Clinical trials: Neurological Diseases
Shoulder Pain
Effects on Shoulder Pain of Simulated Hyper-gravity During Rehabilitation Exercises
Determine if adding "extra-gravity" (sustained increase in vertical loading) during standard rehabilitation exercises has a beneficial effect on pain reduction in subjects suffering from shoulder pain of different origin.
- Trial name
- NCT02589184
- Testing
- Hypergravity, isometric load, normal gravity
- Where
- 2 sites in United States
- Sponsor
- Carrick Institute for Graduate Studies
Tonsillitis
Suprazygomatic Maxillary Nerve Block in Pediatric Tonsillectomy
Tonsillectomies are among the most common surgical procedures performed in pediatric populations, with more than 14,000 procedures performed annually in Ontario, with more than 80% being performed to treat sleep-disordered…
- Trial name
- NCT07176533
- Testing
- Suprazygomatic maxillary nerve block (SZMN) with bupivacaine
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Dementia, Alzheimer Disease
Apathy Associated With Alzheimer's Disease
Apathy, or lack of motivation, affects up to 80% of Alzheimer's disease (AD) patients. These amotivational symptoms increase patient reliance on caregivers, increase caregiver burden and distress, and increase the risk of patient…
- Trial name
- NCT00254033
- Testing
- Dextroamphetamine, Methylphenidate
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cognitive/Functional Effects, Delirium
Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer
RATIONALE: Donepezil and vitamin E may be able to decrease side effects caused by radiation therapy given to prevent brain metastases in patients with small cell lung cancer.
- Conditions
- Cognitive/Functional Effects, Delirium, Depression, Lung Cancer
- Trial name
- NCT00006349
- Testing
- vitamin E, donepezil hydrochloride
- Where
- 15 sites in United States
- Volunteers
- 9 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Chronic Pain, Spinal Cord Injuries
Effects of Spinal Cord Injury Exercise Guidelines
Over 85,000 Canadians live with a spinal cord injury (SCI). The vast majority experience chronic pain from neuropathic or musculoskeletal origins, with many reporting the pain to be more physically, psychologically and socially…
- Trial name
- NCT04160858
- Testing
- Exercise, Control
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Spasticity, Multiple Sclerosis
Phase 3, 28-week, Randomized, Double-blind, Placebo-controlled Safety and Efficacy Study of Nabiximols as an add-on Therapy in Subjects With Spasticity Due to Multiple Sclerosis.
The purpose of this study is to determine the effective dose range and to demonstrate a non-effective dose range of Sativex compared with placebo in relieving symptoms of spasticity due to multiple sclerosis.
- Trial name
- NCT01868048
- Testing
- Sativex
- Sponsor
- GW Research Ltd
Mild Cognitive Impairment, Cognitive Decline
Exercise in Adults With Mild Memory Problems
This study evaluates the effects of physical exercise on cognition, functional status, brain atrophy and blood flow, and cerebrospinal fluid biomarkers of Alzheimer's disease in adults with a mild memory impairment.
- Conditions
- Mild Cognitive Impairment, Cognitive Decline, Memory Impairment
- Trial name
- EXERT (NCT02814526)
- Testing
- Aerobic exercise, Stretching/balance/range of motion exercise
- Where
- 14 sites in United States
- Volunteers
- 296 people
- Sponsor
- Alzheimer's Disease Cooperative Study (ADCS)
Cardiac Arrest, Comatose
Automated Pupillometry for Coma Prognostication After Cardiac Arrest
Background: Sedation and therapeutic hypothermia (TH) delay neurological responses and might reduce the accuracy of clinical examination to predict outcome after cardiac arrest (CA).
- Trial name
- NCT02607878
- Where
- 10 sites in Belgium, France and 6 more
- Volunteers
- 470 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Gait Disorders, Neurologic, Urinary Incontinence, Urge
Time to be Ready to Void: a New Tool to Assess the Time Needed to Perform Micturition in Multiple Sclerosis
The aim of the study is to create a specific test to assess the global time required to go to the toilet and to perform micturition, at the moment the patient decides to urinate in multiple sclerosis population, and to assess its…
- Conditions
- Gait Disorders, Neurologic, Urinary Incontinence, Urge, Multiple Sclerosis
- Trial name
- NCT04024085
- Testing
- completion of the test created Time to be Ready to Void
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Gérard Amarenco
Pain Monitoring, Pain Assessment
Intraoperative Analgesia Based on ANI
Osteoarthritis of the knee joint is common and total knee arthroplasty (TKA) is performed in patients with advanced joint degeneration, no response to conservative treatments, severe pain and joint instability.
