Clinical trials: Neurological di
Dyslexia
VAlidation of an Educational Technological Tool for Dyslexic Adolescents: an Open Controlled Study
Virtual reality (VR) and augmented reality (AR) are gaining importance in the rehabilitation programs for learning disabilities.
- Trial name
- FORDYS (NCT05028647)
- Testing
- Virtual reality training, Augmented reality training
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Eugenio Medea
Postoperative Pain
TAP Block vs CWI for Total Abdominal Hysterectomy, a RCT
This no-profit, monocentric, prospective randomized controlled trial, aims to demonstrate the non-inferiority of continuous wound infusion (CWI) when compared to transversus abdominis plane (TAP) block for postoperative pain…
- Trial name
- WI-HYSTER (NCT05686382)
- Testing
- Continuous Wound Infusion, TAP block
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- Campus Bio-Medico University
Friedreich Ataxia
Efficacy of Stabilometric Platform to Improve Standing Balance in Patients With Friedreich's Ataxia
The primary objective is to evaluate the potential effectiveness of an individualized intensive rehabilitation intervention using the "Prokin 252" stabilometric platform in the treatment of adolescent and adult patients with…
- Trial name
- NCT06692296
- Testing
- Balance training over stabilometric platform, Balance training by means of conventional rehabilitation
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- IRCCS Eugenio Medea
Acute Respiratory Failure, Delirium in Old Age
Exploring the Correlations of Lung Ultrasound with Delirium and Outcomes in Acute GEriatrics World: a Multicenter, Prospective, Observational Study from the GRETA Group of the Italian Society of Gerontology and Geriatrics
The purpose of this observational study is to investigate the prognostic relevance of lung ultrasound (LUS) performed on older patients (aged 65 and above) admitted to the hospital with acute respiratory symptoms.
- Conditions
- Acute Respiratory Failure, Delirium in Old Age, Pneumonia, Acute Heart Failure (AHF)
- Trial name
- ECO-AGE (NCT06670118)
- Where
- Italy
- Volunteers
- 480 people
- Sponsor
- University of Milano Bicocca
Neurological Disorders, Orthopedic Disorders
A Model for Continuous Care of Fragile Patients
This observational study aims to monitor functional status and identify potential declines in the functioning of medically fragile patients with neurological and/or orthopedic conditions, representing an added value for ensuring…
- Conditions
- Neurological Disorders, Orthopedic Disorders, Functional Decline, Fragile and More Vulnerable
- Trial name
- AFTER (NCT07299344)
- Testing
- Telemedicine-Based Functional Monitoring
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Azienda Sanitaria Locale CN2 Alba-Bra
Sarcopenia in Elderly, Frailty/Sarcopenia
Frailty in the Elderly Oncological and Oncohematological Patient.
The Italian population is progressively aging, and cancer incidence increases with age. Older patients are at higher risk of frailty, a condition associated with adverse outcomes such as disability, falls, hospitalization, and…
- Conditions
- Sarcopenia in Elderly, Frailty/Sarcopenia, Oncological Patients, Hematologic Disease
- Trial name
- SALICE (NCT07624370)
- Testing
- Frailty evaluation
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Azienda Socio Sanitaria Territoriale Ovest Milanese, Ospedale di Legnano
Endometriosis
ENDOGYM: A Holistic Approach With Pelvic Floor Physiotherapy and Yoga for Endometriosis Pain Relief
The aim of this study is to evaluate the combined effects of Yoga practice and pelvic floor physiotherapy (PFP) on chronic pelvic pain (CPP) and dyspareunia in endometriosis patients.
- Trial name
- ENDOGYM (NCT07245537)
- Testing
- Yoga, Pelvic Floor Physiotherapy
- Where
- Italy
- Volunteers
- 82 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Neurology, Aromatic Amino Acid Decarboxylase Deficiency
Newborn Screening and Early Diagnosis of AADC Deficiency in the Ligurian Population
Aromatic L-amino acid decarboxylase deficiency (AADC-D) is a rare genetic disorder that affects the production of neurotransmitters in the brain and can cause severe neurological and developmental problems.
- Conditions
- Neurology, Aromatic Amino Acid Decarboxylase Deficiency, Pediatric Neurological Disorder
- Trial name
- NBS3OMD22 (NCT07877714)
- Where
- 10 sites in Italy
- Volunteers
- 16,000 people
- Sponsor
- Istituto Giannina Gaslini
Migraine, Migraine With Aura
Italian Real-life obServational Study on the effecTiveness, sAfety and Tolerability of Atogepant in Migraine Patients
The purpose of this prospective and multicentric study is to evaluate the effectiveness and tolerability of atogepant as preventive migraine treatment in a cohort of episodic or chronic migraine patients.
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura, Chronic Migraine
- Trial name
- STAR (NCT06414044)
- Testing
- Atogepant 60 mg
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- University of Florence
Systemic Disease, Skin Diseases
Nutraceuticals and Functional Foods
Supplements and functional foods are now readily available and usable by the general population. Many supplemnets are commonly used in poly-treated patients where interactions or adverse events may develop, therefore we evaluate…
- Conditions
- Systemic Disease, Skin Diseases, Memory Disorders, Urologic Diseases
- Trial name
- NCT05509075
- Testing
- nutraceuticals
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Catanzaro
Hip Fractures, Arthroplasty, Replacement, Hip
PENG Block + LIA For Endoprosthesis Surgery
The goal of this clinical trial is to learn if a new local anesthesia technique can control pain as well as the standard spinal anesthesia for adults having hip endoprosthesis surgery.
- Conditions
- Hip Fractures, Arthroplasty, Replacement, Hip, Pain, Postoperative, Anesthesia and Analgesia
- Trial name
- PENG 360° (NCT07239817)
- Testing
- Pericapsular Nerve Group Blocks with Local Infiltration Analgesia, spinal anesthesia
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- ASST Gaetano Pini-CTO
Stroke
Funcitonality and Safety of a Knee Device for Gait Rehabilitation in Neurological Patients
This clinical investigation aims to evaluate the safety, feasibility, and preliminary performance of the AKO-R wearable robotic device for knee assistance during walking.
- Trial name
- AKO-R (NCT07670325)
- Testing
- Exo-Assisted
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Scuola Superiore di Studi Universitari e di Perfezionamento Sant'Anna
Serious Game, Asthma in Children
Serious gaMes as Emerging E-health Interventions for Young People With neurologicaL or rEspiratory disoRders
The main purpose of 'Serious Games' (SG) is to provide opportunities for constructive learning and training. They are well-accepted instruments in therapeutic interventions and have been found to be efficient to improve cognitive…
- Conditions
- Serious Game, Asthma in Children, Children, Only
- Trial name
- SMILER (NCT05974917)
- Testing
- Serious Game (SG)
- Volunteers
- 30 people
- Sponsor
- Istituto di Farmacologia Traslazionale - sede di Palermo, Consiglio Nazionale delle Ricerche (CNR)
Stroke, Gait Disorders, Neurologic
Technological Balance and Gait Rehabilitation in Patients With Stroke Sequelae: Functional, Motor and Cognitive Outcomes
Stroke represents the leading cause of disability worldwide, with a significant impact on an individual, family, and economic impact.
- Conditions
- Stroke, Gait Disorders, Neurologic, Balance
- Trial name
- ROAR-S (NCT05280587)
- Testing
- Technological Rehabilitation
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sarcopenia
HIF-1α Stabilization As a Novel Therapeutical Approach for Sarcopenia.
Age-related sarcopenia is associated with reduced mobility, functional decline and disability, falls, and mortality in the elderly.
- Trial name
- HIF2 (NCT06736249)
- Testing
- Sarcopenic group, Muscle harvesting
- Where
- Italy
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Pain, Postoperative
Non-pharmacological Methods for the Control of Anxiety and Pain During Outpatient Hysteroscopy
The administration of pharmacological and non-pharmacological aids during in-office hysteroscopic surgery is often used to both relieve the patient from discomfort and facilitate the operator in performing the procedure.
- Trial name
- NCT05700123
- Testing
- In-Office Hysteroscopy
- Where
- 3 sites in Italy
- Volunteers
- 198 people
- Sponsor
- University of Campania Luigi Vanvitelli
Brain (Nervous System) Cancers, Brain Arterial Disease
A Vision-Language Foundation Model for Brain Disease Diagnosis From Multimodal Data
The goal of this observational study is to develop an innovative, comprehensive, and explainable AI vision-language foundation model (VLM) to advance the diagnosis and interpretation of brain diseases using multi-modal data.
- Conditions
- Brain (Nervous System) Cancers, Brain Arterial Disease, Neuro-Degenerative Disease, Brain Tumors
- Trial name
- NCT07126821
- Testing
- No Interventions
- Where
- China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Muscular Atrophy
Biological and Functional Markers for Precision Astronautical Biomedicine
In the current study the investigators will study early biomarkers of human degradation. In 10-day horizontal bed rest the investigators will enroll 10 healthy male subjects (18-30years, BMI 20-28kg/m2).
- Trial name
- MARS-PRE (NCT04081467)
- Testing
- Bed rest
- Where
- Slovenia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Science and Research Centre Koper
Stroke
Fear of Falling: Clinical and Psychological Determinants in Neurological Patients. A Cross-Sectional Observational Study.
Stroke survivors are at increased risk of falls and often develop Fear of Falling (FoF), which can negatively affect mobility, independence, participation in daily activities, and quality of life.
- Trial name
- NCT07698444
- Testing
- Clinical and neuropsychological evaluation
- Where
- Italy
- Volunteers
- 106 people
- Sponsor
- Universita di Verona
Hemodialysis, Sarcopenia
Innovative Functional Food Based on Apulian Lens Culinaris for Contrasting Sarcopenia in Dialysis Patients
The objective of the pilot study is to validate the clinical use of a dietary supplement for contrasting sarcopenia in dialysis patients.
- Trial name
- ALTIS (NCT04223206)
- Testing
- NATURLENS
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari