Clinical trials: Neurologic Gait Disorder
Parkinson's Disease, Rehabilitation
Instrumental or Physical-Exercise Rehabilitation of Balance in Parkinson's Disease? (IPER-PD)
We hypothesized that rehabilitation specifically addressing balance in Parkinson ́s disease patients might improve not only balance, but locomotion as well.
- Trial name
- IPER-PD (NCT03314597)
- Testing
- Balance exercise, Mobile platform exercise
- Volunteers
- 38 people
- Sponsor
- University of Pavia
Parkinson Disease
Function-based Accelerated Stimulation Therapy (FAST-therapy) for Freezing of Gait (FOG) After Parkinson's Disease (PD)
Parkinson disease (PD) is a common disorder in which reduced speed of movement results from inadequate brain production of the chemical dopamine.
- Trial name
- NCT05509842
- Testing
- rTMS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Multiple Sclerosis
Characterization of the Effects of Prolonged-release Fampridine on Ambulatory Function in Patients With Multiple Sclerosis
The objective of the present investigator-initiated mono-center trial to be performed at the Department of Neurology of the University Hospital Zurich is a detailed characterization of the effects of prolonged-release fampridine…
- Trial name
- FAMPKIN (NCT01576354)
- Testing
- Prolonged-release Fampridine
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University of Zurich
Multiple Sclerosis, Gait Disorders, Neurologic
Multi-joint Muscle Fatigability and Gait Performance in People With Multiple Sclerosis
The purpose of this study is to compare walking to leg strength and endurance in people with multiple sclerosis (PwMS). Using these findings, we hope to be better understand what causes PwMS to have problems walking.
- Conditions
- Multiple Sclerosis, Gait Disorders, Neurologic, Fatigue
- Trial name
- MS_Gait (NCT03735654)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Parkinson's Disease (PD), Freezing of Gait
Pharmacologically Modulating the Noradrenergic Arousal System to Reduce Freezing of Gait in Parkinson's Disease: a Multi-centre and Multi-modal Approach
The goal of this clinical trial is to learn if the medication atomoxetine can reduce freezing of gait in people with Parkinson's disease.
- Conditions
- Parkinson's Disease (PD), Freezing of Gait, Freezing of Gait Symptoms in Parkinson Disease
- Trial name
- AnTi-FREEZE (NCT07316296)
- Testing
- Atomoxetine
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Radboud University Medical Center
Stroke
Comparative Effects of Vestibular Rehabilitation With and Without Cervical JPS Training in Stroke Patients
Stroke is a neurological disorder that often causes long-term disability and affects an individual's quality of life. Patients suffering from stroke commonly experience difficulties with balance, gait, and sensory integration due…
- Trial name
- NCT07905703
- Testing
- vestibular rehabilitation With conventional PT, vestibular rehabilitation and cervical proprioception training with Conventional Pt
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- University of Management and Technology Lahore
Postpolio Syndrome
Effectiveness of Transcranial Magnetic Stimulation Treatment in Patients Diagnosed With Postpolio Syndrome
This randomized, double-blind, sham-controlled trial evaluated the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex on walking capacity, fatigue, post-polio-related…
- Trial name
- NCT06926270
- Testing
- Repetitive transcranial magnetic stimulation (rTMS), Individualized home exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Ege University
Patellofemoral Osteoarthritis
Proximal and Distal Therapeutic Approach in Pain and Lower Limb Kinematic in People With Patellofemoral Osteoarthritis
This is a crossover study that will investigate the immediate effects of a proximal therapeutic approach (SERF strap) and a distal one (foot orthoses) on knee pain intensity, global change, symptoms, ease of performance and…
- Trial name
- NCT04332900
- Testing
- Elastic hip strap, Insole
- Volunteers
- 30 people
- Sponsor
- Universidade Federal de Sao Carlos
Cerebral Palsy
Effectiveness Ankle-7 Orthosis VS HAFO Orthosis on Gait in Diplegic CPChildren
Ankle foot orthoses (AFO) are frequently used to improve locomotor skills of cerebral palsied children (CP) although the level of scientific evidence to support their use is still moderate.
- Trial name
- NCT03333434
- Testing
- Carbon Ankle Seven spring (A7 - Otto Bock, Germany), Hinged AFO
- Volunteers
- 10 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Parkinson's Disease
Non-invasive VNS for Parkinson's Gait
More than 110,000 US Veterans living with Parkinson's disease (PD) currently receive PD-related care and services from the VA. Fall prevention is a priority for Veterans living PD.
