Clinical trials: Neurological Diseases
Sleep Fragmentation, Behavioural and Psychiatric Symptoms of Dementia
Therapy Light Rooms for Improved Sleep in Dementia Patients
This intervention study will investigate the effect of therapy light rooms on sleep, circadian rhythms, mood, behavioural problems and function in nursing home (NH) patients with dementia.
- Conditions
- Sleep Fragmentation, Behavioural and Psychiatric Symptoms of Dementia, Dementia
- Trial name
- DEMLIGHT (NCT03357328)
- Testing
- Therapy light room, Standard light
- Where
- Norway
- Volunteers
- 70 people
- Sponsor
- University of Bergen
COVID-19
The Effects of Long-Term Mask Use in the Pandemic Period
Various restrictions have been made all over the world due to coronavirus pandemics. In addition to situations such as social isolation and hygiene, the use of masks is among these rules.
- Trial name
- NCT05358665
- Testing
- mask use
- Where
- Turkey (Türkiye)
- Volunteers
- 909 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Colon Cancer, Rectum Cancer
The Effect of Art Therapy in Patients Undergoing Colorectal Cancer
With the development of modern techniques, art has become important in the provision of health services and has enabled individuals to better recognise themselves and their surroundings.
- Trial name
- NCT07137000
- Testing
- Art therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Saglik Bilimleri Universitesi
Spasticity, Muscle
Dry Needling and Botulinum Toxin in the Management of Poststroke Spasticity
Stroke is a clinical picture that can result in loss of motor, sensory and cognitive functions or coma. Approximately 75% of stroke survivors develop disability and one of the causes of disability is the presence of spasticity.
- Trial name
- NCT03747900
- Testing
- Botulinum Toxin Type A, Botulinum Toxin Type A and dry needling.
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Open-Heart Surgery
Development of Delirium in Patients Undergoing Open-Heart Surgery
Malnutrition is a prevalent issue among patients undergoing cardiac surgery. This can lead to delirium risk factors, including postoperative functional and cognitive impairment.
- Trial name
- NCT06195592
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kubra Gunes
Pain
Implementation of the Pain Management Toolkit
The overall aim of this research study is to implement and evaluate the toolkitinto the nursing home by using scientific methods, which is cut down in specific aims. 1. To assess the effectiveness of the toolbox on 1.
- Trial name
- NCT07157709
- Testing
- non-pharmacological interventions
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medizinische Universität Graz, Institut für Pflegewissenschaft
Alzheimer Disease, Parkinson Disease
Evaluation of [18F] PBR06 and PET as a Marker of Inflammation in Subjects With Neurological Conditions
The underlying goal of this study is to assess [18F] PBR06 PET imaging as a tool to detect microglial activation in the brain of Alzheimer Disease (AD), Parkinson Disease (PD) and Multiple Sclerosis (MS) research participants.
- Conditions
- Alzheimer Disease, Parkinson Disease, Multiple Sclerosis
- Trial name
- PBR06 (NCT01028209)
- Testing
- [18F] PBR06
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Analgesia
Efficacy and Safety of Remifentanil for Mechanically Ventilated Patients in Intensive Care Unit
Remifentanil has been approved by the FDA for continuation as an analgesic into the immediate postoperative period in adult patients under the direct supervision of an anesthesia practitioner in a postoperative anesthesia care…
- Trial name
- NCT05641909
- Testing
- Remifentanil, Fentanyl
- Where
- 18 sites in China
- Volunteers
- 138 people
- Sponsor
- Southeast University, China
Myofascial Neck Pain
Immediate Effects of Dry Needling and Tens in Chronic Neck Pain
The aim of this study is to determinate the effects of percutaneous electrical nerve stimulation in the short-term for pain in patients with myofascial chronic neck pain.
- Trial name
- NCT02230709
- Testing
- Dry Needling, "TENS" and "dry needling"
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad Rey Juan Carlos
Osteoathritis
Medial-Wedge Insole is Highly Effective in the Treatment of Valgus Knee Osteoarthritis
To assess the efficacy of medial-wedge insole in valgus knee osteoarthritis (OA). We hypothesized that medial-wedged insoles are biomechanically effective and should reduce lateral compartment loading in persons with valgus knee…
- Trial name
- NCT00467337
- Testing
- Medial-Wedge Insole intervention
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Alzheimer's Disease
Short Term Efficacy and Safety of Perispinal Administration of Etanercept in Mild to Moderate Alzheimer's Disease
While the cause of AD is still unknown, evidence suggests it develops because of a complex series of events in the brain that occur over time.
- Trial name
- NCT01716637
- Testing
- Etanercept, Curcum.Luteol.Theaflav.Lip.Acid,FishOil,Quercet.,Resveratr.
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Life Extension Foundation Inc.
Chronic Migraine or Episodic Migraine
Study to Evaluate the Efficacy and Safety of AMG 301 in Migraine Prevention
To evaluate the effect of AMG 301 compared to placebo on the change from the baseline period in monthly migraine days in subjects with migraine.
- Trial name
- NCT03238781
- Testing
- AMG 301
- Where
- 49 sites in United States, Austria and 6 more
- Volunteers
- 343 people
- Sponsor
- Amgen
Apathy, Mild Cognitive Impairment
Transcranial Magnetic Stimulation for Apathy in Mild Cognitive Impairment:Pilot Study
Mild cognitive impairment (MCI) is a precursor of dementia. Apathy, a profound loss of motivation, is a common behavioral problem in MCI.
- Trial name
- NCT02190019
- Testing
- Neurostar repetitive transcranial magnetic stimulator
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Central Arkansas Veterans Healthcare System
Unipolar Depression
Effects of Repeated Attachment Security Priming on Depressed Mood: a Clinical Study
The purpose of this study is to explore whether asking participants to visualise a secure attachment figure or a neutral event leads to differences in self-reported felt security or depressed mood.
- Trial name
- NCT01694030
- Testing
- Attachment security priming
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Southampton
Total Knee Arthroplasty
Local Infiltration Analgesia Versus Quadruple Nerve Blocks in Total Knee Arthroplasty.
Total knee arthroplasty (TKA) is one of the most common orthopedic surgical procedures and is associated with severe pain in the immediate postoperative period, thus limiting early recovery.
- Trial name
- LIAQ (NCT07477730)
- Testing
- Surgical local infiltration, Obturator nerve block, Femoral nerve block
- Where
- France
- Volunteers
- 80 people
- Sponsor
- CMC Ambroise Paré
Cognitive Impairment, Apolipoprotein E, Deficiency or Defect of
Perioperative Research Into Memory, Genomics in the Intensive Therapy Unit: Alzheimer's
The current central dogma of long-term cognitive impairment after intensive care admission suggests an underlying neuroinflammatory dysregulation affecting neuronal function.
- Conditions
- Cognitive Impairment, Apolipoprotein E, Deficiency or Defect of, Critical Illness, Burns
- Trial name
- PRIMoGenITA (NCT03393130)
- Testing
- APOE genotyping
- Volunteers
- 150 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Stress Related Disorder, Musculoskeletal Pain
Immediate Effect of Energy Alignment and Mantra on Stress Related Pain in Adolescents
Psychiatrists have expressed concern at the emergence of education as a serious source of stress for school-going children - causing high incidence of deaths by suicide.
- Conditions
- Stress Related Disorder, Musculoskeletal Pain, Headache
- Trial name
- NCT03308630
- Testing
- Yoga based Energy Alignment and Mantra
- Where
- India
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- NMP Medical Research Institute
Opioid-Related Disorders, Pain, Acute
A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of Different Amounts of Tablets of a New and a Marketed Tablet Formulation in Healthy Adults
This clinical trial is being conducted to compare concentrations of hydrocodone and acetaminophen in the blood after administration of different amounts of tablets of a new and a marketed tablet formulation in healthy adults.
- Conditions
- Opioid-Related Disorders, Pain, Acute, Pain, Postoperative
- Trial name
- NCT03137030
- Testing
- GRT7014 - Abuse Deterrend Tablet, Norco 5Mg-325Mg Tablet
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Asphyxia Neonatorum, Hypoxia
TOBY (TOtal Body hYpothermia): a Study of Treatment for Perinatal Asphyxia
Hypothesis: Prolonged whole body cooling in term infants with perinatal asphyxial encephalopathy reduces death and severe neurodevelopmental disability.
- Conditions
- Asphyxia Neonatorum, Hypoxia, Encephalopathy, Seizures
- Trial name
- NCT00147030
- Testing
- Whole body mild induced hypothermia
- Where
- United Kingdom
- Volunteers
- 325 people
- Sponsor
- Imperial College London
Opioid-Induced Constipation
Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation
The purpose of this study is to evaluate the safety and efficacy of CB-5945 for the treatment of opioid-induced constipation (OIC)in adults taking opioid therapy for chronic non-cancer pain.
- Trial name
- NCT01901328
- Testing
- CB-5945
- Volunteers
- 49 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
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