Clinical trials: Neurological Diseases
Critical Illness, Sedation Complication
Sedation, ANalgesia and Delirium MANagement in Intensive Care Unit
Patients with acute severe health problems often need to be admitted to specialised hospital wards called Intensive Care Units (ICUs) where they can receive emergency treatment such as mechanical ventilation to support their…
- Conditions
- Critical Illness, Sedation Complication, Intensive Care Unit Delirium, Analgesia
- Trial name
- SAnDMAN (NCT05027217)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 3,421 people
- Sponsor
- University of Oxford
Analgesia
Analgesic Protocol With Gabapentin Dexmedetomidine For Postoperative Pain Managment
Assessment of quality of post mastectomy analgesic protocol of Gabapentin and Dexmedetomedine in a placebo-controlled study
- Trial name
- NCT04976374
- Testing
- Dexmedetomidine and Gabapentin, Saline
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute, Egypt
Peripheral Arterial Occlusive Disease
Interest of a Bi-truncal Nerve Block (Femoral + Sciatic) Extended, Systematically Associated With General Anesthesia, in the Femoropopliteal Bypass: Study of Post-operative Analgesia and Peripheral Circulation Downstream
The aim of this study is to assess, in patients scheduled for femoropopliteal bypass, the benefit of a double peripheral nerve block (femoral + sciatic) with levobupivacaine and clonidine in a single dose, performed before…
- Trial name
- BLOC-FEMPOP (NCT01785693)
- Testing
- levobupivacaine, clonidine
- Where
- France
- Volunteers
- 47 people
- Sponsor
- University Hospital, Clermont-Ferrand
Surgical Wound, Post Operative Pain
Effect of Preemptive Etoricoxib and Dexamethasone on Wound Healing and Clinical Parameters After Third Molar Surgery
The goal of this clinical trial is to compare preemptive single-dose selective cyclooxygenase 2 (COX-2) inhibitor - etoricoxib and dexamethasone use in systemically healthy patients during the surgical extraction of impacted…
- Trial name
- NCT05791721
- Testing
- Etoricoxib 90 Mg Oral Tablet, Dexamethasone 4mg
- Where
- Serbia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Aortic Aneurysm, Thoracoabdominal
Paraplegia Prevention in Aortic Aneurysm Repair by Thoracoabdominal Staging
Aortic aneurysms represent the most common and dangerous aortic diseases. Although conventional aortic repair techniques cure the disease, there is a high risk of paraplegia particularly in extensive thoracoabdominal aneurysms…
- Trial name
- PAPAartis (NCT03434314)
- Testing
- Minimally-Invasive Segmental Artery Coil-Embolization
- Where
- 29 sites in Austria, France and 7 more
- Volunteers
- 500 people
- Sponsor
- University of Leipzig
Tinnitus
Treatment Evaluation of Neuromodulation for Tinnitus - Stage A2
This is a four arm, patient subtyping and parameter optimisation study for a neuromodulation treatment for tinnitus.
- Trial name
- TENT-A2 (NCT03530306)
- Testing
- PS1-PS4, PS6-PS10, PS7-PS4
- Where
- Ireland
- Volunteers
- 191 people
- Sponsor
- Neuromod Devices Ltd.
Postpartum Disorder
The Effect of Back Massage Applied to Mothers in the Early Postpartum Period on Parameters
In the literature, there are separate studies on massage, comfort, anxiety, and physiological parameters for massage practice, but there are no studies that measure the physiological parameters of comfort, pain, anxiety, blood…
- Trial name
- NCT06200649
- Testing
- massage
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ordu University
Mitochondrial Diseases, Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation
The KHENEREXT Study
This is an open-label, multi-centre study in subjects with a genetically confirmed mitochondrial deoxyribonucleic acid (DNA) transfer ribonucleic acid (tRNA)Leu(UUR) m.3243A>G mutation who completed study KH176-202.
- Conditions
- Mitochondrial Diseases, Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation, Maternally Inherited Diabetes and Deafness (MIDD), Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke Like Episodes (MELAS)
- Trial name
- NCT04604548
- Testing
- Oral administration of 100 mg KH176 twice daily
- Where
- 4 sites in Denmark, Germany and 2 more
- Volunteers
- 11 people
- Sponsor
- Khondrion BV
Stroke
Telerehabilitation for Post-Stroke Hand Function
This pilot randomized controlled trial will evaluate the feasibility and preliminary effects of a home-based, technology-enabled hand telerehabilitation program for adults with chronic stroke.
- Trial name
- NCT07792655
- Testing
- Technology-Supported Hand Training, Pamphlet-Supported Hand Activity
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Michigan
Temporomandibular Disorder, Myofascial Pain
CBD (Cannabidiol) Intraoral Application and TMD (Temporomandibular Disorders)
The aim of the project is to assess the effectiveness of reducing the masseter muscles tension and hyperactivity in patients with a painful form of TMD by using polymers containing CBD compared to placebo polymers.
- Conditions
- Temporomandibular Disorder, Myofascial Pain, Orofacial Pain, CBD
- Trial name
- NCT05562635
- Testing
- 5% polymer gel with CBD application, 10% polymer gel with CBD application
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Silesia
Sarcopenia
Ankle Assistance and Resistance in Older Adults
The goal of this research protocol is to improve mobility in older individuals through advances in wearable assistive devices by focusing on two specific aims.
- Trial name
- NCT06284525
- Testing
- Ankle resistance and biofeedback
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Fibromyalgia, Sleep Disorders
Effects Of Pregabalin (Lyrica) On Sleep Maintenance In Subjects With Fibromyalgia
The purpose of the study is to demonstrate the effect of Lyrica on Wake after sleep onset in subjects with fibromyalgia with sleep maintenance disturbance (on polysomnogram)
- Trial name
- NCT00883740
- Testing
- Pregabalin
- Where
- 50 sites in United States, Canada and 1 more
- Volunteers
- 119 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Blood Collection
Use of Acupressure, Aromatherapy, and Virtual Reality for Children in During Blood Collection Procedures
This study aims to evaluate the effects of acupressure, music listening, and virtual reality applications, which appeal to the senses of touch, hearing, and sight during blood sampling, on pain, fear, and anxiety levels in…
- Trial name
- NCT07400874
- Testing
- Acupressure, Listening Music, Virtual Reality
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Artvin Coruh University
Old Age; Atrophy, Inflammatory Response
Effects of Parmigiano Reggiano on Skeletal Muscle Damage in Older Adults
Aging is associated with the loss of muscle mass and function (sarcopenia) and reduced tissue regenerative capacity. Eccentric exercise (ECC) is a model of RET that can be used with the elderly, due to the ability of the muscle…
- Conditions
- Old Age; Atrophy, Inflammatory Response, Muscle Soreness
- Trial name
- NCT04872374
- Testing
- Parmigiano Reggiano, Whey Protein
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Padova
Delirium, Sedation Complication
The Relationship Between Fasting Time and Delirium
We investigated the relationship between fasting times and delirium in children undergoing MRI under anesthesia. Paediatric Anaesthesia Emergence Delirium (PAED) scale, last oral intake time and type of food (solid-liquid) and…
- Conditions
- Delirium, Sedation Complication, Magnetic Resonance Imaging, Fasting
- Trial name
- NCT05567718
- Testing
- Paediatric Anaesthesia Emergence Delirium scale
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Age-related Hearing Loss
Prediction of Age-Related Hearing Loss Based on Comprehensive Risk Factors
This study aims to develop a predictive model for age-related hearing loss (ARHL) based on multi-source risk factors and artificial intelligence techniques.
- Trial name
- NCT07612618
- Testing
- Not applicable- observational study
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Erectile Disfunction, Coronary Artery Disease (CAD)
"Erectile Function After PCI in MI and Non-MI Patients"
The goal of this observational study is to assess changes in patients' erectile function after percutaneous coronary intervention (PCI) using a standard IIEF (International Index of Erectile Function) questionnaire at 1, 3, and 6…
- Conditions
- Erectile Disfunction, Coronary Artery Disease (CAD), Diabete Mellitus, Anxiety
- Trial name
- ERECT-PCI (NCT07444697)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Post-thoracotomy Pain Syndrome
Effects of Dexmedetomidine Used in Continuous Thoracic Paravertebral Blocks
The purpose of this study is to explore the effectiveness of dexmedetomidine as an adjunctive analgesic, used in ultrasound-guided continuous thoracic paravertebral blocks for Post-thoracotomy Pain Syndrome(PTPS).
- Trial name
- NCT02619513
- Testing
- Dexmedetomidine, Ropivacaine, Mindray M7 series
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Weifeng Tu
Multiple Sclerosis, Gait Disorders, Neurologic
Walking and Thinking - Brain Activity During Complex Walking in People With Multiple Sclerosis
Every-day life means being part of a complex environment and performing complex tasks that usually involve a combination of motor and cognitive skills.
- Conditions
- Multiple Sclerosis, Gait Disorders, Neurologic, Neuro-Degenerative Disease, Aging
- Trial name
- NCT05787704
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 41 people
- Sponsor
- Karolinska Institutet
Medication-Induced Dyskinesia
Study to Assess the Safety, Tolerability and Preliminary Efficacy of NLX-112 Versus Placebo in L-dopa-induced Dyskinesia
This is a double-blind, randomized, placebo-controlled Phase 2a study evaluating the safety, tolerability, and preliminary efficacy of up to 2 mg/day (1 mg BID) of NLX-112 versus placebo in patients with moderate to severe L-DOPA…
- Trial name
- NCT05148884
- Testing
- NLX-112
- Where
- 5 sites in Sweden
- Volunteers
- 27 people
- Sponsor
- Neurolixis SAS
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