Clinical trials: Neurologic Disorder
Stammering
Effects of Tele Speech Therapy on the Treatment of Stammering in Adults Who Stutter
The aim of the study is to determine the effectiveness of telespeech therapy on the treatment of stammering.
- Trial name
- NCT06937437
- Testing
- Teletherapy, Traditionally speech therapy
- Where
- Pakistan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Sleep Quality, Older Adults (65 Years and Older)
Effect of Health Promotion Model-Based Oculomotor Exercise Program on Sleep Quality in Older Adults
The goal of this clinical trial is to investigate the effect of a Health Promotion Model-based oculomotor exercise program on sleep quality among older adults living in a nursing home.
- Trial name
- NCT07261124
- Testing
- Oculomotor Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Alzheimer Disease
Dose-Escalation Study to Assess the Safety, Tolerability, and Pharmacokinetics of Donepezil From Single Dose of GB-5001 IM Depot and Aricept® Oral Tablets in Healthy Male Volunteers
This study is to evaluate the safety and tolerability of single dose of GB-5001 (donepezil) IM depot in healthy male volunteers.
- Trial name
- NCT05525780
- Testing
- GB-5001, Oral cohort
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- G2GBio, Inc.
Pituitary Tumor
NET-TIME: Inflammatory Tumor Microenvironment in Pituitary Neoplasm
Over the past twenty years, a progressively increasing number of markers biochemical, clinical, imaging, histopathological or genetic have been suggested to attempt to predict aggression and therapeutic outcome, both in secretory…
- Trial name
- NET-TIME (NCT07594262)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Tension-Type Headache, Cervicogenic Headache
The Classification and Treatment of Myofascial Headache: a Cross-sectional Study and Randomized Controlled Trial.
This project comprises two studies; a cross-sectional study and a randomized controlled trial. 1. The goal of the cross-sectional study is to compare multiple outcome parameters in different headache types: tension type (TTH)…
- Conditions
- Tension-Type Headache, Cervicogenic Headache, Myofascial Headache
- Trial name
- COMPHAS_RCT (NCT06100588)
- Testing
- Dry Needling, Manual therapy
- Where
- Belgium
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University Ghent
Pain, Neuropathic, Neuropathic Pain
Effect of GSK1014802 on Electrical Hyperalgesia and Threshold Tracking in Healthy Subjects
This study is being conducted to assess the effects of GSK1014802 and a positive control, lidocaine, on tests of peripheral nerve excitability. This will be a double blind, placebo controlled, 4-period cross over study.
- Trial name
- NCT00964288
- Testing
- GSK1014802 low dose, Lidocaine, GSK1014802 high dose
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Biogen
Diplegic Cerebral Palsy
"Immediate Effect of DAFO on Gross Motor Function and Balance in Diplegic Cerebral Palsy
" Study will investigate the immediate effect of DAFO usage on balance and gross motor functions in individuals with spastic diplegic cerebral palsy.
- Trial name
- NCT06343688
- Testing
- "Assessment of Balance and Lower Extremity Gross Motor Function with and without DAFO"
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Obstructive Sleep Apnea, Diabetes Mellitus
Assessing the Risk of Developing Type II Diabetes Using Serum Biomarkers in Patients Diagnosed With Obstructive Sleep Apnea
The investigators plan to recruit 140 patients (35 subjects in each group) over a period of 18 months in a prospective study of matched/paired case-control subjects across the four groups to measure the 5-year risk of developing…
- Trial name
- OSA & DM (NCT01447251)
- Testing
- PreDx Diabetes Risk Score
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mike O'Callaghan Military Hospital
Sleep Deprivation
Predicting Cognitive Resilience Against Sleep Loss
Resilience is the ability to cope effectively and adapt to a wide range of stressful environmental challenges. Sleep loss has been shown to reduce activity in the brain regions responsible for resilience.
- Trial name
- NCT01651429
- Testing
- Sleep deprivation
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Ischemic Stroke
Immunological Biomarkers in Patients With Acute Ischemic Stroke
Stroke is accompanied by local inflammatory response and systemic immunosuppression. Immunosuppression markers are associated with the occurrence of medical complications (infections), whereas inflammatory markers are associated…
- Trial name
- NCT01894529
- Where
- Spain
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Parkinson Disease Psychosis, Amyotrophic Lateral Sclerosis (ALS)
A Phase 1, SAD and MAD Study to Evaluate the Safety and Tolerability of FB418
The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics and pharmacodynamics of oral doses of FB418 in healthy adult subjects and healthy elderly subjects.
