Clinical trials: Neurologic Deficits, active
Stroke, Attention Disorder
Virtual-reality Exercises for Alleviating Attention Deficits in Patients With Acquired Brain Injury
Stroke is the leading cause of long-term disability with an increasing incidence, especially in young adults. Among the cognitive difficulties following brain damage, deficits in attention are frequent and pervasive, affecting…
- Trial name
- NCT05728840
- Testing
- Immersive virtual reality gamified cognitive activities, Double neuropsychological standard activities
- Where
- Switzerland
- Volunteers
- 135 people
- Sponsor
- Mindmaze SA
Carbon Monoxide Poisoning, Myocardial Injury
CARbon monoxidE intoxiCatiOn in Korea: Prospective Cohort (CARE CO Cohort)
This prospective cohort study enrolls subjects who experience carbon monoxide (CO) poisoning. The purpose of the study is to evaluate therapeutic effects of various treatments and short and long-term outcomes in CO poisoned…
- Conditions
- Carbon Monoxide Poisoning, Myocardial Injury, Neurologic Deficits, Image, Body
- Trial name
- NCT04490317
- Testing
- Cardiac MRI, Hyperbaric oxygen therapy
- Where
- South Korea
- Volunteers
- 1,500 people
- Sponsor
- Wonju Severance Christian Hospital
Developmental Language Disorder
Syntactic Intervention for Cantonese-speaking Children With DLD
The goal of this clinical trial is to compare the efficacy of explicit vs. implicit intervention on subject relative clause production in Cantonese-speaking children with Developmental Language Disorder (DLD).
- Trial name
- NCT06954194
- Testing
- Explicit intervention (Shape Coding+syntactic priming), Implicit intervention (syntactic priming only)
- Where
- Hong Kong
- Volunteers
- 32 people
- Sponsor
- The Hong Kong Polytechnic University
Autism Disorder, Language Development Disorders
Rural Autistic Individuals - Supporting Expression
This research study investigates how hand gestures can support language comprehension and communication skills of hearing speaking, non-speaking, and/or minimally verbal individuals with Autism Spectrum Disorders (ASD), who are…
- Conditions
- Autism Disorder, Language Development Disorders, ADHD, Typical Development
- Trial name
- RAISE (NCT07054866)
- Testing
- Speech-Gesture combinations
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Montana State University
Stroke, Aphasia
Combined Exercise and Targeted Therapy for Post-Stroke Reading Deficits
The goal of the proposed project is to test the effectiveness of a novel hybrid approach to treatment of reading disorders after stroke, in which exercise training will be used in combination with a targeted reading treatment.
- Conditions
- Stroke, Aphasia, Reading Disorder
- Trial name
- NCT06213272
- Testing
- Phono-Motor Therapy, Aerobic Exercise Training (AET), Stretching
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Kessler Foundation
Glioma, Glioma Intracranial
A Study Using Brain Stimulation and Behavioral Therapy to Increase Extent of Resection in Low-Grade Gliomas
This study uses a cranial implant to deliver cortical stimulation that, when paired with physiotherapy, will remap the brain so that critical brain functions can be protected during brain tumor surgery.
- Conditions
- Glioma, Glioma Intracranial, Gliomas Benign, Brain Tumor
- Trial name
- NCT04745156
- Testing
- RNS System Implantation
- Volunteers
- 3 people
- Sponsor
- Medical College of Wisconsin
Stroke, Chronic, Aging
AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions
The AMPLIFI study (Adaptive Modulation of Plasticity through Lactate and Fitness Interventions) investigates how short-term aerobic exercise influences brain plasticity and learning in older adults and stroke survivors.
- Conditions
- Stroke, Chronic, Aging, Cognitive Decline, Motor Dysfunction
- Trial name
- AMPLIFI (NCT06950060)
- Testing
- High intensity cycling, Low-intensity cycling, Health education session
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Neurocognitive Deficit
Validation of MoCA-B and MoCA-Blind for Screening Cognitive Decline
The objective of this observational study is to assess the efficacy of two neuropsychological tests (MoCA-B and MoCA-Blind) in detecting cognitive decline in older adults.
