Clinical trials: Neuropathy, Diabetic
Diabetic Foot Ulcer
The Therapeutical Role of Continuous Intra-femoral Artery Infusion of Urokinase on Diabetic Foot Ulcers
Diabetic foot ulcers (DFU) are one of the chronic consequences of diabetes which constitute the most important cause of non-traumatic amputation of the inferior limbs.
- Trial name
- NCT01108120
- Testing
- continuous intra-femoral thrombolysis group, Conventional therapy group
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xiang Guang-da
Diabetic Foot Ulcer
Safety and Efficacy Study of APIC-PRP in Non-healing Diabetic Foot Ulcers
Patients have a diabetic foot ulcer that is older than 4 weeks and has been treated with physician-selected standard of care treatment such as debridement, hydrogel or saline irrigation, primary dressing, and offloading will be…
- Trial name
- NCT02209662
- Testing
- APIC-PRP
- Volunteers
- 274 people
- Sponsor
- Cytonics Corporation
Diabetic Peripheral Neuropathy
In Vivo Corneal Confocal Microscopy for Non-invasive Assessment of Diabetic Peripheral Neuropathy
Clinical in vivo confocal microscopy (IVCM) is a relatively new technique of corneal evaluation that permits non-invasive imaging of corneal structures on the cellular level.
- Trial name
- NCT01695629
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Diabetic Peripheral Neuropathy
Effect of Pulsing Electrical Fields on Lower Extremity Diabetic Neuropathy: A Pilot, Open-Label Study
To determine if pulsed electric field therapy reduces lower leg and foot pain associated with diabetic neuropathy and lessens the need for medication.
- Trial name
- DPN (NCT00614341)
- Testing
- MedRelief SE 55
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- MedRelief
Diabetic Foot
Can Topical Oxygen Therapy (Natrox™) Improve Wound Healing in Diabetic Foot Ulcers?
Diabetic foot complications care represent a significant burden to the Canadian healthcare system. The estimated annual expenditure in Canada for diabetic foot ulcers is more than $150 million.
- Trial name
- NCT02599805
- Testing
- Natrox™ Oxygen Delivery System (ODS)
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Diabetes Mellitus
Improvement of Sensibility in the Foot in Diabetic Patients Induced by EMLA-application to the Lower Leg
Sensory input from the foot as well as all other body parts results in activation of sensory cortex. It is well known that the cortical body map is experienced-dependant and can rapidly change in response to changes in activity…
- Trial name
- NCT00959595
- Testing
- EMLA cream
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Lund University Hospital
Diabetic Foot Ulcers
Evaluation of Windowed Casts With and Without Regranex® Gel for Healing Diabetic Neuropathic Ulcers
The objective of this study is to compare the effectiveness and safety of windowed casts with Regranex® (topical becaplermin gel) versus placebo (inactive medication) for treatment of diabetic ulcers on the legs and feet.
- Trial name
- NCT00446472
- Testing
- Regranex®, Hydrogel
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Southern California Institute for Research and Education
Diabetic Foot Ulcer
Orthotic Treatment of Diabetic Foot Ulcers
The United States Department of Veterans Affairs spends an estimated $1.5 billion a year on healthcare for patients with diabetes. The prevalence and complications of diabetes increase with age.
- Trial name
- NCT05094037
- Testing
- Removable cam walker boot, Counseling
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- VA Office of Research and Development
Diabetic Neuropathies, Mobility
Effects of Modified Otago Versus Action Observation on Strength, Mobility and Fall Risk in Diabetic Neuropathy
To compare the Effects of Modified Otago Exercise and Action Observation Training on strength, functional mobility and fall risk in patients with diabetic neuropathy.
- Conditions
- Diabetic Neuropathies, Mobility, Fall
- Trial name
- NCT06459375
- Testing
- modified otago exercises, Action Observation Training
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Diabetic Foot Ulcers
Evaluation of Woulgan in Diabetic Foot Ulcer
The aim of the current study is to support the performance and safety of Woulgan® in the treatment of diabetic foot ulcer in comparison with the commercially available hydrogel Intrasite.
- Trial name
- NCT02631512
- Testing
- Woulgan Gel, Intrasite Hydrogel
- Where
- 3 sites in Sweden, United Kingdom
- Volunteers
- 62 people
- Sponsor
- Biotec Pharmacon ASA
Diabetic Foot
Autologous Micro-fragmented Adipose Tissue in the Treatment of Minor Amputations of Diabetic Foot
This is a randomized controlled monocentric study on 114 diabetic patients with the aim of evaluating the efficacy of the lipofilling with Lipogems® system in diabetic patients that are candidates for a minor amputation in the…
- Trial name
- NCT03276312
- Testing
- Lipogems
- Where
- Italy
- Volunteers
- 112 people
- Sponsor
- University of Modena and Reggio Emilia
Diabetic Neuropathies, Chronic Pain
Perineural Platelet-rich Plasma for Diabetic Neuropathy Pain
Peripheral neuropathy is very common in diabetes mellitus (DM). Till now there is no available effective therapy for this pathology.
- Trial name
- NCT03601494
- Testing
- perineural injection of platelet-rich plasma, medical
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Diabetic Neuropathy, Painful, Diabetic Neuralgia
Treatment of Painful Diabetic Neuropathy With Photon Stimulation
1. Objectives: 1. To assess the efficacy of Photon Stimulation compared with placebo, in treating the pain of diabetic neuropathy. 2.
- Conditions
- Diabetic Neuropathy, Painful, Diabetic Neuralgia, Diabetic Polyneuropathy, Diabetic Mononeuropathy
- Trial name
- NCT00539175
- Testing
- infrared light
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- East Bay Institute for Research and Education
Diabetic Foot Ulcers
A Prospective Study of Endothelial Dysfunction and Diabetic Foot Ulcer Risk
This project will identify risk factors for diabetic foot ulcer by studying the relationship between endothelial dysfunction and foot ulcer risk.
- Trial name
- NCT00013286
- Testing
- Prevention Diabetic Foot Ulcer
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- US Department of Veterans Affairs
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Magnetic Resonance Diagnostics of Diabetic Peripheral Neuropathy
This project aims to develop high field MR techniques to detect nerve lesions in diabetic patients. The MRI findings will be compared to results from conventional evaluations and nerve conduction studies to determine the validity…
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Polyneuropathy, Hereditary Axonal Neuropathy
- Trial name
- NCT01847937
- Where
- 5 sites in Denmark, Germany
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Diabetic Peripheral Neuropathy, Diabetic Neuralgia
Neuragen for Peripheral Diabetic Neuropathy
The purpose of this study is to determine if the use of Neuragen (a natural health product oil rubbed into the skin) is effective at reducing pain and improving the quality of life in people with diabetic peripheral neuropathy.
- Trial name
- NCT00861952
- Testing
- Neuragen, Mineral oil
- Where
- 2 sites in Canada
- Sponsor
- The Canadian College of Naturopathic Medicine
Diabetes Complications, Diabetic Neuropathies
Enhance Balance and Mobility in People With Type 2 Diabetic Peripheral Neuropathy
Type 2 diabetes results in a host of neuromuscular, muscular, and autonomic system impairments that accelerate age-associated limitations in functional independence and the risk of falls.
- Trial name
- DPN (NCT02541838)
- Testing
- Muscle power, balance perturbation, aerobic exercise
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- University of Maryland, Baltimore
Diabetic Foot, Diabetic Foot Ulcer
Digital Foot Check by Using the D-Foot, a New Software
Patients with diabetes should be thoroughly examined before they are provided with insoles and shoes. In the study the feet are examined with the help of a new software, the D-Foot. D-Foot includes questions and surveys.
- Conditions
- Diabetic Foot, Diabetic Foot Ulcer, Diabetic Foot Ulcer Neuropathic, Neuropathy;Peripheral
- Trial name
- D-Foot2019 (NCT04054804)
- Testing
- D-Foot
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Sahlgrenska University Hospital
Diabetic Neuropathies, Herpes Zoster
Dextromethorphan Versus Placebo for Neuropathic Pain
In our current clinical trial, we are comparing the effects of two NMDA receptor antagonists to placebo in patients with painful distal symmetrical diabetic neuropathy or post-herpetic neuralgia.
- Conditions
- Diabetic Neuropathies, Herpes Zoster, Neuralgia
- Trial name
- NCT00001344
- Testing
- dextromethorphan
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Diabetes Mellitus, Diabetic Neuropathies
Vitamin B12 Supplementation in Diabetic Neuropathy
This prospective double-blind placebo-controlled trial aims to investigate the safety and efficacy of oral dispersible tablet of vitamin B12 for 1 year, in 90 patients with diabetes mellitus type 2 and neuropathy.
- Conditions
- Diabetes Mellitus, Diabetic Neuropathies, Diabetic Complication, Diabetic Foot
- Trial name
- NCT04706377
- Testing
- B12 fix 1000mcg
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- Aristotle University Of Thessaloniki