Clinical trials: Neuronal Plasticity
Mild Cognitive Impairment, Memory Impairment
Enhancing Frontal Lobes Plasticity in Mild Cognitive Impairment
More than 5 million people live with Alzheimer's dementia (AD) in North America. No effective treatment exists yet probably because by the time AD has developed it is too late to intervene.
- Trial name
- PAS-MCI (NCT04583215)
- Testing
- Paired Associative Stimulation (PAS)
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Autism Spectrum Disorder, Intellectual Disability
TMS for the Investigation of Brain Plasticity in Autism Spectrum Disorders
The main purpose is to study brain plasticity (the changes that occur in the brain through experience) in individuals with autism spectrum disorder (ASD).
- Trial name
- NCT02836405
- Testing
- Transcranial Magnetic Stimulation
- Where
- 2 sites in United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Migraine
Structural and Molecular Neuroplasticity in Migraine
The main purpose of this study is to integrate novel MRI techniques with positron emission tomography(PET) for the study of structural and molecular neuroplasticity in the brain of migraineurs, and its clinical association with…
- Trial name
- NCT03004313
- Testing
- Pet Scan, MRI scan, Quantitative Sensory Testing (QST)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Healthy Aging
Improving Neurological Health in Aging Via Neuroplasticity-based Computerized Exercise
This study is a validation study to evaluate efficacy of a neuroplasticity-based, computerized cognitive training program INHANCE (Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise) to improve…
- Trial name
- INHANCE (NCT04149457)
- Testing
- Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training
- Where
- Canada
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Posit Science Corporation
Healthy Adult Participants, Synaptic Plasticity
Effects of Adolescent Synaptic Pruning
The study will use a PET-based measure of brain cell (neuron) connections (synapses) in young adults who have also obtained an MRI, to assess how the loss of brain cell connections (synaptic pruning) is captured by MRI-based…
- Trial name
- SPA PET (NCT07569718)
- Testing
- PET Imaging Scan using [11C]UCB-J
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beatriz Luna
Aging, Music
Brain Imaging and Behavioural Changes Following Cued-movement Training of Finger Sequences in Healthy Older Adults
The goal of this study is to examine changes in the brain, behavior, and personal experience when music is used to guide learning of finger movement sequences (compared to visual stimuli alone) in healthy older adults.
- Conditions
- Aging, Music, Motor Activity, Magnetic Resonance Imaging
- Trial name
- NMSOA (NCT06174740)
- Testing
- Music-cued audiovisual motor training, Visually-cued motor training
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universiteit Leiden
Fibromyalgia
An Exploration of the Neuroplasticity of Endogenous Analgesia in Health and Chronic Pain
Transcranial magnetic stimulation (TMS) is a neurophysiological tool for studying cortical functions, and in addition, has an analgesic therapeutic effect whose underlying mechanism is unknown.
- Trial name
- NCT02572726
- Testing
- active repeated transcranial magnetic stimulation
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Health Adult Subjects
Prefrontal Neuroplasticity and Coping Strategies in Healthy Population
The current study serves as a pilot for the GRF project "Predicting illness trajectories in fully remitted major depression using concurrent TBS/fNIRS." The project examines whether intermittent theta-burst stimulation (iTBS)…
- Trial name
- NCT07433829
- Testing
- Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Mild Cognitive Impairment
The Effects of Exercise on Synaptic Plasticity in Individuals With Mild Cognitive Impairment and in Healthy Aging.
The research is focused on ameliorating cognitive decline in aging and in individuals diagnosed with Mild Cognitive Impairment (MCI).
- Trial name
- NCT05663918
- Testing
- Self- determined Intensity Interval Training
- Where
- 6 sites in Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- McMaster University
Neuroplasticity
Reaction Time, Cognitive Function and Physical Fitness of Children and Adolescent Soccer Players
Investigation of the effect of an exercise program with visual stimuli on reaction time, cognitive function and physical fitness of children and adolescent soccer players.