- Trial name
- NCT05995782
- Testing
- FB418
- Where
- South Korea
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- 1ST Biotherapeutics, Inc.
Alzheimer Disease, Healthy Volunteers
Phase 1 Evaluation of [18F]MK-6240 PET as an Imaging Marker for Tau Protein
The overall goal of this protocol is to evaluate [18F]MK-6240 (also known as [18F]MNI-946) a tau targeted radiopharmaceutical.
- Trial name
- NCT03071224
- Testing
- [18F] MNI-946, [18F]Florbetapir
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Invicro
Alzheimer Disease, Dementia Alzheimers
Optical Coherence Tomography in Cerebral Amyloidosis
In this observational study, the investigators aim to evaluate whether changes in the retinal and choroidal circulation, as assessed by Optical Coherence Tomography (OCT) and the quantification of retinal amyloid deposits using…
- Conditions
- Alzheimer Disease, Dementia Alzheimers, Dementia, Lewy Body Disease
- Trial name
- NCT03472482
- Testing
- non-invasive retinal imaging
- Where
- Belgium
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Concussion, Mild
Australian UCSF Concussion in Athletes
Analysis of cardiac induced brain forces using cranial accelerometry has been shown to diagnose concussion in high school athletes.
- Trial name
- AUSSIE-1 (NCT05769296)
- Testing
- Headpulse measurements
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pain, Anxiety
Structured Education and Multidisciplinary Team
It is well-known that pre-operative education has a positive effect on patient recovery. This study was conducted to evaluate the impact of structured education given by a multidisciplinary team (surgeon, anesthesiologist, and…
- Conditions
- Pain, Anxiety, Activities of Daily Living
- Trial name
- NCT04850586
- Testing
- Education Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Hypertension, Laughter Yoga
The Effect of Laughter Yoga Practice in Hypertension Patients
Hypertension (HT), which is defined as an arterial blood pressure higher than 140/90 mmHg, is an important health problem because it causes serious complications and is commonly seen in the community.
- Trial name
- HT-Laughter (NCT07148869)
- Testing
- LAUGHTER YOGA, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kilis 7 Aralik University
Parkinson Disease
Effect of Rasagiline on BIA 9-1067 Pharmacokinetics
The purpose of this study is to investigate the effect of rasagiline on BIA 9-1067 pharmacokinetics in healthy subjects.
- Trial name
- NCT01532141
- Testing
- BIA 9-1067, Rasagiline
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Spinal Cord Injuries, Cardiovascular Diseases
Cardioprotective Benefit of Passive Heat Therapy in Higher-Level Spinal Cord Injury: Safety and Proof of Concept
As compared to the general population, those living with a spinal cord injury (SCI) are at a greater risk of cardiovascular (CV) diseases.The investigators know that regular exercise can help lessen the risk of CV diseases.
- Conditions
- Spinal Cord Injuries, Cardiovascular Diseases, Health Behaviour, Physical Inactivity
- Trial name
- NCT06027502
- Testing
- Passive Heating
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Vaccine-induced Thrombotic Thrombocytopenia Syndrome, Guillain-Barre Syndrome
Gene Sequencing as a Strategy for Identifying Genetic Factors Associated With Serious Adverse Events After Covid-19 Vaccines in Use in Brazil
This protocol proposes to investigate genetic factors that may be involved in the pathogenesis of adverse events of interest with selected covid-19 vaccines: vaccine-induced immune thrombotic thrombocytopenia, and neurological…
- Conditions
- Vaccine-induced Thrombotic Thrombocytopenia Syndrome, Guillain-Barre Syndrome, Acute Disseminated Encephalomyelitis, Transverse Myelitis
- Trial name
- NCT05630313
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)
Fibromyalgia
Serious Game for Fibromyalgia Patients
Aim: To check the applicability of LitEmotion© in people with Fibromyalgia. Design: randomized clinical trial, with pre, post and follow-up evaluation. Researchers and outcome evaluator blinded.
- Trial name
- NCT03906188
- Testing
- LitEmotion
- Where
- Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidad de Burgos
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