS Aligned to Locomotor States to Improve Locomotor Functions in Parkinson's Patients
At present, there is no cure for Parkinson's disease. The standard treatment involves taking dopaminergic drugs. When drugs lose their effectiveness, they can be supplemented by Deep Brain Stimulation (DBS) therapy.
- Trial name
- AdapGAIT (NCT06791902)
- Testing
- Adaptive DBS
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Jocelyne Bloch
Alzheimers Disease, Mild Cognitive Impairment
Locomotion Adaptation Deficits in Older Adults With Mild Cognitive Impairment and Alzheimers Disease
In people with Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD), reduced capacity for locomotor adaptation is a fundamental but poorly understood mechanism that can be a sensitive biomarker of cognitive-motor…
- Trial name
- NCT06484244
- Testing
- 5 Sessions of Split-belt Treadmill-based Locomotor Adaptation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Stroke, Motor Dysfunction
Closed-Loop SCS-BCI for Post-Stroke Hemiplegia
This study evaluates a new closed-loop rehabilitation system for stroke survivors with arm weakness. The system combines a brain-computer interface (BCI, a special cap that reads brain signals), spinal cord stimulation (a…
- Conditions
- Stroke, Motor Dysfunction, Brain-computer Interface, Spinal Cord Stimulation (SCS)
- Trial name
- CL-SCS-BCI (NCT07903116)
- Testing
- Spinal Cord Stimulation, Non-invasive Brain-Computer Interface, Hand Exoskeleton
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital
Acquired Brain Injury Including Stroke, TBI
Effects of Neurofeedback Training and tRNS on Attentional Deficits in Patients With Acquired Brain Injury
The goal of this study is to investigate new neuromodulation therapies for attention deficits following acquired brain injury. Brain damage can affect various domains, including motor and cognitive functions.
- Conditions
- Acquired Brain Injury Including Stroke, TBI, Stroke, Anoxia-Ischemia, Brain
- Trial name
- NeMoRe II (NCT07817316)
- Testing
- verum tRNS + Neurofeedback
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospitales Nisa
Telerehabilitation, Multiple Sclerosis
Cognitive Rehabilitation of Deficits in Patients With Multiple Sclerosis
Non-Inferiority Study, Post-Market Clinical Investigation with a Device, Single-Blind Randomized Controlled Trial in a Cohort of Patients Diagnosed with Multiple Sclerosis (MS).
- Conditions
- Telerehabilitation, Multiple Sclerosis, Cognitive Disorders, Neurorehabilitation
- Trial name
- NCT06964581
- Testing
- Cognitive treatment delivered via telerehabilitation., In-person cognitive treatment.
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Universita di Verona
ADHD, Sleep Problems
A Clinical Trial of Iron Supplementation for Youth With ADHD and Restless Sleep
The goal of this clinical trial is to learn if iron supplementation works to restless sleep in youth with ADHD. A second goal is to learn if iron supplementation helps to ease ADHD symptoms.
- Trial name
- NCT07061470
- Testing
- Ferrous Sulfate
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Mild Cognitive Impairment (MCI), Mild Cognitive Impairment (MCI) Amnestic
Deep Brain Stimulation Guided by Brain Mapping to Treat Cognitive Impairment
This trial is a 12-month safety and feasibility study, enrolling up to six participants. These participants will serve as their own controls, structured in multiple parts that follow an initial short-term stereo…
- Conditions
- Mild Cognitive Impairment (MCI), Mild Cognitive Impairment (MCI) Amnestic, Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, Memory Deficit
- Trial name
- NCT07887737
- Testing
- Abbott St Jude Medical Infinity™
- Volunteers
- 6 people
- Sponsor
- University of Texas Southwestern Medical Center
Psychotic Disorders, ADHD
Cognitive Remediation in Forensic Mental Health Care
Forensic patients often display cognitive deficits, particularly in the domain of executive functions, that represent a challenge to forensic rehabilitation.
- Conditions
- Psychotic Disorders, ADHD, TBI (Traumatic Brain Injury), Aggression
- Trial name
- CRFMHC (NCT04610697)
- Testing
- Cognitive Remediation, Active Control
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Leukodystrophy, White Matter Disease
The Myelin Disorders Biorepository Project
The Myelin Disorders Biorepository Project (MDBP) seeks to collect and analyze clinical data and biological samples from leukodystrophy patients worldwide to support ongoing and future research projects.
- Conditions
- Leukodystrophy, White Matter Disease, Leukoencephalopathies, 4H Syndrome
- Trial name
- MDBP (NCT03047369)
- Where
- 23 sites in United States
- Volunteers
- 12,000 people
- Sponsor
- Children's Hospital of Philadelphia