- Trial name
- NCT07846839
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio Grande do Norte
MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
This is a parallel arm non-randomized dose-escalation, open-label basket exploratory phase 1 clinical trial where Mitochondrial encephalopathy, lactic acidosis, stroke-like episodes (MELAS) and Leber's hereditary optic…
- Trial name
- NCT06792500
- Testing
- Glycerol Tributyrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- George Washington University
Optic Nerve Injuries, Sellar Tumor
Optic Nerve Stimulation To Prevent Visual Deficits After Endoscopic Cranial Approaches
Assessing the function of the optic nerve is paramount during various neurosurgical procedures. Effective optic nerve monitoring has remained elusive as Visual Evoked Potentials (the current existing tool) provides only diffuse…
- Conditions
- Optic Nerve Injuries, Sellar Tumor, Skull Base Neoplasms
- Trial name
- NCT06495580
- Testing
- Optic Nerve Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Upper Limb Sensorimotor Deficits
Feasibility and Cost of Robot-assisted Upper Limb Rehabilitation With Different Levels of Supervision
Upper limb impairments are often a result of neurological or traumatic injuries (e.g., stroke, traumatic brain injuries). These impairments may decrease independence in performing activities of daily living, severely affecting…
- Trial name
- RHB Clinic (NCT06725784)
- Testing
- ReHandyBot
- Where
- 2 sites in Switzerland
- Volunteers
- 100 people
- Sponsor
- Swiss Federal Institute of Technology
Motor Disorders, Healthy
Non-invasive BCI-controlled Assistive Devices
Injuries affecting the central nervous system may disrupt the cortical pathways to muscles causing loss of motor control. Nevertheless, the brain still exhibits sensorimotor rhythms (SMRs) during movement intents or motor imagery…
- Conditions
- Motor Disorders, Healthy, Spinal Cord Injuries, Muscular Diseases
- Trial name
- NCT05183152
- Testing
- NMES Feedback, Visual Feedback, TESS
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
ADHD, Sleep Disturbance
A Study to Evaluate the Effects of a Supplement on the Side Effects Associated With Stimulant Medications
This is a hybrid, two-arm, triple-blind, placebo-controlled, randomized clinical trial evaluating the efficacy of the Stasis supplement on reducing oxidative stress, cortisol levels, and side effects associated with stimulant…
- Conditions
- ADHD, Sleep Disturbance, Brain Fog
- Trial name
- NCT07380412
- Testing
- Stasis Daytime and Nighttime
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Outliers, Inc.
Mild Traumatic Brain Injury (mTBI), Concussion, Mild Traumatic Brain Injury
Postural Motor Activation Deficits After mTBI; Translating Laboratory Findings to Clinical Care
This work will address an important gap in physical therapy rehabilitation after concussion. Physical therapy usually focuses on how the brain processes sensory information such as inner ear and vision for balance rehabilitation…
- Trial name
- NCT07549529
- Testing
- Motor Activation Physical Therapy for mTBI, Standard of Care Physical Therapy for mTBI
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Oregon Health and Science University
Gastric Antral Vascular Ectasia, Cirrhosis
Prevalence of Gastric Motor Dysfunction and Upper GI Symptoms in Gastric Antral Vascular Ectasias
The researchers are trying to find out more about Gastric Antral Vascular Ectasia (GAVE). This is a condition that affects the blood vessels in the stomach, leading to their enlargement and possible bleeding.
- Conditions
- Gastric Antral Vascular Ectasia, Cirrhosis, Chronic Kidney Disease
- Trial name
- GAVE (NCT06306963)
- Testing
- Gastric Emptying Breath Test
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Chronic Ischemic Stroke
A Study of ASP2246 for People Who Have Movement Problems Caused by Brain Injury After a Stroke
This study is for adults who have difficulty moving a few months after a stroke. In this study, ASP2246 will be given to people for the first time. This is known as a "first in human" study.
- Trial name
- NCT07318714
- Testing
- ASP2246, Brain surgery, Rehabilitation therapy
- Where
- 5 sites in Japan
- Volunteers
- 84 people
- Sponsor
- Astellas Pharma Inc
Stroke
Feasibility of Real-Time Visual Feedback in Augmented Reality to Reduce Gait Asymmetry Post-Stroke
Unilateral motor deficits, such as paresis and tone disorders, are frequent consequences of stroke and lead to gait impairments.
- Trial name
- NCT07178535
- Testing
- Feasibility of Two Types of Real-Time Visual Feedback in an Augmented Reality
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University
Post-operative Functional Decline, Severe Neurological Impairment
Post-operative Changes Study
The goal of this observational pilot study is to evaluate the feasibility and acceptability of the protocol to explore the functional post-operative trajectory in a developmentally and neurologically impaired pediatric…
- Trial name
- NCT07121660
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- University of British Columbia
Multiple Sclerosis, Cognitive Impairment
MODAFIMS: A Trial to Evaluate Predictors of Response to MODAFinil in Patients With Multiple Sclerosis
This is a phase II/exploratory clinical trial with a single-center, open-label design to evaluate the effect of modafinil on cognitive deficits in adult patients with multiple sclerosis and identify predictors of response using…
- Trial name
- MODAFIMS (NCT06592352)
- Testing
- Modafinil Generis 100 mg
- Where
- Portugal
- Volunteers
- 64 people
- Sponsor
- Clinical Academic Center (2CA-Braga)
Ischemic Stroke, Motor Deficits
Effect of Vagus Nerve Stimulation Via the Outer Ear on Motor and Cognitive Deficits After Ischemic Stroke
The goal of this clinical trial is to learn if transcutaneous auricular vagus nerve stimulation (taVNS) works to treat motor and neurocognitive deficits after ischemic stroke when applied within 30 days after onset of stroke.
- Conditions
- Ischemic Stroke, Motor Deficits, Cognitive Impairment, Vagus Nerve Stimulation
- Trial name
- EVAMOS (NCT06822140)
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- Switzerland
- Volunteers
- 144 people
- Sponsor
- Rheinburg-Klinik