Clinical trials: Neuromuscular Block
Residual Neuromuscular Blockade
Thumb vs Great Toe Recovery
Researches are comparing the accuracy of measuring muscle relaxation in the thumb versus the great toe.
- Trial name
- NCT04312256
- Testing
- TetraGraph
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Mayo Clinic
Elective Surgery
Neuromuscular Blocking Agents in the Elderly
The number of elderly patients (>80 years) is increasing and a large proportion of these patients will require surgery and anaestheasia within the next decades.
- Trial name
- NCT03857750
- Testing
- Rocuronium
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Neuromuscular Blockade, Arthroplasty, Replacement, Hip
Reversal of Neuromuscular Blockade With Sugammadex or Usual Care in Hip Fracture Surgery or Joint (Hip/Knee) Replacement (P07038)
This study will assess the effect of reversal of neuromuscular blockade with sugammadex compared with reversal according to usual care (neostigmine or spontaneous reversal) on the incidence of post-surgical bleeding events and on…
- Conditions
- Neuromuscular Blockade, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Blood Coagulation
- Trial name
- NCT01422304
- Testing
- Sugammadex, neostigmine and glycopyrrolate or atropine
- Volunteers
- 1,198 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Venous Disease, Venous Insufficiency
Venous Insufficiency and Neuromuscular Stimulation
The investigators will be evaluating the immediate and longer term effect of treatment with a medical device on the symptoms of chronic venous disease.
- Conditions
- Chronic Venous Disease, Venous Insufficiency, Deep Venous Obstruction
- Trial name
- VeINS (NCT02137499)
- Testing
- geko device
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Anesthesia, General, Neuromuscular Blockade
Pharmacokinetic-pharmacodynamic Analysis of Sugammadex in Children
This study administers sugammadex sodium to pediatric patients under general anesthesia with rocuronium. Pharmacokinetic and pharmacodynamic analysis are performed based on plasma concentration of sugammadex sodium and monitoring…
- Trial name
- NCT03943888
- Testing
- Sugammadex Injection 2mg/kg, Sugammadex Injection 4mg/kg, Sugammadex Injection 8mg/kg
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Meralgia Paresthetica
Comparing Ways to Freeze the Nerve That Provides Thigh Sensation
Background The sensation on the outside of portion of our thighs is provided by a nerve called the lateral femoral cutaneous nerve (LFCN).
- Trial name
- NCT02577510
- Testing
- Nerve Injection- Nerve Stimulator, Nerve Injection - Ultrasound
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Canadian Forces Health Services Centre Ottawa
Anesthesia, General, Neuromuscular Blockade
Efficacy and Safety of 4.0 mg/kg Sugammadex at 1-2 PTC in Chinese and European Subjects (Study 19.4.335)(P05775AM1)(COMPLETED)
The present trial is set up to evaluate the efficacy and safety of 4.0 mg.kg-1 sugammadex in Chinese and Caucasian subjects for registration purposes in China.
- Trial name
- NCT00826176
- Testing
- Sugammadex
- Volunteers
- 164 people
- Sponsor
- Merck Sharp & Dohme LLC
Sleep Apnea, Obstructive, Hypotonia
Pilot Study of a Self-Supporting Nasopharyngeal Airway in Hypotonia
Children with hypotonic upper airway obstruction have a high prevalence of severe obstructive sleep apnea, which if not treated has significant clinical consequence.
- Conditions
- Sleep Apnea, Obstructive, Hypotonia, Child, Only
- Trial name
- ssNPA (NCT04846400)
- Testing
- ssNPA
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Michigan
Neuromuscular Monitoring After Administration of Neuromuscular Blocking Agents in Different Types of Surgery
Observational Study to Evaluate the Current Neuromuscular Monitoring Practice Used After Different Types of Surgery, for Which Neuromuscular Blocking Agents Were Used, With or Without Blocking Reversal (P06556)
The intent of this observational study is to collect prospective data regarding neuromuscular monitoring practices and extubation standards (Train-Of-Four [TOF] value) during surgery, in countries of Central and Eastern Europe…
- Trial name
- NCT01213264
- Testing
- No neuromuscular blockade (NMB)-reversal agent used, Sugammadex, Other NMB-Reversal Agents Used in Routine Anesthesiology Practice
- Volunteers
- 659 people
- Sponsor
- Merck Sharp & Dohme LLC
Airway Reflexes, Protective, Recovery After Neuromuscular Block
Impact of Anesthetic Choice (Sevoflurane Versus Desflurane) on Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block
Protective airway reflexes may be impaired in the postoperative period, creating the potential for aspiration of gastric contents, even after a patient exhibits appropriate response to command.
- Conditions
- Airway Reflexes, Protective, Recovery After Neuromuscular Block, Anesthetic Recovery
- Trial name
- NCT01199237
- Testing
- Sevoflurane, Desflurane, Rocuronium
- Where
- 2 sites in United States
- Volunteers
- 107 people
- Sponsor
- University of California, San Francisco
Incomplete Reversal of Neuromuscular Block
Sugammadex ED90 Dose in the Obese Patients
The purpose of this study is to determine the minimum effective dose of sugammadex, an antagonist of neuromuscular blockade used during anesthesia practice, in obese patients, considering that sugammadex is indicated in adults…
- Trial name
- NCT02568345
- Testing
- sugammadex ED90
- Volunteers
- 31 people
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
Malignant Neoplasms of Digestive Organs, Malignant Neoplasms of Female Genital Organs
Neuromuscular Blockade on Shoulder Pain of Elderly
Insufflation pressure (IP) is the creation of a pressure barrier of air/gas within the abdomen to allow the surgeon more space to work during abdominal surgery.
- Conditions
- Malignant Neoplasms of Digestive Organs, Malignant Neoplasms of Female Genital Organs, Malignant Neoplasms of Male Genital Organs, Malignant Neoplasms of Urinary Tract
- Trial name
- NCT03210376
- Testing
- Deep Neuromuscular Blockade (NMB), Moderate Neuromuscular Blockade (NMB), Sugammadex
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Postoperative Complications, Neuromuscular Blockade
The Effect of Sugammadex Versus Neostigmine on Postoperative Pulmonary Complications
Substantial respiratory morbidity has been associated with postoperative residual paralysis, which is fairly common after general anesthesia involving a neuromuscular blocking agent.
- Trial name
- NCT02861131
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Cholecystitis, Endometriosis
Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery
This is a two period cross-over study randomizing patients undergoing laparoscopic surgery into 2 different groups: group 1 in which patients receive "deep neuromuscular blockade" in the beginning portion of their laparoscopic…
- Conditions
- Cholecystitis, Endometriosis, Bowel Obstruction, Fibroids
- Trial name
- NCT02812186
- Testing
- Deep to Moderate NMB, Moderate to Deep NMB, Rocuronium
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Stony Brook University
Respiratory Insufficiency
Effect of Neuromuscular Blockade and Reversal on Breathing
In this study the investigators will assess (i) the effect of partial neuromuscular blockade (NMB; TOF ratio 0.8 and 0.6) induced by low-dose rocuronium on the ventilatory response to isocapnic hypoxia and (ii) the effect over…
- Trial name
- BREATH (NCT02845375)
- Testing
- Sugammadex, Neostigmine
- Where
- Netherlands
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Neuromuscular Block, Renal Transplant Donor of Left Kidney
Deep Versus Moderate Muscle Relaxation During Laparoscopic Donor Nephrectomy in Enhancing Postoperative Recovery
Postoperative recovery after live donor nephrectomy (LDN) is largely determined by the consequences of postoperative pain and analgesia consumptions.
- Conditions
- Neuromuscular Block, Renal Transplant Donor of Left Kidney, Renal Transplant Donor of Right Kidney, Surgery
- Trial name
- RELAX (NCT02838134)
- Testing
- Rocuronium, No additional Rocuronium
- Where
- 2 sites in Netherlands
- Volunteers
- 101 people
- Sponsor
- Radboud University Medical Center
Lumbar Radiculopathy
Erector Spinae Block for Spine Surgery
This study is to determine whether or not the addition of liposomal bupivacaine in an ESP block will have long term benefits for patients undergoing lumbar spinal fusion surgery.
- Trial name
- NCT05417113
- Testing
- Liposomal bupivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Kidney Transplant; Complications, Postoperative Residual Curarization
Sugammadex Versus Neostigmine for Reversal of Neuromuscular Blockade at the End of Kidney Transplantation Surgery
The purpose of this study is to compare two medications that reverse muscle paralysis at the end of kidney transplant surgery with the goal of reducing residual muscle weakness and insufficient respiratory function after surgery.
- Conditions
- Kidney Transplant; Complications, Postoperative Residual Curarization, Postoperative Residual Weakness
- Trial name
- NCT03923556
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Colorado, Denver
Neuromuscular Blockade
Study on the Level of Neuromuscular Blockade
On the basis of moderate pneumoperitoneum pressure(10 mmHg), this study evaluates the effect of different level of neuromuscular blockade to gastrointestinal barrier function during laparoscopic gastrectomy.
- Trial name
- NCT03782233
- Testing
- A continuous intravenous infusion of 0.5-0.6 mg/kg/h Rocuronium Bromide Intravenous Solution (50 Mg/5 mL) to keep the target neuromuscular blockade (PTC = 1-2)., A continuous intravenous infusion of 0.2-0.3 mg/kg/h Rocuronium Bromide Intravenous Solution (50 Mg/5 mL) to keep the target neuromuscular blockade (TOF = 1-2).
- Where
- China
- Volunteers
- 83 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Chronic Otitis Media, Anesthesia
Optimal Dose of Combination of Rocuronium and Cisatracurium
BACKGROUND: The combinations of rocuronium and cisatracurium have a synergic effect. The investigators studied whether the prediction is possible to have a sufficient effect of reducing the dose when combining the two…
- Trial name
- CRC (NCT02495038)
- Testing
- 10% reduction of combination of Esmeron® and Nimbex®, 20% reduction of combination of Esmeron® and Nimbex®
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Yonsei University