Clinical trials: Neurologic Disorders
Neuropathic Pain
Balance and Gait on Neuropathic Pain Due to Lumbar Disc Degeneration
Chronic lumbar neuropathic pain, characterized by pain, numbness, tingling and muscle weakness in the lower extremities, is one of the most common neuropathic pain syndromes.
- Trial name
- NCT05223439
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Postoperative Cognitive Dysfunction, Postoperative Delirium
Study of Depressive Symptoms Predicting Postoperative Cognitive Dysfunction
Postoperative cognitive dysfunction (POCD) describes a condition where cognitive functions such as attention, perception, concentration, learning, abstract thinking and problem solving are impaired postoperatively.
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Delirium, Depressive Symptoms
- Trial name
- DeprPOCD (NCT02210312)
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Sleep Apnea
Health Coaching for Positive Airway Pressure Adherence
This study tested a low-resource, brief telephonic health coaching intervention to improve adherence to positive airway pressure therapy for treatment of sleep apnea.
- Trial name
- NCT04067128
- Testing
- Health coaching
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Stroke, Acute Stroke
The Effects of Gait Rehabilitation After Stroke by Treadmill-based Robotics Versus Traditional Gait Training
This multicenter non-randomized controlled trial aims to investigate the effectiveness (an increase of the walking speed in the 10 Meter Walk Test - 10MWT) of the robotic treatment with exoskeleton or end-effector system compared…
- Conditions
- Stroke, Acute Stroke, Chronic Stroke
- Trial name
- TREAD_STROKE (NCT03688165)
- Testing
- Treadmill-based Robotic Gait Training, Traditional Over-ground Gait Training
- Where
- 4 sites in Italy
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Healthy
Effectiveness of the Serious Game 'Broodles' for Siblings of Children With Visual Impairment and/or Intellectual Disability
The support for siblings of children with disabilities is scarce and fragmented, even though studies have shown that these siblings can benefit from support.
- Trial name
- NCT05376007
- Testing
- Serious game 'Broodles'
- Where
- Netherlands
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- VU University of Amsterdam
The Comorbidity Between the Trigger Digit and Carpal Tunnel Syndrome
Investigation of the Relation Between Trigger Digit and Carpal Tunnel Syndrome
The purpose of this study is to comprehend the association between the trigger digit and carpal tunnel syndrome based on the quantification of the tendon and nerve characteristics. It includes three parts.
- Trial name
- NCT04072692
- Testing
- Hybrid rehabilitation training, Traditional rehabilitation training, Wearable anti-bowstringing orthosis (WABO)
- Where
- Taiwan
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Vision Loss Partial, Hemianopia
Effect of Visual Retraining on Visual Loss Following Visual Cortical Damage
This project is intended to collect data using standard clinical tests and psychophysics to quantify the effect of visual cortical damage on the structure of the residual visual system, visual perception, spatial awareness, and…
- Conditions
- Vision Loss Partial, Hemianopia, Hemianopia Homonymous, Quadrantanopia
- Trial name
- NCT05098236
- Testing
- Training in the Blind Field, Training in the Sighted Field
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Hearing Disorders and Deafness
ListenFuture-Listening for Their Future: Deaf and Hard-of-Hearing Adolescents
ListenFuture, a nation-wide multidisciplinary project, brings new knowledge on complex associations between listening, cognition, language, literacy, and psychosocial wellbeing in deaf and hard-of-hearing (DHH) adolescents.
- Trial name
- ListenFuture (NCT07416292)
- Where
- 7 sites in Finland
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Heikki Löppönen
Musculoskeletal Pain
Transformative Learning to Virtual Inter-Professional Education in Musculoskeletal Pain
Musculoskeletal (MSK) pain is amongst the leading reasons for people seeking medical attention in local primary care, accounting for 6-28% of principal diagnoses.
- Trial name
- NCT05589311
- Testing
- Transformative Learning principles, Conventional didactic approach
- Where
- Singapore
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- SingHealth Polyclinics
Multiple Sclerosis
Validation of Ella Platform for Serum Nfl And GFAP Measures In Multiple Sclerosis Patients
Serum neurofilament-light chain (NfL) and glial fibrillary acidic protein (GFAP) measured by single molecule array (SIMOA) are novel biomarkers of multiple sclerosis patients (MS) activity and progression.
