Clinical trials: Neuropathic
Phantom Limb Pain
Peripheral Magnetic Stimulation (PMS) Effects on Somatosensory Perception in Patients with Upper Limb Amputation
The study investigates the capabilities of peripheral magnetic stimulation (PMS) as a tool for creating somatosensory sensations of various submodalities and analyzing the dynamics of bioelectric signals of the brain (using…
- Trial name
- NCT06813937
- Testing
- Procedure: Peripheral Magnetic Stimulation (PMS), Electroencephalography (EEG)
- Where
- Russia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Skolkovo Institute of Science and Technology
Chronic Noncancer Pain
Integrating Patient Reported Outcomes (I-PRO) Study for Multidisciplinary Pain Care
The purpose of this study is to assess the impact of clinician education, electronic health record integrated patient reported outcomes, and electronic health record integrated decision support on pain-related care quality…
- Trial name
- I-PRO (NCT02188667)
- Testing
- Providers of Novel Care, Providers of Usual Care
- Where
- 4 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Florida
Osteoarthritis, Pain
A SAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers
A First-in-Human, Double-blind, Randomized, Placebo-controlled, Single Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics/Pharmacodynamics of iN1011-N17 after Oral Administration in Healthy Volunteers.
- Conditions
- Osteoarthritis, Pain, Post Herpetic Neuralgia, Neuropathic Pain
- Trial name
- NCT05496205
- Testing
- iN1011-N17
- Where
- Australia
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- iN Therapeutics Co., Ltd.
Neuropathic Pain Diagnostic Questionnaire (DN4) ≥ 4
Reiki and Reflexology Massage Diyabetik Neuropathy Pain
Diabetes Mellitus is a chronic endocrine and metabolic disease that occurs as a result of insufficiency, absence and/or deficiency of the insulin hormone secreted from the beta cells of the pancreas, and is characterized by…
- Trial name
- NCT06979739
- Testing
- reiki, refleksologia, reiki and refleksologia
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Traumatic Spinal Cord Injury, Neuropathic Pain
Biomarkers for Pain in Spinal Cord Injury Patients
The investigators propose to compare plasma protein profiles for SCI patients with/without chronic neuropathic pain in order identify biomarker(s) that are associated with this medical condition.
- Trial name
- SCI Pain (NCT00913471)
- Testing
- blood samples
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Chronic Post-surgical Pain, Postoperative Pain After Thoracic Surgery
Prevalence and Risk Factors for Chronic Post-Surgical Pain Following Video-Assisted Thoracic Surgery : The EVATHO Prospective Bicentric Cohort Study.
Chronic post-surgical pain (CPSP) remains a common complication after thoracic surgery and may significantly impair patients' quality of life.
- Conditions
- Chronic Post-surgical Pain, Postoperative Pain After Thoracic Surgery, Neuropathic Pain, Thoracic Surgical Procedures
- Trial name
- EVATHO (NCT07687082)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Healthy Adult Participants
Safety, Tolerability and Pharmacokinetics of Oral Ketamir-2 in Healthy Adult Subjects
This is a prospective, randomized, double-blind, placebo-controlled study designed to evaluate the safety, tolerability, and pharmacokinetics of oral Ketamir-2 in healthy adult participants.
- Trial name
- NCT07791303
- Testing
- Ketamir-2
- Where
- Israel
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- MIRA Pharmaceuticals
Neuropathic Pain
Adrenocorticotropic Axis and Neuropathic Pain
Chronic pain is often associated with a chronic stress and HHSG axis plays a pivotal role in maintaining homeostasis. The literature reports that pain in patients treated with opioids, significant changes are taking place in this…
- Trial name
- HORMONES (NCT01543425)
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Diabetes Mellitus, Patient Engagement
Foot Reflexology in Diabetic Patients With Neuropathic Pain
This study was carried out to determine the effect of foot reflexology applied to diabetic patients with neuropathic pain on their quality of life, hope and pain levels.
- Conditions
- Diabetes Mellitus, Patient Engagement, Reflexology
- Trial name
- NCT05878431
- Testing
- Foot Reflexology
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Muş Alparslan University
Ipsi- and Contralateral Hypoesthesia
A Human Experimental Model for Neuropathic Pain Using Combined Application of Capsaicin and Local Anesthetics
Main of the present study was to develop a model of concomitant C-fibre block and sensitization eliciting spontaneous pain as well applying topical capsaicin and local anesthetics (LA) to examine the sensory alterations after…
- Trial name
- NCT01540877
- Testing
- Application of capsaicin 0.6%, Application of local anesthetics (EMLA plaster), Application of 1 capsaicin 0.6% and 2. EMLA
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Peripheral Nerve Injuries
Chronic Neuropathic Pain After Nerve Repair Hand Surgery
This study intends to compare the patients with pain with those who underwent same procedure without developing pain. The patients with pain and without pain will be further analyzed in respect to clinical differences, biomarkers…
- Trial name
- NCT03174665
- Testing
- No intervention
- Volunteers
- 990 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Chronic Pain Syndrome, Pain
Veteran Ear Acupuncture Pilot Project
Veterans who have responded well to Battlefield Acupuncture (BFA), a form of auricular acupuncture, in routine clinical practice will be invited to receive education to insert the needles themselves at home.
- Conditions
- Chronic Pain Syndrome, Pain, Fibromyalgia, Low Back Pain
- Trial name
- SAAAPP (NCT04208659)
- Testing
- Self-administration of auricular acupuncture without prosthesis, Self-administration of auricular acupuncture with prosthesis
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Chillicothe VA Medical Center
Diabetes Mellitus, Diabetes Complications
Comparison of Resin Salve and Octenidine in Patients With Neuropathic Diabetic Foot Ulcers
Prevalence of diabetic foot ulcers are reported to be 15% in patients who suffer from diabetes and ulcerations are present in 84% of all diabetes-related amputations.
- Conditions
- Diabetes Mellitus, Diabetes Complications, Diabetic Neuropathies, Wound Infection
- Trial name
- NCT02169167
- Testing
- Resin salve treatment, Octenidine treatment
- Where
- Poland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Janne J. Jokinen
Neuropathic Pain, Osteo Arthritis Knee
WHIRLPOOL FOR OSTEOARHRITIS
Both neuropathic and nociceptive mechanisms may contribute to the OA pain experience. Aims: The aim of this study was to determine the efficacy of warm whirlpool on pain, disability, quality of life (QoL) and sleep for patients…
- Conditions
- Neuropathic Pain, Osteo Arthritis Knee, Sleep Disorder
- Trial name
- NCT03299114
- Testing
- Whirlpool
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ufuk University
Neuropathic Pain
Analgesic Effect of Non Invasive Stimulation : Transcranial Direct Current Stimulation of Opercular-insular Cortex
The aim of this study is to evaluate, versus placebo, the analgesic efficacy of the opercular-insular cortex stimulation with Transcranial Direct Current Stimulation (tDCS), in both healthy subjects and chronic neuropathic pain…
- Trial name
- STIM-INSULA (NCT03015558)
- Testing
- transcranial direct current stimulation of opercular-insular cortex - anodal active tDCS session, transcranial direct current stimulation of opercular-insular cortex - active control session
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Healthy Volunteers, Chronic Pain Syndrome
A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Oral Administration of AJH-2947 in Healthy Korean and/or Caucasian Adult Male Subjects
The purpose of this randomized, double-blind, placebo-controlled Phase 1 study was to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple oral doses of AJH-2947 in healthy Korean or…
- Trial name
- NCT06155487
- Where
- South Korea
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- JMackem Co., Ltd
Neuralgia, Neuralgia; Postherpetic
Evaluation of an Effectiveness and Safety of the Electroacupuncture in the Management of Intractable Neuropathic Pain
The investigators will evaluate the effectiveness and safety of acupuncture treatment in refractory neuropathic pain patients.
- Conditions
- Neuralgia, Neuralgia; Postherpetic, Diabetic Neuropathy, Painful, Failed Back Surgery Syndrome
- Trial name
- NCT03315598
- Testing
- Electroacupuncture
- Where
- South Korea
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Seoul National University
Neuropathic Pain
GABAergic Modulation in Pain Transmission in Human: Effect of the GABAA Agonist Clobazam on Peripheral and Central Sensitisation
In animal, the GABAergic system modulates central sensitisation, which is a key phenomenon in pain processing. The development of GABAA agonists targeting the subunits of the GABAA receptor implicated in nociception, but not the…
- Trial name
- NCT01291316
- Testing
- Clonazepam, Tolterodine, clobazam
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Pain, Pruritus
Desensitization of Nociceptive Afferents by Application of Topical Capsaicin, Trans-cinnamaldehyde and L-menthol
The purpose of this study is to investigate the potential desensitising effects of repeated applications of capsaicin, trans-cinnamaldehyde and L-menthol on thermal, mechanical and chemical sensory stimulations.
- Conditions
- Pain, Pruritus, Neuropathic Pain, Dermatology/Skin - Other
- Trial name
- NCT03132142
- Testing
- Capsaicin, Trans-cinnamaldehyde, L-Menthol
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Behcet's Disease, Central Sensitisation
Assessment of Central Sensitization, Neuropathic Pain, Sleep Quality and Daily Life Activities in Behcet's Disease
There are few studies in the literature regarding increased frequency of neuropathic pain and sleep disturbance and decreased quality of life in Behçet's disease.
- Trial name
- NCT03531385
- Testing
- Central sensitisation, Neuropathic pain, Sleep disturbance
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital