Clinical trials: Neurological Diseases
Neuropathic Pain
Balance and Gait on Neuropathic Pain Due to Lumbar Disc Degeneration
Chronic lumbar neuropathic pain, characterized by pain, numbness, tingling and muscle weakness in the lower extremities, is one of the most common neuropathic pain syndromes.
- Trial name
- NCT05223439
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Pain
Augmented Cerebral Pain Processing in Chronic, Unexplained Pain: a fMRI Study
Chronic, unexplained pain symptoms are very common in all layers of the population, but it is largely unknown what causes them. This study examines the hypothesis that patients with these pain symptoms process pain abnormally in…
- Trial name
- NCT00463177
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- UMC Utrecht
Neuropathic Pain
A High Frequency Spinal Cord Stimulation PET-CT Scan Study
This study aims to investigate the clinical response to Spinal Cord Stimulation frequency parameters: 40Hz, 4000Hz and 10000Hz and explore the brain imaging changes using PET-CT scans.
- Trial name
- NCT03716557
- Testing
- Spinal Cord Stimulation 4000Hz, Spinal Cord Stimulation 10000Hz, Spinal Cord Stimulation 40Hz
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Barts & The London NHS Trust
Chromosome 13 Aneuploidy, Chromosome 18 Aneuploidy
Non-invasive Prenatal Diagnostic Validation Study
The primary purpose of this study is to collect maternal blood samples from pregnant women to develop a non-invasive prenatal diagnostic test based on fetal DNA isolated from maternal blood.
- Conditions
- Chromosome 13 Aneuploidy, Chromosome 18 Aneuploidy, Chromosome 21 Aneuploidy, Sex Chromosome Aberrations
- Trial name
- NIPD (NCT01574781)
- Testing
- Blood draw, Cheek swab/Saliva Sampling
- Where
- United States
- Volunteers
- 1,781 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.
Chronic Pain, Ptsd
Improving Dysregulated Neural Networks With EEG-neurofeedback
Comorbid PTSD in the context of chronic pain rehabilitation is a major problem. The lack of effective and efficient methods that can be integrated into current practice is needed.
- Trial name
- NCT06587919
- Testing
- Neurofeedback
- Where
- Denmark
- Volunteers
- 63 people
- Sponsor
- University of Southern Denmark
Primary Sjögren Syndrome, Sarcopenia
Possible Sarcopenia, Sarcopenia, and Functional Status in Patients With Primary Sjögren's Syndrome
The aim of this study is to evaluate the frequency of probable sarcopenia and sarcopenia in patients with primary Sjögren syndrome and to investigate the effects of sarcopenia on functional status, muscle strength, and quality of…
- Trial name
- NCT07804719
- Testing
- dexa, hand grip strength, myostatin, follistatin
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Antalya Training and Research Hospital
Cirrhosis, Aerobic Exercises
The Efficacy of Aerobic Exercise Training on ANS and Endothelial Function in Compensated Cirrhosis
The goal of this randomized controlled trial is to investigate whether a 16-week structured aerobic exercise program combined with nutritional consultation can improve autonomic and endothelial function in patients with…
- Conditions
- Cirrhosis, Aerobic Exercises, Lifestyle Modification, Endothelial Function
- Trial name
- NCT06288828
- Testing
- Aerobic exercise + Nutrition consultant, Nutrition consultant
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Colposcopy
Lidocaine Spray vs Coughing for Pain Relief During Colposcopy
Cervical cancer is the third most common genital cancer worldwide. The diagnosis of cervical cancer is performed with the cervical biopsy which is guided by the colposcopy.
- Trial name
- NCT03100565
- Testing
- local lidocaine spray, forced coughing
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Yuzuncu Yil University
Phrenic Nerve Paralysis
Supraclavicular Block vs Retroclavicular Block: Incidence of Phrenic Nerve Paralysis
The aim of this study is to evaluate differences between ultrasound guided supraclavicular versus retroclavicular brachial plexus blocks: two similar brachial plexus nerve block techniques that differ in their needle trajectory…
- Trial name
- NCT02631122
- Testing
- Supraclavicular vs Retroclavicular Nerve Block
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Brigham and Women's Hospital
Ankyloglossia, Speech Delay
Frenuloplasty for Speech and Myofunctional Outcomes
Children with ankyloglossia (tongue tie) can have abnormal tongue function, putting them at a disadvantage when it comes to speech and articulation.