- Trial name
- NCT05587907
- Testing
- FitLight Trainer
- Where
- Greece
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Mild Cognitive Impairment
Vision-based Speed of Processing Cognitive Training and Mild Cognitive Impairment
This project seeks to identify neural changes that occur in adults with mild cognitive impairment (MCI) after engagement in computerized cognitive training.
- Trial name
- NCT02559063
- Testing
- Vision-based speed of processing training, Mental leisure activities
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Muscle Weakness
Mitigating Neural Hypoexcitability and Weakness During Disuse in Women
Clinical trial The goal of this clinical trial is to learn how muscle weakness and atrophy develop during short periods of arm immobilization and whether a type of exercise called cross-education can help reduce these effects in…
- Trial name
- MiND (NCT07166198)
- Testing
- Wrist immobilization, Resistance training, Resistance training rehabilitation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kansas State University
Spatial Orientation, Balance
Neuroanatomical and Functional Changes in Response to an Intensive Balance Training
The purpose of this study is to determine whether intensive slackline training improves spatial orientation abilities, balancing skills and causes neuroplasticity in related brain cortical regions.
- Trial name
- NCT03056430
- Testing
- Training
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- German Center for Neurodegenerative Diseases (DZNE)
Methamphetamine Abuse
Contingency Management for Meth in South Africa Methamphetamine Abuse in South Africa
This study will link findings from neuroscience with clinical outcomes using contingency management (CM) to identify changes in brain structure and function that emerge during purely behavioral therapy for methamphetamine (MA)…
- Trial name
- NCT02907853
- Testing
- Contingency Management
- Where
- South Africa
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Stroke, Hemiplegia
Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) Over the Brain on the Neurotransmitter Binding
The purpose of this study is to determine whether repetitive transcranial magnetic stimulation (rTMS) over the brain can modulate the binding of neurotransmitter (GABA in this study) to its receptor using the special PET study.
- Trial name
- NCT01819675
- Testing
- Low frequency rTMS, High frequency rTMS
- Where
- South Korea
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Stroke With Hemiparesis
Strategies for Recovery of Dexterity Post Stroke
Motor learning can be affected by the sensory difficulties that may be experienced as a result of a stroke. This study will help us better understand what kinds of sensory information can help with the re-learning of grasping…
- Trial name
- NCT01977027
- Testing
- Alternate Hand Training or Affected Hand Training
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Normal Healthy Adults
Imaging Biomarkers of Neuroplasticity and Neurodegeneration in the Living Human Brain
Following our recently completed whole body dosimetry study for [18F] TRACK in 6 healthy control subjects, the objective of this project is to evaluate brain uptake, regional distribution and in vivo pharmacokinetics for [18F]…
- Trial name
- F18TRACK (NCT05427656)
- Testing
- [18F] TRACK, Measurement of Arterial Input Function
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Thiel, Alexander, M.D.
Depression, Healthy
Comparison of Measures of Plasticity
Neuroplasticity refers to the ability of the nerve cells to modify their structure or function in response to injury or insult, or other environmental stimuli, with these changes outlasting the period of exposure.
- Trial name
- NCT01317303
- Testing
- cTBS-PAS25, cTBS-iTBS, PAS25
- Where
- Australia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The University of New South Wales
Olfactory Disorder
Steroid Nasal Irrigation for Flavor Evaluation and Detection Study
The purpose of this research study is to examine the efficacy of a 12-week smell training intervention for participants with olfactory dysfunction following an infection of the upper respiratory tract.
- Trial name
- SNIFFED (NCT02985515)
- Testing
- Smell training
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Alzheimer's Disease
Neuroplasticity Enhancement From Cognitive Training Reinforced by Psilocybin
Background: Normal aging, as well as dementias such as Alzheimer s disease, can cause changes in the brain that affect memory, attention, and thinking.
- Trial name
- NCT07721467
- Testing
- Psilocybin, Cognitive Training
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)