Clinical trials: Neuromuscular Blocking Agents
Cystoscopy
Accuracy and Precision of Train-of-Four Ratios Obtained With Acceleromyography and Electromyography in Restricted-Movement Settings in the Absence of Neuromuscular Blocking Drugs
The purpose of this research is to compare the performance of acceleromyograph and electromyograph-based quantitative neuromuscular monitors when the arms are tucked for surgical positioning.
- Trial name
- NCT06805032
- Testing
- Observation of EMG and AMG readings
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Drug Allergy, Neuromuscular Blockade
High Dimensional Analysis of Immune Cells in Pediatric Patients
The purpose of this study is to characterize immune cells using single-cell transcriptomic analysis in pediatric patients aged 2 to 18 years undergoing general anesthesia who are expected to receive Rocuronium, a non-depolarizing…
- Trial name
- NCT05820802
- Where
- South Korea
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Anaesthesia
Laryngeal Mask Supreme During Laparoscopic Gynecologic Surgery
Laryngeal mask (LM) use in gynecological laparoscopy, contrary to widespread opinion, does not increase the incidence of gastric aspiration, the failure of ventilation or the risk of pulmonary aspiration .
- Trial name
- NCT02125838
- Testing
- Laryngeal Mask Airway-Supreme, Endotracheal Tube
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Dokuz Eylul University
Tracheal Intubation, Rapid Sequence Induction and Intubation
Sequential Order of RSI on Tracheal Intubation
This clinical trial aims to understand the effect of the order of administration of Neuromuscular Blocking Agents (NMBAs) and sedatives on the success rate of intubation during Rapid Sequence Intubation (RSI) in the emergency…
- Trial name
- NCT07741578
- Testing
- Drug Sequence
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Zhongnan Hospital
Acute Respiratory Distress Syndrome
Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS)
Mortality in Acute Respiratory Distress Syndrome is high (40 to 60 %). Protective mechanical ventilation, until 2010, was the cornerstone of the ARDS therapeutic strategies.
- Trial name
- NCT01573715
- Testing
- NIMBEX, WITHOUT NIMBEX
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Neuromuscular Blockade
Use of Neuromuscular Blocking Agents and Neuromuscular Monitoring in 7 Danish Teaching Hospitals
Aim: To explore the frequency of use of objective neuromuscular monitoring for assessment of depth of neuromuscular blockade in general anaesthesia the incidence of residual neuromuscular blockade, and the timing of reversal of…
- Trial name
- NCT02914119
- Testing
- Rocuronium, Succinylcholine, Cisatracurium
- Where
- Denmark
- Volunteers
- 30,430 people
- Sponsor
- Jakob Louis Thomsen
General Surgery
Sugammadex vs Placebo to Prevent Residual Neuromuscular Block
The study is designed to determine whether patients who receive sugammadex immediately after tracheal extubation will exhibit a decrease in the incidence of postoperative residual paralysis and an associated decrease in the…
- Trial name
- NCT02728726
- Testing
- Sugammadex
- Where
- 2 sites in United States
- Volunteers
- 260 people
- Sponsor
- Mayo Clinic
Neuromuscular Blocking Agents, Residual Neuromuscular Block
Reversal of Pipecuronium-induced Neuromuscular Blockade With Sugammadex During Sevoflurane Anesthesia
Safety during modern practice of anaesthesia is of great concern. Patients admitted daily for surgical procedures undergoing general anaesthesia for different types of operations are exposed to different risks, starting from the…
- Conditions
- Neuromuscular Blocking Agents, Residual Neuromuscular Block, Reversal of Neuromuscular Blockade
- Trial name
- RPINMBWS (NCT07044193)
- Testing
- pipecuronium bromide, Rocuronium bromide
- Where
- Hungary
- Volunteers
- 80 people
- Sponsor
- Tamas Vegh, MD
Hypersensitivity, Drug
GERAP's Epidemiological Survey on Perioperative Hypersensitivity Reactions
Perioperative hypersensitivity reactions are still associated with significant morbidity and mortality despite early recognition and use of epinephrine.
- Trial name
- SERAP (NCT04654923)
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- University Hospital, Strasbourg, France
Airway Morbidity, Anaesthesia
I-gel vs LMA Supreme in Laparoscopic Gynecological Surgery
To compare the effects of i-gel and Laryngeal mask airway Supreme (LMA-Supreme) on ventilation parameters and surgical view during Trendelenburg Position laparoscopic gynecological surgery in cases administered positive pressure…
- Trial name
- NCT02923427
- Testing
- Laryngeal mask Supreme Evaluation, i-gel Evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people
- Sponsor
- Dokuz Eylul University
Healthy
The Efficacy and Safety of Gantacurium Chloride for Injection in Tracheal Intubation in Healthy Adult Patients Undergoing Surgery Under General Anesthesia
This is a multicenter, randomized, controlled, observer-blinded, dose-response study to evaluate the efficacy in tracheal intubation and safety of gantacurium chloride for injection in healthy adult patients undergoing surgery…
- Trial name
- NCT00235976
- Testing
- Gantacurium Chloride for Injection (AV430A)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Avera Pharmaceuticals
Neuromuscular Blockade
Comparison of Acceleromyography (AMG) and Mechanomyography (MMG) for Establishing Potency of Neuromuscular Blocking Agents
The purpose of this study was to compare two methods for neuromuscular monitoring, acceleromyography and mechanomyography for establishing the dose-response relationship and the potency of a neuromuscular blocking agent using…
- Trial name
- NCT00660413
- Testing
- TOF-Watch SX (Acceleromyography)
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Obstructive Sleep Apnea
Impact of Sugammadex vs. Neostigmine Reversal on Post-Operative Recovery and Complications
Sugammadex or neostigmine are given at the end of the surgery to reverse neuro muscular blocking drugs (NMBD). This study will evaluate whether reversal of NMBD with sugammadex is associated with faster recovery than neostigmine…
- Trial name
- Sugammadex (NCT03679611)
- Testing
- Sugammadex Sodium, Neostigmine
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Catheter Site Discomfort, Complications
Effect of Glycopyrrolate and Atropine on Catheter-Related Bladder Discomfort
We want to evaluate the efficacy of the glycopyrrolate and atropine for the prevention of catheter-related bladder discomfort.
- Conditions
- Catheter Site Discomfort, Complications, Anesthesia, Urinary Bladder Neoplasms
- Trial name
- NCT02228473
- Testing
- Glycopyrrolate, Atropine
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- Seoul National University Hospital
Patients Ongoing Elective Abdominal Laparoscopy
Laparoscopic Surgery and Abdominal Compliance
The objective of the study is to describe factors influencing abdominal compliance during laparoscopic surgery, including neuromuscular blocking agents (NMBA).
- Trial name
- COELIOCUR (NCT02816567)
- Testing
- propofol, NMBA - cisatracurium, sufentanil
- Where
- France
- Volunteers
- 180 people
- Sponsor
- CHU de Reims
Traumatic Brain Injury, Intracranial Hypertension
Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents
Severely brain injured patients are at high risk of intracranial hypertension. Among medical treatments (sedatives), neuromuscular blocking agents (NMBA) are recommended by french but not english speaking societies.
- Trial name
- THIC Cu (NCT02404779)
- Testing
- cisatracurium besilate
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Clermont-Ferrand
Infant, Premature, Intubation, Intratracheal
Fentanyl and Rocuronium for Tracheal Intubation in Newborns
Tracheal intubation is a common and critical procedure in neonatal intensive care units (NICU). Despite its clinical importance, first-attempt success rates remain low (approximately 50%), and adverse events - including oxygen…
- Conditions
- Infant, Premature, Intubation, Intratracheal, Respiratory Distress Syndrome, Newborn, Apnea of Prematurity
- Trial name
- NEORIN (NCT07650552)
- Testing
- Rocuronium Bromide 10 MG/ML, Fentanyl 1 mcg/kg IV, single dose, administered before non-emergent tracheal intubation.
- Where
- Brazil
- Volunteers
- 102 people
- Sponsor
- UEA - Universidade Do Estado Do Amazonas
Acute Respiratory Distress Syndrome
Reevaluation Of Systemic Early Neuromuscular Blockade
This study evaluates whether giving a neuromuscular blocker (skeletal muscle relaxant) to a patient with acute respiratory distress syndrome will improve survival.
- Trial name
- ROSE (NCT02509078)
- Testing
- Cisatracurium Besylate
- Where
- 44 sites in United States
- Volunteers
- 1,008 people
- Sponsor
- Massachusetts General Hospital
Neuromuscular Blockade
Improving Neuromuscular Monitoring and Reducing Residual Neuromuscular Blockade Via E-learning
To assess the impact of an e-learning course in neuromuscular monitoring on the frequency of application of objective neuromuscular monitoring for assessment of depth of neuromuscular blockade in general anaesthesia and…
- Trial name
- INVERT (NCT02925143)
- Testing
- E-learning course in neuromuscular monitoring
- Where
- Denmark
- Volunteers
- 6,525 people
- Sponsor
- Herlev Hospital
Nerve Conduction Study, Elective Surgery
Median Nerve Electromyography to Monitor Intraoperative Neuromuscular Function
The effect of muscle relaxants need to be followed during surgery and before waking up the patient, the anesthesiologist has to make sure that the effect of muscle relaxants is gone.
- Conditions
- Nerve Conduction Study, Elective Surgery, Neuromuscular Monitoring After Administration of Neuromuscular Blocking Agents in Different Types of Surgery
- Trial name
- NCT07571395
- Testing
- Electromyography
- Where
- Hungary
- Volunteers
- 45 people
- Sponsor
- Pongrácz Adrienn