- Conditions
- Ankyloglossia, Speech Delay, Dentofacial Abnormalities
- Trial name
- NCT06089629
- Testing
- Lingual frenuloplasty
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Oregon Clinic
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Low Back Pain
Wallis Mechanical Normalization System for Low Back Pain
The purpose of this study is to compare improvement in low back pain with Wallis (interspinous process implant) to exercise and injections.
- Trial name
- NCT00134537
- Testing
- Interspinous process and dynamic stabilization, Conservative Care
- Where
- 17 sites in United States
- Volunteers
- 300 people
- Sponsor
- Zimmer Spine
Neuropathic Pain
The Role of N-acetyl-l-cysteine (NAC) as an Adjuvant to Opioid Treatment in Patients With Chronic Neuropathic Pain
This study will test whether treatment with N-acetyl-L-cysteine (NAC) is safe and decreases pain in patients with chronic neuropathic pain.
- Trial name
- NCT01840345
- Testing
- N-acetyl-l-cysteine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Virginia Commonwealth University
Memory Disorders
Neuropsychological Rehabilitation of Spontaneous Confabulation
Confabulators consistently generate false memories without intention to deceive and with great feeling of rightness. However, there is currently no known effective treatment for them.
- Trial name
- NCT02540772
- Testing
- Neuropsychological treatment
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Monica Triviño Mosquera
Sarcopenia
Human Irisin Concentration in Sarcopenia
Irisin has been identified as a novel myokine that drives brown-fat-like conversion of white adipose tissue. In this cross-sectional study, the researches investigated whether serum irisin levels are decreased in patients with…
- Trial name
- NCT01874912
- Where
- South Korea
- Volunteers
- 406 people, healthy volunteers welcome
- Sponsor
- Korea University
Cysticercosis, Cysts
Brain Tissue Swelling and Seizure Activity in Inactive Cysticercosis
This study will examine what causes seizures in patients with cysticercosis (pork tapeworm infection). A better understanding of this could lead to improved methods of controlling or preventing seizures.
- Conditions
- Cysticercosis, Cysts, Seizures
- Trial name
- NCT00001912
- Where
- 2 sites in United States, Peru
- Volunteers
- 6 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Vasovagal Syncope
Assessment of Midodrine in the Prevention of Vasovagal Syncope: The Prevention of Syncope Trial IV
About 20% of adults faint recurrently. These patients are often highly symptomatic, have problems with employment and driving and have reduced quality of life.
- Trial name
- POST 4 (NCT01456481)
- Testing
- midodrine hydrochloride
- Where
- 17 sites in United States, Canada and 1 more
- Volunteers
- 134 people
- Sponsor
- Dr. Bob Sheldon
Ocular Pain, Dry Eye
Study to Evaluate the Ocular Tolerance of SYL1001 in Healthy Volunteers
The purpose of this study is to determine whether SYL1001 is safe for the prevention and treatment of ocular pain and dry eye syndrome.
- Trial name
- NCT01438281
- Testing
- SYL1001
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sylentis, S.A.
Sarcopenia
Effect of Technology-assisted Physical Therapy for Patient With High Risk of Sarcopenia
This research aims to identify whether the effects of video-assisted physical therapy, including home resistance training, is superior to traditional physical therapy, education leaflet for example.
- Trial name
- HRS (NCT05687630)
- Testing
- elastic band resisted exercise
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Preoperative Anxiety, Emergence Delirium
Effects of Music on Preoperative Anxiety and Emergence Delirium in Children
This randomized controlled trial aims to evaluate the effects of classical music listening on preoperative anxiety and postoperative emergence delirium in children aged 9-12 years undergoing elective surgery.
- Trial name
- NCT07877428
- Testing
- Music Group
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Uludag University
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