Clinical trials: Neuropathy
Neuropathy;Peripheral, Thermal Hypesthesia
Effect of Topical Lidocaine on Warm and Cold Sensation in Healthy Individuals
The purpose of the present study is to systematically test the occurrence of paradoxical and illusory responses to cold and warm stimuli in healthy volunteers with artificial sensory loss.
- Trial name
- NCT04865185
- Testing
- Xylocaine spray 100mg/ml, Ethanol
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Sciatica, Low Back Pain
Effect of Muscle Energy Techniques on Functional Abilities in Patients With Discogenic Unilateral Sciatica
The purpose of the study to investigate the effect of muscle energy techniques on functional abilities of patients with chronic discogenic unilateral sciatica and to explain it from a physiological and functional point of view
- Trial name
- NCT04918238
- Testing
- Conventional program, Muscle energy technique
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Horus University
Carpal Tunnel Syndrome, Psoriatic Arthritis
Carpal Tunnel Syndrome in Patients With Psoriatic Arthritis
This study aimed to investigate median nerve hypervasculatitation in psoriatic arthritis (PsA) patients with CTS or without CTS by using SMI, then compare them with normal people.
- Trial name
- NCT05086029
- Testing
- Superb Microvascular Imaging
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Cubital Tunnel Syndrome
Cubital Tunnel Syndrome and Diffusion MRI: A Proof of Concept Study
Cubital Tunnel Syndrome (CTS) results from compression of the ulnar nerve at the elbow (colloquially termed the "funny bone"). CTS affects up to 6% of the population and 6000 patients undergo surgery annually in the UK.
- Trial name
- NCT04470245
- Testing
- magnetic resonance imaging (MRI)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Diabetes Mellitus, Type 2, Diabetic Polyneuropathy
Use of GDF15 as a Biomarker for Early Diagnosis of DM and Monitoring of Progress of Complications in Asians
Significant differences in the expression of individual Growth Differentiation Factor 15 (GDF-15) proteins among Taiwanese harboring different mitochondrial genotypes are noted, and their blood serum levels also exhibited…
- Conditions
- Diabetes Mellitus, Type 2, Diabetic Polyneuropathy, Diabetic Nephropathies
- Trial name
- NCT04119167
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Chemotherapy-induced Peripheral Neuropathy
Evaluation by Oncologists of Strategies for the Prevention and Treatment of Chemotherapy-induced Peripheral Neuropathies
Chemotherapy induced peripheral neuropathy (CIPN) is one of the most deleterious adverse effect of neurotoxic anticancer drugs affecting up to 40% of patients.
- Trial name
- EVANEURO (NCT03854864)
- Testing
- survey
- Where
- France
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Complex Regional Pain Syndrome, Sciatica
[18F]FTC-146 PET/MRI in Healthy Volunteers and in CRPS and Sciatica
Chronic pain can result from injured or inflamed nerves, as occurs in people suffering from sciatica and CRPS. These nerve injuries or regions of nerve irritation are often the cause of pain in these conditions, but the current…
- Trial name
- NCT02753101
- Testing
- [18F]-FTC-146
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Stanford University
Carpal Tunnel Syndrome
Treatment of Carpal Tunnel Syndrome With Dynamic Splinting
The Purpose of this study is to examine the effect of using the Carpal Tunnel Dynasplint® System on patients diagnosed with CTS in a randomized, controlled, cross-over study.
- Trial name
- NCT00558116
- Testing
- Dynamic splinting
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Advanced Centers for Orthopaedic Surgery and Sports Medicine
Carpal Tunnel Syndrome (CTS)
Diagnostic Value of Digital Infrared Thermographic Imaging in Diagnosing Carpal Tunnel Syndrome
The goal of this observational study is to evaluate skin temperature patterns measured by infrared thermography in patients with carpal tunnel syndrome (CTS).
- Trial name
- NCT07699289
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Small Fiber Neuropathy
Autofluorescent Flavoprotein Imaging of Intraepidermal Nerve Fibers: a Pilot Study
Small fiber neuropathy (SFN) is a common disorder, which has a profound negative impact on quality of life because of severe neuropathic pain.
- Trial name
- NCT02537951
- Testing
- AFI microscope, negative control 1: lidocaine/prilocaine, negative control 2: 8% capsaicin
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Breast Cancer, Peripheral Neuropathy
NBP in Women With Metastatic Breast Cancer to Prevent Nab-paclitaxel Induced Toxic Neuropathy
Phase 2, randomized, double-blind, Placebo-Controlled, Multiple Dose Study for the treatment of Patients with Metastatic Breast Cancer.
- Trial name
- NCT04675450
- Testing
- NBP Softgel Capsules
- Volunteers
- healthy volunteers welcome
- Sponsor
- Conjupro Biotherapeutics, Inc.
Carpal Tunnel Syndrome
Lidocaine With Epinephrine vs. Bupivacaine With Epinephrine as Local Anesthetic Agents in Wide-awake Hand Surgery
This study is focused on comparing patients' pain scores on a visual analogue scale (VAS) and the difference in analgesics use post-operatively (with the same prescription defining only the maximum frequency) between lidocaine…
- Trial name
- NCT02315573
- Testing
- Wrist block anesthesia
- Where
- Canada
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- St. Mary's Research Center, Canada
Complex Regional Pain Syndromes, Fibromyalgia
Virtual Environment Rehabilitation for Patients With Motor Neglect Trial
Motor neglect describes a loss of function without a loss of strength, reflexes or sensation. Motor neglect has been described in patients with traumatic brain injury, stroke and chronic pain conditions, e.g.
- Conditions
- Complex Regional Pain Syndromes, Fibromyalgia, Stroke, Traumatic Brain Injury
- Trial name
- VERMONT (NCT03887962)
- Testing
- Virtual Environment Biofeedback, Treadmill walking with no Virtual Environment Biofeedback
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Overactive Bladder
Urinary Neurotrophin Levels in Healthy Children
The aim of this study is to analyse urinary neurotrophin levels in healthy children. Urine samples will be collected at 3 different times of day (morning, noon, and evening) at urge sensation from all age groups of children who…
- Trial name
- NCT02389270
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Zagreb
Intensive Care Unit Acquired Weakness, Intensive Care Unit Delirium
Efficacy of the "Start to Move" Protocol on Functionality, Delirium and Acquired Weakness in ICU
Background: ICU hospitalization is associated with loss of strength, functionality and delirium. The "Start to Move protocol" demonstrated efficacy in improving and minimizing such effects.
- Conditions
- Intensive Care Unit Acquired Weakness, Intensive Care Unit Delirium, Intensive Care Neuropathy, Intensive Care Unit Syndrome
- Trial name
- STM (NCT05053724)
- Testing
- Star to move Protocol
- Where
- Chile
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Hospital Felix Bulnes
Lower Limb Amputation, Drop Foot
Evaluating Mobility Interventions in the Real World
This study is intended to test the comparative biomechanical benefits of different lower-limb prostheses and orthoses using data collected over extended periods of everyday life using wearable sensors.
- Trial name
- NCT04275973
- Testing
- Lower limb prostheses, Orthoses for Drop-foot
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Buerger's Exercises and Proprioceptive Drills on Postural Stability and Foot Perfusion in Elderly Patients With Chemotherapy
Buerger's Exercises and Proprioceptive Drills on Postural Stability and Foot Perfusion in Elderly Patients With Chemotherapy
Chemotherapy-induced peripheral neuropathy (CIPN) is a common, dose-limiting side effect of neurotoxic chemotherapy agents, characterized by sensory loss, impaired proprioception, and muscle weakness, predominantly affecting the…
- Trial name
- NCT07756073
- Testing
- Buerger's Exercises
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- South Valley University
All Minor Hand Surgery Including, Carpal Tunnel Syndrome
Nylon Versus Chromic Gut Sutures for Minor Hand Surgery
This study aims to assess the relationship between overall satisfaction with treatment in a group of randomized patients undergoing elective hand surgery using either absorbable (4-0 Chromic) or non-absorbable (5-0 Nylon)…
- Conditions
- All Minor Hand Surgery Including, Carpal Tunnel Syndrome, Trigger Finger, Ganglion Cysts
- Trial name
- NCT03407820
- Testing
- Absorbable Chromic gut sutures, Non-absorbable Nylon sutures
- Where
- 3 sites in United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Peripheral Neuropathy Due to Chemotherapy
Fall Risk and Quality of Life: in Individuals With Cancer Treatment Related Peripheral Neuropathy.
The purpose of this research is to examine the impact of peripheral neuropathy on fall risk and quality of life in people who had cancer and neuropathy from cancer treatments.
- Trial name
- NCT06313359
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Texas Woman's University
Diabetic Peripheral Neuropathy
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Food Effect of SYHA1402 in Healthy Subjects
A Multiple Doses Study to Evaluate the Safety, Tolerability, Pharmacokinetics (Including Food Effect) of SYHA1402 in Healthy Subjects.
- Trial name
- NCT04453618
- Testing
- FE-SYHA1402 100mg, SYHA1402-25mg, SYHA1402-50mg
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.