Clinical trials: Neuroplasticity
Sedentary Behavior
Cognition and Neuroplasticity Sedentary Adults After 8 Weeks of Aerobic Exercise
The overall goal of the proposed study is to evaluate the effects of an 8-week aerobic exercise program on cognition and determine the relationship between cognitive improvements and Transcranial Magnetic Stimulation (TMS)…
- Trial name
- NCT03804528
- Testing
- Aerobic Exercise
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Miami
Reproducibility of Results
Reproducibility of Brain MRI
The aim of this study is to assess the reproducibility over time of functional and structural magnetic resonance imaging, as well as specific biomarkers in plasma in healthy volunteers before and after a two-hour rest.
- Trial name
- DANA0 (NCT03876236)
- Where
- 2 sites in Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
ACL Injury
Neuroplasticity Associated With Anterior Cruciate Ligament Injury
Activation of the brain for knee movement changes after anterior cruciate ligament (ACL) reconstruction. The brain activation profile after ACL reconstruction indicates a shift to a visual-motor control strategy, as opposed to a…
- Trial name
- NCT03654495
- Testing
- Exergame training, Usual Care Training
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
SCI - Spinal Cord Injury, Cardiovascular Risk Factor
Cardiovascular Risk Markers in Spinal Cord Injured Subjects of the Wheelchair Dancer Study
The present study will analyze if exercise is able to elicit the well-known anti-atherogenic effects in patients with SCI. This will be evaluated by measuring vascular parameters such as endothelial and inflammatory blood…
- Trial name
- NCT03352505
- Where
- 2 sites in Austria
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Paracelsus Medical University
Cognitive Ability, General, Brain Health
Investigating the Combined Effects of Intermittent Hypoxia and Exercise on Cognitive and Cerebral Function in Middle-Aged Adults
This study investigates whether intermittent hypoxia (IH) and physical activity (PA), either alone or in combination (simultaneously or sequentially), can improve cognitive function and brain health in middle-aged adults (50-65…
- Conditions
- Cognitive Ability, General, Brain Health, Cerebral Oxygenation
- Trial name
- HYPOX-AGE (NCT06874387)
- Testing
- Hypoxia, intermittent, physical exercise
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Ayoub Boulares
Amelia of Upper Limb
Computer-aided and Mental Trainings Induced Plasticity of Sensorimotor Cortex in Patients Born Without Upper Limbs
This project will explore a potentially powerful trainings that may be administered before upper extremity transplantation to induced plasticity of sensorimotor cortex in humans with congenital absence of upper limbs.
- Trial name
- NCT04048083
- Testing
- Mental trainings, Computer-aided trainings, Computer-aided and mental trainings
- Where
- Poland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Wroclaw University of Health and Sport Sciences
Healthy Adults, Adults With Stress-related Symptoms
Exercise Intensity on Brain & Mental Health in Stress
This study aims to examine the role of exercise intensity in the acute effects of a single bout of aerobic exercise on neurotrophic factors, biomarkers of stress and inflammation, working memory task-related changes in prefrontal…
- Trial name
- ExStress (NCT06245538)
- Testing
- Seated rest, Exercise at moderate intensity, Exercise at vigorous intensity
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The Swedish School of Sport and Health Sciences
Schizophrenia
Cerebral Reorganization in Schizophrenia
The purpose of this study is to reveal the specific effects of computer-aided cognitive training on cerebral reorganization in schizophrenia
- Trial name
- NCT01781000
- Testing
- Brain Fitness & Brain Training- Posit Science, Facial Affect Training- FAT, Treatment as usual
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Konstanz
Depression, Major Depressive Disorder
RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS
In this research study, investigators examine how brain activity changes during tests of emotional processing, attention, and memory using multimodal neuroimaging methods including electroencephalography (EEG), functional…
- Conditions
- Depression, Major Depressive Disorder, Suicidal Ideation
- Trial name
- NCT05977439
- Testing
- Single-Pulse Transcranial Magnetic Stimulation, EEG-Synchronized Repetitive Transcranial Magnetic Stimulation (rTMS), Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Breast Pain, Mastalgia
Hormones, Outcomes, and Pain Pathways in Exercise Study
The goal of the proposed project is to evaluate a mechanical intervention (sports bras designed specifically for full busted women) to alleviate neck, shoulder, arm, and back pain in full-busted women and investigate the…
- Conditions
- Breast Pain, Mastalgia, Back Pain, Back Pain, Low
- Trial name
- HOPE (NCT07579182)
- Testing
- Interventional Sports bra
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Houston
Dravet Syndrome (DS)
Biomarkers of Neurodegeneration, Synaptic Plasticity and Neuroinflammation in Dravet Syndrome
Dravet syndrome (DS) is a developmental and epileptic encephalopathy, usually caused by de novo pathogenic SCN1A variants, characterized by early-onset prolonged febrile seizures, subsequent drug-resistant polymorphic epilepsy…
- Trial name
- TEMBO-DS (NCT07801404)
- Where
- 9 sites in Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Morphine, Itch
A Relation of Morphine-induced Itch and Pain Processing
In This experiment, the investigators would like to test the two following hypotheses regarding the mechanisms by which opioids cause itch: 1.
- Trial name
- NCT04115462
- Testing
- Morphine, Histamine, Cowhage (Mucuna Pruriens)
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Gender Dysphoria
Cross-sex Hormone Therapy and Neuronal Plasticity
Transgender women (male-to-female) were invited to participate in this study to test the impact of Cross-Sex Hormone Therapy (CSHT) in the brain.
- Trial name
- NCT03651427
- Testing
- Estradiol
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Head Injury
Warfighter Head Injury Study
This study will examine the long-term outcome of brain injuries, the effects of treatment on outcome and the effects of brain injury on people s behavior and abilities.
- Trial name
- NCT00754169
- Where
- United States
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Alzheimer's Disease
Enhancing Neuroplasticity and Frontal Lobe Function in Patients With Mild Alzheimer's Disease
The purpose of this study is to determine if a novel brain stimulation approach using magnetic stimulation (Transcranial Magnetic Stimulation [TMS]) can improve memory and thinking processes in individuals with mild Alzheimer's…
- Trial name
- TMS-AD (NCT01847586)
- Testing
- Paired Associative Stimulation, Paired Associative Stimulation-Control
- Where
- Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Anxiety Disorders
Biomarkers for Exercise
The overarching objective is to examine the brain-based biological mechanistic pathway by which exercise exerts anxiolytic effects.
- Trial name
- NCT07340281
- Testing
- Exercise Intervention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Brain Injuries
D-aspartate and Therapeutic Exercise
An important mechanism responsible for clinical recovery after neurological damage of different types is synaptic plasticity. Nervous tissue can enhance or de-energize inter-neuronal transmission at synaptic level in a lasting…
- Trial name
- DAsp&TerapEx (NCT03228524)
- Testing
- D-Aspartate, Therapeutic exercise
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Parkinson Disease, Physical Activity
Physical Training Induced Plasticity of Motor Control Mechanisms in Parkinson's Disease Patients
There are experimental evidences of the important role of exercise in the PD, that induces similar effects to pharmacotherapy. So far, the mechanisms of the impact of these changes on the brain subcortical and cortical regions…
- Trial name
- NCT03753503
- Testing
- exercise, conventional physical therapy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wroclaw University of Health and Sport Sciences
Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting
The Synergistic Effects of AIH and FES in Persons With MS
The purpose of this study is to examine how neuromuscular electrical stimulation (NMES), may synergistically enhance corticospinal excitability in people with relapsing form multiple sclerosis (MS).
- Conditions
- Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Secondary Progressive
- Trial name
- NCT06413602
- Testing
- Acute Intermittent Hypoxia, Neuromuscular Electrical Stimulation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Stroke
HEROES: Human Extremity Robotic Rehabilitation and Outcome Enhancement for Stroke
HEROES is a multidisciplinary neurophysiological \& neural rehabilitation engineering project, developed by the Lab of Medical Physics \& Digital Innovation, School of Medicine, Faculty of Health Science Aristotle University of…
- Trial name
- HEROES (NCT06160453)
- Testing
- Brain-Computer Interface control of robotic arms with augmented reality, Serious game with augmented reality
- Where
- Greece
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki