Clinical trials: Neuropathy
Chronic Pancreatitis
Pain Phenotypes in Chronic Pancreatitis
Chronic pancreatitis (CP) is characterised by recurrent abdominal pain. The pathological hallmarks of CP is pancreatic stellate cell activation that results in persistent inflammation and progressive fibrosis.
- Trial name
- PIP (NCT05713344)
- Testing
- Clinical history, Clinical examination, Evaluation of quality of life
- Where
- India
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Diabetes Mellitus, Peripheral Neuropathy
Diabetes Peripheral Neuropathy and Small-fibre Nerve Damage: A Comparative Study
The purpose of this study is to investigate whether patients with diabetes-related peripheral neuropathic pain also have non-recognized damage to the intestine caused by autonomic neuropathy.
- Conditions
- Diabetes Mellitus, Peripheral Neuropathy, Small Fibre Neuropathy, Autonomic Neuropathy
- Trial name
- NCT01160887
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Carpal Tunnel Syndrome
The Effectiveness of Extracorporeal Shock Wave Therapy for Management of Carpal Tunnel Syndrome
Peripheral nerve entrapment neuropathies are the most common mononeuropathies in clinical practice. Carpal Tunnel Syndrome (CTS), n.
- Trial name
- NCT05681663
- Testing
- Electroshock Wave therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ahi Evran University Education and Research Hospital
Carpal Tunnel Syndrome
Efficacy of Pulsed Radiofrequency of the Median Nerve Under Ultrasound Guidance in Patients With Carpal Tunnel Syndrome
Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy. Although many conservative forms of management including the use of wrist splint, steroid injections and therapeutic ultrasound are applicable…
- Trial name
- NCT02217293
- Testing
- Pulsed Radiofrequency
- Where
- Taiwan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Tri-Service General Hospital (TSGH)
Wound Heal, Diabetic Foot Ulcer
Effect of Topical Ozone on The Healing Diabetic Foot Ulcer
Despite conflicting and contradictory evidence regarding its efficacy, some wound care centres have advocated and adopted ozone for treating DFU. However, there are gaps in the application of topical ozone therapy.
- Conditions
- Wound Heal, Diabetic Foot Ulcer, Ozone
- Trial name
- NCT05977309
- Testing
- Topical ozone therapy
- Where
- Indonesia
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Asmat Burhan
Small Fiber Neuropathy, Primary Sjögren Syndrome
Cutaneous Silent Period Assessment in Primary Sjögren's Syndrome
Primary Sjögren's syndrome (pSS) is a chronic, immune-mediated inflammatory disease mainly characterized by exocrine gland involvement.
- Trial name
- NCT05380804
- Testing
- cutaneous silent period (CSP) measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Marmara University
Dry Needling, Carpal Tunnel Syndrome
Dry Needling and Rehabilitatin Carpal Tunnel Syndrome
Dry needling is used for myofascial release. However, its effectiveness in carpal tunnel syndrome (CTS) is not well known. It is thought that dry needling may also be an effective treatment for CTS by providing relaxation in the…
- Conditions
- Dry Needling, Carpal Tunnel Syndrome, Myofacial Pain
- Trial name
- NCT06358326
- Testing
- Dry needling, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Mitochondrial Diseases, Developmental Delay Disorder
Reference Values of Intraepidermal Nerve Fiber Density in Children and Small Fiber Neuropathy in Neurodevelopmental Disorders
Background: Small-Fiber-Neuropathy describes the degeneration of mildly or unmyelinated nerve fibers and causes neuropathic pain and autonomic dysfunction.
- Conditions
- Mitochondrial Diseases, Developmental Delay Disorder, Small Fiber Neuropathy, Cerebral Palsy
- Trial name
- SFN_children (NCT05645874)
- Testing
- Skin biopsy
- Where
- Germany
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Peripheral Neuropathy Due to Chemotherapy
Preventive Approach Using Venlafaxine
Peripheral and Motor neuropathy represent a main obstacle for a better quality of life for cancer patients, Venlafaxine is introduced in a new dosing regimen for treating of oxaliplatin and taxanes induced peripheral neuropathy…
- Trial name
- NCT05875610
- Testing
- Venlafaxine 75 MG, Gabapentin 400 mg
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mit Ghamr Oncology Center
Safety, Peripheral Neuropathy
Xanamem™ in Healthy Elderly Subjects
Xanamem™ is being developed as a potential drug for Alzheimer's disease. This study drug has been designed to change the cortisol levels in the brain. Cortisol is a naturally occurring hormone in the body.
- Conditions
- Safety, Peripheral Neuropathy, Cortisol, Central Nervous System
- Trial name
- XanaHES (NCT03830762)
- Testing
- Xanamem
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Actinogen Medical
Small Fiber Neuropathy, Diabetic Neuropathies
Skin Biopsy in the Diagnosis of Small Fiber Neuropathy in Chinese Patients With Diabetes
To detect small fiber neuropathy in patients with possible or established diabetic peripheral neuropathy (DPN) by skin biopsy and explore clinical characteristics and pathological features in Chinese patients with diabetes.
- Conditions
- Small Fiber Neuropathy, Diabetic Neuropathies, Diabetes Mellitus
- Trial name
- NCT04071535
- Testing
- sudoscan、nerve conduction tests
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Non-arteritic Ischemic Optic Neuropathy
Citicoline in Non-Arteritic Ischemic Optic Neuropathy
The investigators tested the hypothesis whether the treatment with Citicoline in oral solution (OS-Citicoline) would increase or stabilize visual acuity, retinal ganglion cells (RGCs) function and neural conduction along the…
- Trial name
- NCT03758118
- Testing
- Citicoline
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione G.B. Bietti, IRCCS
Cubital Tunnel Syndrome
Cubital Tunnel Syndrome and Diffusion MRI: A Proof of Concept Study
Cubital Tunnel Syndrome (CTS) results from compression of the ulnar nerve at the elbow (colloquially termed the "funny bone"). CTS affects up to 6% of the population and 6000 patients undergo surgery annually in the UK.
- Trial name
- NCT04470245
- Testing
- magnetic resonance imaging (MRI)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Intensive Care Unit Acquired Weakness, Intensive Care Unit Delirium
Efficacy of the "Start to Move" Protocol on Functionality, Delirium and Acquired Weakness in ICU
Background: ICU hospitalization is associated with loss of strength, functionality and delirium. The "Start to Move protocol" demonstrated efficacy in improving and minimizing such effects.
- Conditions
- Intensive Care Unit Acquired Weakness, Intensive Care Unit Delirium, Intensive Care Neuropathy, Intensive Care Unit Syndrome
- Trial name
- STM (NCT05053724)
- Testing
- Star to move Protocol
- Where
- Chile
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Hospital Felix Bulnes
Diabetic Foot, Diabetic Neuropathies
Peripheral Protective Sensation in Type 2 Diabetes Mellitus
The aim of our study was to investigate the effect of sole sensation on peripheral muscle strength, functional capacity, balance and physical activity level in individuals with Type 2 Diabetes Mellitus.
- Trial name
- NCT05904262
- Testing
- Foot Sole Sensation Evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Istanbul Kent University
Autonomic Neuropathy
A Comparison Between Pupillometry, Heart Rate Variability and Metaiodobenzylguanidine Scintigraphy for the Diagnosis of Early Diabetic Autonomic Neuropathy in Type 1 Diabetes
This study will examine if one of the following methods: pupillometry, spectral analysis of heart rate variability and metaiodobenzylguanidine scintigraphy, is more capable to detect early diabetic autonomic neuropathy in…
- Trial name
- NCT01822431
- Testing
- metaiodobenzylguanidine scintigraphy
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- AHEPA University Hospital
Neuropathic Pain
Brain Activation During Thermal Stimulation in Neuropathic Pain
Patients with peripheral neuropathy frequently exhibit treatment-refractory neuropathic pain. Although both peripheral and central determinants are recognized for the pathophysiological basis of neuropathic pain following…
- Trial name
- NCT00525018
- Testing
- contact heat evoked potential stimulator
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Axonal Change, Neuronal, Pain
Effect of the Kv7-channel Opener Flupirtine on the Excitability of Human Peripheral Myelinated Axons in Vivo
Slow axonal Kv7 potassium channels are found along unmyelinated axons and at the nodes of Ranvier of myelinated axons in peripheral nerve.
- Trial name
- NCT01450865
- Testing
- flupirtine
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Carpal Tunnel Syndrome (CTS)
Ultrasound Elastography of Carpal Tunnel Syndrome
Carpal Tunnel Syndrome (CTS) is the most common peripheral nerve compression disorder in adults. Although electromyography (EMG) is the current gold standard for diagnosis, it is invasive, time-consuming, and may yield…
- Trial name
- UE-CTS (NCT07486284)
- Testing
- Ultrasound Elastography
- Where
- Vietnam
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Da Nang Family General Hospital
Diabetes Mellitus
INTACT Trial - an Observational Study to Assess Neuropathy in Diabetic Children
It is a prospective, cross-sectional, observational, controlled, single centre clinical study. Diabetic patients fulfilling the inclusion criteria and healthy controls will have uroflowmetry examination, cardiovascular autonomic…
- Trial name
- INTACT (NCT05247840)
- Testing
- uroflowmetry, Cardiovascular autonomic dysfunction test proposed by Ewing et al., peripheral nerve conduction test
- Where
- Hungary
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Heim Pal Children's Hospital