Clinical trials: Neuropathy, Diabetic
Diabetic Foot Ulcer
AmnioExcel® Plus vs SOC in the Management of Diabetic Foot Ulcers
This is a prospective, multicenter, randomized, parallel-group Trial comparing the outcomes associated with the use of AmnioExcel® Plus Placental Allograft Membrane (AmnioExcel® Plus) used in conjunction with Standard of Care…
- Trial name
- NCT05024656
- Testing
- AmnioExcel Plus Amniotic Membrane, Standard of Care
- Sponsor
- Integra LifeSciences Corporation
Diabetic Peripheral Neuropathy
Comparative Effects of Balance and Resisted Training in Diabetic Peripheral Neuropathy.
The aim of this study is to determine comparative effects of balance and resisted training on pain and balance in patients with daibetic peripheral neuropathy.
- Trial name
- NCT06303453
- Testing
- Balance exercises, Resisted exercises
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- Riphah International University
Painful Diabetic Peripheral Neuropathy
High-frequency SCS Versus SCS in the Treatment of Diabetic Peripheral Neuropathic Pain
Application of High-Frequency Spinal Cord Stimulation (HF-SCS) in the Treatment of Painful Diabetic Peripheral Neuropathy (PDPN): A multicenter, randomized controlled study comparing its clinical efficacy with traditional spinal…
- Trial name
- NCT06158529
- Testing
- spinal cord stimulator, high frequency spinal cord stimulation
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Fan BiFa
Diabetic Peripheral Neuropathy, Neuralgia
A Study of the Efficacy and Safety of Amitriptyline/Ketamine Topical Cream in Patients With Diabetic Peripheral Neuropathy
This is a multicenter, randomized, placebo-controlled, parallel group study of EpiCept™ NP-1 Topical Cream (amitriptyline 4%/ketamine 2%) in approximately 200 patients with pain in the lower extremities due to diabetic nerve pain.
- Trial name
- NCT00476151
- Testing
- EpiCept NP-1 (4% Amitriptyline/ 2% Ketamine) Topical Cream
- Where
- India
- Volunteers
- 226 people
- Sponsor
- EpiCept Corporation
Diabetic Neuropathies, Mobility
Effects of Modified Otago Versus Action Observation on Strength, Mobility and Fall Risk in Diabetic Neuropathy
To compare the Effects of Modified Otago Exercise and Action Observation Training on strength, functional mobility and fall risk in patients with diabetic neuropathy.
- Conditions
- Diabetic Neuropathies, Mobility, Fall
- Trial name
- NCT06459375
- Testing
- modified otago exercises, Action Observation Training
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Diabetic Neuropathies
Effect of Educational Booklet for Foot-related Exercises for Prevention and Treatment in People With Diabetic Neuropathy
The main objective of this trial is to investigate the effect of an educational booklet foot-related exercise in diabetic neuropathy status, functional outcomes and gait biomechanics in people with diabetic neuropathy.
- Trial name
- FOCA-II (NCT04008745)
- Testing
- Educational and home-based physical therapy by foot-related exercises
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
Diabetes Mellitus (DM)
Central Sensitization in Painful and Painless Diabetic Peripheral Neuropathy
This research is structured as a cross-sectional observational study. The primary objective is to compare central sensitization across painful and painless phenotypes of diabetic peripheral neuropathy.
- Trial name
- NCT07316322
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Inonu University
Diabetic Foot Ulcer, Venous Leg Ulcer
Assessment of Wound Closure Comparing Synthetic Hybrid-Scale Fiber Matrix With Standard of Care in Treating Diabetic Foot Ulcers (DFU) and With Living Cellular Skin Substitute in Treating Venous Leg Ulcers (VLU)
In participants with diabetic foot ulcers (DFUs), this study will assess complete wound closure by comparing synthetic hybrid-scale fiber matrix (Restrata®) with standard of care.
- Trial name
- NCT04927702
- Testing
- Synthetic Hybrid-Scale Fiber Matrix, Standard of Care, Living Cellular Skin Substitute
- Where
- 6 sites in United States
- Volunteers
- 48 people
- Sponsor
- Acera Surgical, Inc.
Diabetic Neuropathy, Painful; Diabetic Neuropathies
Safety, Tolerability and Preliminary Efficacy of AZD5213 in Combination With Pregabalin in Subjects With PDN and Good Pain Reporting Ability
This is a 2-part study. In Part 1 of the study, subjects will undergo a pain reporting training program in which a painful stimulus will be applied to the subject's hand, and the subjects will be asked to report how painful the…
- Trial name
- NCT01928381
- Testing
- AZD5213 + pregabalin, pregabalin capsules
- Where
- 9 sites in United States
- Volunteers
- 150 people
- Sponsor
- AstraZeneca
Painful Diabetic Neuropathy, Diabetic Neuropathy
Study of Clonidine Hydrochloride Topical Gel, 0.1% in the Treatment of Pain Associated With Diabetic Neuropathy
The purpose of the study is to determine whether clonidine gel is an effective treatment for reducing the pain associated with painful diabetic neuropathy.
- Conditions
- Painful Diabetic Neuropathy, Diabetic Neuropathy, Neuropathy
- Trial name
- NCT02068027
- Testing
- Clonidine Gel 0.1%
- Where
- 23 sites in United States
- Volunteers
- 260 people
- Sponsor
- BioDelivery Sciences International
Multidisciplinary Approach, Clinical Pharmacists
Multidisciplinary Approach to Improve Diabetic Foot Care: an Investigation of Clinical and Economic Outcomes.
The study intervention was applying multidisciplinary approach consisting of an endocrinologist, a diabetes specialized nurse, and a clinical pharmacist to assess and improve diabetic foot care using a systematic screening…
- Conditions
- Multidisciplinary Approach, Clinical Pharmacists, Diabetic Foot Ulcer (DFU), Multidisciplinary Care Team
- Trial name
- NCT06658691
- Testing
- Multidisciplinary approach
- Where
- Jordan
- Volunteers
- 119 people
- Sponsor
- University of Jordan
Painful Diabetic Neuropathy
Multimodal Intervention for Painful Diabetic Neuropathy: NeuOst Feasibility Trial
This is the feasibility study of a single-site parallel three-armed participant-blinded controlled randomised efficacy trial of a 5-week course of the 'NeuOst treatment', compared to a designated control intervention, and to…
- Trial name
- NeuOst (NCT06423391)
- Testing
- NeuOst, Control Intervention, Usual Care
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University College of Osteopathy
Foot Ulcer, Diabetic Foot
A Study on the Efficacy and Safety of Long-Term Treatment and Re-Treatment of Lower Extremity Diabetic Ulcers With REGRANEX
The purpose of this study is to evaluate the efficacy and safety of REGRANEX® Gel compared with placebo when applied for up to 52 consecutive weeks to recurring or non-healing ulcers of the ankle or foot related to diabetes.
- Conditions
- Foot Ulcer, Diabetic Foot, Skin Ulcer, Diabetic Neuropathies
- Trial name
- NCT00034788
- Testing
- Becaplermin
- Volunteers
- 84 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Diabetes Mellitus, Diabetic Foot
Educational Interventions on Diabetic Foot Care
Diabetes mellitus currently affects 463 million people worldwide. One of the most serious complications of diabetes is the diabetic foot.
- Trial name
- NCT04811989
- Testing
- Instructive video on diabetic foot care, Informative leaflet with real-time guided reading, Informative leaflet to read at home
- Where
- 2 sites in Portugal
- Volunteers
- 71 people
- Sponsor
- University of Minho
Diabetes Mellitus, Diabetic Foot Ulcer
Evaluation of 3D Imaging Ulcer Camera
The aim of the study is to evaluate the intra- and inter-rater variability of wound measurements using the 3D camera and to compare with standard measurement methods (2D image method and gel injection).
- Conditions
- Diabetes Mellitus, Diabetic Foot Ulcer, Wound, Chronic Disease
- Trial name
- 3D-DFU (NCT03063138)
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Odense University Hospital
Diabetic Ulcer of Plantar Aspect of Left Foot, Diabetic Ulcer of Plantar Aspect of Right Foot
Nerve Decompression for Ulcer Recurrence Avoidance (DURA)
Anecdotal reports and scientific literature suggest that the risk of recurrence of diabetic foot ulcers can be minimized by nerve decompression procedures at anatomic sites of nerve pinching and entrapment.
- Conditions
- Diabetic Ulcer of Plantar Aspect of Left Foot, Diabetic Ulcer of Plantar Aspect of Right Foot, Diabetic Polyneuropathy
- Trial name
- DURA (NCT01762085)
- Testing
- nerve decompression
- Where
- 6 sites in United States
- Volunteers
- 120 people
- Sponsor
- Association of Extremity Nerve Surgeons
Diabetic Neuropathies
Plantar Cutaneous Sensory Stimulation in Patients With Diabetic Neuropathy
To determine the effects of plantar cutaneous sensory stimulation on foot tactile sensitivity, postural control, and spatiotemporal gait parameters in patients with diabetic neuropathy.
- Trial name
- NCT06292468
- Testing
- Traditional physical therapy, Plantar cutaneous sensory stimulation
- Where
- 2 sites in Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Diabetic Foot Ulcer
Effectiveness and Safety of Early-Stage Amputation and External Herbs Chitosan for Diabetic Foot Ulcer
Diabetic Foot as the popular chronic complications of diabetes, is one of the main factors leading to limb amputation, it was reported that the amputation rate is 15 times of the non-diabetic patients.
- Trial name
- NCT02413086
- Testing
- Early-stage amputation, Amputation, External herbs chitosan
- Volunteers
- 320 people
- Sponsor
- Heilongjiang University of Chinese Medicine
Venous Hypertension Ulcers, Venous Stasis Ulcer
Cooling Leg and Foot Ulcer Skin Post Healing to Prevent Ulcer Recurrence
The goal of this study is to test MUSTCOOL, a home-based self-monitoring and self-management ulcer prevention intervention for patients with newly healed chronic venous leg and diabetic foot ulcers.
- Conditions
- Venous Hypertension Ulcers, Venous Stasis Ulcer, Venous Ulcer, Venous Insufficiency
- Trial name
- MUSTCOOL (NCT02626156)
- Testing
- Cooling gel pack, Cooling cotton pack
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Medical University of South Carolina
Osteomyelitis, Prosthetic Joint Infection
Short or Long Antibiotic Regimes in Orthopaedics
Research question: If adults with bone or joint infection have local antibiotic therapy, can they do without prolonged treatment with antibiotics by mouth (oral) or injection? Adults with bone or joint infections are usually…
- Conditions
- Osteomyelitis, Prosthetic Joint Infection, Diabetic Foot
- Trial name
- SOLARIO (NCT03806166)
- Testing
- Shorter Systemic Antibiotics, Standard treatment
- Where
- 23 sites in Germany, Portugal and 2 more
- Volunteers
- 500 people
- Sponsor
- Oxford University Hospitals NHS Trust
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.