Clinical trials: Neuroplasticity
Spinal Cord Injuries
Measuring the Neurological Benefits of Intermittent Hypoxia Therapy With MRI
This study uses Magnetic Resonance Imaging to image the brain and spinal cord before and after an Intermittent Hypoxia intervention.
- Trial name
- NCT05183113
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Stroke
High-definition Transcranial Electrical Stimulation for Upper Extremity Rehabilitation
Upper limb hemiparesis is the most common sequelae in patients, severely impacting their independence and quality of life. Transcranial electrical stimulation (tCES) is a non-invasive and safe treatment, which uses a low direct…
- Trial name
- NCT06409143
- Testing
- HD-tES, UE rehabilitation, HD-tES (Bilateral)
- Where
- 3 sites in Taiwan
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Auditory Perceptual Disorders, Aging Problems
Neuroplasticity in Auditory Aging_Project 2 Aims 1 and 2
Millions of elderly adults in the USA have age related hearing loss (ARHL), a malady that affects half of adults 60-69 years, and the majority of older adults.
- Trial name
- NCT03475043
- Testing
- Auditory training: temporal cues
- Where
- United States
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Cognitive Change
Brain Exercises for Synaptic Plasticity
The BEST study will investigate the feasibility of cognitive interventions in a randomized, placebo-controlled, clinical trial. The investigators will recruit 45 cognitively normal subjects and engage them in one of three cohorts…
- Trial name
- BEST (NCT03058055)
- Testing
- Origami, Reading
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Brain Function, Cerebral Palsy
7T Anatomo-functional Characterization of Structures in the Action Observation Network
The goal of this study is to explore the anatomical-functional characteristics of the AON circuit (with particular interest for subcortical areas and the cerebellum), and the cortico-subcortical connectivity of the nodes of the…
- Trial name
- 7T-ATHENA (NCT06826287)
- Testing
- 7T MR exam, clinical assessment
- Where
- 2 sites in Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Stroke
Potentiation of Procedural Motor Learning in Health and Disease
The investigators plan to improve the learning of motor skills by pharmacological means (dopamine), and by noninvasive brain stimulation. They will study both healthy subjects and chronic stroke patients.
- Trial name
- NCT00126087
- Testing
- dopamine
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Healthy Control Subjects
Impact of Spaced iTBS on Plasticity in the Motor Cortex
The goal of this clinical trial is to explore the effects of non-invasive brain stimulation protocols using intermittent theta-burst stimulation (iTBS) on brain plasticity in healthy, right-handed individuals aged 18 to 50 years.
- Trial name
- STEP-MC (NCT06735794)
- Testing
- Compressed iTBS, Spaced iTBS
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Visual Cortical Plasticity, Repetitive Transcranial Magnetic Stimulation
Measuring rTMS-induced Neuroplasticity With EEG Steady-state Visual-evoked Potentials
The goals of this study are to 1) use EEG steady-state visual evoked potentials as a noninvasive measure of the neuroplasticity induced by repetitive transcranial magnetic stimulation (rTMS), 2) use visual contrast detection…
- Conditions
- Visual Cortical Plasticity, Repetitive Transcranial Magnetic Stimulation, Visual Attention
- Trial name
- NCT05853939
- Testing
- repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Stroke With Hemiparesis
Transfer of Grasp Control Across Hands After Stroke
The purpose of this study is to examine if the strong hand can assist in the recovery of muscle function in the weak hand after a stroke.
- Trial name
- NCT00589368
- Testing
- Transfer of grasp control across hands
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Alzheimer's Disease
Enhancing Working Memory in Patients With Early Alzheimer's Disease Through the Use of rTMS
In this study the investigators aim at assessing and then enhancing neuroplasticity in the dorsolateral prefrontal cortex (DLPFC) and working memory - a key function of DLPFC - in patients with mild Alzheimer's disease (AD).
- Trial name
- rTMS-AD (NCT02537496)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Cervical Spinal Cord Injury
Combined Therapeutic Air Mixture and Electrical Stimulation to Improve Breathing and Hand Function in Spinal Cord Injury
The goal of this clinical trial is to determine whether people with paralysis due to a spinal cord injury can benefit from breathing short intermittent bouts of air with low oxygen (O2) combined with slightly higher levels of…
- Trial name
- AIHH+tSCS (NCT06101199)
- Testing
- Acute Intermittent Hypercapnic Hypoxia, Transcutaneous spinal cord stimulation
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Alzheimer's Disease
Neuroplasticity Enhancement From Cognitive Training Reinforced by Psilocybin
Background: Normal aging, as well as dementias such as Alzheimer s disease, can cause changes in the brain that affect memory, attention, and thinking.
- Trial name
- NCT07721467
- Testing
- Psilocybin, Cognitive Training
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Olfactory Disorder
Steroid Nasal Irrigation for Flavor Evaluation and Detection Study
The purpose of this research study is to examine the efficacy of a 12-week smell training intervention for participants with olfactory dysfunction following an infection of the upper respiratory tract.
- Trial name
- SNIFFED (NCT02985515)
- Testing
- Smell training
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Healthy Controls
Serotonin and Motor Plasticity
With this study, the investigators aim to test whether acute administration of selective serotonin reuptake inhibitors (SSRI) improves motor performance in a sequential motor learning task in comparison to placebo in healthy…
- Trial name
- NCT03162185
- Testing
- Escitalopram
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Max Planck Institute for Human Cognitive and Brain Sciences
Healthy Participants
Dopamine and Brain Computer Interface
The use of Brain-Computer Interface system (BCI system) allows for the detection of neurophysiological signals on the surface of the head and provides feedback to subjects or patients.
- Trial name
- BCI_LDOPA (NCT06729658)
- Testing
- Madopar
- Where
- Germany
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Max Planck Institute for Human Cognitive and Brain Sciences
Anxiety, Depressive Symptoms
A Single-Session Intervention for Adolescents and Young Adults With Internalizing Problems
With the increasing number of adolescents and young adults (AYA) experiencing depression and anxiety, paired with the lack of time, access, and funding towards social services, AYA need a mental health intervention that is…
- Trial name
- NCT05826392
- Testing
- Adolescent/Young Adult Self-Administered Web-Based Single-Session Intervention
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Stroke, Chronic, Aging
AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions
The AMPLIFI study (Adaptive Modulation of Plasticity through Lactate and Fitness Interventions) investigates how short-term aerobic exercise influences brain plasticity and learning in older adults and stroke survivors.
- Conditions
- Stroke, Chronic, Aging, Cognitive Decline, Motor Dysfunction
- Trial name
- AMPLIFI (NCT06950060)
- Testing
- High intensity cycling, Low-intensity cycling, Health education session
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy Volunteer
Combining Motor Imagery and Tendon Vibration on the Effectiveness of Motor Imagery
Kinesthetic motor imagery (kMI) involves imagining the sensations of movement, activating brain regions similar to actual movement execution.
- Trial name
- IMVT (NCT06845176)
- Testing
- Tendon vibration (TV), Kinesthetic motor imagery (kMI)
- Where
- France
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Multiple Sclerosis
Improving Hand Movement and Coordination in People With Multiple Sclerosis Using Transcranial Magnetic Stimulation (TMS) and Muscle Electrostimulation (FES) To Support Manual Dexterity and Daily Function
The goal of this interventional study is to test whether combining transcranial magnetic stimulation (TMS) with functional electrical stimulation (FES) can improve hand and upper limb function in adults with Multiple Sclerosis…
- Trial name
- MANTRAStim (NCT07098273)
- Testing
- TMS and FES- based rehabilitation, FES-based rehabilitation
- Where
- 2 sites in Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Schizophrenia
Glutamate, Learning, and Working Memory
Impairments in plasticity and working memory in schizophrenia have been hypothesized to reflect dysfunction at the N-methyl-D-aspartate glutamate receptor (NMDAR).
- Trial name
- NCT02769936
- Testing
- D-cycloserine
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles