Clinical trials: Neurological Disease
Cerebral Vasospasm
Predictive Model for the Occurrence of Cerebral Vasospasm Complicating Subarachnoid Haemorrhage by Combined Analysis of the Kinetics of a Panel of Biomarkers.
The objective is to create a dynamic clinical prediction model that includes routinely measured care and biological biomarkers to predict cerebral vasospasm within 14 days of bleeding in patients treated in the neurosurgical…
- Trial name
- CVSBIODIAG (NCT06303349)
- Testing
- Samples collection
- Where
- France
- Volunteers
- 155 people
- Sponsor
- University Hospital, Bordeaux
Low Back Pain
The Efficacy of A Smartphone Application in Treating Non-Specific Low Back Pain
Evaluating the efficacy of a newly developed self-monitored mobile application in reducing office workers low back pain.
- Trial name
- NCT03994458
- Testing
- Smartphone Full version application, Samartphone limited version application
- Where
- Jordan
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Stroke, Quality of Life
Quality of Life and Rehabilitation Pathway in Northern Norway and Denmark.
The aim of this study is to analyze and describe rehabilitation pathways of stroke patients in a region of North Norway and Central Denmark Region in relation to how patients perceive quality of life, health and functioning one…
- Trial name
- NCT02369055
- Where
- Norway
- Volunteers
- 369 people
- Sponsor
- University Hospital of North Norway
Atrial Fibrillation
Preventing Stroke, Premature Death and Cognitive Decline in a Broader Community of Patients With Atrial Fibrillation
The DaRe2 approach (healthcare Data for pragmatic clinical Research in the NHS - primary 2 secondary) is designed to operationalise efficient, nationwide, primary care approaches for randomised trials embedded within the UK…
- Trial name
- DaRe2THINK (NCT04700826)
- Testing
- Direct Oral Anticoagulants
- Where
- United Kingdom
- Volunteers
- 3,000 people
- Sponsor
- University of Birmingham
Fibromyalgia
Pregabalin In Adolescent Patients With Fibromyalgia
The main purpose of this study is to evaluate the long-term safety of pregabalin in adolescent patients who participated in the previous fibromyalgia study (A0081180) and who wish to recieve open-label pregabalin
- Trial name
- NCT01020526
- Testing
- pregabalin
- Where
- 26 sites in United States, Czechia and 1 more
- Volunteers
- 63 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Leukoencephalopathy
Study of Neurological Complication After Radiotherapy for High Grade Glioblastoma
The survival time and the number of long time survivors after radiotherapy in brain cancer patients have increased for the last decades.
- Trial name
- EPIBRAINRAD (NCT02544178)
- Testing
- brain radiotherapy
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- Sophie JACOB
Obstructive Sleep Apnea Syndrome
m-Rehab OSA : Impact of a Telerehabilitation Program Associated With CPAP on Severity Markers of Obstructive Sleep Apnea Syndrome
Obstructive sleep apnea syndrome (OSA) is a common condition associated with major repercussions such as excessive daytime sleepiness and impaired quality of life as well as metabolic and cardiovascular complications.
- Trial name
- mRehabOSA (NCT05049928)
- Testing
- Telerehabilitation solution (m-Rehab)
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Montpellier
Muscular Dystrophy, Duchenne
Spironolactone Versus Prednisolone in DMD
This is a randomized, open-label, pilot clinical trial of spironolactone suspension versus oral prednisolone for use in Duchenne muscular dystrophy.
- Trial name
- NCT03777319
- Testing
- Spironolactone, Prednisolone
- Where
- 4 sites in United States
- Volunteers
- 2 people
- Sponsor
- Kevin Flanigan
Stroke
Step Test and Six Minute Walk Test in Stroke
The purpose of this study is to investigate the viability of using the Step Test (ST) in stroke patients, and to compare the functional performance of the physiologic variables in stroke patients during ST and Six Minute Walk…
- Trial name
- NCT01436630
- Testing
- Step Test and Six Minute Walk.
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- Faculdades Metropolitanas Unidas
Down Syndrome
Evaluation of a Simplified Method for Diagnosis of Sleep Apnea in Children and Adults With Down Syndrome
People with Down syndrome are at increased risk of sleep apnea, not only from obstruction of the upper airway, but also of central origin.