- Conditions
- Pain Monitoring, Pain Assessment, Opioid Consumption
- Trial name
- NCT06236035
- Testing
- Analgesia nociception index
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Sarcopenia
Efficacy of Dietary Supplementation and Physical Activity in Sarcopenic Elderly
This 3 months randomized, double-blind, placebo-controlled supplementation trial tested the hypothesis that nutritional supplementation with whey protein, essential amino acids and vitamin D concurrent with regular, controlled…
- Trial name
- NCT02402608
- Testing
- dietary supplement
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- Azienda di Servizi alla Persona di Pavia
Pain, Postoperative, Ureter Stone
Local Anaesthetic and Steroid in the Ureter
Précis: Randomised control trial to evaluate safety and efficacy of intraluminal injection of high pH-high concentration of a long-acting local anesthetic and long-acting glucocorticoid in the ureter after ureteroscopy.
- Trial name
- LASTE (NCT03296189)
- Testing
- Levobupivacaine, Dexamethasone Sodium Phosphate
- Where
- Ireland
- Volunteers
- 150 people
- Sponsor
- The Adelaide and Meath Hospital, incorporating The National Children's Hospital
Fibromyalgia
Emotional Freedom Technique (EFT) on Pain and Stress Levels in Fibromyalgia (FMS)
The main aim of the study was to investigate self-administered emotional to determine the effect of the freedom technique on pain and stress levels. The sub-objectives of the study are as follows: 1.
- Trial name
- EFT-FMS (NCT06391268)
- Testing
- Emotional Freedom Technique (EFT) works on cognitive and energetic levels.
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ege University
Down Syndrome
An Online Health Tool About Down Syndrome: Down Syndrome Clinic to You
The investigators conducted a national two-arm, randomized controlled trial of caregivers of individuals with DS to assess the efficacy of DSC2U in assuring adherence to evidence-based guidelines.
- Trial name
- DSC2U (NCT04227197)
- Testing
- Down Syndrome Clinic to You (DSC2U)
- Where
- United States
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Shoulder Impingement Syndrome, Pain
Graded Motor Imagery and Task-Oriented Exercise in Shoulder Impingement
This study aims to compare the effects of graded motor imagery and task-oriented exercise training in individuals with shoulder impingement syndrome.
- Conditions
- Shoulder Impingement Syndrome, Pain, Motor Imagery Training, Task Oriented Training
- Trial name
- NCT07290660
- Testing
- Electrotherapy + Conventional Exercise Group, The graded motor imagery program, The task-oriented exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Fenerbahce University
Coronary Artery Disease, Atherosclerosis
Coronary Artery Geometry and the Severity of Coronary Atherosclerosis
The purpose of this study is to investigate the potential association of coronary artery geometry, based on coronary CT angiography (CCTA), with the complexity and the severity of coronary atherosclerosis.
- Conditions
- Coronary Artery Disease, Atherosclerosis, Atherosclerotic Plaque, Stable Angina
- Trial name
- GEOMETRY-CTA (NCT04185493)
- Testing
- CCTA
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aristotle University Of Thessaloniki
Pilates Exercise, Mirror Therapy
Pilates Exercises Versus Mirror Therapy on Shoulder Dysfunction Post Neck Dissection Surgeries
The purpose of this study is to compare the therapeutic effects of pilates exercises and mirror therapy on shoulder dysfunction post-neck dissection surgeries.
- Conditions
- Pilates Exercise, Mirror Therapy, Shoulder Pain, Dissection
- Trial name
- NCT07297706
- Testing
- Pilates exercises, Mirror therapy, Traditional physical therapy
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Cairo University
Knee Osteoarthritis
Comparison of the Efficacy of Duloxetine and Pregabalin in Patients With Knee Osteoarthritis With Mix Type Pain
Osteoarthritis (OA) is a common degenerative joint disorder associated with chronic pain at older age.It is known that patients with osteoarthritis experience nociceptive and neuropathic pain to varying degrees.
- Trial name
- NCT04532684
- Testing
- Duloxetine, Pregabalin
- Volunteers
- 66 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Huntington Disease
An Exploratory Clinical Trial in Early Stage Huntington's Disease Patients With SEN0014196
The primary objective of this study is to provide biological samples from patients with Huntington's disease to allow characterisation of the pharmacological mechanism of action of SEN0014196.
- Trial name
- PADDINGTON (NCT01485952)
- Testing
- SEN0014196 (Low Dose), SEN0014196 (High Dose)
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- Siena Biotech S.p.A.
Acute Stroke
Efficacy of Whole Extract of Licorice in Neurological Improvement of Patients After Acute Ischemic Stroke
Stroke is one of the most important causes of mortality and disability both in developed and developing countries. The only food and drug administration (FDA) approved therapy for acute stroke is recombinant tissue plasminogen…
- Trial name
- NCT02473458
- Testing
- Licorice whole extract
- Where
- Iran
- Volunteers
- 75 people
- Sponsor
- Shiraz University of Medical Sciences
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