Clinical trials: Neuromuscular Block
Lumbar Spine Disease
Deep Neuromuscular Block on Postoperative Delirium in Lumbar Surgery
The effect of deep neuromuscular blockade (NMB) during spine surgery reduced postoperative pain and bleeding in recent studies. Therefore by reducing these two factors, which were the contributing factors for postoperative…
- Trial name
- NCT05453929
- Testing
- Rocuronium for deep NMB, Rocuronium for moderate NMB
- Where
- South Korea
- Volunteers
- 230 people
- Sponsor
- Korea University Guro Hospital
Post-Operative Nausea and Vomiting, Breast Cancer
Intraoperative Acupoint Stimulation to Prevent Post-Operative Nausea and Vomiting (PONV)
The goal of this clinical research study is to learn if light electrical stimulation to the wrist area during surgery is feasible in women having breast surgery.
- Trial name
- NCT02473042
- Testing
- Electrical Stimulation, Zofran, Dexamethasone
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- M.D. Anderson Cancer Center
Neuromuscular Blockade Reversal Agent, Sugammadex
Comparison of QoR-15 in Laparoscopic Cholecystectomy: Sugammadex vs. Neostigmine
The quality of recovery in patients who were reversed neuromuscular blockade by using Sumamadex and Neostigmine in laparoscopic cholecystectomy was compared through the QoR(Quality of Recovery)-15 questionnaire.
- Conditions
- Neuromuscular Blockade Reversal Agent, Sugammadex, Neostigmine, Quality of Recovery
- Trial name
- NCT04332627
- Testing
- Sugammadex, Neostigmine
- Where
- South Korea
- Volunteers
- 77 people
- Sponsor
- Seoul National University Bundang Hospital
Neuromuscular Blockade
Efficacy and Safety of Sugammadex Dosed According to Actual Body Weight (ABW) or Ideal Body Weight (IBW) in Reversal of Neuromuscular Blockade (NMB) in Morbidly Obese Participants (MK-8616-146)
The purpose of this trial is to evaluate the safety and efficacy of Sugammadex when administered according to actual body weight (ABW) as compared to ideal body weight (IBW) for the reversal of both moderate and deep…
- Trial name
- NCT03346070
- Testing
- Sugammadex 2 mg/kg ABW, Sugammadex 2 mg/kg IBW, Sugammadex 4 mg/kg ABW
- Where
- 24 sites in United States, Austria and 3 more
- Volunteers
- 207 people
- Sponsor
- Merck Sharp & Dohme LLC
Low Back Pain
Fatty Infiltration in Paraspinal Muscles and Lumbar Erector Spina Plane Block
This study aimed to investigate the relationship between fatty infiltration in the lumbar paraspinal (multifidus and erector spinae) muscles, clinical characteristics, and treatment response after lumbar erector spinae plane…
- Trial name
- NCT06208865
- Testing
- lumbar erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 147 people
- Sponsor
- Diskapi Teaching and Research Hospital
Anesthesia, Surgery
Time Prediction for Complete Recovery From Neuromuscular Blockade After Visual Recovery With Double Burst Stimulation
The purpose is to calculate the time for an optimal recovery (T4/T1 > 0.9) from the moment when 2 responses to double burst stimulation are visually identical and this for 95% of patients.
- Trial name
- DBS PREDICTION (NCT02893436)
- Testing
- Surgery with tracheal intubation curarisation
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Anaesthesia
Sugammadex and Brain Waves
According to our experience, electroencephalogram-based indices of anaesthetic state show elevated numbers after administration of sugammadex (new reversal of neuromuscular blockade).
- Trial name
- NCT01142648
- Testing
- Sugammadex, Neostigmine and glycopyrrolate
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Tampere University Hospital
Bulbar Palsy
A Nerve Block Therapy for Bulbar Palsy Pharyngeal Dysphagia
This was a multicenter randomized controlled study. 66 post-stroke patients with pharyngeal dysphagia were randomly allocated to the observation group or the control group.
- Trial name
- NCT06347250
- Testing
- Nerve Block, Lidocaine Hydrochloride, routine therapy
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Babujinaya Cela
Sciatica Acute
Comparing Ultrasound-Guided Transgluteal Nerve Block to Standard Care
The goal of this clinical trial is to compare transgluteal sciatic nerve block to standard of care to treat sciatic back pain in adult patients who present to the emergency department.
- Trial name
- TGSNB vs SoC (NCT07397117)
- Testing
- nerve block with ropivacaine, Standard medical treatment
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Reversal of Neuromuscular Blockade
Efficacy and Safety of Sugammadex in Thoracoscopy Thymectomy for Chinese Adults With Myasthenia Gravis
The purpose of this study was to demonstrate in patients with myasthenia gravis (MG) undergoing thoracoscopic thymectomy faster recovery from a moderate neuromuscular block induced by rocuronium after reversal at reappearance of…
- Trial name
- NCT06436768
- Testing
- Sugammadex, Neostigmine
- Where
- 2 sites in China
- Volunteers
- 62 people
- Sponsor
- Beijing Tongren Hospital
Cluneal Syndrome, Nerve Entrapment Syndrome
Study on the Efficacy of Infiltration of Upper Cluneal Nerves in Chronic Pain Related to Cluneal Syndrome
Lower back pain is a very common complaint in the Chronic Pain Clinic. Its etiology is nonspecific in 85% of the cases. In 1957, Strong and Davila reported that the superior cluneal nerves (SCNs) and middle cluneal nerves (MCNs)…
- Trial name
- NCT05423132
- Testing
- Ropivacaine injection, Physiological serum injection
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Post Operative Pulmonary Complications, Neuromuscular Blockade
Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease
The purpose of the study is to determine which combination of neuromuscular blocking agent and reversal agent is safer to use during anesthesia for patients with chronic kidney disease.
- Conditions
- Post Operative Pulmonary Complications, Neuromuscular Blockade, General Anesthesia
- Trial name
- NCT07203287
- Testing
- Rocuronium, Cisatracurium, Sugammadex
- Where
- United States
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Cardiac Amyloidosis
Screening Algorithm for Early Detection of Occult Cardiac Amyloidosis
Early diagnosis of cardiac amyloidosis (CA) is crucial because of the poor overall survival, high mortality and the need for early therapy including new treatment possibilities for transthyretin amyloidosis.
- Trial name
- EARLY-CA (NCT05693376)
- Where
- Germany
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University Hospital, Essen
Neuromuscular Blockade
Incidence of Incomplete Postoperative Neuromuscular Recovery From Anesthesia (P07535)(Completed)
This is a multicenter, observational study in adult participants undergoing different types of elective surgical procedures requiring general anesthesia.
- Trial name
- INSPIRE (NCT01181349)
- Testing
- Neuromuscular Blocking Agent (NMBA)
- Volunteers
- 350 people
- Sponsor
- Merck Sharp & Dohme LLC
Neuromuscular Blockade
Comparison of Onset of Neuromuscular Blockade With Electromyographic and Acceleromyographic Monitoring
The purpose of this research is to use 2 devices to compare the difference in the amount of time it takes for each device to register complete muscle relaxation after the muscle relaxing medication is given.
- Trial name
- NCT05120999
- Testing
- Train of four measurement
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Postcardiac Arrest Therapeutic Hypothermia
When Cooling a Patient After Cardiac Arrest, Does Use of a Neuromuscular Blocking Agent Make Your Job Easier?
After successful resuscitation from cardiac arrest, cooling the whole body is a well established treatment that improves the chances of the brain recovering.
- Trial name
- NCT02033733
- Testing
- Cisatracurium infusion, Cisatracurium prn bolus
- Where
- 2 sites in Canada
- Volunteers
- 400 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Neuromuscular Blockade
Safety and Efficacy of HRS-9190 Compared to Rocuronium for Tracheal Intubation and Bolus Maintenance in Adults
The study will enroll adult patients scheduled for elective surgery requiring general anesthesia. Participants will be randomly assigned to receive either HRS-9190 for Injection or Rocuronium.
- Trial name
- NCT07746726
- Testing
- HRS-9190, Rocuronium
- Where
- 2 sites in China
- Volunteers
- 320 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Migraine in Children, Pain, Neuropathic
Transnasal Sphenopalatine Ganglia Block for Management of Chronic Migraines in Pediatric Patients
Single-center, open-label, pre-post treatment pilot study to evaluate the safety and effectiveness of sphenopalatine ganglia blocks for the treatment of chronic migraine in the pediatric population.
- Trial name
- NCT04466826
- Testing
- Headache Journal, Sphenopalatine Block, Tx360
- Where
- United States
- Sponsor
- Washington University School of Medicine
Cesarean Section, Pain Management
Comparison of Two Pain-treatment Techniques After Cesarean Section
Comparison of two types of analgesia after cesarean section. All patients will anaesthetised with spinal technique. Ultrasound-guided transversus abdominis plane or quadratus lumborum block to treat postoperative pain.
- Conditions
- Cesarean Section, Pain Management, Neuropathic Pain
- Trial name
- NCT02804126
- Testing
- TAP (transversus abdominis plane block), QL (quadratus lumborum block), Bupivacaine
- Where
- Poland
- Volunteers
- 232 people
- Sponsor
- Michał Borys
Disorder of Maxillary and Mandibular Dental Arch Relationship
Impact of Complete Removable Prosthetic Rehabilitations Performed by an Innovative DDTENS Protocol, on the Quality of Masticatory Function and the Management of Completely Edentulous Patients
Total edentulism is a profound physical, psychic and social handicap, which affects 5 million people in France. The most frequent complaint of edentulous patients rehabilitated by conventional Complete Removable Prostheses (CRP)…
- Trial name
- DD-TENS (NCT05096624)
- Testing
- DD-TENS system, Gold Standard, Digital Denture system
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier