Clinical trials: Neurological Diseases
Aortic Valve Replacement, Aortic Stenosis
TAVI Protocol - Paravertebral Block Study
Trans-apical aortic valve replacement is a new treatment for severe aortic stenosis. It is offered to elderly patients with medical problems that would markedly increase the risk of conventional cardiac surgery.
- Trial name
- TAVI PVB (NCT01404975)
- Testing
- Thoracic paravertebral block (PVB)
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University Health Network, Toronto
Menorrhagia, Dysmenorrhea
Menorrhagia, Dysmenorrhea and Iron Deficiency Among Young Women Soldiers and Effect on Activity
As combat women soldiers are required to more intensive daily activity the investigators believe that the impact of menorrhagia, dysmenorrhea and its clinical consequence (as characterized by, anemia iron deficiency and reduced…
- Conditions
- Menorrhagia, Dysmenorrhea, Iron Deficiency Anemia
- Trial name
- NCT02685501
- Testing
- no intervention
- Where
- 2 sites in Israel
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Parkinson Disease, Dyskinesia, Medication-Induced
Efficacy, Safety and Pharmacokinetic Study of CPL500036 in Patients with Levodopa Induced Dyskinesia
The aim of the study is to determine potential anti-dyskinetic properties of CPL500036 (PDE10A inhibitor) in Parkinson disease patients suffering from levodopa Induced dyskinesia.
- Trial name
- NCT05297201
- Testing
- CPL500036 - low dose, CPL500036 - high dose
- Where
- 16 sites in Poland, Ukraine
- Volunteers
- 105 people
- Sponsor
- Celon Pharma SA
Headache, Migraine With Aura
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.
The aim of the present study to investigate whether Opening of KATP channels causes migraine pain by activation of meningeal nociceptors and ascending trigeminal nociceptive pathways.
- Conditions
- Headache, Migraine With Aura, Migraine Without Aura
- Trial name
- NCT05565001
- Testing
- Levcromakalim
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Danish Headache Center
Orthopedic Disorder, Post Operative Pain
TENS for Relief of Postoperative Pain in Orthopedic Patients
To ensure early mobilization, minimize suffering, and to prevent postoperative complications postoperative pain should be reduced as soon and as effectively as possible.
- Conditions
- Orthopedic Disorder, Post Operative Pain, Hip Fractures, Arthroplasty, Replacement, Hip
- Trial name
- NCT05678101
- Testing
- transcutaneous electrical nerve stimulation (TENS)
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska University Hospital
Muscle Weakness, Cervical Disability
Effectiveness of a Training Protocol With the Cervical Device in Subjects With Deep Cervical Muscle Strength Deficit.
The purpose of this study is to evaluate the clinical results produced by a training protocol with the new device for cervical treatment (CDAT) and the conventional training protocol (CT) versus a control group (C) in subjects…
- Trial name
- NCT05288712
- Testing
- Training protocol with the device cervical for treatment (CDAT), Conventional training protocol
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Universitat Internacional de Catalunya
Pain, Apnea
Could Apnea Induce Hypoalgesia?
A randomized controlled trial (RCT) in healthy subjects will be conducted with the following aims: (1) Explore the effect of low pulmonary volume dynamic apnoea bouts on Pressure Pain Threshold (PPT) and conditioned pain…
- Trial name
- NCT05991141
- Testing
- Apnea, Control Intervention
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centro Universitario La Salle
Angina Pectoris
Spinal Cord Stimulation (SCS) in Refractory Angina
The study aims at assessing safety and efficacy of Spinal Cord Stimulation (SCS) for the treatment of refractory angina pectoris in a single blind, prospective, multicenter study.
- Trial name
- NCT00121654
- Testing
- Spinal cord stimulation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Catholic University of the Sacred Heart
Noise-induced Hearing Loss and Tinnitus
TUNE! Teaching the UK About Noise Exposure: A Pilot Study
In 1986 The Medical Research Council estimated that 4 million UK adolescents were at risk of hearing damage from over-exposure to loud music from personal audio players (PAPs), gigs, clubs, pubs and festivals.
- Trial name
- gildeaf1 (NCT00916305)
- Testing
- Modified Audio video, Unmodified audio video
- Where
- United Kingdom
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Intraarticular, Ozone
Effect of Intraarticular Ozone, Prolotherapy or Dexmedetomidine in Pain Limitation in Knee Osteoarthritis
This study aimed to compare intraarticular ozone injection, prolotherapy, or dexmedetomidine effectiveness in knee osteoarthritis patients.
- Conditions
- Intraarticular, Ozone, Prolotherapy, Dexmedetomidine
- Trial name
- NCT06909305
- Testing
- Ozone, Dextrose prolotherapy, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Relative Afferent Pupil Defect (RAPD)
Measuring Relative Afferent Pupillary Defect
The goal of this prospective reliability study is to test the effectiveness of a commercially available, off-the-shelf virtual reality head-mounted display (VR HMD) and machine learning (ML) algorithms in detecting Relative…
- Trial name
- RAPD (NCT05799066)
- Testing
- Swinging Light test, Virtual Reality Head-Mounted Display (VR HMD)
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Breast Cancer
Paravertebral Block (PVC) Versus Pectoral Nerve Block (PEC)
The purpose of this study is to compare two standard methods of pain control management used at Spectrum Health for patients undergoing breast surgery.
- Trial name
- NCT03152929
- Testing
- Paravertebral Block, Pectoral Nerve Block
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Corewell Health West
Shoulder Joint Disorder
The Effectiveness of Megadose Shinbaro Pharmacopuncture for Patients With Chronic Shoulder Pain
This study is a prospective, case-control observational trial. The investigators will compare the Megadose Shinbaro Pharmacopuncture group to the control group to analyze the effectiveness of shoulder Megadose Shinbaro…
- Trial name
- NCT04222829
- Testing
- Megadose Shinbaro Pharmacopuncture
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Jaseng Medical Foundation
Critical Illness, Intensive Care (ICU) Myopathy
Muscle Dysfunction in Critical Illness
Patients surviving critical illness suffered significant skeletal muscle dysfunction and weakness that impacts their functionality and independence.
- Conditions
- Critical Illness, Intensive Care (ICU) Myopathy, PICS, Muscle Weakness
- Trial name
- NCT03717831
- Testing
- Observational study of standard of care
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Kentucky
Dementia, Cognitive Impairment
Effective Strategies for Dementia Care
The purpose of this study is to determine whether the interventions of Snoezelen, structured reminiscence therapy and 10-minutes activation are effective to reduce apathy in long term care residents with dementia.
- Trial name
- WISDE (NCT00653731)
- Testing
- Snoezelen ©, structured reminiscence therapy, 10-minutes activation
- Where
- Germany
- Volunteers
- 327 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Ankle Inversion Sprain, Chronic Instability of Joint
Effectiveness of Balance Training and Dynamic Neuromuscular Stabilization Training in Amateur Athletes with Chronic Ankle Instability
The goal of this clinical trial is to determine and compare the effects of balance and dynamic neuromuscular stabilization training on ankle function ability, functional instability severity, physical activity level, muscle…
- Conditions
- Ankle Inversion Sprain, Chronic Instability of Joint, Chronic Pain, Athlete Foot
- Trial name
- NCT06296537
- Testing
- Dynamic Neuromuscular Stabilization Training (DNS), Balance Training, Conventional Training
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Medipol University
Parkinson s Disease, Dystonic Disorders
Genetics of Motor Learning
Background: New studies in human genetics have revealed information about genetic connections to memory and motor behavior. Researchers are interested in investigating the role of genetics in motor learning, in conjunction with…
- Conditions
- Parkinson s Disease, Dystonic Disorders, Focal Dystonia, Movement Disorders
- Trial name
- NCT01105845
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Pain, Anxiety
Effect of Virtual Reality Glasses on Pain and Anxiety During Intrauterine Device Insertion in Women
This study aims to evaluate the effect of virtual reality glasses on pain perception and anxiety levels during intrauterine device insertion in women.
- Trial name
- NCT07325695
- Testing
- Virtual Reality Headset
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Serap Ozturk Altinayak
Alzheimer Disease
Advancing Alzheimer's Care: Home-based tDCS for Affective Symptoms
Participants will be asked to participate in this research study of a device that creates transcranial direct current stimulation (tDCS).
- Trial name
- NCT06801639
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Shoulder Impingement Syndrome
Effectiveness of High-Volume Corticosteroid Injection in Shoulder Impingement
This study aimed to compare the effectiveness of high-volume versus low-volume ultrasound-guided corticosteroid injections diluted with saline in patients with subacromial impingement syndrome, finding no significant difference…
- Trial name
- NCT07113639
- Testing
- Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- TC Erciyes University
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