Clinical trials: Neuromuscular Function
Mitochondrial Myopathies, Mitochondrial Diseases
Validation of Oxygen Nanosensor in Mitochondrial Myopathy
Past mitochondrial disease treatment studies have been unsuccessful in determining treatment efficacy, and a major factor has been the lack of validated biomarkers in mitochondrial myopathy (MM).
- Trial name
- NCT04086329
- Testing
- Nanosensor
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Neuromuscular Control, Functional Training
Comparison of Lower Limb COP and Muscle Activation During Single-Leg Deadlift Using Elastic and Inelastic Barbells
This study aims to investigate the effects of barbell type (elastic vs. inelastic) and lifting speed on lower limb balance and muscle activation during the Single-Leg Deadlift (SLDL) exercise.
- Conditions
- Neuromuscular Control, Functional Training, Lower Limb Stability
- Trial name
- NCT07061314
- Testing
- Elastic Barbell, Inelastic Barbell
- Where
- South Korea
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Busan University of Foreign Studies
Obesity, Sarcopenia
Biological Effects of Weight Loss In Older, Obese Women
Obesity and sedentary lifestyle are associated with physical impairments and biological changes in older adults. Weight loss combined with exercise may reduce inflammation and may improve physical functioning in older adults who…
- Trial name
- WL+E (NCT01032733)
- Testing
- Lifestyle Counseling, Educational Control
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Florida
Muscle Weakness
Effects of Creatine Supplementation on Muscle Mass and Function Among Older Women Subjected to Resistance Training
To determine, in a double blind trial, the effects of creatine supplementation during 12 weeks on muscle mass and function of community living older women subjected to resistance training.
- Trial name
- NCT02188849
- Testing
- Resistance exercise training, Creatine
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Chile
Becker Muscular Dystrophy
Tadalafil in Becker Muscular Dystrophy
Summary for Patients: This study, funded by the Muscular Dystrophy Association, is intended to build on recent findings published in the journal Nature showing beneficial effects of tadalafil (also known as Cialis) in mice with…
- Trial name
- NCT01070511
- Testing
- Tadalafil
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Amyotrophic Lateral Sclerosis
Remote Speech and Swallowing Assessment in ALS
The investigators propose a longitudinal home study of ALS patients to measure the severity of speech and swallowing (bulbar) impairment via a smartphone-based, remote speech and swallow assessment (rSSA).
- Trial name
- NCT04889898
- Testing
- Digital recording of speech and swallow sounds using the Beiwe Digital Health App on a personal smartphone, Modified Barium Swallow Study (MBSS), Speech Intelligibility Test (SIT)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
System; Lupus Erythematosus
Myofascial Techniques and Proprioceptive Neuromuscular Facilitation in Patients With Systemic Lupus Erythematosus.
Introduction. Systemic lupus erythematosus is an autoimmune disease. The musculoskeletal system is affected in 90% of patients. The most common manifestations are myalgias, arthralgias and arthritis. Objective.
- Trial name
- NCT06383104
- Testing
- Intervention
- Where
- Spain
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Muscle Atrophy, Weightlessness
The Effects of Whole Body Unloading on Physiological Function
This study is a collaboration between the Centre of Human \& Aerospace Physiological Sciences (CHAPS) and the Sleep and Brain Plasticity Centre (Department of Neuroimaging) at King's College London and the Sleep Disorders Centre…
- Conditions
- Muscle Atrophy, Weightlessness, Sleep Disturbance, Astronaut-Bone Demineralisation Syndrome
- Trial name
- NCT03195348
- Testing
- HBF Bed Rest
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- King's College London
Spinal Muscular Atrophy (SMA), Neuromuscular Disease
Ultrasonographic Muscle Assessment and Functional Scales in Spinal Muscular Atrophy
This study aims to investigate the relationship between ultrasonographic muscle thickness measurement and echogenicity assessment with functional scales in children with spinal muscular atrophy (SMA).
- Trial name
- NCT06599606
- Testing
- Ultrasonographic Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Sarcopenia, Aging
Dual-benefits of Aerobic and Resistance Training
This study evaluates the effect of three different exercise strategies on physical function in older adults. Participants will be randomly assigned to one of three exercise groups: resistance training, moderate-intensity…
- Conditions
- Sarcopenia, Aging, Disability Physical
- Trial name
- DART (NCT03978572)
- Testing
- Resistance Training, Moderate-Intensity Continuous Cycling, High-Intensity Interval Cycling
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ohio University
Neuromuscular Function
Vitamin D Supplementation and Muscle Function in Older Adults
The purpose of this study is to see if vitamin D supplementation improves muscle function in older adults.
- Trial name
- EVIDENCE (NCT02015611)
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Neuromuscular Disease
Development of a Proxy Motor Outcome Measure in Young Children With Neuromuscular Disease
Patient reported outcomes (PROs) instruments are often used to measure meaningful treatment benefit or risk in clinical trials. PROs allow patients voices to be heard in ways that assist healthcare clinicians to address treatment…
- Trial name
- NCT02007213
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Safety, Peripheral Neuropathy
Xanamem™ in Healthy Elderly Subjects
Xanamem™ is being developed as a potential drug for Alzheimer's disease. This study drug has been designed to change the cortisol levels in the brain. Cortisol is a naturally occurring hormone in the body.
- Conditions
- Safety, Peripheral Neuropathy, Cortisol, Central Nervous System
- Trial name
- XanaHES (NCT03830762)
- Testing
- Xanamem
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Actinogen Medical
Dietary Supplement, Placebo
Neuromuscular Responses to Acute Beetroot Ingestion in Women Older Adults
Beetroot juice supplementation has shown the capacity for provoking different physiological effects (e.g. vasodilation and muscle contraction increments).
- Trial name
- BEET_ELDERLY (NCT05337527)
- Testing
- beetroot juice
- Where
- Spain
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Universidad Francisco de Vitoria
Healthy Adult Participants, Exercise Training
The Effect of Olive Leaf Extract Supplementation on Training-induced Skeletal Muscle Functional and Molecular Adaptations in Healthy Volunteers
The goal of this study is to investigate the effect of combining olive leaf extract supplementation with endurance training (moderate intensity continuous training or sprint interval training).
- Conditions
- Healthy Adult Participants, Exercise Training, Neuromuscular Adaptations, Nutritional Intervention
- Trial name
- OLE_Training_1 (NCT07729072)
- Testing
- Olive leaf extract
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Diplegic Cerebral Palsy
"Immediate Effect of DAFO on Gross Motor Function and Balance in Diplegic Cerebral Palsy
" Study will investigate the immediate effect of DAFO usage on balance and gross motor functions in individuals with spastic diplegic cerebral palsy.
- Trial name
- NCT06343688
- Testing
- "Assessment of Balance and Lower Extremity Gross Motor Function with and without DAFO"
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Duchenne Muscular Dystrophy
PDE Inhibitors in DMD Study (Acute Dosing Study)
PDE5A inhibition, which boosts NO-cGMP signaling, will relieve functional muscle ischemia and restore normal blood flow regulation (i.e., functional sympatholysis) during exercise in boys with DMD.
- Trial name
- NCT01580501
- Testing
- Tadalafil and Sildenafil
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Prevention and Control
Effects of a Neuromuscular Training Ankle Preventive Program in Soccer Player
Objetive:To determine the effects of a functional ankle instability prevention neuromuscular training (PENMT) program compared to the conventional FIFA 11+ program on the occurrence of ankle sprains, flexibility, balance and…
- Trial name
- PENT (NCT05688930)
- Testing
- PENMT (Experimental Group), FIFA 11+ (Control Group)
- Where
- Colombia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Autónoma de Manizales, Colombia
Muscle Damage, Inflammation
Protein and Recovery From Exercise-induced Muscle Damage
Intense, eccentric resistance exercise causes muscle damage, soreness, inflammation, and a loss of muscle function. Protein-amino acid supplementation before, during, and following damaging resistance exercise may reduce muscle…
- Trial name
- NCT02034721
- Testing
- Protein supplement
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Urinary Incontinence, Pelvic Floor Muscle Weakness
The Effects of Pelvic Floor Muscle Training Combined With Otago Exercises in Elderly People With Incontinence
Pelvic floor muscle weakness is one of the most important causes of incontinence. There are many studies supporting that pelvic floor muscle training prevents incontinence and reduces symptom severity, and with A level of…
- Conditions
- Urinary Incontinence, Pelvic Floor Muscle Weakness, Muscle Weakness
- Trial name
- NCT06331039
- Testing
- PFMT, PFMT+Otago
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Manisa Celal Bayar University