- Trial name
- NCT06562569
- Testing
- non-invasive cervical vagal nerve stimulation ncVNS
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Spinocerebellar Ataxias
Cycling-Based Priming Coordination Training for Enhancing Ataxia Recovery and Brain Plasticity
Effective walking and balance require not only lower limb muscle strength but also coordinated movement. For individuals with Spinocerebellar Ataxia (SCA), rehabilitation strategies targeting coordination are essential to…
- Trial name
- NCT06600269
- Testing
- Cycling Training
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung University
Stroke
Active Limb Orthosis for Home-Use Stroke Hemiparetic Gait Rehabilitation
The objective of this research is to test a passive shoe to correct gait in individuals with asymmetric walking patterns. This will be done in a clinic and within their own home.
- Trial name
- NCT03649217
- Testing
- wearing the iStride device
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- University of South Florida
Parkinson's Disease
Effects of Cholinergic Augmentation on Measures of Balance and Gait
This study will compare the effects of placebo and donepezil, a drug that helps conserve concentrations of the neurotransmitter, acetylcholine, on measures of balance and gait in subjects with Parkinson's disease (PD).
- Trial name
- NCT02206620
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Oregon Health and Science University
Ataxia
Impact of Foot Orthoses on Gait in Individuals With Ataxia
This study is the first to assess the impact of lower extremity orthoses on gait and balance in individuals with CA. By investigating how orthoses influence mobility and stability, this research will provide critical data to…
- Trial name
- NCT07720700
- Testing
- Home wearing schedule
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas Southwestern Medical Center
Spastic Paresis, Stroke
GOAT (Gait Observation of Achilles Tendon)
The purpose of this study is to evaluate the mechanical properties of the Achilles tendon (stiffness, length, volume) and the force production capacities of the gastrocnemius medialis muscle in patients with spastic paresis…
- Conditions
- Spastic Paresis, Stroke, Spinal Cord Injury
- Trial name
- GOAT (NCT07467382)
- Testing
- 3D Gait Analysis, Ultrasound, Dynamometry
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Stroke, Cerebrovascular Accident
The Effectiveness of Body Weight Supported Treadmill Training in Stroke Patients
In this study, the investigators aimed to evaluate the effects of exercise on body weight-supported treadmill in stroke patients on gait parameters, activity, body functions and quality of life, and to determine whether it has an…
- Conditions
- Stroke, Cerebrovascular Accident, Gait Disorders, Neurologic, Walking, Difficulty
- Trial name
- NCT04597658
- Testing
- Bodyweight supported treadmill training (BWSTT), Conventional rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University
Spinal Cord Injury, Spinal Cord Injuries
Testosterone Plus Finasteride Treatment After Spinal Cord Injury
The purpose of this study is to determine whether testosterone plus finasteride treatment will improve musculoskeletal health, neuromuscular function, body composition, and metabolic health in hypogonadal men who have experienced…
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Trauma, Nervous System, Wounds and Injuries
- Trial name
- NCT02248701
- Testing
- Testosterone Enanthate, Finasteride
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
Stroke
Home-Based Functional Electrical Stimulation for Lower Limb Rehabilitation in Stroke Patients.
This assessor-blinded, randomized, parallel-group feasibility trial will evaluate the feasibility and preliminary effectiveness of a home-based Functional Electrical Stimulation (FES) system for lower-limb rehabilitation in…
- Trial name
- FES (NCT07785700)
- Testing
- Functional Electrical Stimulation (FES), Standard Rehabilitation
- Where
- 3 sites in India
- Volunteers
- 70 people
- Sponsor
- Christian Medical College and Hospital, Ludhiana, India
Hemiparesis After Stroke, Traumatic Brain Injury
Partial Blocks of Rectus Femoris and Soleus With Botulinum Toxin Type A (Xeomin®) to Improve Gait in Hemiparesis
The most common motor deficiency after stroke or traumatic brain injury is hemiparesis. Most hemiparetic patients recover walking, but rarely with a speed permitting easy ambulation outdoors with family or friends.
- Trial name
- GENUFLEX (NCT03119948)
- Testing
- Botulinum toxin injection
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cerebellar Ataxia
Longitudinal Monitoring of Energy Expenditure, Dynamic Stability and Fatigue During Gait in Patients With Cerebellar Ataxia Gene
Genetic cerebellar ataxias involves progressive degeneration of the cerebellum. Their overall prevalence is estimated at 2-4 cases per 100 000 people.
- Trial name
- NCT02903290
- Testing
- Longitudinal Monitoring of Energy Expenditure, Dynamic Stability and Fatigue During Gait, walking track GAITRite,manual dynamometer, and treadmill
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
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