- Trial name
- Nf-Ella Loca (NCT05352971)
- Testing
- Biomarker quantification
- Where
- 10 sites in France
- Volunteers
- 664 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Alzheimer Disease, Alzheimer Dementia
Multimodal Ocular Imaging in Neurodegeneration
Alzheimer's disease (AD) and frontotemporal dementia (FTD) are two of the most common types of age-related neurodegenerative disorders.
- Conditions
- Alzheimer Disease, Alzheimer Dementia, Frontotemporal Dementia
- Trial name
- NCT03699644
- Testing
- Spectral-Domain Optical Coherence Tomography (SD-OCT), Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Sleep, Relaxation
Sleep and Morning Wellbeing Study
The study will be a prospective randomized, controlled clinical study. There will be interventional treatment for a total of 30 days. The subjects will complete questionnaires throughout the study at pre-specified timepoints.
- Conditions
- Sleep, Relaxation, Stress, Daytime Sleepiness
- Trial name
- NCT07311434
- Testing
- Sleep Supplement
- Where
- United States
- Volunteers
- 331 people, healthy volunteers welcome
- Sponsor
- Athletic Greens International
Healthy
A Safety, Tolerability and Pharmacokinetics Study of JNJ-54861911 in Healthy Japanese Male Participants
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics (PK, study of the way a drug enters and leaves the blood and tissues over time) of single-ascending oral doses of JNJ-54861911 in healthy…
- Trial name
- NCT02180269
- Testing
- JNJ-54861911 (25 mg), JNJ-54861911 (50 mg), JNJ-54861911 (100 mg)
- Where
- Japan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Janssen Pharmaceutical K.K.
Carpal Tunnel Syndrome, Median Nerve Injury
Sonographic Measurement of Intraneural Blood Flow in the Median Nerve
Carpal tunnel syndrome (CTS) is the most common nerve compression disease and the most expensive upper-extremity work-related musculoskeletal disorder, affecting approximately 10 million people in the US.
- Trial name
- NCT05057754
- Testing
- Cooling, Heating, Exercising
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Erectile Dysfunction
the Diagnostic Value of Rigiscan Test (Nocturnal Penile Tumescence and Rigidity, NPTR) in Chinese Males
The purpose of this study is to evaluate the diagnostic value of Rigiscan (nocturnal penile tumescence and rigidity, NPTR ) test in erectile dysfunction of Chinese males.
- Trial name
- NPTR (NCT02573805)
- Testing
- Rigiscan test
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Body Weight, Obesity
Meta-analysis of the Nordic Dietary Pattern on Cardiometabolic Risk and Cardiovascular Outcomes
The Nordic Diet is a dietary pattern rich in traditional Nordic foods, including berries, grains, and fatty fish common in northern Europe.
- Conditions
- Body Weight, Obesity, Overweight and Obesity, Obesity, Abdominal
- Trial name
- NCT04094194
- Testing
- Nordic diet
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Parkinson Disease
A Phase I Study of TRN501 in Healthy Volunteers
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of TRN501 following a single administration of TRN501 or placebo to healthy adult male volunteers.
- Trial name
- NCT06453551
- Testing
- TRN501 - Dose 1, TRN501 - Dose 2, TRN501 - Dose 3
- Where
- Japan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- SNLD, Ltd.
Migraine, Headache
The Role of CGRPand Nociceptin in Migraine
The release of the neuropeptide calcitonin gene-related peptide (CGRP) is thought to play a causative role in migraine. Nociceptin immunoreactivity and ORL-1 mRNA have been detected in human trigeminal ganglia where it was…
- Trial name
- NCT00155129
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Multiple Sclerosis, Fatigue
Cubii for Exercise in People With MS
The goals of this observational study are to evaluate (1) the feasibility, usability, and satisfaction with the Cubii elliptical and (2) the preliminary efficacy of the Cubii elliptical for increasing activity (primary outcome)…
- Conditions
- Multiple Sclerosis, Fatigue, Activity, Motor, Quality of Life
- Trial name
- Cubii (NCT05826431)
- Testing
- Cubii elliptical
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Washington
Myofascial Pain Syndrome
Latent Myofascial Trigger Points in the Craniocervical Region
Myofascial pain is a clinical problem that has generated interest, debate and confusion for decades. According to studies anywhere between 33 and 97 % of patients with musculoskeletal pain visiting physicians and manual…
- Trial name
- NCT03327545
- Testing
- Neural mobilization, Soft tissue techniques and Stretching, Control group
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
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