- Trial name
- SAOS/T21 (NCT00951730)
- Testing
- Polysomnography
- Where
- 3 sites in France
- Volunteers
- 97 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cerebrovascular Disorders
Blood Pressure Reduction to Limit the Evolution of Vascular Brain Lesions in Elderly Individuals
The purpose of the study is to test the hypothesis of slowing the progression of White Matter Lesions (WML) by lowering blood pressure (BP) in patients with cognitive complaints and a moderate to high grade of WML on brain MRI.
- Trial name
- LEOPOLD (NCT02472028)
- Testing
- blood pressure lowering algorithm, usual strategy
- Where
- 2 sites in France
- Volunteers
- 820 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intracerebral Hemorrhage
Effects and Mechanisms of Celecoxib on Intracerebral Hemorrhage
This trial is a phase IIa human clinical study, in which 60 patients with intracerebral hemorrhage (ICH) at basal ganglion or thalamus within 6 h after onset will be enrolled.
- Trial name
- NCT05434065
- Testing
- Celecoxib 200mg
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Mechanically Ventilated, Critically Ill Children
Sedation Efficacy of Dexmedetomidine Versus Midazolam in Critically Ill Ventilated Children
There is a significant lack of adequately powered randomized clinical trial (RCT) data to determine the comparative safety and effectiveness of sedative treatments in pediatric patients.
- Trial name
- NCT04082767
- Testing
- Precedex, Midazolam
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Douglas Fraser
Dementia
Group Digital Gaming: Experiences of Older Adults Living With Dementia in an Activity for Cognitive Impairment
The study examines the effects of a group digital gaming intervention on cognitive function, mood, and behaviors in people with early to moderate levels of dementia, using Obie Technology by employing a pretest and posttest…
- Trial name
- PLwD (NCT07541144)
- Testing
- Group-Based Digital Gaming
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- George Mason University
Fibromyalgia
Effects of Aerobic Exercise Training With and Without Blood Flow Restriction in Fibromyalgia
In our study, we aimed to evaluate and compare the effects of low-intensity aerobic exercise training with blood flow restriction and without blood flow restriction, on pain, functional status, quality of life and catecholamine…
- Trial name
- NCT04500444
- Testing
- exercise training
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Cleft Lip and Palate
Liposomal Bupivacaine Use in Alveolar Bone Graft Patients
The goal of this clinical trial is to learn if a pain medication called liposomal bupivacaine (brand name EXPAREL®) with epinephrine will provide better pain control, increased activity, and reduced use of opioids compared with…
- Trial name
- NCT06284434
- Testing
- Liposomal Bupivacaine, Bupivacain, Epinephrine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Kerry O'Rourke
Giant Cell Arteritis
Tocilizumab Dose-tapering and Interruption in Patients With Giant Cell Arteritis Achieving the Clinical Remission.
Interleukin-6 (IL-6), a pro-inflammatory cytokine, has been found to have a crucial role in the pathogenesis of Giant cel arteritis (GCA).
- Trial name
- NCT03244709
- Testing
- Tocilizumab
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Hospital of Prato
Epilepsy
HOBSCOTCH Phase II
The purpose of this study is to determine the feasibility and efficacy of the home-based cognitive self-management program "HOBSCOTCH" delivered at four New England medical centers.
- Trial name
- NCT02394509
- Testing
- Home Based Self-management and Cognitive Training Changes lives (HOBSCOTCH)
- Where
- 4 sites in United States
- Volunteers
- 106 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Hypoxic Ischemic Brain Injury, Neonatal Encephalopathy
Perinatal Brain Injury: Potential of Innovative NIRS to Optimize Hypothermia
The purpose of this study is to improve the ability of the investigators to monitor brain health in newborn babies at risk of brain injuries.
- Trial name
- NCT02793999
- Testing
- Near-Infrared Spectroscopy (NIRS)
- Where
- 3 sites in United States
- Volunteers
- 125 people
- Sponsor
- Boston Children's Hospital
Angina Pectoris, Left Ventricular Wall Motion Abnormalities
Intraprocedural Determination of Myocardial Vitality Using 2 Different Imaging Methods
The investigators will compare myocard vitality diagnostics using 2D-Strain echography and MRI.
- Trial name
- NCT01934699
- Testing
- Cardiac ultrasound, MRI scanner
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- RWTH Aachen University
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