Clinical trials: Neuropathic
Neuropathic Pain
'Fix the Dysfunction' Concept for Mechanism-based Pharmacological Treatment of Neuropathic Pain by Drug
Introduction Treatment of neuropathic pain has been a goal of numerous research projects for the last half century, with overall disappointing results.
- Trial name
- 0381-16 (NCT03276689)
- Testing
- Duloxetine, Pregabaline
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Traumatic Spinal Cord Injury, Neuropathic Pain
Biomarkers for Pain in Spinal Cord Injury Patients
The investigators propose to compare plasma protein profiles for SCI patients with/without chronic neuropathic pain in order identify biomarker(s) that are associated with this medical condition.
- Trial name
- SCI Pain (NCT00913471)
- Testing
- blood samples
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Chronic Pain
Motivational Behavioral and Functional MRI Impairment in Patients With Chronic Neuropathic Pain
The main hypothesis of this study is that the alteration of the reward circuitry underlying the motivational deficit in chronic pain patients compared to healthy subjects results in a decrease in the capacity for reward learning.
- Trial name
- MOTION (NCT05701852)
- Testing
- reward learning task
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Peripheral Neuropathic Pain, Nociceptive Pain
Determine the Effect of AZD3161,Injected Intradermally, on Quantitative Sensory Testing Variables in Normal and Ultraviolet-C (UVC) Exposed Skin in Healthy Volunteers
The purpose of this study is to investigate the effect of AZD3161 on mechanical pain sensitivity and axon reflex flare in normal and ultraviolet C irradiated skin.
- Trial name
- NCT01240148
- Testing
- AZD3161, Lidocaine
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Neuropathic Pain
Evaluation of an ATP-Containing Parenteral Vitamin B Complex in Patients With Symptomatic Diabetic Polyneuropathy
Epinosine B Forte ampoule is an intramuscular injectable supplement containing adenosine triphosphate (ATP), Cocarboxylase (vitamin B1 derivative), vitamin B12, and nicotinamide (vitamin B3).
- Trial name
- NCT07296354
- Testing
- adenosine triphosphate, Vitamin B Complex
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Egyptian International Pharmaceutical Industries Co
Corneal Pain, Chronic Pain
Effects of Transcranial Direct Current Stimulation (tDCS) in Chronic Corneal Pain
In this study the investigators aim to examine the effects of Transcranial Direct Current Stimulation (tDCS) on pain levels as well as the changes in cognitive (thought) processing in individuals with chronic pain of the cornea…
- Conditions
- Corneal Pain, Chronic Pain, Neuropathic Pain
- Trial name
- NCT01575002
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Neuropathic Pain
Exploring the Role of the GABAergic Modulation in Pain Transmission in Human
Neuropathic pain affects about 7% of the general population in European countries. Meta-analyses indicate that only a minority of neuropathic pain patients has adequate response to drug therapy and management of neuropathic pain…
- Trial name
- NDMC-101 (NCT03375034)
- Testing
- NDMC 20mg, NDMC60mg, Clonazepam 1.5mg
- Where
- Switzerland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Jules Desmeules
Pain, Acute, Pain, Neuropathic
Exercise and Pain in Non-Hispanic Blacks and Whites
Non-Hispanic Blacks tend to report higher levels of pain, experience pain more frequently, and be under-treated for pain compared to non-Hispanic Whites.
- Conditions
- Pain, Acute, Pain, Neuropathic, Analgesia, Aerobic Exercise
- Trial name
- NCT03609957
- Testing
- Aerobic Exercise Training, Interval Training
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Georgia State University
Chronic Pain, Acute Pain
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary…
- Conditions
- Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Primary
- Trial name
- NCT05754190
- Testing
- SOMA pain manager smartphone application
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Brown University
Neuropathic Pain
Development of Stimulator Pneumatic for Realization of Evoked Potential Allodynic/Somatosensory
The stimuli used in the evoked potentials are electrical or laser. They are started and synchronized with the collection of the EEG by signals TTL (transistor-transistor logic).
- Trial name
- STIMEA (NCT02527590)
- Testing
- pneumatic stimulations(allodynic area), pneumatic stimulations (healthy area), pneumatic stimulations no auditory masking
- Where
- France
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Dry Eye, Neuropathic Pain
Effect of Trigeminal Nerve Stimulation on Corneal Nerves and Chronic Ocular Pain
Individuals with dry eye tend to present with ocular pain which persists despite the use of topical treatment. This could be secondary to somatosensory impairment attributable to neuropathic pain.
- Conditions
- Dry Eye, Neuropathic Pain, Eye Pain
- Trial name
- NCT04648085
- Testing
- Trigeminal Nerve Stimulation
- Where
- Mexico
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Neuropathic Pain
GABAergic Modulation in Pain Transmission in Human: Effect of the GABAA Agonist Clobazam on Peripheral and Central Sensitisation
In animal, the GABAergic system modulates central sensitisation, which is a key phenomenon in pain processing. The development of GABAA agonists targeting the subunits of the GABAA receptor implicated in nociception, but not the…
- Trial name
- NCT01291316
- Testing
- Clonazepam, Tolterodine, clobazam
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Pain Management, Peripheral Neuropathic Pain
Wearable Focused Ultrasound Stimulation for Peripheral Nerve Pain Management
This study will evaluate the feasibility of a novel wearable focused ultrasound (FUS) device for peripheral nerve stimulation in healthy volunteers.
- Trial name
- PERNEUS (NCT07160049)
- Testing
- Cold Pressor Task - Upper Limb, Algometry Pain Tests in the Upper Limb, Algometry Pain Tests in the Lower Limb
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Evan (Huiliang) Wang
Epilepsy and Neuropathic Pain
Evaluation of Individual Bioequivalence of Gabasandoz® Relative to Neurontin® in Healthy Volunteers
The NO SWITCH list is based on the hypothesis that the pharmacokinetic differences between different batches of one medicines are smaller than the pharmacokinetic differences between two medicines (from a different manufacturer…
- Trial name
- DRUG13-GABA (NCT01821235)
- Testing
- Neurontin® (gabapentin) batch A, Neurontin® (gabapentin) batch B, Gabasandoz® (gabapentin) batch A
- Where
- Belgium
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Pain, Neuropathic
Pregabalin add-on for Neuropathic Pain in Cervical Myelopathy
There is no information on the effect of pregabalin in patients with neuropathic pain in cervical myelopathy under routine clinical practice.
- Trial name
- NCT03618589
- Testing
- Pregabalin, Opioid
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Diabetes, Peripheral Neuropathy
Metanx Effects on Nerve Fiber Density in Neuropathic Diabetics
This study focuses on the use of Metanx® as the sole treatment for improving and reversing nerve damage in type 2 diabetic patients with peripheral neuropathy.
- Trial name
- SLHN2011-18 (NCT01503892)
- Testing
- Metanx
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St. Luke's Hospital and Health Network, Pennsylvania
Chronic Pain
Human Pain Atlas for Sensory Neurons
This study aims to improve our understanding of how the nerves that detect and transmit pain signals work in humans. Chronic pain affects millions of people worldwide and can be difficult to treat because the biological…
- Trial name
- H-Passion (NCT07740681)
- Testing
- Microneurography
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Neuropathic Pain
The Prevalence of Neuropathic Pain Pathophysiology Associated With Ankle Fracture
This application addresses the Peer Reviewed Medical Research Program Investigator-Initiated Research Award FY21 W81XWH-22-CPMRP-IIRA area of Chronic Pain Management Research Program- The investigators will utilize subjects who…
- Trial name
- AFNP (NCT06420141)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Indiana University
Pain, Pruritus
Desensitization of Nociceptive Afferents by Application of Topical Capsaicin, Trans-cinnamaldehyde and L-menthol
The purpose of this study is to investigate the potential desensitising effects of repeated applications of capsaicin, trans-cinnamaldehyde and L-menthol on thermal, mechanical and chemical sensory stimulations.
- Conditions
- Pain, Pruritus, Neuropathic Pain, Dermatology/Skin - Other
- Trial name
- NCT03132142
- Testing
- Capsaicin, Trans-cinnamaldehyde, L-Menthol
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Neuralgia, Neuralgia; Postherpetic
Evaluation of an Effectiveness and Safety of the Electroacupuncture in the Management of Intractable Neuropathic Pain
The investigators will evaluate the effectiveness and safety of acupuncture treatment in refractory neuropathic pain patients.
- Conditions
- Neuralgia, Neuralgia; Postherpetic, Diabetic Neuropathy, Painful, Failed Back Surgery Syndrome
- Trial name
- NCT03315598
- Testing
- Electroacupuncture
- Where
- South Korea
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Seoul National University