Clinical trials: Neuronal Plasticity
Neuronal Plasticity
Simultaneous PET/MR Imaging of Human Brain Plasticity
Background: Neuronal plasticity is the brain's ability to continuously adapt to experiences and learning of new skills. Although this affects multiple characteristics of the brain such as structure, function and metabolism…
- Trial name
- NCT03485066
- Testing
- Tetris
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rupert Lanzenberger
Old Age; Dementia, Aging
Compensatory Brain Activity in Older Adults.
There are two important aspects in which the present project will allow to enrich our understanding of compensatory brain activity in older adults.
- Conditions
- Old Age; Dementia, Aging, Cognitive Decline
- Trial name
- BrainAct (NCT06235840)
- Testing
- working memory adaptive training, multi-domain non-adaptive control training
- Where
- Poland
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Kazimierz Wielki University
Cognitive Change
Brain Exercises for Synaptic Plasticity
The BEST study will investigate the feasibility of cognitive interventions in a randomized, placebo-controlled, clinical trial. The investigators will recruit 45 cognitively normal subjects and engage them in one of three cohorts…
- Trial name
- BEST (NCT03058055)
- Testing
- Origami, Reading
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Spinal Cord Injuries
Measuring the Neurological Benefits of Intermittent Hypoxia Therapy With MRI
This study uses Magnetic Resonance Imaging to image the brain and spinal cord before and after an Intermittent Hypoxia intervention.
- Trial name
- NCT05183113
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Analgesia Disorder, Pain
Neuroplasticity:Melatonin and Transcranial Current Stimulation in Healthy Subjects.
Pain exerts a tremendous cost in healthy care, rehabilitation and lost productivity. It is is associated with a wide range of diseases and their social consequences is a public health problem.
- Trial name
- NCT02195271
- Testing
- Transcranial Direct Current Stimulation (tDCS), Melatonin
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Healthy, Psychedelic Experiences
The ENHANCE Study: taVNS and Psilocybin
This study will examine whether combining a single dose of psilocybin with non-invasive transcutaneous auricular vagus nerve stimulation (taVNS), a potential inducer of neuroplasticity and enhanced memory formation, will enhance…
- Conditions
- Healthy, Psychedelic Experiences, Vagus Nerve Stimulation
- Trial name
- ENHANCE (NCT05866471)
- Testing
- Psilocybin, Transcutaneous auricular Vagus Nerve Stimulation (taVNS), Psychosocial Support Alone
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Anxiety
Neuroplasticity in an Extended Amygdala Network as a Target Mechanism for Attention Bias Modification Outcome
Anxiety disorders are one of the most common psychological disorders. Underlying anxiety is an increased attentional bias to threat, which has been identified as a causal contributor in the development of anxiety.
- Trial name
- NCT03092609
- Testing
- Attention Bias Modification, Attention Control
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Northern Michigan University
Healthy Ageing
Neuroplasticity: The Effects of Exercise Training on Cognitive and Affective Functioning of Older People
This study investigates the effects of exercise on older people's cognitive and affective functions, and the possible underlying neurobiological pathways.
- Trial name
- NCT04641429
- Testing
- Qigong exercise, Stretching exercise
- Where
- Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Motor Neuropathy
Stroke Recovery Research Based on EEG-fMRI
This study is aimed to investigate the post-stroke motor recovery of patients with ischemic stroke based on their neural features extracted from EEG-fMRI data.
- Trial name
- EEG-fMRI (NCT05427422)
- Testing
- MRI recording, EEG recording
- Where
- China
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Xi'an Jiaotong University
Amblyopia
An Active Approach to Treat Amblyopia: Perceptual Learning and Video Games
Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast.
- Trial name
- NCT01115283
- Testing
- Perceptual learning, Video Games, Occlusion therapy
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Depression, Depressive Disorder
Acute Aerobic Exercise and Neuroplasticity in Depression
Depression is associated with a disruption in the mechanisms that regulate neuroplasticity. Effective treatment and rehabilitation of depression, and other neurological and neuropsychiatric disorders, relies on neuroplasticity.
- Trial name
- NCT02839837
- Testing
- Aerobic Exercise, Paired Associative Stimulation
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Fibromyalgia
Neurophysiology of Fibromyalgia
Fibromyalgia is a syndrome associated with fatigue and chronic pain, leading to significant physical limitations and impaired quality of life.
- Trial name
- NCT06006130
- Testing
- Active Controlled Pulse Parameter Transcranial Magnetic Stimulation (cTMS)
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- McMaster University
The Current Study Focuses on Investigating the Short-term Effect of BFRT on the Somatosensory System Among Healthy Young Adults
The Short-term Effect of Low-load Resistance Training with Blood-flow Restriction on Somatosensory-evoked Potentials in Healthy Young Adults
The goal of this clinical trial is to investigate the short-term effect of lower limb BFRT on the somatosensory processing and related changes in SSEP amplitude and latency.
- Trial name
- NCT06762912
- Testing
- Passive application of BFR cuff, Resistance exercise with BFR, Resistance exercise without BFR
- Where
- United Arab Emirates
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sharjah
Healthy, Healthy Adult
Effects of Repetitive Transcranial Magnetic Stimulation on Two Cerebellar Targets
The purpose of this study is to understand how different areas of the cerebellum (a part of the brain) control different functions and how they can be influenced by non-invasive brain stimulation.
- Trial name
- StimCervelet (NCT07561229)
- Testing
- Active rTMS - Lobule VIII, Active rTMS - Crus I/II, Cognitive and Motor Assessment Battery
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Pain, Postoperative, Pain, Chronic
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
- Conditions
- Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury
- Trial name
- NCT04439552
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Parkinson Disease
Evidence of Neuroplasticity After Performing a Cognitive Task in Idiopathic Parkinson's Disease Patients
As seen in previous studies Diffusion Tensor Imaging (DTI) MRI is able to detect very subtle changes in brain tissue even after a very short timescale of hours resulting from performing a cognitive task and learning, We wish to…
- Trial name
- NCT02494908
- Testing
- Playing a computer game simulating a car race
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Dr. Sharon Hassin
Cerebral Palsy
Robot-assisted Training in Children With CP
Cerebral palsy (CP) is the most common physical disability in early childhood causing serious motor and sensory impairments. Effective interventions for the recovery of motor functions are of profound significance to children…
- Trial name
- NCT06450158
- Testing
- Robot (Amadeo)-assisted Training
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cook Children's Health Care System
Healthy Controls
Serotonin and Motor Plasticity
With this study, the investigators aim to test whether acute administration of selective serotonin reuptake inhibitors (SSRI) improves motor performance in a sequential motor learning task in comparison to placebo in healthy…
- Trial name
- NCT03162185
- Testing
- Escitalopram
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Max Planck Institute for Human Cognitive and Brain Sciences
Normal Healthy Adults
Imaging Biomarkers of Neuroplasticity and Neurodegeneration in the Living Human Brain
Following our recently completed whole body dosimetry study for [18F] TRACK in 6 healthy control subjects, the objective of this project is to evaluate brain uptake, regional distribution and in vivo pharmacokinetics for [18F]…
- Trial name
- F18TRACK (NCT05427656)
- Testing
- [18F] TRACK, Measurement of Arterial Input Function
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Thiel, Alexander, M.D.
Cocaine Use Disorder, Cocaine Dependence
Theta-Burst Stimulation as a Treatment for Reducing Cocaine Use
Objective: The goal of this clinical trial is to assess the tolerability of an accelerated intermittent theta burst stimulation (iTBS), a form of transcranial magnetic stimulation, intervention in participants with cocaine use…
- Trial name
- NCT02927236
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)